ATE319729T1 - 9a-azalide mit entzündungshemmender wirkung - Google Patents

9a-azalide mit entzündungshemmender wirkung

Info

Publication number: ATE319729T1
Authority: AT; Austria
Prior art keywords: azalide; inflammatory effect; inflammatory activity; azalides; cladinose
Prior art date: 2002-10-29

Application number

AT03809747T

Other languages

English (en)

Inventor

Mauro Napoletano

Andrea Mereu

Ermanno Moriggi

Fernando Ornaghi

Gabriele Morazzoni

Franco Pellacini

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-29

Filing date

2003-10-28

Publication date

2006-03-15

2003-10-28 Application filed by Zambon Spa filed Critical Zambon Spa

2006-03-15 Application granted granted Critical

2006-03-15 Publication of ATE319729T1 publication Critical patent/ATE319729T1/de

Links

230000003110 anti-inflammatory effect Effects 0.000 title abstract 3
YHVUVJYEERGYNU-UHFFFAOYSA-N 4',8-Di-Me ether-5,7,8-Trihydroxy-3-(4-hydroxybenzyl)-4-chromanone Natural products COC1(C)CC(O)OC(C)C1O YHVUVJYEERGYNU-UHFFFAOYSA-N 0.000 abstract 1
AJSDVNKVGFVAQU-BIIVOSGPSA-N cladinose Chemical group O=CC[C@@](C)(OC)[C@@H](O)[C@H](C)O AJSDVNKVGFVAQU-BIIVOSGPSA-N 0.000 abstract 1
239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
229940041033 macrolides Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Pulmonology (AREA)
Biotechnology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT03809747T 2002-10-29 2003-10-28 9a-azalide mit entzündungshemmender wirkung ATE319729T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT002292A ITMI20022292A1 (it)	2002-10-29	2002-10-29	9a-azalidi ad attivita' antiinfiammatoria.

Publications (1)

Publication Number	Publication Date
ATE319729T1 true ATE319729T1 (de)	2006-03-15

Family

ID=32211389

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03809747T ATE319729T1 (de)	2002-10-29	2003-10-28	9a-azalide mit entzündungshemmender wirkung

Country Status (12)

Country	Link
US (1)	US7419961B2 (de)
EP (1)	EP1556397B1 (de)
JP (1)	JP4536516B2 (de)
CN (1)	CN100486985C (de)
AT (1)	ATE319729T1 (de)
AU (1)	AU2003276214B2 (de)
CA (1)	CA2502347C (de)
DE (1)	DE60303967D1 (de)
IL (1)	IL167882A (de)
IT (1)	ITMI20022292A1 (de)
RU (1)	RU2320668C2 (de)
WO (1)	WO2004039821A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20021726A1 (it) *	2002-08-01	2004-02-02	Zambon Spa	Macrolidi ad attivita' antiinfiammatoria.
EP1638549A4 (de)	2003-03-10	2011-06-15	Optimer Pharmaceuticals Inc	Neue antibakterielle mittel
WO2006077501A2 (en) *	2005-01-13	2006-07-27	Glaxosmithkline Istrazivacki Centar Zagreb D.O.O.	Decladinosyl-macrolides with anti-inflammatory activity
JP2008526945A (ja) *	2005-01-14	2008-07-24	グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ	抗炎症活性を有する９ａ−カルバモイルおよびチオカルバモイルアザライド
WO2007125414A2 (en) *	2006-05-03	2007-11-08	Glaxosmithkline Istrazivacki Centar Zagreb D.O.O.	9a-substituted azalides for the tratment of malaria
CA2703475A1 (en) *	2007-10-25	2009-04-30	Cempra Pharmaceuticals, Inc.	Process for the preparation of macrolide antibacterial agents
US8796232B2 (en) *	2008-10-24	2014-08-05	Cempra Pharmaceuticals, Inc.	Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) *	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja)	2009-09-10	2016-05-11	センプラファーマシューティカルズ，インコーポレイテッド	マラリア、結核、及びｍａｃ病の治療方法
CN103080122A (zh)	2010-03-22	2013-05-01	森普拉制药公司	大环内脂的结晶形式及其用途
WO2011146829A1 (en)	2010-05-20	2011-11-24	Cempra Pharmaceuticals, Inc.	Processes for preparing macrolides and ketolides and intermediates therefor
JP6042334B2 (ja)	2010-09-10	2016-12-14	センプラファーマシューティカルズ，インコーポレイテッド	疾患治療のための水素結合形成フルオロケトライド
CN104470527B (zh)	2012-03-27	2019-05-28	森普拉制药公司	用于施用大环内酯抗生素的肠胃外制剂
RU2015138796A (ru)	2013-03-14	2017-04-19	Семпра Фармасьютикалс, Инк.	Способы и составы для лечения респираторных заболеваний
WO2014145210A1 (en)	2013-03-15	2014-09-18	Cempra Pharmaceuticals, Inc.	Convergent processes for preparing macrolide antibacterial agents
CA2908620A1 (en) *	2013-04-10	2014-10-16	Probiotic Pharmaceuticals Aps	Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect
GB201520419D0 (en)	2015-11-19	2016-01-06	Epi Endo Pharmaceuticals Ehf	Compounds
IL281879B2 (en)	2018-10-02	2026-04-01	Lunella Biotech Inc	AZITHROMYCIN AND ROXITHROMYCIN DERIVATIVES AS SENSOLITIC DRUGS
EP4118092B1 (de)	2020-03-12	2025-07-16	Zoetis Services LLC	Immunomodulierende o-het-aryl-azaalide
MX2024002892A (es)	2021-09-07	2024-04-05	Zoetis Services Llc	Azalidos inmunomoduladores.

