ATE319729T1 - 9a-azalide mit entzündungshemmender wirkung - Google Patents

9a-azalide mit entzündungshemmender wirkung

Info

Publication number: ATE319729T1
Authority: AT; Austria
Prior art keywords: azalide; inflammatory effect; inflammatory activity; azalides; cladinose
Prior art date: 2002-10-29

Application number

AT03809747T

Other languages

English (en)

Inventor

Mauro Napoletano

Andrea Mereu

Ermanno Moriggi

Fernando Ornaghi

Gabriele Morazzoni

Franco Pellacini

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-29

Filing date

2003-10-28

Publication date

2006-03-15

2003-10-28 Application filed by Zambon Spa filed Critical Zambon Spa

2006-03-15 Application granted granted Critical

2006-03-15 Publication of ATE319729T1 publication Critical patent/ATE319729T1/de

Links

230000003110 anti-inflammatory effect Effects 0.000 title abstract 3
YHVUVJYEERGYNU-UHFFFAOYSA-N 4',8-Di-Me ether-5,7,8-Trihydroxy-3-(4-hydroxybenzyl)-4-chromanone Natural products COC1(C)CC(O)OC(C)C1O YHVUVJYEERGYNU-UHFFFAOYSA-N 0.000 abstract 1
AJSDVNKVGFVAQU-BIIVOSGPSA-N cladinose Chemical group O=CC[C@@](C)(OC)[C@@H](O)[C@H](C)O AJSDVNKVGFVAQU-BIIVOSGPSA-N 0.000 abstract 1
239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
229940041033 macrolides Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Pulmonology (AREA)
Biotechnology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Biochemistry (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Immunology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT03809747T 2002-10-29 2003-10-28 9a-azalide mit entzündungshemmender wirkung ATE319729T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT002292A ITMI20022292A1 (it)	2002-10-29	2002-10-29	9a-azalidi ad attivita' antiinfiammatoria.

Publications (1)

Publication Number	Publication Date
ATE319729T1 true ATE319729T1 (de)	2006-03-15

Family

ID=32211389

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03809747T ATE319729T1 (de)	2002-10-29	2003-10-28	9a-azalide mit entzündungshemmender wirkung

Country Status (12)

Country	Link
US (1)	US7419961B2 (de)
EP (1)	EP1556397B1 (de)
JP (1)	JP4536516B2 (de)
CN (1)	CN100486985C (de)
AT (1)	ATE319729T1 (de)
AU (1)	AU2003276214B2 (de)
CA (1)	CA2502347C (de)
DE (1)	DE60303967D1 (de)
IL (1)	IL167882A (de)
IT (1)	ITMI20022292A1 (de)
RU (1)	RU2320668C2 (de)
WO (1)	WO2004039821A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20021726A1 (it) *	2002-08-01	2004-02-02	Zambon Spa	Macrolidi ad attivita' antiinfiammatoria.
EP3738591A3 (de)	2003-03-10	2021-03-24	Merck Sharp & Dohme Corp.	Neuartige antibakterielle wirkstoffe
ATE419261T1 (de) *	2005-01-13	2009-01-15	Glaxosmithkline Zagreb	Decladinosyl-macrolide mit entzündungshemmender wirkung
US20080200403A1 (en) *	2005-01-14	2008-08-21	Glaxosmithkline	9A-Carbamoyl and Thiocarbamoyl Azalides with Anti-Inflammatory Activity
US20090105301A1 (en) *	2006-05-03	2009-04-23	Sulejman Alihodzic	9a-substituted azalides for the treatment of malaria
US9453042B2 (en) *	2007-10-25	2016-09-27	Cempra Pharmaceuticals, Inc.	Process for the preparation of macrolide antibacterial agents
CN107854477A (zh)	2008-10-24	2018-03-30	森普拉制药公司	使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en) *	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
CN108310000A (zh)	2009-09-10	2018-07-24	森普拉制药公司	治疗疟疾、结核病和mac疾病的方法
US8975386B2 (en)	2010-03-22	2015-03-10	Cempra Pharmaceuticals, Inc.	Crystalline forms of a macrolide, and uses therefor
CN102917708B (zh)	2010-05-20	2015-11-25	森普拉制药公司	制备大环内酯和酮内酯及其中间体的方法
KR20180110181A (ko)	2010-09-10	2018-10-08	셈프라 파마슈티컬스, 인크.	질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
SG11201405895UA (en)	2012-03-27	2014-10-30	Cempra Pharmaceuticals Inc	Parenteral formulations for administering macrolide antibiotics
US9861616B2 (en)	2013-03-14	2018-01-09	Cempra Pharmaceuticals, Inc.	Methods for treating respiratory diseases and formulations therefor
MX356772B (es)	2013-03-15	2018-06-13	Cempra Pharmaceuticals Inc	Procesos convergentes para la preparacion de agentes antibacterianos macrolidos.
EP2984087A1 (de) *	2013-04-10	2016-02-17	Probiotic Pharmaceuticals APS	Antimikrobielle azithromycinderivate mit nicht-antibiotischer pharmazeutischer wirkung
GB201520419D0 (en) *	2015-11-19	2016-01-06	Epi Endo Pharmaceuticals Ehf	Compounds
PE20211006A1 (es) *	2018-10-02	2021-06-01	Lunella Biotech Inc	Derivados de azitromicina y roxitromicina como farmacos senoliticos
EP4118092B1 (de)	2020-03-12	2025-07-16	Zoetis Services LLC	Immunomodulierende o-het-aryl-azaalide
JP7770547B2 (ja)	2021-09-07	2025-11-14	ゾエティス・サービシーズ・エルエルシー	免疫調節性アザライド

