ATE316972T1 - Trizyklische crf rezeptor antagonisten - Google Patents

Trizyklische crf rezeptor antagonisten

Info

Publication number: ATE316972T1
Authority: AT; Austria
Prior art keywords: tricyclic; receptor antagonists; crf receptor; formula; crf
Prior art date: 2001-07-17

Application number

AT02752340T

Other languages

English (en)

Inventor

Fabio Romano Di

Fabrizio Micheli

Collin F Regan

Michael K Schwaebe

Yves St-Denis

Original Assignee

Sb Pharmco Puerto Rico Inc Csc

Neurocrine Biosciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-17

Filing date

2002-07-15

Publication date

2006-02-15

2002-07-15 Application filed by Sb Pharmco Puerto Rico Inc Csc, Neurocrine Biosciences Inc filed Critical Sb Pharmco Puerto Rico Inc Csc

2006-02-15 Application granted granted Critical

2006-02-15 Publication of ATE316972T1 publication Critical patent/ATE316972T1/de

Links

239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
102000012289 Corticotropin-Releasing Hormone Human genes 0.000 abstract 2
108010022152 Corticotropin-Releasing Hormone Proteins 0.000 abstract 2
239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 2
230000001404 mediated effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
150000003222 pyridines Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Anesthesiology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
External Artificial Organs (AREA)
Mechanical Coupling Of Light Guides (AREA)

AT02752340T 2001-07-17 2002-07-15 Trizyklische crf rezeptor antagonisten ATE316972T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0117395.4A GB0117395D0 (en)	2001-07-17	2001-07-17	Chemical compounds

Publications (1)

Publication Number	Publication Date
ATE316972T1 true ATE316972T1 (de)	2006-02-15

Family

ID=9918654

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02752340T ATE316972T1 (de)	2001-07-17	2002-07-15	Trizyklische crf rezeptor antagonisten

Country Status (20)

Country	Link
EP (1)	EP1425281B1 (de)
JP (1)	JP2004537555A (de)
KR (1)	KR20040027880A (de)
CN (1)	CN1541217A (de)
AT (1)	ATE316972T1 (de)
AU (1)	AU2002354916B2 (de)
BR (1)	BR0211220A (de)
CA (1)	CA2452009A1 (de)
DE (1)	DE60209014T2 (de)
ES (1)	ES2256506T3 (de)
GB (1)	GB0117395D0 (de)
HU (1)	HUP0400460A2 (de)
IL (1)	IL159521A0 (de)
MX (1)	MXPA04000492A (de)
NO (1)	NO20040203L (de)
NZ (1)	NZ530508A (de)
PL (1)	PL367965A1 (de)
RU (1)	RU2004104464A (de)
WO (1)	WO2003008414A1 (de)
ZA (1)	ZA200309942B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP0304035A2 (hu)	2001-04-30	2004-04-28	Glaxo Group Limited	Kortikotropin-releasing faktor (CRF) receptor antagonisták, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
PL367771A1 (en)	2001-05-21	2005-03-07	Neurocrine Biosciences Inc.	Tri-and tetraaza-acenaphthylen derivatives as crf receptor antagonists
DE602008003055D1 (de) *	2007-05-31	2010-12-02	Nerviano Medical Sciences Srl	Zyklokondensierte Azaindole, die als Kinase-Hemmer wirken
JP5719840B2 (ja)	2009-06-08	2015-05-20	武田薬品工業株式会社	Ｊａｋの阻害剤としてのジヒドロピロロナフチリジノン化合物
RU2498986C2 (ru) *	2011-07-20	2013-11-20	Учреждение Российской Академии Наук Институт Проблем Химической Физики Ран (Ипхф Ран)	ТЕТРАЦИАНОЗАМЕЩЕННЫЕ 1,4,9b-ТРИАЗАФЕНАЛЕНЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ
CN106279011A (zh) *	2016-08-16	2017-01-04	成都百事兴科技实业有限公司	一种2,4‑二羟基‑6‑甲基烟酸乙酯的制备方法
KR102462991B1 (ko) *	2020-11-02	2022-11-04	한국해양과학기술원	남극-유래 진균 균주 아크레모늄(Acremonium sp.) SF-7394에서 분리한 화합물 및 이를 포함하는 항염증, 항암 또는 항당뇨용 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4605642A (en) *	1984-02-23	1986-08-12	The Salk Institute For Biological Studies	CRF antagonists
DK1129091T3 (da) *	1998-11-12	2002-11-04	Neurocrine Biosciences Inc	Antagonister for CRF-receptorer og fremgangsmåder med relation dertil
CA2349904A1 (en) *	1998-11-12	2000-05-18	Neurocrine Biosciences, Inc.	Crf receptor antagonists and methods relating thereto

