ATE318819T1 - Pyrazinochinoxalin-derivate als serotonin- agonisten und -antagonisten - Google Patents

Pyrazinochinoxalin-derivate als serotonin- agonisten und -antagonisten

Info

Publication number: ATE318819T1
Authority: AT; Austria
Prior art keywords: disorders; antagonists; novel compounds; serotonin agonists; formulations
Prior art date: 2000-12-20

Application number

AT01997097T

Other languages

English (en)

Inventor

Albert Robichaud

Ian S Mitchell

Taekyu Lee

Wenting Chen

Original Assignee

Bristol Myers Squibb Pharma Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-20

Filing date

2001-12-19

Publication date

2006-03-15

2001-12-19 Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co

2006-03-15 Application granted granted Critical

2006-03-15 Publication of ATE318819T1 publication Critical patent/ATE318819T1/de

Links

239000003420 antiserotonin agent Substances 0.000 title abstract 2
239000000952 serotonin receptor agonist Substances 0.000 title abstract 2
CVSGFMWKZVZOJD-UHFFFAOYSA-N pyrazino[2,3-f]quinoxaline Chemical class C1=CN=C2C3=NC=CN=C3C=CC2=N1 CVSGFMWKZVZOJD-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
208000019901 Anxiety disease Diseases 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
206010041250 Social phobia Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000004064 dysfunction Effects 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000004899 motility Effects 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1
208000012201 sexual and gender identity disease Diseases 0.000 abstract 1
208000015891 sexual disease Diseases 0.000 abstract 1
208000019116 sleep disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT01997097T 2000-12-20 2001-12-19 Pyrazinochinoxalin-derivate als serotonin- agonisten und -antagonisten ATE318819T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US25676500P	2000-12-20	2000-12-20

Publications (1)

Publication Number	Publication Date
ATE318819T1 true ATE318819T1 (de)	2006-03-15

Family

ID=22973498

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01997097T ATE318819T1 (de)	2000-12-20	2001-12-19	Pyrazinochinoxalin-derivate als serotonin- agonisten und -antagonisten

Country Status (23)

Country	Link
US (1)	US6638934B2 (de)
EP (1)	EP1345942B9 (de)
JP (2)	JP4346307B2 (de)
KR (1)	KR20030069192A (de)
CN (1)	CN1505631A (de)
AT (1)	ATE318819T1 (de)
AU (1)	AU2002248216B2 (de)
BG (1)	BG107864A (de)
BR (1)	BR0116347A (de)
CA (1)	CA2431970A1 (de)
DE (1)	DE60117617T2 (de)
EE (1)	EE200300301A (de)
ES (1)	ES2260335T3 (de)
HU (1)	HUP0303513A3 (de)
IL (1)	IL156201A0 (de)
IS (1)	IS6850A (de)
MX (1)	MXPA03005437A (de)
NO (1)	NO20032795L (de)
PL (1)	PL366060A1 (de)
RU (1)	RU2003121406A (de)
SK (1)	SK7022003A3 (de)
WO (1)	WO2002059127A2 (de)
ZA (1)	ZA200304303B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL366060A1 (en) *	2000-12-20	2005-01-24	Bristol-Myers Squibb Pharma Company	Substituted pyrazinoquinoxaline derivatives as serotonin receptor agonists and antagonists
US7244843B2 (en)	2003-10-07	2007-07-17	Bristol-Myers Squibb Company	Modulators of serotonin receptors
GB0417558D0 (en) *	2004-08-06	2004-09-08	Merck Sharp & Dohme	Novel combination therapy
JP5173190B2 (ja)	2004-08-25	2013-03-27	武田薬品工業株式会社	腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法
EP2727585A1 (de)	2006-05-16	2014-05-07	Takeda Pharmaceutical Company Limited	In-vivo Screening-Methode
EP2789338A3 (de)	2007-11-15	2015-01-14	Takeda Pharmaceutical Company Limited	Kondensiertes Pyridinderivat und seine Verwendung
EP2510949A4 (de)	2009-12-11	2013-11-13	Astellas Pharma Inc	Therapeutikum für fibromyalgie
US20130267500A1 (en)	2010-09-01	2013-10-10	Arena Pharmaceuticals, Inc.	5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
WO2015066344A1 (en)	2013-11-01	2015-05-07	Arena Pharmaceuticals, Inc.	5-ht2c receptor agonists and compositions and methods of use
US20210052600A1 (en)	2017-12-27	2021-02-25	Takeda Pharmaceutical Company Limited	Therapeutic agents for stress urinary incontinence and incotinence of feces

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4183936A (en)	1972-06-19	1980-01-15	Endo Laboratories, Inc.	Pyridopyrrolobenzheterocycles
US4238607A (en)	1972-06-19	1980-12-09	Endo Laboratories Inc.	Pyridopyrrolo benzheterocycles
US3914421A (en)	1972-06-19	1975-10-21	Endo Lab	Pyridopyrrolobenzheterocycles for combatting depression
US4115577A (en)	1972-06-19	1978-09-19	Endo Laboratories, Inc.	Pyridopyrrolobenzheterocycles
US4013652A (en)	1972-06-19	1977-03-22	Endo Laboratories, Inc.	Pyridopyrrolobenzoxazine
US4219550A (en)	1978-11-09	1980-08-26	E. I. Du Pont De Nemours And Company	Cis- and trans- octahydropyridopyrrolobenzheterocycles
HUT61548A (en) *	1990-08-27	1993-01-28	Sandoz Ag	Process for producing indolonaphthyridine derivatives and pharmaceutical compositions comprising such compounds
NZ512765A (en) *	1998-12-17	2003-10-31	Wyeth Corp	2,3,4,4A-tetrahydro-1H-pyrazino(1,2-A)quinoxalin- 5(6H)one derivatives being 5HT2C agonists
PL366060A1 (en) *	2000-12-20	2005-01-24	Bristol-Myers Squibb Pharma Company	Substituted pyrazinoquinoxaline derivatives as serotonin receptor agonists and antagonists

