ATE319478T1 - Screening-methode für inhibitoren von acrab und acrab-ähnlichen ausfluss-pumpen - Google Patents
Screening-methode für inhibitoren von acrab und acrab-ähnlichen ausfluss-pumpenInfo
- Publication number
- ATE319478T1 ATE319478T1 AT00950577T AT00950577T ATE319478T1 AT E319478 T1 ATE319478 T1 AT E319478T1 AT 00950577 T AT00950577 T AT 00950577T AT 00950577 T AT00950577 T AT 00950577T AT E319478 T1 ATE319478 T1 AT E319478T1
- Authority
- AT
- Austria
- Prior art keywords
- acrab
- inhibitors
- screening method
- outflow pumps
- drugs
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000012216 screening Methods 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/358,948 US6346391B1 (en) | 1999-07-22 | 1999-07-22 | Methods of reducing microbial resistance to drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE319478T1 true ATE319478T1 (de) | 2006-03-15 |
Family
ID=23411689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00950577T ATE319478T1 (de) | 1999-07-22 | 2000-07-21 | Screening-methode für inhibitoren von acrab und acrab-ähnlichen ausfluss-pumpen |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US6346391B1 (de) |
| EP (2) | EP1674112A1 (de) |
| JP (2) | JP2003523317A (de) |
| AT (1) | ATE319478T1 (de) |
| AU (1) | AU783818B2 (de) |
| CA (2) | CA2718926A1 (de) |
| DE (1) | DE60026532D1 (de) |
| WO (1) | WO2001007030A2 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO5180550A1 (es) | 1999-04-19 | 2002-07-30 | Smithkline Beecham Corp | Inhibidores de fab i |
| AR024158A1 (es) | 1999-06-01 | 2002-09-04 | Smithkline Beecham Corp | Compuestos antibacterianos |
| US6346391B1 (en) * | 1999-07-22 | 2002-02-12 | Trustees Of Tufts College | Methods of reducing microbial resistance to drugs |
| ES2231275T3 (es) | 1999-10-08 | 2005-05-16 | Affinium Pharmaceuticals, Inc. | Inhibidores de fab i. |
| US6730684B1 (en) | 1999-10-08 | 2004-05-04 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| US6762201B1 (en) | 1999-10-08 | 2004-07-13 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| US6656703B1 (en) * | 1999-12-29 | 2003-12-02 | Millennium Pharamaceuticals, Inc. | High throughput screen for inhibitors of fatty acid biosynthesis in bacteria |
| JP4387804B2 (ja) * | 2001-04-06 | 2009-12-24 | アフィニアム・ファーマシューティカルズ・インコーポレイテッド | ＦａｂＩ阻害剤 |
| US7075582B2 (en) | 2001-07-13 | 2006-07-11 | Paratek Pharmaceuticals, Inc. | Methods for identifying and using MarR family polypeptide binding compounds |
| US7202339B2 (en) * | 2001-07-13 | 2007-04-10 | Trustees Of Tufts College | Crystals of MarR polypeptides, regulators of multiple antibiotic resistance |
| US20060084678A1 (en) * | 2001-07-13 | 2006-04-20 | Paratek Pharmaceuticals, Inc. | Methods for identifying and using MarR family polypeptide binding compounds |
| US20030158156A1 (en) * | 2001-11-21 | 2003-08-21 | Kimberly-Clark Worldwide, Inc. | Methods for inhibiting the production of TSST-1 |
| US7118759B2 (en) * | 2001-11-21 | 2006-10-10 | Kimberly-Clark Worldwide, Inc. | Absorbent articles containing additives |
| US7691403B2 (en) * | 2001-11-21 | 2010-04-06 | Kimberly-Clark Worldwide, Inc. | Non-absorbent tampon containing additives inhibiting TSST-1 |
| US20050255538A1 (en) * | 2002-03-15 | 2005-11-17 | Buxser Stephen E | Methods for screening for AcrAB efflux pump inhibitors |
| PT1575951E (pt) | 2002-12-06 | 2014-09-15 | Debiopharm Int Sa | Compostos heterocíclicos, métodos para os preparar e sua utilização em terapia |
| WO2004062674A2 (en) * | 2003-01-07 | 2004-07-29 | Paratek Pharmaceuticals, Inc. | Substituted polyamines as inhibitors of bacterial efflux pumps |
| EP1608377B1 (de) | 2003-03-17 | 2008-10-01 | Affinium Pharmaceuticals, Inc. | Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend |
