ZA986593B - A method for the treatment of staphylococcal disease - Google Patents

A method for the treatment of staphylococcal disease

Info

Publication number: ZA986593B
Authority: ZA; South Africa
Prior art keywords: lysostaphin; staphylococcal; treatment; staphylococcal disease; penicillins
Prior art date: 1997-07-23

Application number

ZA986593A

Other languages

English (en)

Inventor

Beth P Goldstein

Michael W Climo

Richard P Novick

Gordon L Archer

Original Assignee

Ambi Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-23

Filing date

1998-07-23

Publication date

1999-02-04

1998-07-23 Application filed by Ambi Inc filed Critical Ambi Inc

1999-02-04 Publication of ZA986593B publication Critical patent/ZA986593B/xx

Links

201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
108090000988 Lysostaphin Proteins 0.000 abstract 3
241000894006 Bacteria Species 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
229930182555 Penicillin Natural products 0.000 abstract 1
206010041925 Staphylococcal infections Diseases 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
230000000941 anti-staphylcoccal effect Effects 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
MYPYJXKWCTUITO-KIIOPKALSA-N chembl3301825 Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)C(O)[C@H](C)O1 MYPYJXKWCTUITO-KIIOPKALSA-N 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000007911 parenteral administration Methods 0.000 abstract 1
150000002960 penicillins Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24075—Lysostaphin (3.4.24.75)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA986593A 1997-07-23 1998-07-23 A method for the treatment of staphylococcal disease ZA986593B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US5347097P	1997-07-23	1997-07-23

Publications (1)

Publication Number	Publication Date
ZA986593B true ZA986593B (en)	1999-02-04

Family

ID=21984478

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA986593A ZA986593B (en)	1997-07-23	1998-07-23	A method for the treatment of staphylococcal disease

Country Status (20)

