ATE31921T1 - Amidine, verfahren zu ihrer herstellung und deren anwendung in der therapie. - Google Patents
Amidine, verfahren zu ihrer herstellung und deren anwendung in der therapie.Info
- Publication number
- ATE31921T1 ATE31921T1 AT84401447T AT84401447T ATE31921T1 AT E31921 T1 ATE31921 T1 AT E31921T1 AT 84401447 T AT84401447 T AT 84401447T AT 84401447 T AT84401447 T AT 84401447T AT E31921 T1 ATE31921 T1 AT E31921T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- mono
- pct
- alkyl group
- alkyl
- Prior art date
Links
- 150000001409 amidines Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 abstract 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8311717A FR2549049B1 (fr) | 1983-07-13 | 1983-07-13 | Nouvelles amidines, leur procede de preparation et leur application therapeutique |
| EP84401447A EP0132190B1 (de) | 1983-07-13 | 1984-07-06 | Amidine, Verfahren zu ihrer Herstellung und deren Anwendung in der Therapie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE31921T1 true ATE31921T1 (de) | 1988-01-15 |
Family
ID=9290821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84401447T ATE31921T1 (de) | 1983-07-13 | 1984-07-06 | Amidine, verfahren zu ihrer herstellung und deren anwendung in der therapie. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4665085A (de) |
| EP (1) | EP0132190B1 (de) |
| JP (1) | JPS60502204A (de) |
| AT (1) | ATE31921T1 (de) |
| CA (1) | CA1243681A (de) |
| DE (1) | DE3468682D1 (de) |
| FR (1) | FR2549049B1 (de) |
| WO (1) | WO1985000366A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4665095A (en) * | 1985-12-11 | 1987-05-12 | Abbott Laboratories | Use of 2-[(3,5-dihalo-4-aminobenzyl)]imidazolines to stimulate alpha-1 adrenergic receptors and to treat nasal congestion |
| US4870210A (en) * | 1987-12-18 | 1989-09-26 | American Home Products Corporation | Aminoguanidine derivative as anti-inflammatory agents |
| GB8903592D0 (en) * | 1989-02-16 | 1989-04-05 | Boots Co Plc | Therapeutic agents |
| US5304569A (en) * | 1989-11-13 | 1994-04-19 | Orion-Yhtyma Oy | Compositions and their use in lowering intraocular pressure |
| FR2669927B1 (fr) * | 1990-11-29 | 1994-04-08 | Adir Cie | Nouveaux derives de guanidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| GB2277090A (en) * | 1993-04-16 | 1994-10-19 | Shell Int Research | Fungicidal tetrahydropyrimidine and imidazoline derivatives |
| US5629345A (en) * | 1993-07-23 | 1997-05-13 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
| US5965620A (en) * | 1993-07-23 | 1999-10-12 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
| CZ284395B6 (cs) * | 1994-03-16 | 1998-11-11 | Sankyo Company Limited | Prostředek pro snižování očního tlaku |
| CA2250426C (en) * | 1996-03-29 | 2006-05-02 | 3-Dimensional Pharmaceuticals, Inc. | Amidinohydrazones as protease inhibitors |
| FR2761061B1 (fr) * | 1997-03-20 | 1999-04-23 | Synthelabo | Derives de benzenesulfonamide, leur preparation et leur application en therapeutique |
| SG72827A1 (en) * | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
| AU3166299A (en) * | 1998-04-09 | 1999-11-01 | Eisai Co. Ltd. | Arginine peptide analogs useful as fibroblast growth factor antagonists |
| US9034910B2 (en) | 2008-06-09 | 2015-05-19 | Allergan, Inc. | Methods of treating alpha adrenergic mediated conditions |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH396881A (de) * | 1961-01-16 | 1965-08-15 | Ciba Geigy | Verfahren zur Herstellung neuer Hydrazone |
| FR1332543A (fr) * | 1962-01-09 | 1963-07-19 | Ciba Geigy | Nouvelles hydrazones et leur procédé de préparation |
| CH430694A (de) * | 1962-04-03 | 1967-02-28 | Ciba Geigy | Verfahren zur Herstellung neuer Guanylhydrazone |
| BE663481A (de) * | 1964-05-05 | |||
| GB1174349A (en) * | 1966-08-25 | 1969-12-17 | Boehringer Sohn Ingelheim | Novel 2-Anilinomethylimidazoline Derivatives and process for the preparation thereof |
| FR8343M (de) * | 1967-10-13 | 1970-12-21 | ||
| AU1218670A (en) * | 1969-03-06 | 1971-09-09 | Sandoz Patents Limited | Improvements in or relating to organic compounds |
| GB1356470A (en) * | 1971-06-02 | 1974-06-12 | Seperic | Ortho-disubstituted aryl-guanidines process for their preparation and applications thereof |
| DE2329295A1 (de) * | 1972-06-12 | 1974-01-03 | Sandoz Ag | Aromatische verbindungen und verfahren zu ihrer herstellung |
| FR2207706B1 (de) * | 1972-11-24 | 1975-11-28 | Orsymonde | |
| JPS51141822A (en) * | 1975-05-23 | 1976-12-07 | Rorer Inc William H | Preparation of guanidine compound |
| GB1550401A (en) * | 1976-01-07 | 1979-08-15 | Hexachimie | Hydrazine derivatives their preparation and their use |
| GB1538097A (en) * | 1976-01-26 | 1979-01-10 | Lafon Labor | Substituted phenyl-amidines |
| US4287201A (en) * | 1980-03-03 | 1981-09-01 | Merck & Co., Inc. | Anovulatory method and chicken feed compositions |
| DE3168754D1 (en) * | 1980-07-09 | 1985-03-21 | Beecham Group Plc | Clonidine derivatives useful in the treatment of diarrhoea |
| ES8302665A1 (es) * | 1981-04-06 | 1983-02-16 | Hexachimie | "procedimiento de preparacion de nuevos derivados de la hidrazina, utiles como fungicidas y bactericidas". |
| CA1201066A (en) * | 1981-11-20 | 1986-02-25 | Alcon Laboratories, Inc. | N-¬3,5-dichloro-4-(2-imidazolidinylideneamino)- phenyl|-acetamide solutions for lowering intraocular pressure |
-
1983
- 1983-07-13 FR FR8311717A patent/FR2549049B1/fr not_active Expired
-
1984
- 1984-07-06 EP EP84401447A patent/EP0132190B1/de not_active Expired
- 1984-07-06 AT AT84401447T patent/ATE31921T1/de not_active IP Right Cessation
- 1984-07-06 US US06/717,185 patent/US4665085A/en not_active Expired - Fee Related
- 1984-07-06 JP JP59502736A patent/JPS60502204A/ja active Pending
- 1984-07-06 DE DE8484401447T patent/DE3468682D1/de not_active Expired
- 1984-07-06 WO PCT/FR1984/000170 patent/WO1985000366A1/fr not_active Ceased
- 1984-07-12 CA CA000458794A patent/CA1243681A/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0132190B1 (de) | 1988-01-13 |
| WO1985000366A1 (fr) | 1985-01-31 |
| EP0132190A1 (de) | 1985-01-23 |
| FR2549049A1 (fr) | 1985-01-18 |
| US4665085A (en) | 1987-05-12 |
| DE3468682D1 (en) | 1988-02-18 |
| FR2549049B1 (fr) | 1986-06-20 |
| JPS60502204A (ja) | 1985-12-19 |
| CA1243681A (fr) | 1988-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |