ATE319704T1 - Farnesyltransferase hemmende, in der 4-stellung substituierte chinolin- und chinazolinderivate - Google Patents
Farnesyltransferase hemmende, in der 4-stellung substituierte chinolin- und chinazolinderivateInfo
- Publication number
- ATE319704T1 ATE319704T1 AT01988065T AT01988065T ATE319704T1 AT E319704 T1 ATE319704 T1 AT E319704T1 AT 01988065 T AT01988065 T AT 01988065T AT 01988065 T AT01988065 T AT 01988065T AT E319704 T1 ATE319704 T1 AT E319704T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- quinoline
- farnesyl transferase
- quinazoline derivatives
- derivatives substituted
- Prior art date
Links
- 102000007317 Farnesyltranstransferase Human genes 0.000 title abstract 2
- 108010007508 Farnesyltranstransferase Proteins 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical group N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 2
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical group N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00204715 | 2000-12-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE319704T1 true ATE319704T1 (de) | 2006-03-15 |
Family
ID=8172507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01988065T ATE319704T1 (de) | 2000-12-27 | 2001-12-21 | Farnesyltransferase hemmende, in der 4-stellung substituierte chinolin- und chinazolinderivate |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7129356B2 (de) |
| EP (1) | EP1347966B1 (de) |
| JP (1) | JP4351445B2 (de) |
| AT (1) | ATE319704T1 (de) |
| DE (1) | DE60117847T2 (de) |
| ES (1) | ES2260316T3 (de) |
| WO (1) | WO2002051835A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005268166B2 (en) * | 2004-08-04 | 2011-10-20 | Meiji Seika Pharma Co., Ltd. | Quinoline derivative and insecticide containing same as active constituent |
| EP1883403A4 (de) * | 2005-04-29 | 2011-02-16 | Univ Ohio State Res Found | Keratinocytenwachstumsfaktorrezeptor tyrosinspezifische inhibitoren für die prävention der krebsmetastase |
| TW200803855A (en) * | 2006-02-24 | 2008-01-16 | Kalypsys Inc | Quinolones useful as inducible nitric oxide synthase inhibitors |
| DK2160386T3 (da) | 2007-05-23 | 2012-08-27 | Allergan Inc | Terapeutiske ((phenyl)imidazolyl)methylquinolinylforbindelser |
| US8232402B2 (en) | 2008-03-12 | 2012-07-31 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
| DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| US20100068204A1 (en) * | 2008-09-12 | 2010-03-18 | Wyeth | 4-aryloxyquinolin-2(1h)-ones as mtor kinase and pi3 kinase inhibitors, for use as anti-cancer agents |
| MX2011005096A (es) | 2008-11-13 | 2011-11-18 | Link Medicine Corp | Derivados de azaquinolinona y usos de los mismos. |
| US9309222B2 (en) | 2012-10-16 | 2016-04-12 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| JP6466335B2 (ja) | 2012-10-16 | 2019-02-06 | ヤンセン ファーマシューティカ エヌ．ベー． | ＲＯＲ−γ−Ｔのメチレン連結キノリニルモジュレーター |
| CN104884448A (zh) | 2012-10-16 | 2015-09-02 | 詹森药业有限公司 | Rorγt的杂芳基连接的喹啉基调节剂 |
| CN105873439A (zh) | 2013-10-15 | 2016-08-17 | 詹森药业有限公司 | RORγt的烷基连接的喹啉基调节剂 |
| US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| KR20160068956A (ko) | 2013-10-15 | 2016-06-15 | 얀센 파마슈티카 엔.브이. | RORyT의 퀴놀리닐 조절제 |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| WO2015130445A1 (en) | 2014-02-27 | 2015-09-03 | Janssen Pharmaceutica Nv | Quinoline derivatives useful as cb-1 inverse agonists |