Country	Link
US (1)	US20020006406A1 (de)
EP (1)	EP1001804B1 (de)
JP (1)	JP2001510805A (de)
KR (1)	KR20010022237A (de)
CN (1)	CN1269727A (de)
AT (1)	ATE316794T1 (de)
AU (1)	AU754806B2 (de)
BR (1)	BR9811535A (de)
CA (1)	CA2297083C (de)
DE (1)	DE69833377T2 (de)
HU (1)	HUP0002662A3 (de)
IL (1)	IL134056A0 (de)
NO (1)	NO320884B1 (de)
NZ (1)	NZ502359A (de)
PL (1)	PL338178A1 (de)
RU (1)	RU2234940C2 (de)
SK (1)	SK732000A3 (de)
TW (1)	TWI235656B (de)
WO (1)	WO1999004809A1 (de)
ZA (1)	ZA986593B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6277399B1 (en)	1997-10-31	2001-08-21	New Horizon Diagnostics Corporation	Composition incorporating bacterial phage associated lysing enzymes for treating dermatological infections
US6399097B1 (en)	1997-10-31	2002-06-04	New Horizons Diagnostics Corporation	Composition for treatment of a bacterial infection of the digestive tract
US6423299B1 (en)	1997-10-31	2002-07-23	Vincent Fischetti	Composition for treatment of a bacterial infection of an upper respiratory tract
US7232576B2 (en)	1997-10-31	2007-06-19	New Horizons Diagnostics Corp	Throat lozenge for the treatment of Streptococcus Group A
US6399098B1 (en)	1997-10-31	2002-06-04	New Horizons Diagnostics Corp	Composition for treating dental caries caused by streptococcus mutans
US6056954A (en) *	1997-10-31	2000-05-02	New Horizons Diagnostics Corp	Use of bacterial phage associated lysing enzymers for the prophylactic and therapeutic treatment of various illnesses
US6432444B1 (en)	1997-10-31	2002-08-13	New Horizons Diagnostics Corp	Use of bacterial phage associated lysing enzymes for treating dermatological infections
US6406692B1 (en)	1997-10-31	2002-06-18	New Horizons Diagnostics Corp	Composition for treatment of an ocular bacterial infection
US6428784B1 (en)	1997-10-31	2002-08-06	New Horizons Diagnostics Corp	Vaginal suppository for treating group B Streptococcus infection
US6569830B1 (en) *	1999-03-05	2003-05-27	Ambi, Inc.	Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains
US7063837B2 (en)	1999-09-14	2006-06-20	New Horizons Diagnostics Corp	Syrup composition containing phage associated lytic enzymes
US20020127215A1 (en) *	1999-09-14	2002-09-12	Lawrence Loomis	Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections
AU2001259205A1 (en) *	2000-04-28	2001-11-12	New Horizons Diagnostic Corporation	The use of bacterial phage associated lysing enzymes for treating various illnesses
US6395504B1 (en)	2000-09-01	2002-05-28	New Horizons Diagnostics Corp.	Use of phage associated lytic enzymes for the rapid detection of bacterial contaminants
US7572439B2 (en) *	2002-03-26	2009-08-11	Biosynexus Incorporated	Enzyme disruption of bacterial biofilms
EP1567868A4 (de) *	2002-12-02	2008-02-06	Biosynexus Inc	ZELLWAND-TEICHONSûURE ALS ZIEL F RANTI-STAPHYLOCOCCUS-THERAPIEN UND -IMPFSTOFFE
AU2003296937A1 (en) *	2002-12-10	2004-06-30	Biosynexus Incorporated	Topical anti-infective formulations
US20100221237A1 (en) *	2003-03-26	2010-09-02	Biosynexus Incorporated	Enzyme disruption of bacterial biofilms
EP1850867A1 (de) *	2005-01-10	2007-11-07	Nabi Biopharmaceuticals	Verfahren zur behandlung einer infektion mit staphylococcus aureus
EP1885403B1 (de)	2005-04-12	2013-05-08	Nektar Therapeutics	Poly(ethylenglykol)-Konjugate von Lysostaphin
ATE470451T1 (de) *	2006-03-31	2010-06-15	Univ St Andrews	Antimikrobielle zusammensetzungen mit einem kationischen peptid und glycylglycin- endopeptidase
CN103436507B (zh) *	2006-05-05	2016-04-20	冈戈根股份有限公司	噬菌体衍生的抗微生物活性剂
WO2009114520A2 (en) *	2008-03-10	2009-09-17	Pharmain Corporation	Compositions for treatment with metallopeptidases, methods of making and using the same
US20090304673A1 (en) *	2008-06-10	2009-12-10	Bernd Buchberger	Method of Treatment of Inflammatory Diseases
RU2377011C1 (ru) *	2008-06-23	2009-12-27	Федеральное Государственное Образовательное Учреждение Высшего Профессионального Образования "Саратовский Государственный Аграрный Университет Имени Н.И. Вавилова"	Способ лечения хронического остеомиелита у животных
WO2015020765A2 (en)	2013-08-06	2015-02-12	Trustees Of Dartmouth College	Unglycosylated lysostaphin variant protein
RU2572341C2 (ru) *	2013-09-20	2016-01-10	Федеральное государственное бюджетное учреждение Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе Российской академии медицинских наук (ФГБУ "НИИНА" РАМН)	АНТИБИОТИК ИНА 5812, ШТАММ-ПРОДУЦЕНТ Streptomyces roseoflavus ИНА-Ас-5812 И СПОСОБ ПОЛУЧЕНИЯ АНТИБИОТИКА
RU2718554C1 (ru) *	2017-09-25	2020-04-08	Георгий Георгиевич Чумбуридзе	Термостабильная композиция, обладающая антивирусной и антибактериальной активностью и ее использование
US11565024B2 (en)	2017-11-16	2023-01-31	Georgia Tech Research Corporation	Lysostaphin containing synthetic hydrogel carriers for bone repair
CN110917339B (zh) *	2019-12-27	2023-07-07	遵义医学院附属医院	一种溶葡萄球菌酶凝胶剂及其在mrsa感染创面中的应用

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3278378A (en) *	1962-04-19	1966-10-11	Schindler Charles Alvin	Staphylococcus-derived antibiotic
US4931390A (en) *	1986-04-16	1990-06-05	Public Health Research Institute Of The City Of New York, Inc.	Expression of the cloned lysostaphin gene
US5858962A (en) *	1987-05-11	1999-01-12	Ambi Inc.	Composition for treating mastitis and other staphylococcal infections
AU623864B2 (en) *	1988-08-29	1992-05-28	Applied Microbiology, Inc	Method of treating mastitis and other staphylococcal infections

