ATE320442T1 - Verfahren zur entschützung von geschützten thiolen - Google Patents

Verfahren zur entschützung von geschützten thiolen

Info

Publication number
ATE320442T1
ATE320442T1 AT00946168T AT00946168T ATE320442T1 AT E320442 T1 ATE320442 T1 AT E320442T1 AT 00946168 T AT00946168 T AT 00946168T AT 00946168 T AT00946168 T AT 00946168T AT E320442 T1 ATE320442 T1 AT E320442T1
Authority
AT
Austria
Prior art keywords
thioles
peptides
deprotection
protected thiol
disulphide
Prior art date
Application number
AT00946168T
Other languages
English (en)
Inventor
Alan Cuthbertson
Original Assignee
Amersham Health As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9916919.5A external-priority patent/GB9916919D0/en
Priority claimed from GB0003926A external-priority patent/GB0003926D0/en
Priority claimed from GB0007865A external-priority patent/GB0007865D0/en
Application filed by Amersham Health As filed Critical Amersham Health As
Application granted granted Critical
Publication of ATE320442T1 publication Critical patent/ATE320442T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Cephalosporin Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
AT00946168T 1999-07-19 2000-07-19 Verfahren zur entschützung von geschützten thiolen ATE320442T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9916919.5A GB9916919D0 (en) 1999-07-19 1999-07-19 Process for the deprotection of protected thiols
GB0003926A GB0003926D0 (en) 2000-02-18 2000-02-18 Process for the deprotection of protected thiols
GB0007865A GB0007865D0 (en) 2000-03-31 2000-03-31 Process for the deprotection of protected thiols

Publications (1)

Publication Number Publication Date
ATE320442T1 true ATE320442T1 (de) 2006-04-15

Family

ID=27255545

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00946168T ATE320442T1 (de) 1999-07-19 2000-07-19 Verfahren zur entschützung von geschützten thiolen

Country Status (8)

Country Link
US (1) US6906171B2 (de)
EP (1) EP1196429B1 (de)
JP (1) JP4738683B2 (de)
AT (1) ATE320442T1 (de)
AU (1) AU6004100A (de)
DE (1) DE60026708T2 (de)
ES (1) ES2267551T3 (de)
WO (1) WO2001005757A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772188B2 (en) * 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
ES2237356T3 (es) * 2003-04-07 2007-04-01 Novetide Ltd. Procedimiento para la produccion de peptidos ciclicos.
NZ551210A (en) * 2004-06-16 2009-10-30 Ge Healthcare As Peptide-based compounds
EP1781339B1 (de) 2004-06-25 2013-12-25 Thomas Jefferson University Guanylylcyclase C Liganden
EP1921087A1 (de) * 2006-11-10 2008-05-14 Primm S.R.L. Verfahren zur Herstellung von cyclischen Peptiden
US20110306561A1 (en) * 2009-02-12 2011-12-15 Yeda Research And Devlopment Co. Ltd. COMPLEMENT C3a DERIVED DIMERIC PEPTIDES AND USES THEREOF
GB0918321D0 (en) 2009-10-20 2009-12-02 Ge Healthcare As Cyclic peptide synthesis
CA2877868C (en) 2012-06-15 2020-04-21 Husky Injection Molding Systems Ltd. A multi-property injection molding nozzle
US10858389B2 (en) 2015-03-26 2020-12-08 Amgen Inc. Solution phase method for preparing etelcalcetide

Also Published As

Publication number Publication date
DE60026708D1 (de) 2006-05-11
JP2003505368A (ja) 2003-02-12
ES2267551T3 (es) 2007-03-16
AU6004100A (en) 2001-02-05
US6906171B2 (en) 2005-06-14
DE60026708T2 (de) 2006-12-14
EP1196429B1 (de) 2006-03-15
WO2001005757A3 (en) 2001-07-19
JP4738683B2 (ja) 2011-08-03
EP1196429A2 (de) 2002-04-17
WO2001005757A2 (en) 2001-01-25
US20020143207A1 (en) 2002-10-03

Similar Documents

Publication Publication Date Title
BR0008759A (pt) Métodos para a produção de proteinas contendo resìduos de cisteina livre
Botti et al. Native chemical ligation through in situ O to S acyl shift
ATE320442T1 (de) Verfahren zur entschützung von geschützten thiolen
DE69936409D1 (de) Verfahren zur schrittweise Bindung von Polyethylenglykol (PEG) an Polypeptide
DE60118598D1 (de) Verfahren zur rückfaltung von chemisch hergestellten polypeptiden
ATE377006T1 (de) Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer
DE60320362D1 (de) Verfahren zur Herstellung von Dipeptiden
ATE356866T1 (de) Polymerasenchimären
DE60222612D1 (de) Verfahren zur Herstellung von wasserfreiem Alkalisulfid
DE602005020165D1 (de) Verfahren zur herstellung von l-arginin, l-ornithin oder l-citrullin
DE60010285D1 (de) Verfahren zur Herstellung von Amino-Oxide
CY1108570T1 (el) Gd3-μιμητικα πεπτιδια
DE60233186D1 (de) Verbessertes System zur Behandlung von Elementarschwefel-Rückständen
AR034869A1 (es) Procedimiento para la sintesis rapida de un peptido en solucion, metodos para la sintesis combinatoria de bibliotecas de peptidos y para l a sintesis automatizada de peptidos en solucion que aplican dicho procedimiento y un peptido o una mezcla de peptidos asi obtenido(a)
ATE165868T1 (de) Verfahren zur enzymatischen herstellung geschützter und ungeschützter di- und oligopeptide in wässrigen lösungen
DE50107254D1 (de) Verfahren zur Instandsetzung von metallischen Bauteilen
BR9911891A (pt) Proteases fundidas com variantes de inibidor de subtilisina de streptomyces
JPH0523260B2 (de)
DE50113374D1 (de) Verfahren zur agglomeration von feinteiligen polybutadienlatices
EP1513945A4 (de) Verfahren zur universellen enzymatischen herstellung bioaktiver peptide
DE60331437D1 (de) Nachspaltige sulfurentschützung zur konvergenten proteinherstellung beim verfahren von chemischer ligation
DE69927315D1 (de) Verfahren zur Herstellung von L-Asparaginsäure
DE60018937D1 (de) Somatostatin analoge und deren verwendung zur behandlung von krebs
DE60032308D1 (de) Verfahren zur Herstellung von Trichloressigsäure
DE50300411D1 (de) Verfahren zur Herstellung von wasserfreiem Alkalisulfid

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties