ATE364384T1 - Benzylimidazolyl substituierte 2-chinolon und chinazolinon derivate zur verwendung als farnesyl transferase inhibitoren - Google Patents

Benzylimidazolyl substituierte 2-chinolon und chinazolinon derivate zur verwendung als farnesyl transferase inhibitoren

Info

Publication number: ATE364384T1
Authority: AT; Austria
Prior art keywords: benzylimidazolyl; quinolone; substituted; farnesyl transferase; transferase inhibitors
Prior art date: 2002-03-22

Application number

AT03720339T

Other languages

English (en)

Inventor

Patrick Angibaud

Marc Venet

Christophe Meyer

Henry Breslin

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-22

Filing date

2003-03-18

Publication date

2007-07-15

2003-03-18 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2007-07-15 Application granted granted Critical

2007-07-15 Publication of ATE364384T1 publication Critical patent/ATE364384T1/de

Links

AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title 1
-1 BENZYLIMIDAZOLYL Chemical group 0.000 title 1
239000003528 protein farnesyltransferase inhibitor Substances 0.000 title 1
LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title 1
102000007317 Farnesyltranstransferase Human genes 0.000 abstract 1
108010007508 Farnesyltranstransferase Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Endocrinology (AREA)
Oncology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Virology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Otolaryngology (AREA)
Reproductive Health (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)

AT03720339T 2002-03-22 2003-03-18 Benzylimidazolyl substituierte 2-chinolon und chinazolinon derivate zur verwendung als farnesyl transferase inhibitoren ATE364384T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02076157		2002-03-22

Publications (1)

Publication Number	Publication Date
ATE364384T1 true ATE364384T1 (de)	2007-07-15

Family

ID=28051805

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03720339T ATE364384T1 (de)	2002-03-22	2003-03-18	Benzylimidazolyl substituierte 2-chinolon und chinazolinon derivate zur verwendung als farnesyl transferase inhibitoren

Country Status (9)

Country	Link
US (2)	US7241777B2 (de)
EP (1)	EP1490065B1 (de)
JP (1)	JP4450628B2 (de)
AT (1)	ATE364384T1 (de)
AU (1)	AU2003223970B2 (de)
CA (1)	CA2478813C (de)
DE (1)	DE60314381T2 (de)
ES (1)	ES2287466T3 (de)
WO (1)	WO2003080058A1 (de)

Families Citing this family (14)

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US8426429B2 (en) *	2004-08-06	2013-04-23	Jansssen Pharmaceutica N.V.	2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8436006B2 (en) *	2004-08-06	2013-05-07	Jansssen Pharmaceutica N.V.	2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8383637B2 (en) *	2004-08-06	2013-02-26	Jansssen Pharmaceutica N.V.	2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
EP1968591A4 (de)	2005-12-23	2010-02-17	Link Medicine Corp	Behandlung von synucleinopathien
WO2007092846A2 (en) *	2006-02-06	2007-08-16	Janssen Pharmaceutica N.V.	2-AMINO-3,4-DIHYDRO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE)
US7868022B2 (en) *	2006-02-06	2011-01-11	Janssen Pharmaceutica Nv	2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE)
WO2007092839A2 (en) *	2006-02-06	2007-08-16	Janssen Pharmaceutica N.V.	Macrocycle derivatives useful as inhibitors of beta-secretase (bace)
NZ586831A (en) *	2008-01-28	2012-02-24	Janssen Pharmaceutica Nv	6-substituted-thio-2-amino-quinoline derivatives useful as inhibitors of beta-secretase (bace)
EP2240472B1 (de) *	2008-01-29	2012-11-21	Janssen Pharmaceutica NV	Als inhibitoren von beta-sekretase (bace) geeignete 2-aminochinolinderivate
US8232402B2 (en)	2008-03-12	2012-07-31	Link Medicine Corporation	Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
DE102008022221A1 (de) *	2008-05-06	2009-11-12	Universität des Saarlandes	Inhibitoren der humanen Aldosteronsynthase CYP11B2
MX2011005096A (es)	2008-11-13	2011-11-18	Link Medicine Corp	Derivados de azaquinolinona y usos de los mismos.
EA201890512A1 (ru) *	2015-08-17	2018-09-28	Кура Онколоджи, Инк.	Способы лечения пациентов со злокачественными опухолями с использованием ингибиторов фарнезилтрансферазы
RS61745B1 (sr)	2016-11-03	2021-05-31	Kura Oncology Inc	Inhibitori farneziltransferaze za upotrebu u tretiranju kancera

