ATE322501T1 - Verfahren zur rückfaltung von chemisch hergestellten polypeptiden - Google Patents

Verfahren zur rückfaltung von chemisch hergestellten polypeptiden

Info

Publication number: ATE322501T1
Authority: AT; Austria
Prior art keywords: refolding; produced polypeptides; chemically produced; cysteine; reducing agent
Prior art date: 2000-11-27

Application number

AT01990489T

Other languages

English (en)

Inventor

Antonio Verdini

Giampietro Corradin

Mario Roggero

Original Assignee

Rmf Dictagene Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-27

Filing date

2001-11-27

Publication date

2006-04-15

2001-11-27 Application filed by Rmf Dictagene Sa filed Critical Rmf Dictagene Sa

2006-04-15 Application granted granted Critical

2006-04-15 Publication of ATE322501T1 publication Critical patent/ATE322501T1/de

Links

229920001184 polypeptide Polymers 0.000 title abstract 3
102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 3
239000003638 chemical reducing agent Substances 0.000 abstract 2
GFQRKHUHTJYDPB-LURJTMIESA-O CCCC[S+]=C([C@H](CS)N)O Chemical group CCCC[S+]=C([C@H](CS)N)O GFQRKHUHTJYDPB-LURJTMIESA-O 0.000 abstract 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
235000018417 cysteine Nutrition 0.000 abstract 1
235000018102 proteins Nutrition 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
Analytical Chemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT01990489T 2000-11-27 2001-11-27 Verfahren zur rückfaltung von chemisch hergestellten polypeptiden ATE322501T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP00204207		2000-11-27

Publications (1)

Publication Number	Publication Date
ATE322501T1 true ATE322501T1 (de)	2006-04-15

Family

ID=8172340

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01990489T ATE322501T1 (de)	2000-11-27	2001-11-27	Verfahren zur rückfaltung von chemisch hergestellten polypeptiden

Country Status (22)

Country	Link
US (2)	US20020082384A1 (de)
EP (2)	EP1337549B1 (de)
JP (1)	JP2004516300A (de)
KR (1)	KR20030081315A (de)
CN (2)	CN1830999A (de)
AT (1)	ATE322501T1 (de)
AU (2)	AU2960302A (de)
BR (1)	BR0113091A (de)
CA (1)	CA2416054A1 (de)
CU (1)	CU23034A3 (de)
DE (1)	DE60118598T2 (de)
DK (1)	DK1337549T3 (de)
ES (1)	ES2261509T4 (de)
HU (1)	HUP0302395A3 (de)
IL (1)	IL155506A0 (de)
MX (1)	MXPA03003576A (de)
NO (1)	NO20032356D0 (de)
NZ (1)	NZ523679A (de)
PL (1)	PL364932A1 (de)
RU (1)	RU2275377C2 (de)
WO (1)	WO2002050099A2 (de)
ZA (1)	ZA200300642B (de)