2001
- 2001-12-19 PL PL01366060A patent/PL366060A1/xx not_active Application Discontinuation
- 2001-12-19 DE DE60117617T patent/DE60117617T2/de not_active Expired - Lifetime
- 2001-12-19 KR KR10-2003-7008273A patent/KR20030069192A/ko not_active Withdrawn
- 2001-12-19 JP JP2002559429A patent/JP4346307B2/ja not_active Expired - Fee Related
- 2001-12-19 BR BR0116347-7A patent/BR0116347A/pt not_active Application Discontinuation
- 2001-12-19 AT AT01997097T patent/ATE318819T1/de active
- 2001-12-19 WO PCT/US2001/049374 patent/WO2002059127A2/en not_active Ceased
- 2001-12-19 EE EEP200300301A patent/EE200300301A/xx unknown
- 2001-12-19 EP EP01997097A patent/EP1345942B9/de not_active Expired - Lifetime
- 2001-12-19 RU RU2003121406/04A patent/RU2003121406A/ru not_active Application Discontinuation
- 2001-12-19 ES ES01997097T patent/ES2260335T3/es not_active Expired - Lifetime
- 2001-12-19 HU HU0303513A patent/HUP0303513A3/hu not_active Application Discontinuation
- 2001-12-19 SK SK702-2003A patent/SK7022003A3/sk unknown
- 2001-12-19 AU AU2002248216A patent/AU2002248216B2/en not_active Ceased
- 2001-12-19 CA CA002431970A patent/CA2431970A1/en not_active Abandoned
- 2001-12-19 IL IL15620101A patent/IL156201A0/xx unknown
- 2001-12-19 CN CNA01822704XA patent/CN1505631A/zh active Pending
- 2001-12-19 US US10/026,404 patent/US6638934B2/en not_active Expired - Lifetime
- 2001-12-19 MX MXPA03005437A patent/MXPA03005437A/es unknown
2003
- 2003-05-30 BG BG107864A patent/BG107864A/bg unknown
- 2003-06-02 ZA ZA200304303A patent/ZA200304303B/en unknown
- 2003-06-18 IS IS6850A patent/IS6850A/is unknown
- 2003-06-19 NO NO20032795A patent/NO20032795L/no not_active Application Discontinuation
2009
- 2009-05-11 JP JP2009114360A patent/JP5117440B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN1505631A (zh)	2004-06-16
RU2003121406A (ru)	2004-12-27
EP1345942B9 (de)	2006-11-15
US20020177596A1 (en)	2002-11-28
JP4346307B2 (ja)	2009-10-21
NO20032795L (no)	2003-08-04
US6638934B2 (en)	2003-10-28
JP2009215304A (ja)	2009-09-24
DE60117617T2 (de)	2007-01-25
PL366060A1 (en)	2005-01-24
CA2431970A1 (en)	2002-08-01
DE60117617D1 (de)	2006-04-27
JP2004524298A (ja)	2004-08-12
BR0116347A (pt)	2004-07-06
KR20030069192A (ko)	2003-08-25
ES2260335T3 (es)	2006-11-01
EE200300301A (et)	2003-10-15
WO2002059127A2 (en)	2002-08-01
IL156201A0 (en)	2003-12-23
EP1345942A2 (de)	2003-09-24
JP5117440B2 (ja)	2013-01-16
WO2002059127A3 (en)	2002-10-03
MXPA03005437A (es)	2003-09-10
HUP0303513A3 (en)	2005-12-28
AU2002248216B2 (en)	2007-03-01
IS6850A (is)	2003-06-18
SK7022003A3 (en)	2004-08-03
NO20032795D0 (no)	2003-06-19
HUP0303513A2 (hu)	2004-01-28
EP1345942B1 (de)	2006-03-01
ZA200304303B (en)	2004-09-02
BG107864A (bg)	2004-03-31

Legal Events

Date

Code

Title

Description

2006-09-15

UEP

Publication of translation of european patent specification

Ref document number: 1345942

Country of ref document: EP

Publication	Publication Date	Title
ATE438646T1 (de)	2009-08-15	Substituierte pyrrolochinoline und pyridochinoline als serotonin- agonisten und- antagonisten
HK1043112A1 (zh)	2002-09-06	取代的稠杂环γ-咔啉
MXPA03005438A (es)	2004-05-05	Pirioindoles substituidos como agonistas y antagonistas de serotonina.
ATE509929T1 (de)	2011-06-15	Substituierte tricyclische gamma-carbolineals serotonin-rezeptor-agonisten und antagonisten
ATE318819T1 (de)	2006-03-15	Pyrazinochinoxalin-derivate als serotonin- agonisten und -antagonisten
ATE342720T1 (de)	2006-11-15	Kombination aus quetiapin und zolmitriptan
GB0311349D0 (en)	2003-06-25	Therapeutic agents, compositions, preparations and uses