2001
- 2001-07-17 GB GBGB0117395.4A patent/GB0117395D0/en not_active Ceased
2002
- 2002-07-15 AU AU2002354916A patent/AU2002354916B2/en not_active Ceased
- 2002-07-15 NZ NZ530508A patent/NZ530508A/en unknown
- 2002-07-15 KR KR10-2004-7000714A patent/KR20040027880A/ko not_active Withdrawn
- 2002-07-15 HU HU0400460A patent/HUP0400460A2/hu unknown
- 2002-07-15 CN CNA02815746XA patent/CN1541217A/zh active Pending
- 2002-07-15 BR BR0211220-5A patent/BR0211220A/pt not_active IP Right Cessation
- 2002-07-15 IL IL15952102A patent/IL159521A0/xx unknown
- 2002-07-15 WO PCT/US2002/022394 patent/WO2003008414A1/en not_active Ceased
- 2002-07-15 AT AT02752340T patent/ATE316972T1/de not_active IP Right Cessation
- 2002-07-15 EP EP02752340A patent/EP1425281B1/de not_active Expired - Lifetime
- 2002-07-15 ES ES02752340T patent/ES2256506T3/es not_active Expired - Lifetime
- 2002-07-15 DE DE60209014T patent/DE60209014T2/de not_active Expired - Fee Related
- 2002-07-15 JP JP2003513973A patent/JP2004537555A/ja active Pending
- 2002-07-15 PL PL02367965A patent/PL367965A1/xx not_active Application Discontinuation
- 2002-07-15 CA CA002452009A patent/CA2452009A1/en not_active Abandoned
- 2002-07-15 MX MXPA04000492A patent/MXPA04000492A/es active IP Right Grant
- 2002-07-15 RU RU2004104464/04A patent/RU2004104464A/ru not_active Application Discontinuation
2003
- 2003-12-23 ZA ZA200309942A patent/ZA200309942B/xx unknown
2004
- 2004-01-16 NO NO20040203A patent/NO20040203L/no unknown

Also Published As

Publication number	Publication date
DE60209014T2 (de)	2006-07-13
ES2256506T3 (es)	2006-07-16
IL159521A0 (en)	2004-06-01
AU2002354916B2 (en)	2006-10-19
ZA200309942B (en)	2004-05-25
CA2452009A1 (en)	2003-01-30
HUP0400460A2 (hu)	2005-01-28
DE60209014D1 (de)	2006-04-13
NO20040203L (no)	2004-03-16
PL367965A1 (en)	2005-03-07
JP2004537555A (ja)	2004-12-16
EP1425281B1 (de)	2006-02-01
GB0117395D0 (en)	2001-09-05
BR0211220A (pt)	2004-07-13
WO2003008414A1 (en)	2003-01-30
EP1425281A1 (de)	2004-06-09
MXPA04000492A (es)	2005-03-07
NZ530508A (en)	2005-11-25
CN1541217A (zh)	2004-10-27
KR20040027880A (ko)	2004-04-01
RU2004104464A (ru)	2005-08-10

Legal Events

Date	Code	Title	Description
2006-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE602004005960D1 (de)	2007-05-31	Heteroaryl-substituierte pyrrolä2, 3- büpyridin-derivate als crf-rezeptor-antagonisten
TW200508212A (en)	2005-03-01	Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
CY1107747T1 (el)	2013-04-18	Υποκατεστημενα τετρακυκλικα παραγωγα πυρρολοκινολονης χρησιμα ως αναστολεις της φωσφοδιεστερασης
MXPA02012033A (es)	2003-04-25	Derivados de 2-aminocarbonil-9h-purina.
MXPA03005464A (es)	2004-04-20	Agentes antivirales.
WO2006011050A3 (en)	2006-10-05	Pyridine derivatives
PL1716152T3 (pl)	2009-01-30	Skondensowane związki heterocykliczne i ich zastosowanie jako antagonistów receptora metabotropowego do leczenia zaburzeń żołądkowo-jelitowych
MXPA05012247A (es)	2006-02-10	Derivados de bencimidazol nuevos.
CY1109808T1 (el)	2014-09-10	Αρυλινδενο-πυριδινες και αρυλινδενο-πυριμιδινες και η χρηση τους ως ανταγωνιστων των υποδοχεων αδενοσινης α2α
DE60229530D1 (de)	2008-12-04	Substituierte piperazine als modulatoren des melanocortinrezeptors
DE60214401D1 (de)	2006-10-12	Hetero-bicyclische crf antagonisten
DE60209014D1 (de)	2006-04-13	Tricylische CRF Rezeptorantagonisten
ATE274515T1 (de)	2004-09-15	Pyrazolopyridinderivate
ATE397609T1 (de)	2008-06-15	Corticotropinfreisetzungsfaktor antagonisten
BR0209035A (pt)	2004-08-10	Antagonistas de receptor crf
YU82302A (sh)	2005-11-28	Derivati 2-aminokarbonil-9h-purina
BG105427A (en)	2001-12-29	Esters of (+)-alpha-(2,3-dimethyloxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pi peridinemethanol and their use as prodrugs of the 5ht2a receptor antagonist mdl 100,907