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US7091310B2 (en) *	2002-09-13	2006-08-15	Chemokine Therapeutics Corporation	Chemokine analogs for the treatment of human disease
US7214660B2 (en)	2001-10-10	2007-05-08	Neose Technologies, Inc.	Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en)	2001-10-10	2007-02-06	Neose Technologies, Inc.	Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
EP1615945B1 (de)	2003-04-09	2011-09-28	BioGeneriX AG	Glycopegylierungsverfahren und durch die verfahren hergestellte proteine/peptide
WO2005012484A2 (en)	2003-07-25	2005-02-10	Neose Technologies, Inc.	Antibody-toxin conjugates
US20080305992A1 (en)	2003-11-24	2008-12-11	Neose Technologies, Inc.	Glycopegylated erythropoietin
KR20070083815A (ko) *	2004-10-26	2007-08-24	론자 아게	고체상 합성에서 ｓ-알킬-술페닐 보호기
EP1814573B1 (de)	2004-10-29	2016-03-09	ratiopharm GmbH	Remodellierung und glykopegylierung von fibroblasten-wachstumsfaktor (fgf)
CA2593682C (en)	2005-01-10	2016-03-22	Neose Technologies, Inc.	Glycopegylated granulocyte colony stimulating factor
EP1871795A4 (de)	2005-04-08	2010-03-31	Biogenerix Ag	Zusammensetzungen und verfahren zur herstellung von glycosylierungsmutanten eines proteaseresistenten menschlichen wachstumshormons
JP5335422B2 (ja) *	2005-06-17	2013-11-06	ノボノルディスクヘルスケアアクチェンゲゼルシャフト	少なくとも１つの非天然のシステインを含んでいる操作されたタンパク質の選択的な還元および誘導体化
US20070105755A1 (en)	2005-10-26	2007-05-10	Neose Technologies, Inc.	One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (en)	2005-11-03	2007-05-18	Neose Technologies, Inc.	Nucleotide sugar purification using membranes
JP2009520739A (ja) *	2005-12-23	2009-05-28	アプラゲンゲーエムベーハー	ジスルフィド架橋の形成方法
EP2013223A2 (de) *	2006-05-03	2009-01-14	Mallinckrodt Inc.	Zusammensetzung und verfahren zur freisetzung geschützter peptide aus einem harz
US9187532B2 (en)	2006-07-21	2015-11-17	Novo Nordisk A/S	Glycosylation of peptides via O-linked glycosylation sequences
US20100075375A1 (en)	2006-10-03	2010-03-25	Novo Nordisk A/S	Methods for the purification of polypeptide conjugates
EP2125863A1 (de) *	2006-12-23	2009-12-02	AplaGen GmbH	Verfahren zur ausbildung von disulfidbrücken
CN101796063B (zh)	2007-04-03	2017-03-22	拉蒂奥法姆有限责任公司	使用糖聚乙二醇化g‑csf的治疗方法
WO2008154639A2 (en)	2007-06-12	2008-12-18	Neose Technologies, Inc.	Improved process for the production of nucleotide sugars
CN103497247A (zh)	2008-02-27	2014-01-08	诺沃—诺迪斯克有限公司	缀合的因子viii分子
CN104844693B (zh) *	2015-06-10	2018-08-03	成都圣诺生物科技股份有限公司	一种合成利那洛肽的方法
EP3746157B1 (de)	2018-02-02	2024-05-15	Novo Nordisk A/S	Medikamenteninjektionsgerät mit auslenkbarem messgeber
CN111100188A (zh) *	2018-10-25	2020-05-05	成都医学院	一种制备蜘蛛抗菌肽的方法
CN109593119A (zh) *	2019-01-27	2019-04-09	上海丽珠制药有限公司	一种[2-d-组氨酸]-醋酸亮丙瑞林的制备方法
JP7453745B2 (ja) *	2019-03-28	2024-03-21	株式会社ヤクルト本社	毒性タンパク質の活性を阻害するペプチドのスクリーニング方法及び毒性タンパク質の製造方法
CN110845595A (zh) *	2019-11-14	2020-02-28	连云港职业技术学院	一种固相合成5-tmara标记的铁调素-25的方法
EP4126971A1 (de) *	2020-03-30	2023-02-08	Ablynx N.V.	Verfahren zur herstellung und reinigung multivalenter variabler immunglobulin-einzeldomänen

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DE2923787A1 (de) *	1979-06-12	1980-12-18	Max Planck Gesellschaft	Verfahren zur selektiven bildung von disulfidbruecken in polypeptiden und die dabei erhaltenen produkte als wirkstoffe enthaltende arzneimittel
DE3236849A1 (de) *	1982-10-05	1984-04-05	Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen	Neue thiohydrazin-1,2-dicarbonsaeure-derivate, verfahren zu ihrer herstellung und ihre verwendung
IL96682A0 (en) *	1989-12-15	1991-09-16	Amgen Inc	Production of biologically active platelet-derived growth factor from high expression host cell systems
RU2148586C1 (ru) *	1991-03-15	2000-05-10	Эмджен Инк.	Ковалентное модифицирование полипептидов полиэтиленгликолями
CA2072249C (en) *	1991-06-28	2003-06-17	Saiko Hosokawa	Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane
EP0628573A1 (de) *	1993-05-24	1994-12-14	Kao Corporation	Verfahren zur Herstellung solubilisierten Proteins
US5663304A (en) *	1993-08-20	1997-09-02	Genentech, Inc.	Refolding of misfolded insulin-like growth factor-I
DE4431317A1 (de) *	1994-09-02	1996-03-07	Biotechnolog Forschung Gmbh	Schutz- bzw. Ankergruppen und deren Verwendung

