ATE319848T1 - Herstellung von polyketiden - Google Patents

Herstellung von polyketiden

Info

Publication number
ATE319848T1
ATE319848T1 AT00973861T AT00973861T ATE319848T1 AT E319848 T1 ATE319848 T1 AT E319848T1 AT 00973861 T AT00973861 T AT 00973861T AT 00973861 T AT00973861 T AT 00973861T AT E319848 T1 ATE319848 T1 AT E319848T1
Authority
AT
Austria
Prior art keywords
product
precursor
polyketides
produce
host cells
Prior art date
Application number
AT00973861T
Other languages
English (en)
Inventor
Leonard Katz
Peter Revill
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Application granted granted Critical
Publication of ATE319848T1 publication Critical patent/ATE319848T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Saccharide Compounds (AREA)
AT00973861T 1999-10-25 2000-10-25 Herstellung von polyketiden ATE319848T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16141499P 1999-10-25 1999-10-25

Publications (1)

Publication Number Publication Date
ATE319848T1 true ATE319848T1 (de) 2006-03-15

Family

ID=22581090

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00973861T ATE319848T1 (de) 1999-10-25 2000-10-25 Herstellung von polyketiden

Country Status (6)

Country Link
US (2) US6627427B1 (de)
EP (1) EP1224317B1 (de)
AT (1) ATE319848T1 (de)
AU (1) AU1231701A (de)
DE (1) DE60026563D1 (de)
WO (1) WO2001031049A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713279B1 (en) 1995-12-07 2004-03-30 Diversa Corporation Non-stochastic generation of genetic vaccines and enzymes
US6939689B2 (en) 1995-12-07 2005-09-06 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US6790605B1 (en) 1995-12-07 2004-09-14 Diversa Corporation Methods for obtaining a desired bioactivity or biomolecule using DNA libraries from an environmental source
US5830696A (en) 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
US6838265B2 (en) * 2000-05-02 2005-01-04 Kosan Biosciences, Inc. Overproduction hosts for biosynthesis of polyketides
US7413878B2 (en) 2002-07-15 2008-08-19 Kosan Biosciences, Inc. Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit
US7067290B2 (en) 2002-11-12 2006-06-27 Kosan Biosciences Incorporated Method for production of polyketides
US20060069360A1 (en) * 2004-09-29 2006-03-30 Kimberly-Clark Worldwide, Inc. Absorbent article with insult indicators
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
CN102317436B (zh) * 2008-07-23 2014-06-25 Opx生物工艺学公司 用于增加微生物对3-羟基丙酸(3-hp)的耐受性以及增加3-羟基丙酸产量的方法、系统和组合物
MX2012003604A (es) 2009-09-27 2012-09-12 Opx Biotechnologies Inc Metodo para producir acido 3-hidroxipropionico y otros productos.
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
CN102695792B (zh) 2009-10-08 2015-02-18 加利福尼亚大学董事会 对辛伐他汀合成表现出改善性质的LovD突变体
WO2012089349A2 (en) * 2010-12-31 2012-07-05 Acies Bio D.O.O. Novel polyketide compounds and methods of making same
MX2015001780A (es) 2012-08-10 2015-09-28 Opx Biotechnologies Inc Microorganismos y métodos para la producción de ácidos grasos y productos derivados de ácidos grasos.
US20150119601A1 (en) 2013-03-15 2015-04-30 Opx Biotechnologies, Inc. Monofunctional mcr + 3-hp dehydrogenase
EP2976141A4 (de) 2013-03-15 2016-10-05 Cargill Inc Blitzverdampfung für produktionsreinigung und rückgewinnung
EP3022310B1 (de) 2013-07-19 2019-10-16 Cargill, Incorporated Mikroorganismen und verfahren zur herstellung von fettsäuren und aus fettsäuren gewonnenen produkten
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP2993228B1 (de) 2014-09-02 2019-10-09 Cargill, Incorporated Herstellung von fettsäureestern
US11345938B2 (en) 2017-02-02 2022-05-31 Cargill, Incorporated Genetically modified cells that produce C6-C10 fatty acid derivatives
WO2018226893A2 (en) 2017-06-06 2018-12-13 Zymergen Inc. A high-throughput (htp) genomic engineering platform for improving saccharopolyspora spinosa
CN111454975B (zh) * 2020-04-17 2023-06-20 长沙微智生物科技有限公司 一种与多杀菌素相关的ech基因的应用
WO2025235965A1 (en) * 2024-05-10 2025-11-13 The Regents Of The University Of California Hybrid polyketide synthase biosynthesis of alcohols and derivatives thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824513A (en) * 1991-01-17 1998-10-20 Abbott Laboratories Recombinant DNA method for producing erythromycin analogs
US5672491A (en) 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US6066721A (en) 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
ATE286133T1 (de) 1995-07-06 2005-01-15 Univ Leland Stanford Junior Zellfreie synthese von polyketiden
CA2232230C (en) 1995-10-13 2005-06-28 Ralph H. Lambalot Phosphopantetheinyl transferases and uses thereof
US6033883A (en) 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
NZ500693A (en) 1997-04-30 2004-01-30 Kosan Biosciences Inc Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
WO1999002669A2 (en) 1997-07-10 1999-01-21 Kosan Biosciences, Inc. Production of polyketides in plants
MXPA01003376A (es) * 1998-10-02 2002-11-07 Kosan Biosciences Inc Enzimas policetido sintetasa y construcciones de acido desoxirribonucleico recombinante para las mismas.
WO2000031247A2 (en) * 1998-11-20 2000-06-02 Kosan Biosciences, Inc. Recombinant methods and materials for producing epothilone and epothilone derivatives
ES2335385T3 (es) 1999-10-13 2010-03-26 The Board Of Trustees Of The Leland Stanford Junior University Biosintesis de sustratos de policetido sintasa.
CA2388422A1 (en) 1999-10-27 2001-05-03 Kosan Biosciences, Inc. Heterologous production of polyketides

Also Published As

Publication number Publication date
DE60026563D1 (de) 2006-05-04
AU1231701A (en) 2001-05-08
EP1224317A2 (de) 2002-07-24
WO2001031049A3 (en) 2002-01-24
EP1224317B1 (de) 2006-03-08
US20030235892A1 (en) 2003-12-25
US6627427B1 (en) 2003-09-30
WO2001031049A2 (en) 2001-05-03

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