1998
- 1998-07-21 IL IL13405698A patent/IL134056A0/xx unknown
- 1998-07-21 RU RU2000104516/15A patent/RU2234940C2/ru not_active IP Right Cessation
- 1998-07-21 CN CN98808669A patent/CN1269727A/zh active Pending
- 1998-07-21 AU AU85095/98A patent/AU754806B2/en not_active Ceased
- 1998-07-21 HU HU0002662A patent/HUP0002662A3/hu unknown
- 1998-07-21 NZ NZ502359A patent/NZ502359A/en unknown
- 1998-07-21 CA CA002297083A patent/CA2297083C/en not_active Expired - Fee Related
- 1998-07-21 BR BR9811535-9A patent/BR9811535A/pt not_active IP Right Cessation
- 1998-07-21 EP EP98935954A patent/EP1001804B1/de not_active Expired - Lifetime
- 1998-07-21 US US09/120,030 patent/US20020006406A1/en not_active Abandoned
- 1998-07-21 PL PL98338178A patent/PL338178A1/xx not_active Application Discontinuation
- 1998-07-21 KR KR1020007000810A patent/KR20010022237A/ko not_active Withdrawn
- 1998-07-21 AT AT98935954T patent/ATE316794T1/de not_active IP Right Cessation
- 1998-07-21 SK SK73-2000A patent/SK732000A3/sk unknown
- 1998-07-21 WO PCT/US1998/015257 patent/WO1999004809A1/en not_active Ceased
- 1998-07-21 JP JP2000503861A patent/JP2001510805A/ja active Pending
- 1998-07-21 DE DE69833377T patent/DE69833377T2/de not_active Expired - Lifetime
- 1998-07-23 ZA ZA986593A patent/ZA986593B/xx unknown
- 1998-08-29 TW TW087112047A patent/TWI235656B/zh not_active IP Right Cessation
2000
- 2000-01-21 NO NO20000314A patent/NO320884B1/no unknown

Also Published As

Publication number	Publication date
EP1001804B1 (de)	2006-02-01
DE69833377D1 (de)	2006-04-13
TWI235656B (en)	2005-07-11
IL134056A0 (en)	2001-04-30
HUP0002662A2 (hu)	2000-12-28
RU2234940C2 (ru)	2004-08-27
SK732000A3 (en)	2001-03-12
EP1001804A1 (de)	2000-05-24
HUP0002662A3 (en)	2003-08-28
JP2001510805A (ja)	2001-08-07
ATE316794T1 (de)	2006-02-15
DE69833377T2 (de)	2006-11-16
NO320884B1 (no)	2006-02-06
PL338178A1 (en)	2000-10-09
KR20010022237A (ko)	2001-03-15
HU0002662D0 (en)	2000-08-28
US20020006406A1 (en)	2002-01-17
BR9811535A (pt)	2000-08-29
AU8509598A (en)	1999-02-16
NO20000314L (no)	2000-03-16
NO20000314D0 (no)	2000-01-21
AU754806B2 (en)	2002-11-28
NZ502359A (en)	2005-02-25
CA2297083A1 (en)	1999-02-04
CN1269727A (zh)	2000-10-11
WO1999004809A1 (en)	1999-02-04
CA2297083C (en)	2007-10-30

Publication	Publication Date	Title
ZA986593B (en)	1999-02-04	A method for the treatment of staphylococcal disease
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CA2253130A1 (en)	1999-05-06	A medicament for treating obesity and improving lipid metabolism
WO2000012049A3 (en)	2000-05-25	A method for the treatment of staphylococcal disease
WO1997018790A3 (en)	1997-07-31	Therapeutic and diagnostic agents for the treatment of microbial infections
AP2002002652A0 (en)	2002-12-31	The use of azalide antibiotic composition for treating or preventing a bacterial or protozoal infection in mammals.
WO2002005642A3 (en)	2002-08-29	Synergistic biocidal compositions
WO2001091796A8 (en)	2002-05-23	Methods, compounds and compositions for treating gout
AU6633596A (en)	1997-02-26	Improved therapeutic agents
WO2000030435A3 (en)	2000-10-26	Foulbrood treatments
BG103958A (en)	2000-07-31	Pharmaceutical compositions of thioxanide and nitazoxanide
AUPP325398A0 (en)	1998-05-21	Improved method for eradicating h. pylori
BG103512A (en)	2000-07-31	Substituted pyramidine compounds and their application
EP1671644A3 (de)	2006-12-06	Lysostaphin allein oder in Kombination mit einem Antibiotikum enthaltende pharmazeutische Zusammensetzungen zur Behandlung von Staphylokokkeninfektionen
WO2004041244A3 (en)	2004-07-15	Oral extended release tablets and methods of making and using the same
AU1261601A (en)	2001-05-14	Treatment of C. difficile toxin B associated conditions
MX9604692A (es)	1998-04-30	Derivados de quinoxalina para el tratamiento de tinnitus.
WO1995005364A3 (en)	1995-03-23	Inhibitors of biogenic amine transporters