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1100504A (en)	1967-08-16	1968-01-24	Pliva Pharm & Chem Works	Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide
US3928387A (en)	1974-02-04	1975-12-23	Hoffmann La Roche	Antibiotic 1745A/X and methods for the production thereof
SI7910768A8 (en)	1979-04-02	1996-06-30	Pliva Pharm & Chem Works	Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
SI8110592A8 (en)	1981-03-06	1996-06-30	Pliva Pharm & Chem Works	Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4464527A (en)	1983-06-30	1984-08-07	Pfizer Inc.	Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
EP0283055B1 (de) *	1987-09-03	1990-08-29	SOUR PLIVA farmaceutska, Kemijska prehrambena i kozmeticka industrija, n.sol.o.	10-Dihydro-10-deoxo-11-azaerythronolid-A-Verbindungen,Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung in Arzneimitteln und in deren Herstellung
SI9011409A (en)	1990-07-18	1995-10-31	Pliva Pharm & Chem Works	O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
WO1992016226A1 (en)	1991-03-19	1992-10-01	Smithkline Beecham Corporation	Il-1 inhibitors
FR2691464B1 (fr) *	1992-05-21	1995-06-02	Roussel Uclaf	Nouveaux dérivés de la 1-oxa 6-azacyclopentadécane 13,15-dione, leur procédé de préparation et leur application comme médicaments.
WO1996004920A1 (en)	1994-08-12	1996-02-22	Taisho Pharmaceutical Co., Ltd.	Interleukin-5 production inhibitor
KR970704455A (ko)	1994-08-12	1997-09-06	우에하라 아끼라	인터류킨 5 생성 억제제(Interleukin 5 Production Inhibitor)
WO1999000124A1 (en) *	1997-06-26	1999-01-07	Merck & Co., Inc.	9a-azalides, compositions containing such compounds and methods of treatment
PT1437359E (pt) *	1997-10-16	2007-04-30	Glaxosmithkline Zagreb	Novos 3,6-hemicetais da classe dos 9a-azalidos
ATE275151T1 (de) *	1998-03-03	2004-09-15	Pfizer Prod Inc	3,6-ketal-makrolidantibiotika
US6262030B1 (en) *	1998-11-03	2001-07-17	Pfizer Inc.	Erythromycin derivatives
IT1306205B1 (it) *	1999-01-15	2001-05-30	Zambon Spa	Macrolidi ad attivita' antiinfiammatoria.

