ATE318906T1 - Fibroblasten-wachstumsfaktoren homologefibroblasten-wachstumsfaktoren homologe - Google Patents

Fibroblasten-wachstumsfaktoren homologefibroblasten-wachstumsfaktoren homologe

Info

Publication number
ATE318906T1
ATE318906T1 AT97910128T AT97910128T ATE318906T1 AT E318906 T1 ATE318906 T1 AT E318906T1 AT 97910128 T AT97910128 T AT 97910128T AT 97910128 T AT97910128 T AT 97910128T AT E318906 T1 ATE318906 T1 AT E318906T1
Authority
AT
Austria
Prior art keywords
growth factors
nucleotide
homologofibroblast
homologous
polynucleotide molecule
Prior art date
Application number
AT97910128T
Other languages
English (en)
Inventor
Theresa A Deisher
Darrell C Conklin
Fenella C Raymond
Thomas R Bukowski
Susan D Holderman
Brigit Hansen
Paul O Sheppard
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of ATE318906T1 publication Critical patent/ATE318906T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
AT97910128T 1996-10-16 1997-10-16 Fibroblasten-wachstumsfaktoren homologefibroblasten-wachstumsfaktoren homologe ATE318906T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2864696P 1996-10-16 1996-10-16

Publications (1)

Publication Number Publication Date
ATE318906T1 true ATE318906T1 (de) 2006-03-15

Family

ID=21844629

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05021714T ATE491029T1 (de) 1996-10-16 1997-10-16 Fibroblasten-wachstumsfaktoren-homologe
AT97910128T ATE318906T1 (de) 1996-10-16 1997-10-16 Fibroblasten-wachstumsfaktoren homologefibroblasten-wachstumsfaktoren homologe

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT05021714T ATE491029T1 (de) 1996-10-16 1997-10-16 Fibroblasten-wachstumsfaktoren-homologe

Country Status (19)

Country Link
US (3) US5989866A (de)
EP (4) EP2339002A1 (de)
JP (1) JP4091122B2 (de)
KR (1) KR100611063B1 (de)
CN (1) CN1127568C (de)
AT (2) ATE491029T1 (de)
AU (1) AU725551B2 (de)
BR (2) BR9712348B1 (de)
CA (1) CA2269083C (de)
CZ (1) CZ299288B6 (de)
DE (2) DE69735352T2 (de)
DK (2) DK0931148T3 (de)
ES (3) ES2403880T3 (de)
IL (1) IL129379A (de)
NO (1) NO326459B1 (de)
PL (1) PL192537B1 (de)
PT (2) PT931148E (de)
UA (1) UA75316C2 (de)
WO (1) WO1998016644A1 (de)

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Publication number Publication date
US20040096936A1 (en) 2004-05-20
KR20000049207A (ko) 2000-07-25
BR9712348A (pt) 1999-08-31
EP2264175B1 (de) 2012-11-21
DK1632574T3 (da) 2011-02-28
UA75316C2 (uk) 2006-04-17
US5989866A (en) 1999-11-23
DE69735352T2 (de) 2006-10-12
CZ299288B6 (cs) 2008-06-04
BR9712348B1 (pt) 2013-06-18
IL129379A0 (en) 2000-02-17
PL192537B1 (pl) 2006-11-30
EP0931148B1 (de) 2006-03-01
JP4091122B2 (ja) 2008-05-28
IL129379A (en) 2008-12-29
NO991796D0 (no) 1999-04-15
DK0931148T3 (da) 2006-06-19
CA2269083C (en) 2009-06-09
HK1148030A1 (en) 2011-08-26
HK1089206A1 (en) 2006-11-24
AU725551B2 (en) 2000-10-12
CN1247568A (zh) 2000-03-15
ES2357215T3 (es) 2011-04-20
WO1998016644A1 (en) 1998-04-23
EP1632574A1 (de) 2006-03-08
AU4758397A (en) 1998-05-11
NO991796L (no) 1999-06-16
ES2258788T3 (es) 2006-09-01
EP2264175A1 (de) 2010-12-22
EP2339002A1 (de) 2011-06-29
JP2001502178A (ja) 2001-02-20
US6352971B1 (en) 2002-03-05
CN1127568C (zh) 2003-11-12
DE69740074D1 (de) 2011-01-20
EP0931148A1 (de) 1999-07-28
PT1632574E (pt) 2011-03-17
ATE491029T1 (de) 2010-12-15
KR100611063B1 (ko) 2006-08-09
ES2403880T3 (es) 2013-05-22
EP1632574B1 (de) 2010-12-08
NO326459B1 (no) 2008-12-08
DE69735352D1 (de) 2006-04-27
PL332851A1 (en) 1999-10-25
CZ131599A3 (cs) 1999-11-17
BRPI9712348C8 (pt) 2020-04-22
PT931148E (pt) 2006-06-30
CA2269083A1 (en) 1998-04-23
US7247608B2 (en) 2007-07-24

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