| US20050192240A1 (en) * | 2004-01-09 | 2005-09-01 | Yun-Liang Yang | Methods and compositions relating to expression factors |
| CA2559208A1 (en) * | 2004-03-17 | 2005-09-29 | Mpex Pharmaceuticals, Inc. | Use and administration of bacterial efflux pump inhibitors |
| US7994225B2 (en) * | 2004-03-17 | 2011-08-09 | Rempex Pharmaceuticals, Inc. | Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections |
| US8450307B2 (en) * | 2004-06-04 | 2013-05-28 | Affinium Pharmaceuticals, Inc. | Therapeutic agents, and methods of making and using the same |
| GB0511203D0 (en) * | 2005-06-02 | 2005-07-06 | Univ Birmingham | Vaccines |
| US20090156578A1 (en) * | 2005-12-05 | 2009-06-18 | PAULS Henry | 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents |
| EP2054422B1 (de) | 2006-07-20 | 2017-06-14 | Debiopharm International SA | Acrylamidderivate als fab-i-inhibitoren |
| US8343536B2 (en) | 2007-01-25 | 2013-01-01 | Cook Biotech Incorporated | Biofilm-inhibiting medical products |
| WO2008098374A1 (en) * | 2007-02-16 | 2008-08-21 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab i inhibitors |
| US20100130439A1 (en) * | 2007-04-26 | 2010-05-27 | Romesberg Floyd E | Genomic mutation inhibitors that inhibit y family dna polymerases |
| FR2970964B1 (fr) | 2011-01-28 | 2013-12-13 | Univ Claude Bernard Lyon | Nouveaux derives d'azacoumarines presentant une activite inhibitrice des pompes mdr |
| EP2861608B8 (de) | 2012-06-19 | 2019-06-19 | Debiopharm International SA | Prodrug-derivate von (e)-n-methyl-n-((3-methylbenzofuran-2-yl) methyl)-3- (7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamid |
| RU2016143590A (ru) * | 2014-04-08 | 2018-05-11 | Арадайм Корпорейшн | Липосомальные композиции ципрофлоксацина, обладающие активностью против нетуберкулезных микробактерий |
| CN110417797B (zh) * | 2015-04-02 | 2021-07-30 | 创新先进技术有限公司 | 认证用户的方法及装置 |
| AU2016379399B2 (en) * | 2015-12-23 | 2022-12-08 | Board Of Regents, The University Of Texas System | Antisense antibacterial compounds and methods |
| DK3419628T3 (da) | 2016-02-26 | 2021-01-11 | Debiopharm Int Sa | Medikament til behandling af diabetiske fodinfektioner |
| GB201615693D0 (en) | 2016-09-15 | 2016-11-02 | Combinatorx Infection Ltd | Combinations |
| ES2944535T3 (es) | 2019-02-14 | 2023-06-22 | Debiopharm Int Sa | Formulación de afabicina, método para preparar la misma |
| UA129222C2 (uk) | 2019-06-14 | 2025-02-12 | Дебіофарм Інтернешнл С.А. | Лікарський засіб і його застосування для лікування бактеріальних інфекцій, пов'язаних з біоплівкою |
| US20240398890A1 (en) * | 2023-05-31 | 2024-12-05 | Government Of The United States As Represented By The Secretary Of The Air Force | Method for Treatment of Microbial Infections |
| CN116763790B (zh) * | 2023-07-10 | 2024-09-03 | 重庆大学附属肿瘤医院 | ChemDiv L676-1461在制备鲍曼不动杆菌AdeABC外排泵抑制剂中的应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5589470A (en) | 1990-02-26 | 1996-12-31 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| US4806529A (en) | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
| US5064821A (en) | 1982-11-18 | 1991-11-12 | Trustees Of Tufts College | Method and compositions for overcoming tetracycline resistance within living cells |
| FR2655545B1 (fr) | 1989-12-11 | 1994-06-10 | Rhone Poulenc Sante | Nouvelle application therapeutique des derives des fluoroquinolones. |
| TW318189B (de) | 1991-12-06 | 1997-10-21 | American Cyanamid Co | |
| DE69322166T2 (de) | 1992-08-28 | 1999-04-22 | The Trustees Of Tufts College, Medford, Mass. | Prüfung auf ein vielfache resistenz gegen antibiotika verursachendes operon |
| CA2211131A1 (en) | 1995-01-23 | 1996-08-01 | Microcide Pharmaceuticals, Inc. | Screening for modulators of biomolecules |
| US5989832A (en) | 1995-04-21 | 1999-11-23 | Microcide Pharmaceuticals, Inc. | Method for screening for non-tetracycline efflux pump inhibitors |
