ATE320001T1 - Durch fluoreszierenden polymer markierte konjugate und zwischen produkte - Google Patents

Durch fluoreszierenden polymer markierte konjugate und zwischen produkte

Info

Publication number
ATE320001T1
ATE320001T1 AT94923455T AT94923455T ATE320001T1 AT E320001 T1 ATE320001 T1 AT E320001T1 AT 94923455 T AT94923455 T AT 94923455T AT 94923455 T AT94923455 T AT 94923455T AT E320001 T1 ATE320001 T1 AT E320001T1
Authority
AT
Austria
Prior art keywords
polymer
conjugates
fluorescent polymer
intermediate products
fluorescent
Prior art date
Application number
AT94923455T
Other languages
English (en)
Inventor
Jeffrey Bruce Huff
Christopher Bieniarz
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE320001T1 publication Critical patent/ATE320001T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Luminescent Compositions (AREA)
  • Polyamides (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Graft Or Block Polymers (AREA)
AT94923455T 1993-07-13 1994-07-13 Durch fluoreszierenden polymer markierte konjugate und zwischen produkte ATE320001T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9114993A 1993-07-13 1993-07-13

Publications (1)

Publication Number Publication Date
ATE320001T1 true ATE320001T1 (de) 2006-03-15

Family

ID=22226323

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94923455T ATE320001T1 (de) 1993-07-13 1994-07-13 Durch fluoreszierenden polymer markierte konjugate und zwischen produkte

Country Status (8)