2001
- 2001-11-27 AU AU2960302A patent/AU2960302A/xx active Pending
- 2001-11-27 MX MXPA03003576A patent/MXPA03003576A/es active IP Right Grant
- 2001-11-27 IL IL15550601A patent/IL155506A0/xx unknown
- 2001-11-27 NZ NZ523679A patent/NZ523679A/en unknown
- 2001-11-27 RU RU2003119075/04A patent/RU2275377C2/ru not_active IP Right Cessation
- 2001-11-27 CA CA002416054A patent/CA2416054A1/en not_active Abandoned
- 2001-11-27 PL PL01364932A patent/PL364932A1/xx not_active Application Discontinuation
- 2001-11-27 AT AT01990489T patent/ATE322501T1/de not_active IP Right Cessation
- 2001-11-27 CU CU20030094A patent/CU23034A3/es unknown
- 2001-11-27 AU AU2002229603A patent/AU2002229603B2/en not_active Expired - Fee Related
- 2001-11-27 CN CNA2006100047520A patent/CN1830999A/zh active Pending
- 2001-11-27 DK DK01990489T patent/DK1337549T3/da active
- 2001-11-27 EP EP01990489A patent/EP1337549B1/de not_active Expired - Lifetime
- 2001-11-27 US US09/995,335 patent/US20020082384A1/en not_active Abandoned
- 2001-11-27 JP JP2002551992A patent/JP2004516300A/ja active Pending
- 2001-11-27 BR BR0113091-9A patent/BR0113091A/pt not_active IP Right Cessation
- 2001-11-27 DE DE60118598T patent/DE60118598T2/de not_active Expired - Fee Related
- 2001-11-27 HU HU0302395A patent/HUP0302395A3/hu unknown
- 2001-11-27 EP EP06075237A patent/EP1679318A1/de not_active Withdrawn
- 2001-11-27 KR KR10-2003-7004957A patent/KR20030081315A/ko not_active Ceased
- 2001-11-27 ES ES01990489T patent/ES2261509T4/es not_active Expired - Lifetime
- 2001-11-27 WO PCT/EP2001/014163 patent/WO2002050099A2/en not_active Ceased
- 2001-11-27 CN CNB018147968A patent/CN1249078C/zh not_active Expired - Fee Related
2003
- 2003-01-23 ZA ZA200300642A patent/ZA200300642B/en unknown
- 2003-05-26 NO NO20032356A patent/NO20032356D0/no unknown
2005
- 2005-05-19 US US11/132,987 patent/US20050239162A1/en not_active Abandoned

Also Published As

Publication number	Publication date
KR20030081315A (ko)	2003-10-17
RU2275377C2 (ru)	2006-04-27
CN1449406A (zh)	2003-10-15
WO2002050099A2 (en)	2002-06-27
CN1249078C (zh)	2006-04-05
PL364932A1 (en)	2004-12-27
JP2004516300A (ja)	2004-06-03
MXPA03003576A (es)	2003-10-14
HUP0302395A3 (en)	2007-05-02
BR0113091A (pt)	2003-07-08
EP1679318A1 (de)	2006-07-12
US20020082384A1 (en)	2002-06-27
DK1337549T3 (da)	2006-07-31
EP1337549A2 (de)	2003-08-27
CU23034A3 (es)	2005-03-22
ES2261509T4 (es)	2008-02-16
CA2416054A1 (en)	2002-06-27
NO20032356L (no)	2003-05-26
WO2002050099A3 (en)	2002-09-19
CN1830999A (zh)	2006-09-13
NZ523679A (en)	2005-10-28
DE60118598D1 (de)	2006-05-18
AU2960302A (en)	2002-07-01
IL155506A0 (en)	2003-11-23
US20050239162A1 (en)	2005-10-27
DE60118598T2 (de)	2007-02-15
NO20032356D0 (no)	2003-05-26
HUP0302395A2 (hu)	2003-10-28
ES2261509T3 (es)	2006-11-16
ZA200300642B (en)	2004-07-16
EP1337549B1 (de)	2006-04-05
AU2002229603B2 (en)	2007-11-08

Legal Events

Date

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2007-01-15

UEP

Publication of translation of european patent specification

Ref document number: 1337549

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2009-08-15

REN

Ceased due to non-payment of the annual fee

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