| AU9785698A (en) | 1997-10-02 | 1999-04-27 | Microcide Pharmaceuticals, Inc. | Fungal efflux pump inhibitors |
| AU4803597A (en) * | 1997-10-02 | 1999-04-27 | Trustees Of Tufts College | Methods and compositions for reducing bacterial tolerance of disinfectants and organic solvents |
| US6068972A (en) | 1997-10-03 | 2000-05-30 | Trustees Of Tufts College | Methods and compositions for reducing bacterial tolerance to antibacterials, disinfectants and organic solvents |
| AU5903398A (en) | 1997-12-23 | 1999-07-12 | Microcide Pharmaceuticals, Inc. | Staphylococcus aureus histidine protein kinase essential genes |
| AU2337599A (en) | 1998-01-23 | 1999-08-09 | Microcide Pharmaceuticals, Inc. | Efflux pump inhibitors |
| US20040024068A1 (en) * | 1998-01-23 | 2004-02-05 | Trustees Of Tufts College | Antimicrobial compounds |
| JP2002510463A (ja) | 1998-01-23 | 2002-04-09 | トルスティーズ オブ トゥフツ カレッジ | 抗菌化合物 |
| US6410041B1 (en) * | 1998-04-28 | 2002-06-25 | Trustees Of Tufts College | Culturing cells in presence of amphipathic weak bases and/or cations and multiple drug resistance inhibitor containing reserpine |
| US6399629B1 (en) | 1998-06-01 | 2002-06-04 | Microcide Pharmaceuticals, Inc. | Efflux pump inhibitors |
| AU757777B2 (en) | 1998-12-04 | 2003-03-06 | Influx, Inc. | Inhibitors of multidrug transporters |
| US6346391B1 (en) * | 1999-07-22 | 2002-02-12 | Trustees Of Tufts College | Methods of reducing microbial resistance to drugs |
| US20050255538A1 (en) * | 2002-03-15 | 2005-11-17 | Buxser Stephen E | Methods for screening for AcrAB efflux pump inhibitors |
-
1999
- 1999-07-22 US US09/358,948 patent/US6346391B1/en not_active Expired - Fee Related
-
2000
- 2000-07-21 JP JP2001511916A patent/JP2003523317A/ja active Pending
- 2000-07-21 CA CA2718926A patent/CA2718926A1/en not_active Abandoned
- 2000-07-21 CA CA2378883A patent/CA2378883C/en not_active Expired - Fee Related
- 2000-07-21 AT AT00950577T patent/ATE319478T1/de not_active IP Right Cessation
- 2000-07-21 DE DE60026532T patent/DE60026532D1/de not_active Expired - Lifetime
- 2000-07-21 EP EP06004644A patent/EP1674112A1/de not_active Withdrawn
- 2000-07-21 AU AU63666/00A patent/AU783818B2/en not_active Ceased
- 2000-07-21 WO PCT/US2000/020014 patent/WO2001007030A2/en not_active Ceased
- 2000-07-21 EP EP00950577A patent/EP1276503B1/de not_active Expired - Lifetime
-
2001
- 2001-09-28 US US09/966,835 patent/US6677133B2/en not_active Expired - Fee Related
-
2003
- 2003-07-28 US US10/629,340 patent/US7026136B2/en not_active Expired - Fee Related
-
2005
- 2005-10-26 US US11/260,676 patent/US20060264517A1/en not_active Abandoned
-
2009
- 2009-06-01 US US12/476,053 patent/US8012711B2/en not_active Expired - Fee Related
-
2011
- 2011-02-24 JP JP2011038562A patent/JP2011137028A/ja not_active Withdrawn
- 2011-08-16 US US13/210,853 patent/US20110301127A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001007030A3 (en) | 2002-11-14 |
| US8012711B2 (en) | 2011-09-06 |
| US6677133B2 (en) | 2004-01-13 |
| EP1276503A2 (de) | 2003-01-22 |
| US20090298873A1 (en) | 2009-12-03 |
| WO2001007030A2 (en) | 2001-02-01 |
| JP2011137028A (ja) | 2011-07-14 |
| EP1276503B1 (de) | 2006-03-08 |
| DE60026532D1 (de) | 2006-05-04 |
| CA2378883A1 (en) | 2001-02-01 |
| US20050261165A1 (en) | 2005-11-24 |
| CA2718926A1 (en) | 2001-02-01 |
| US20020132814A1 (en) | 2002-09-19 |
| AU783818B2 (en) | 2005-12-08 |
| US20110301127A1 (en) | 2011-12-08 |
| CA2378883C (en) | 2011-01-11 |
| JP2003523317A (ja) | 2003-08-05 |
| US6346391B1 (en) | 2002-02-12 |
| US20060264517A1 (en) | 2006-11-23 |
| US7026136B2 (en) | 2006-04-11 |
| EP1674112A1 (de) | 2006-06-28 |
| AU6366600A (en) | 2001-02-13 |
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