Country Link
EP (1) EP0708837B1 (de)
JP (1) JPH09500411A (de)
AT (1) ATE320001T1 (de)
AU (1) AU7331794A (de)
CA (1) CA2172999A1 (de)
DE (1) DE69434649T2 (de)
ES (1) ES2259791T3 (de)
WO (1) WO1995002700A1 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319670B1 (en) * 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US5994143A (en) * 1996-02-01 1999-11-30 Abbott Laboratories Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment
FR2757162B1 (fr) * 1996-12-12 1999-03-26 Cis Bio Int Conjugues fluorescents non agreges
US5877310A (en) * 1997-04-25 1999-03-02 Carnegie Mellon University Glycoconjugated fluorescent labeling reagents
AT408150B (de) * 2000-04-14 2001-09-25 Oesterr Forsch Seibersdorf Verfahren zur immobilisierung eines analyten an einer festen oberfläche
CA2415338C (en) * 2000-08-04 2012-10-23 Sensors For Medicine And Science, Inc. Detection of analytes in aqueous environments
US9371559B2 (en) 2002-06-20 2016-06-21 The Regents Of The University Of California Compositions for detection and analysis of polynucleotides using light harvesting multichromophores
US10001475B2 (en) 2002-06-20 2018-06-19 The Regents Of The University Of California Light harvesting multichromophore compositions and methods of using the same
US7144950B2 (en) 2003-09-17 2006-12-05 The Regents Of The University Of California Conformationally flexible cationic conjugated polymers
CA2497152C (en) 2002-08-26 2016-06-07 The Regents Of The University Of California Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores
CN1771335A (zh) 2003-02-13 2006-05-10 加州大学评议会 使用集光多生色团检测和分析多核苷酸－结合蛋白相互作用的方法和组合物
FR2878853B1 (fr) * 2004-12-07 2007-03-16 Biocydex Soc Par Actions Simpl Procede d'obtention d'un complexe fluorescent, complexe obtenu et utilisation
WO2006074471A2 (en) 2005-01-10 2006-07-13 The Regents Of The University Of California Cationic conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays
WO2006074482A2 (en) 2005-01-10 2006-07-13 The Regents Of The University Of California Methods and kits for strand-specific polynucleotide detection with cationic multichromophores
US7666594B2 (en) 2005-01-31 2010-02-23 The Regents Of The University Of California Methods for assaying a sample for an aggregant
JP5420414B2 (ja) 2006-10-06 2014-02-19 シリゲン グループ リミテッド 指向性バイオマーカシグナル増幅用の蛍光方法および材料
JP2010528122A (ja) * 2007-05-09 2010-08-19 日東電工株式会社 白金薬剤と結合されたポリマー
US7985557B2 (en) 2007-05-23 2011-07-26 Ventana Medical Systems, Inc. Polymeric carriers for immunohistochemistry and in situ hybridization
SG177355A1 (en) 2009-06-26 2012-02-28 Sirigen Inc Signal amplified biological detection with conjugated polymers
ES2977359T3 (es) 2010-01-19 2024-08-22 Sirigen Ii Ltd Nuevos reactivos para la amplificación dirigida de la señal de un biomarcador
EP3019559A4 (de) 2013-08-22 2017-04-05 Sony Corporation Wasserlösliche fluoreszierende oder gefärbte farbstoffe und verfahren zu verwendung
EP3094687B1 (de) 2014-01-16 2020-02-12 Sony Corporation Wasserlösliche fluoreszierende oder gefärbte farbstoffe
JP6344647B2 (ja) * 2014-08-20 2018-06-20 学校法人日本大学 蛍光物質及びその製造方法
WO2016138461A1 (en) 2015-02-26 2016-09-01 Sony Corporation Water soluble fluorescent or colored dyes comprising conjugating groups
KR102646956B1 (ko) 2015-02-26 2024-03-14 소니그룹주식회사 페닐에티닐나프탈렌 염료 및 이의 사용 방법
KR102765335B1 (ko) 2015-05-11 2025-02-13 소니그룹주식회사 초휘도 이량체성 또는 중합체성 염료
CN105237658B (zh) * 2015-09-24 2018-05-22 荆楚理工学院 一种荧光修饰环糊精及其制备方法和应用
EP3436528B1 (de) 2016-04-01 2025-07-02 Sony Group Corporation Ultrahelle dimere oder polymere farbstoffe mit gruppen mit starrem abstand
BR112018070164B1 (pt) 2016-04-01 2022-09-27 Sony Corporation Of America Corantes diméricos ou poliméricos ultrabrilhantes
CN109153860B (zh) 2016-04-06 2021-04-23 索尼公司 具有间隔连接体基团的超高亮二聚体或聚合物染料
JP7527537B2 (ja) 2016-05-10 2024-08-05 ソニーグループ株式会社 ペプチド骨格を有する超明色ポリマー染料
US11390754B2 (en) 2016-05-10 2022-07-19 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
BR112018073199A2 (pt) 2016-05-11 2019-04-16 Sony Corporation corantes diméricos ou poliméricos ultrabrilhantes
EP3464477A1 (de) 2016-06-06 2019-04-10 Sony Corporation Ionische polymere mit fluoreszierenden oder gefärbten reportergruppen
WO2018022925A1 (en) 2016-07-29 2018-02-01 Sony Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
JP7041884B2 (ja) * 2017-08-29 2022-03-25 東芝インフラシステムズ株式会社 水質分析用試薬及び水質分析方法
KR20260011205A (ko) 2017-10-05 2026-01-22 소니그룹주식회사 프로그램가능한 중합체성 약물
US12290571B2 (en) 2017-10-05 2025-05-06 Sony Group Corporation Programmable dendritic drugs
CN111836645A (zh) 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
US12076407B2 (en) 2018-01-12 2024-09-03 Sony Group Corporation Polymers with rigid spacing groups comprising biologically active compounds
WO2019140128A1 (en) 2018-01-12 2019-07-18 Sony Corporation Phosphoalkyl polymers comprising biologically active compounds
EP3737417B1 (de) 2018-01-12 2025-08-27 Sony Group Corporation Phosphoalkyl-ribose-polymere mit biologisch aktiven verbindungen
EP3769085B1 (de) 2018-03-19 2022-08-24 Sony Group Corporation Verwendung von zweiwertigen metallen zur verstärkung von fluoreszenzsignalen
KR102864292B1 (ko) 2018-03-21 2025-09-26 소니그룹주식회사 링커 군을 갖는 중합체성 텐덤 염료
JP7580689B2 (ja) 2018-06-27 2024-11-12 ソニーグループ株式会社 デオキシリボースを含むリンカー基を有するポリマー色素
US12578342B2 (en) 2018-07-13 2026-03-17 Sony Group Corporation Polymeric dyes having a backbone comprising organophosphate units
EP3861074A2 (de) 2019-09-26 2021-08-11 Sony Group Corporation Polymere tandemfarbstoffe mit linkergruppen
EP4038081A1 (de) 2019-09-30 2022-08-10 Sony Group Corporation Nukleotidsonden
EP4256078A1 (de) 2020-12-07 2023-10-11 Sony Group Corporation Abstandslinkergruppendesign zur helligkeitsverstärkung in dimeren oder polymeren farbstoffen
WO2022182837A1 (en) * 2021-02-26 2022-09-01 Collins James J Devices and methods for rapid nucleic acid preparation and detection
CN114344483A (zh) * 2022-01-18 2022-04-15 西安交通大学 基于超小分子H-dot纳米载药系统的肺癌诊疗一体化的靶向纳米药物及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169137A (en) * 1974-12-20 1979-09-25 Block Engineering, Inc. Antigen detecting reagents
US5068227A (en) * 1989-01-18 1991-11-26 Cyclex, Inc. Cyclodextrins as carriers
WO1991002040A1 (en) * 1989-08-04 1991-02-21 Kosak Kenneth M Cyclodextrin labels for nucleic acid and biochemical analysis
WO1991005605A1 (en) * 1989-10-10 1991-05-02 Kosak Kenneth M Cyclodextrin labels for immunoassay and biochemical analysis

Also Published As

Publication number Publication date
EP0708837B1 (de) 2006-03-08
ES2259791T3 (es) 2006-10-16
JPH09500411A (ja) 1997-01-14
DE69434649T2 (de) 2007-02-22
CA2172999A1 (en) 1995-01-26
DE69434649D1 (de) 2006-05-04
WO1995002700A1 (en) 1995-01-26
AU7331794A (en) 1995-02-13
EP0708837A1 (de) 1996-05-01
EP0708837A4 (de) 2002-11-20

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