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GB1488412A (en) *	1975-01-16	1977-10-12	Wyeth John & Brother Ltd	Imidazo(1,2-a)quinolines
US4468400A (en) *	1982-12-20	1984-08-28	Schering Corporation	Antiulcer tricyclic imidazo [1,2-a]pyridines
GB8415540D0 (en) *	1984-06-18	1984-07-25	Fujisawa Pharmaceutical Co	Imidazoisoquinoline compounds
TW349948B (en)	1995-10-31	1999-01-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 2-quinolone derivatives
EE03484B1 (et) *	1995-12-08	2001-08-15	Janssen Pharmaceutica N.V.	Farnesüülproteiintransferaasi inhibeerivad (5-imidasolüül)metüül-2-kinolinooni derivaadid ja nende kasutamine
AU715658B2 (en)	1996-04-03	2000-02-10	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
TW591030B (en)	1997-03-10	2004-06-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
BR9809398A (pt)	1997-04-25	2000-06-13	Janssen Pharmaceutica Nv	Quinazolinonas que inibem a farnesil transferase
ATE222104T1 (de)	1997-06-02	2002-08-15	Janssen Pharmaceutica Nv	(imidazol-5-yl)methyl-2-quinolinone derivativen als inhibitoren von proliferation der glatten muskelzellen
WO2000001388A1 (en)	1998-07-02	2000-01-13	Kyowa Hakko Kogyo Co., Ltd.	Remedies for diabetes
US6545020B1 (en)	1998-07-06	2003-04-08	Janssen Pharmaceutica, N.V.	Farnesyl Protein transferase inhibitors with in vivo radiosensitizing properties
HRP20000904A2 (en)	1998-07-06	2001-12-31	Janssen Pharmaceutica Nv	Farnesyl protein transferase inhibitors for treating arthropathies
ATE289602T1 (de)	1998-08-27	2005-03-15	Pfizer Prod Inc	Quinolin-2-on-derivate verwendbar als antikrebsmittel
TR200101343T2 (tr)	1998-08-27	2001-09-21	Pfizer Products Inc.	Kansere karşı kullanılan maddeler olarak alkinil-ikame edilmiş kinolin-2-on türevleri
BR9916827A (pt) *	1998-12-23	2001-10-16	Janssen Pharmaceutica Nv	Derivados de quinolina 1,2-anelados
KR20010102073A (ko) *	1999-02-11	2001-11-15	실버스타인 아써 에이.	항암제로 유용한 헤테로아릴-치환된 퀴놀린-2-온 유도체
HN2000000266A (es)	2000-01-21	2001-05-21	Pfizer Prod Inc	Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
WO2002024686A2 (en)	2000-09-25	2002-03-28	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives
JP4974439B2 (ja) *	2000-09-25	2012-07-11	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ファルネシルトランスフェラーゼを阻害する６−ヘテロシクリルメチルキノリノン誘導体
US7569580B2 (en) *	2004-06-03	2009-08-04	Rigel Pharmaceuticals, Inc.	Heterotricyclic compounds for use as HCV inhibitors

2003
- 2003-03-18 AT AT03720339T patent/ATE364384T1/de active
- 2003-03-18 ES ES03720339T patent/ES2287466T3/es not_active Expired - Lifetime
- 2003-03-18 WO PCT/EP2003/002874 patent/WO2003080058A1/en not_active Ceased
- 2003-03-18 EP EP03720339A patent/EP1490065B1/de not_active Expired - Lifetime
- 2003-03-18 AU AU2003223970A patent/AU2003223970B2/en not_active Ceased
- 2003-03-18 JP JP2003577885A patent/JP4450628B2/ja not_active Expired - Fee Related
- 2003-03-18 US US10/508,185 patent/US7241777B2/en not_active Expired - Lifetime
- 2003-03-18 DE DE60314381T patent/DE60314381T2/de not_active Expired - Lifetime
- 2003-03-18 CA CA2478813A patent/CA2478813C/en not_active Expired - Lifetime
2007
- 2007-06-05 US US11/758,346 patent/US7943635B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1490065B1 (de)	2007-06-13
JP4450628B2 (ja)	2010-04-14
CA2478813A1 (en)	2003-10-02
JP2005523909A (ja)	2005-08-11
US20050171111A1 (en)	2005-08-04
DE60314381D1 (de)	2007-07-26
AU2003223970A1 (en)	2003-10-08
US20080255191A1 (en)	2008-10-16
WO2003080058A1 (en)	2003-10-02
US7943635B2 (en)	2011-05-17
US7241777B2 (en)	2007-07-10
EP1490065A1 (de)	2004-12-29
ES2287466T3 (es)	2007-12-16
DE60314381T2 (de)	2008-02-21
CA2478813C (en)	2011-10-18
AU2003223970B2 (en)	2008-03-06

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