2002
- 2002-10-29 IT IT002292A patent/ITMI20022292A1/it unknown
2003
- 2003-10-28 CA CA2502347A patent/CA2502347C/en not_active Expired - Fee Related
- 2003-10-28 WO PCT/EP2003/012071 patent/WO2004039821A1/en not_active Ceased
- 2003-10-28 EP EP03809747A patent/EP1556397B1/de not_active Expired - Lifetime
- 2003-10-28 CN CNB2003801023509A patent/CN100486985C/zh not_active Expired - Fee Related
- 2003-10-28 JP JP2004547618A patent/JP4536516B2/ja not_active Expired - Fee Related
- 2003-10-28 RU RU2005116248/04A patent/RU2320668C2/ru not_active IP Right Cessation
- 2003-10-28 AU AU2003276214A patent/AU2003276214B2/en not_active Ceased
- 2003-10-28 DE DE60303967T patent/DE60303967D1/de not_active Expired - Lifetime
- 2003-10-28 US US10/531,462 patent/US7419961B2/en not_active Expired - Fee Related
- 2003-10-28 AT AT03809747T patent/ATE319729T1/de not_active IP Right Cessation
2005
- 2005-04-06 IL IL167882A patent/IL167882A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE60303967D1 (de)	2006-05-04
CA2502347C (en)	2011-06-28
JP4536516B2 (ja)	2010-09-01
RU2005116248A (ru)	2006-01-20
US20060166904A1 (en)	2006-07-27
RU2320668C2 (ru)	2008-03-27
AU2003276214A1 (en)	2004-05-25
EP1556397A1 (de)	2005-07-27
US7419961B2 (en)	2008-09-02
WO2004039821A1 (en)	2004-05-13
EP1556397B1 (de)	2006-03-08
CN100486985C (zh)	2009-05-13
CN1708507A (zh)	2005-12-14
IL167882A (en)	2010-06-30
JP2006513157A (ja)	2006-04-20
AU2003276214B2 (en)	2009-05-28
ITMI20022292A1 (it)	2004-04-30
CA2502347A1 (en)	2004-05-13

Legal Events

Date	Code	Title	Description
2006-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60303967D1 (de)	2006-05-04	9a-azalide mit entzündungshemmender wirkung
ATE509938T1 (de)	2011-06-15	Makrolidverbindungen mit antiinflammatorischer wirkung
NO2025027I1 (no)	2025-06-13	Pharmaceutical mixture or association that includes as active ingredients: (1) ceftazidime or a salt thereof, and (2) avibactam or a pharmaceutically acceptable salt thereof - forlenget.
ATE374016T1 (de)	2007-10-15	Tablette mit hohem wirkstoffgehalt
BR0115810B1 (pt)	2011-10-18	composições cosméticas, dermatológicas e farmacêuticas isentas de tensoativos.
ITTO20010005A0 (it)	2001-01-09	Formulazione farmaceutica.
ATE514418T1 (de)	2011-07-15	Rasch zerfallende feste darreichungsformen mit nichtbröseliger konsistenz und pullulan
NO992102D0 (no)	1999-04-30	Peptidblanding, samt farmasøytisk sammensetning og kreftvaksine som innbefatter peptidblandingen
PT1121127E (pt)	2005-03-31	Composicoes farmaceuticas orais contendo buprenorfina
WO1999055332A8 (en)	2000-02-17	Medicinal compositions
IS2258B (is)	2007-06-15	Setin tríasóló-pýridasín afleiða, lyfjasamsetningar gerðar úr henni
DE60142913D1 (de)	2010-10-07	Arzneilösungen enthaltend modafinilverbindungen
DE69915487D1 (de)	2004-04-15	Erythromycin-derivate mit antibiotischer wirkung
DE60102590D1 (de)	2004-05-06	Darreichungsformen zur behandlung von oralen mykosen
ITMI20031396A1 (it)	2005-01-10	Composizione per uso farmaceutico o dietetico o cosmetico dotata di attivita' antiossidante.
NL1023790A1 (nl)	2004-02-03	Farmaceutische samenstellingen met antibiotische activiteit.
ITRM20030363A0 (it)	2003-07-24	Composizioni comprendenti la 3, 5diiodotironina e uso farmaceutico diesse.
DE602004014787D1 (de)	2008-08-14	Anti-tumorale formulierungen mit defibrotid allein oder in kombination mit anderen antitumoralen mitteln
SE0001916D0 (sv)	2000-05-23	Novel formulation
DE60035133D1 (de)	2007-07-19	Pharmazeutische zusammensetzungen mit wundheilender und anti-komplementärer wirkung die ein dextranderivat enthalten
HRP20080597T3 (en)	2008-12-31	Cancer combination therapy comprising azd2171 and zd1839
HRP20020159B1 (en)	2007-08-31	Multi-dose erythropoietin formulations
MXPA04003851A (es)	2004-07-08	Antipruriticos.
BRPI0510820A (pt)	2007-11-27	composição farmacêutica, forma unitária de dosagem e seus usos
PT1358159E (pt)	2009-10-27	Tartrato e fosfato de 3,4 diaminopiridina, as suas composições farmacêuticas e as suas utilizações