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1100504A (en) *	1967-08-16	1968-01-24	Pliva Pharm & Chem Works	Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide
US3928387A (en) *	1974-02-04	1975-12-23	Hoffmann La Roche	Antibiotic 1745A/X and methods for the production thereof
SI7910768A8 (en) *	1979-04-02	1996-06-30	Pliva Pharm & Chem Works	Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
SI8110592A8 (en)	1981-03-06	1996-06-30	Pliva Pharm & Chem Works	Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4464527A (en) *	1983-06-30	1984-08-07	Pfizer Inc.	Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
HU198913B (en) *	1987-09-03	1989-12-28	Pliva Pharm & Chem Works	Process for producing 10-dihydro-10-deoxo-11-aza-erythronolide a-derivatives and pharmaceutical compositions containing them as active components
SI9011409A (en) *	1990-07-18	1995-10-31	Pliva Pharm & Chem Works	O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
WO1992016226A1 (en)	1991-03-19	1992-10-01	Smithkline Beecham Corporation	Il-1 inhibitors
FR2691464B1 (fr) *	1992-05-21	1995-06-02	Roussel Uclaf	Nouveaux dérivés de la 1-oxa 6-azacyclopentadécane 13,15-dione, leur procédé de préparation et leur application comme médicaments.
CA2196878A1 (en)	1994-08-12	1996-02-22	Akihiko Hoshino	Interleukin-5 production inhibitor
AU3192595A (en)	1994-08-12	1996-03-07	Taisho Pharmaceutical Co., Ltd.	Interleukin-5 production inhibitor
AU7961498A (en) *	1997-06-26	1999-01-19	Merck & Co., Inc.	9a-azalides, compositions containing such compounds and methods of treatment
JP2001520234A (ja) *	1997-10-16	2001-10-30	プリバフアルマセウトスカインダストリヤデイオニツコドルストヴオ	９ａ−アザリド類から誘導される新規３，６−ヘミケタール類
DK0941998T3 (da) *	1998-03-03	2004-09-20	Pfizer Prod Inc	3,6-ketalmakrolidantibiotika
US6262030B1 (en) *	1998-11-03	2001-07-17	Pfizer Inc.	Erythromycin derivatives
IT1306205B1 (it)	1999-01-15	2001-05-30	Zambon Spa	Macrolidi ad attivita' antiinfiammatoria.

