ATE364384T1 - Benzylimidazolyl substituierte 2-chinolon und chinazolinon derivate zur verwendung als farnesyl transferase inhibitoren - Google Patents

Benzylimidazolyl substituierte 2-chinolon und chinazolinon derivate zur verwendung als farnesyl transferase inhibitoren

Info

Publication number: ATE364384T1
Authority: AT; Austria
Prior art keywords: benzylimidazolyl; quinolone; substituted; farnesyl transferase; transferase inhibitors
Prior art date: 2002-03-22

Application number

AT03720339T

Other languages

English (en)

Inventor

Patrick Angibaud

Marc Venet

Christophe Meyer

Henry Breslin

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-22

Filing date

2003-03-18

Publication date

2007-07-15

2003-03-18 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2007-07-15 Application granted granted Critical

2007-07-15 Publication of ATE364384T1 publication Critical patent/ATE364384T1/de

Links

AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title 1
-1 BENZYLIMIDAZOLYL Chemical group 0.000 title 1
239000003528 protein farnesyltransferase inhibitor Substances 0.000 title 1
LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title 1
102000007317 Farnesyltranstransferase Human genes 0.000 abstract 1
108010007508 Farnesyltranstransferase Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Tropical Medicine & Parasitology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Reproductive Health (AREA)
Molecular Biology (AREA)
Psychiatry (AREA)

AT03720339T 2002-03-22 2003-03-18 Benzylimidazolyl substituierte 2-chinolon und chinazolinon derivate zur verwendung als farnesyl transferase inhibitoren ATE364384T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02076157		2002-03-22

Publications (1)

Publication Number	Publication Date
ATE364384T1 true ATE364384T1 (de)	2007-07-15

Family

ID=28051805

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03720339T ATE364384T1 (de)	2002-03-22	2003-03-18	Benzylimidazolyl substituierte 2-chinolon und chinazolinon derivate zur verwendung als farnesyl transferase inhibitoren

Country Status (9)

Country	Link
US (2)	US7241777B2 (de)
EP (1)	EP1490065B1 (de)
JP (1)	JP4450628B2 (de)
AT (1)	ATE364384T1 (de)
AU (1)	AU2003223970B2 (de)
CA (1)	CA2478813C (de)
DE (1)	DE60314381T2 (de)
ES (1)	ES2287466T3 (de)
WO (1)	WO2003080058A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8436006B2 (en) *	2004-08-06	2013-05-07	Jansssen Pharmaceutica N.V.	2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8383637B2 (en) *	2004-08-06	2013-02-26	Jansssen Pharmaceutica N.V.	2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8426429B2 (en) *	2004-08-06	2013-04-23	Jansssen Pharmaceutica N.V.	2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
AU2006331542A1 (en)	2005-12-23	2007-07-05	Link Medicine Corporation	Treatment of synucleinopathies
US7776882B2 (en) *	2006-02-06	2010-08-17	Baxter Ellen W	2-amino-3,4-dihydro-quinoline derivatives useful as inhibitors of β-secretase (BACE)
US7932261B2 (en) *	2006-02-06	2011-04-26	Janssen Pharmaceutica Nv	Macrocycle derivatives useful as inhibitors of β-secretase (BACE)
WO2007092854A2 (en) *	2006-02-06	2007-08-16	Janssen Pharmaceutica N.V.	2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE)
WO2009097278A1 (en) *	2008-01-28	2009-08-06	Janssen Pharmaceutica N.V.	6-SUBSTITUTED-THIO-2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE)
ES2397682T3 (es) *	2008-01-29	2013-03-08	Janssen Pharmaceutica Nv	Derivados de 2-amino-quinolina útiles como inhibidores de la beta-secretasa (BACE)
WO2009151683A2 (en)	2008-03-12	2009-12-17	Link Medicine Corporation	Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
DE102008022221A1 (de) *	2008-05-06	2009-11-12	Universität des Saarlandes	Inhibitoren der humanen Aldosteronsynthase CYP11B2
AU2009313927A1 (en)	2008-11-13	2010-05-20	Astrazeneca Ab	Azaquinolinone derivatives and uses thereof
US10471055B2 (en)	2015-08-17	2019-11-12	Kura Oncology, Inc.	Methods of treating cancer patients with farnesyltransferase inhibitors
HRP20210544T1 (hr)	2016-11-03	2021-08-20	Kura Oncology, Inc.	Inhibitori farneziltransferaze za uporabu u liječenju raka