| WO2015130444A1 (en) | 2014-02-27 | 2015-09-03 | Janssen Pharmaceutica Nv | Quinoline derivatives useful as cb-1 inverse agonists |
| US10696637B2 (en) * | 2015-07-17 | 2020-06-30 | Fujifilm Corporation | Nitrogen-containing heterocyclic compound |
| CA3048602A1 (en) | 2016-12-27 | 2018-07-05 | Fujifilm Corporation | Antitumor agent and bromodomain inhibitor |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5268380A (en) * | 1988-11-29 | 1993-12-07 | Janssen Pharmaceutica N.V. | (1H-azol-1-ylmethyl) substituted quinoline derivatives |
| CA2002864C (en) | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
| TW316902B (de) * | 1994-12-28 | 1997-10-01 | Janssen Pharmaceutica Nv | |
| TW349948B (en) | 1995-10-31 | 1999-01-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 2-quinolone derivatives |
| EE03484B1 (et) * | 1995-12-08 | 2001-08-15 | Janssen Pharmaceutica N.V. | Farnesüülproteiintransferaasi inhibeerivad (5-imidasolüül)metüül-2-kinolinooni derivaadid ja nende kasutamine |
| US6011029A (en) * | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| TW591030B (en) | 1997-03-10 | 2004-06-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles |
| BR9809398A (pt) | 1997-04-25 | 2000-06-13 | Janssen Pharmaceutica Nv | Quinazolinonas que inibem a farnesil transferase |
| ATE222104T1 (de) | 1997-06-02 | 2002-08-15 | Janssen Pharmaceutica Nv | (imidazol-5-yl)methyl-2-quinolinone derivativen als inhibitoren von proliferation der glatten muskelzellen |
| US6545020B1 (en) | 1998-07-06 | 2003-04-08 | Janssen Pharmaceutica, N.V. | Farnesyl Protein transferase inhibitors with in vivo radiosensitizing properties |
| HRP20000904A2 (en) | 1998-07-06 | 2001-12-31 | Janssen Pharmaceutica Nv | Farnesyl protein transferase inhibitors for treating arthropathies |
| ATE289602T1 (de) | 1998-08-27 | 2005-03-15 | Pfizer Prod Inc | Quinolin-2-on-derivate verwendbar als antikrebsmittel |
| TR200101343T2 (tr) | 1998-08-27 | 2001-09-21 | Pfizer Products Inc. | Kansere karşı kullanılan maddeler olarak alkinil-ikame edilmiş kinolin-2-on türevleri |
| BR9916827A (pt) | 1998-12-23 | 2001-10-16 | Janssen Pharmaceutica Nv | Derivados de quinolina 1,2-anelados |
| KR20010102073A (ko) | 1999-02-11 | 2001-11-15 | 실버스타인 아써 에이. | 항암제로 유용한 헤테로아릴-치환된 퀴놀린-2-온 유도체 |
| HN2000000266A (es) | 2000-01-21 | 2001-05-21 | Pfizer Prod Inc | Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto. |
-
2001
- 2001-12-21 WO PCT/EP2001/015234 patent/WO2002051835A1/en not_active Ceased
- 2001-12-21 JP JP2002552930A patent/JP4351445B2/ja not_active Expired - Fee Related
- 2001-12-21 DE DE60117847T patent/DE60117847T2/de not_active Expired - Lifetime
- 2001-12-21 EP EP01988065A patent/EP1347966B1/de not_active Expired - Lifetime
- 2001-12-21 AT AT01988065T patent/ATE319704T1/de not_active IP Right Cessation
- 2001-12-21 ES ES01988065T patent/ES2260316T3/es not_active Expired - Lifetime
- 2001-12-21 US US10/451,902 patent/US7129356B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1347966B1 (de) | 2006-03-08 |
| DE60117847D1 (de) | 2006-05-04 |
| US20040063944A1 (en) | 2004-04-01 |
| US7129356B2 (en) | 2006-10-31 |
| JP4351445B2 (ja) | 2009-10-28 |
| ES2260316T3 (es) | 2006-11-01 |
| DE60117847T2 (de) | 2006-11-16 |
| JP2004516323A (ja) | 2004-06-03 |
| WO2002051835A1 (en) | 2002-07-04 |
| EP1347966A1 (de) | 2003-10-01 |
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