2002
- 2002-10-29 IT IT002292A patent/ITMI20022292A1/it unknown
2003
- 2003-10-28 RU RU2005116248/04A patent/RU2320668C2/ru not_active IP Right Cessation
- 2003-10-28 JP JP2004547618A patent/JP4536516B2/ja not_active Expired - Fee Related
- 2003-10-28 CA CA2502347A patent/CA2502347C/en not_active Expired - Fee Related
- 2003-10-28 EP EP03809747A patent/EP1556397B1/de not_active Expired - Lifetime
- 2003-10-28 CN CNB2003801023509A patent/CN100486985C/zh not_active Expired - Fee Related
- 2003-10-28 AT AT03809747T patent/ATE319729T1/de not_active IP Right Cessation
- 2003-10-28 US US10/531,462 patent/US7419961B2/en not_active Expired - Fee Related
- 2003-10-28 AU AU2003276214A patent/AU2003276214B2/en not_active Ceased
- 2003-10-28 DE DE60303967T patent/DE60303967D1/de not_active Expired - Lifetime
- 2003-10-28 WO PCT/EP2003/012071 patent/WO2004039821A1/en not_active Ceased
2005
- 2005-04-06 IL IL167882A patent/IL167882A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2006513157A (ja)	2006-04-20
EP1556397A1 (de)	2005-07-27
US7419961B2 (en)	2008-09-02
IL167882A (en)	2010-06-30
RU2320668C2 (ru)	2008-03-27
EP1556397B1 (de)	2006-03-08
DE60303967D1 (de)	2006-05-04
JP4536516B2 (ja)	2010-09-01
ITMI20022292A1 (it)	2004-04-30
AU2003276214B2 (en)	2009-05-28
RU2005116248A (ru)	2006-01-20
CA2502347C (en)	2011-06-28
US20060166904A1 (en)	2006-07-27
AU2003276214A1 (en)	2004-05-25
CN1708507A (zh)	2005-12-14
CA2502347A1 (en)	2004-05-13
CN100486985C (zh)	2009-05-13
WO2004039821A1 (en)	2004-05-13

Legal Events

Date	Code	Title	Description
2006-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE319729T1 (de)	2006-03-15	9a-azalide mit entzündungshemmender wirkung
ATE509938T1 (de)	2011-06-15	Makrolidverbindungen mit antiinflammatorischer wirkung
NO2025027I1 (no)	2025-06-13	Pharmaceutical mixture or association that includes as active ingredients: (1) ceftazidime or a salt thereof, and (2) avibactam or a pharmaceutically acceptable salt thereof - forlenget.
ATE374016T1 (de)	2007-10-15	Tablette mit hohem wirkstoffgehalt
BR0115810B1 (pt)	2011-10-18	composições cosméticas, dermatológicas e farmacêuticas isentas de tensoativos.
NO20053076D0 (no)	2005-06-23	Farmasoytisk formulering med en uloselig aktiv forbindelse.
ITTO20010005A0 (it)	2001-01-09	Formulazione farmaceutica.
NO992102D0 (no)	1999-04-30	Peptidblanding, samt farmasøytisk sammensetning og kreftvaksine som innbefatter peptidblandingen
PT1121127E (pt)	2005-03-31	Composicoes farmaceuticas orais contendo buprenorfina
DE60142913D1 (de)	2010-10-07	Arzneilösungen enthaltend modafinilverbindungen
DE69915487D1 (de)	2004-04-15	Erythromycin-derivate mit antibiotischer wirkung
ITMI20031396A1 (it)	2005-01-10	Composizione per uso farmaceutico o dietetico o cosmetico dotata di attivita' antiossidante.
NL1023790A1 (nl)	2004-02-03	Farmaceutische samenstellingen met antibiotische activiteit.
ITRM20030363A0 (it)	2003-07-24	Composizioni comprendenti la 3, 5diiodotironina e uso farmaceutico diesse.
DE602004014787D1 (de)	2008-08-14	Anti-tumorale formulierungen mit defibrotid allein oder in kombination mit anderen antitumoralen mitteln
DE60001266D1 (de)	2003-02-27	Betahistin-hältige formulierung mit kontrollierter wirkstofffreisetzung
SE0001916D0 (sv)	2000-05-23	Novel formulation
DE60035133D1 (de)	2007-07-19	Pharmazeutische zusammensetzungen mit wundheilender und anti-komplementärer wirkung die ein dextranderivat enthalten
HRP20080597T3 (en)	2008-12-31	Cancer combination therapy comprising azd2171 and zd1839
HRP20020159B1 (en)	2007-08-31	Multi-dose erythropoietin formulations
MXPA04003851A (es)	2004-07-08	Antipruriticos.
BRPI0510820A (pt)	2007-11-27	composição farmacêutica, forma unitária de dosagem e seus usos
ES2196769T3 (es)	2003-12-16	Uso topico de loperamide para el tratamiento de infecciones microbianas.
ITMI20020872A1 (it)	2003-10-23	Derivati dell'iperforina loro uso e formulazioni che li contengono
DK1086695T3 (da)	2005-04-25	Antivirale præparater omfattende yohimbin som aktivt princip