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GB1488412A (en) *	1975-01-16	1977-10-12	Wyeth John & Brother Ltd	Imidazo(1,2-a)quinolines
US4468400A (en) *	1982-12-20	1984-08-28	Schering Corporation	Antiulcer tricyclic imidazo [1,2-a]pyridines
GB8415540D0 (en) *	1984-06-18	1984-07-25	Fujisawa Pharmaceutical Co	Imidazoisoquinoline compounds
TW349948B (en)	1995-10-31	1999-01-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 2-quinolone derivatives
DE69635966T2 (de) *	1995-12-08	2006-11-30	Janssen Pharmaceutica N.V.	(Imidazol-5-yl)Methyl-2-Chinolinonderivate als Farnesyl Protein transferase Inhibitoren
CA2249615A1 (en)	1996-04-03	1997-10-09	Robert Gomez	Inhibitors of farnesyl-protein transferase
TW591030B (en)	1997-03-10	2004-06-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
SK146199A3 (en)	1997-04-25	2000-06-12	Janssen Pharmaceutica Nv	Farnesyltransferase inhibiting quinazolinones
IL133212A (en)	1997-06-02	2005-12-18	Janssen Pharmaceutica Nv	History of use (imidazolil-5-yl) methyl-2-quinolinone that act as culture inhibitors of smooth muscle cells
AU4396899A (en)	1998-07-02	2000-01-24	Kyowa Hakko Kogyo Co. Ltd.	Remedies for diabetes
ID26987A (id)	1998-07-06	2001-02-22	Janssen Pharmaceutica Nv	Inhibitor-inhibitor transferase protein farnesil dengan sifat-sifat peka terhadap sinar radiasi in vivo
HRP20000904A2 (en)	1998-07-06	2001-12-31	Janssen Pharmaceutica Nv	Farnesyl protein transferase inhibitors for treating arthropathies
CA2341739C (en)	1998-08-27	2005-07-12	Pfizer Products Inc.	Quinolin-2-one derivatives useful as anticancer agents
KR20010072991A (ko)	1998-08-27	2001-07-31	실버스타인 아써 에이.	항암제로서 유용한 알키닐-치환된 퀴놀린-2-온 유도체
PT1140935E (pt)	1998-12-23	2003-10-31	Janssen Pharmaceutica Nv	Derivados da quinolina 1,2-ciclizada
TR200201296T2 (tr)	1999-02-11	2002-07-22	Pfizer Products Inc.	Antikanser maddeleri olarak faydalı heteroaril-ikame edilmiş kinolin-2-on türevleri
HN2000000266A (es)	2000-01-21	2001-05-21	Pfizer Prod Inc	Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
JP4974439B2 (ja) *	2000-09-25	2012-07-11	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ファルネシルトランスフェラーゼを阻害する６−ヘテロシクリルメチルキノリノン誘導体
ATE409189T1 (de)	2000-09-25	2008-10-15	Janssen Pharmaceutica Nv	Farnesyl transferase-hemmende 6- heterocyclylmethyl-chinolin und chinazol-derivate
US7569580B2 (en) *	2004-06-03	2009-08-04	Rigel Pharmaceuticals, Inc.	Heterotricyclic compounds for use as HCV inhibitors

2003
- 2003-03-18 ES ES03720339T patent/ES2287466T3/es not_active Expired - Lifetime
- 2003-03-18 AT AT03720339T patent/ATE364384T1/de active
- 2003-03-18 AU AU2003223970A patent/AU2003223970B2/en not_active Ceased
- 2003-03-18 EP EP03720339A patent/EP1490065B1/de not_active Expired - Lifetime
- 2003-03-18 WO PCT/EP2003/002874 patent/WO2003080058A1/en not_active Ceased
- 2003-03-18 DE DE60314381T patent/DE60314381T2/de not_active Expired - Lifetime
- 2003-03-18 JP JP2003577885A patent/JP4450628B2/ja not_active Expired - Fee Related
- 2003-03-18 US US10/508,185 patent/US7241777B2/en not_active Expired - Lifetime
- 2003-03-18 CA CA2478813A patent/CA2478813C/en not_active Expired - Lifetime
2007
- 2007-06-05 US US11/758,346 patent/US7943635B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO2003080058A1 (en)	2003-10-02
US20080255191A1 (en)	2008-10-16
EP1490065A1 (de)	2004-12-29
JP4450628B2 (ja)	2010-04-14
CA2478813C (en)	2011-10-18
EP1490065B1 (de)	2007-06-13
US7943635B2 (en)	2011-05-17
DE60314381T2 (de)	2008-02-21
US7241777B2 (en)	2007-07-10
US20050171111A1 (en)	2005-08-04
DE60314381D1 (de)	2007-07-26
JP2005523909A (ja)	2005-08-11
CA2478813A1 (en)	2003-10-02
ES2287466T3 (es)	2007-12-16
AU2003223970A1 (en)	2003-10-08
AU2003223970B2 (en)	2008-03-06

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