ATE322501T1 - Verfahren zur rückfaltung von chemisch hergestellten polypeptiden - Google Patents

Verfahren zur rückfaltung von chemisch hergestellten polypeptiden

Info

Publication number: ATE322501T1
Authority: AT; Austria
Prior art keywords: refolding; produced polypeptides; chemically produced; cysteine; reducing agent
Prior art date: 2000-11-27

Application number

AT01990489T

Other languages

English (en)

Inventor

Antonio Verdini

Giampietro Corradin

Mario Roggero

Original Assignee

Rmf Dictagene Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-27

Filing date

2001-11-27

Publication date

2006-04-15

2001-11-27 Application filed by Rmf Dictagene Sa filed Critical Rmf Dictagene Sa

2006-04-15 Application granted granted Critical

2006-04-15 Publication of ATE322501T1 publication Critical patent/ATE322501T1/de

Links

229920001184 polypeptide Polymers 0.000 title abstract 3
102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 3
239000003638 chemical reducing agent Substances 0.000 abstract 2
GFQRKHUHTJYDPB-LURJTMIESA-O CCCC[S+]=C([C@H](CS)N)O Chemical group CCCC[S+]=C([C@H](CS)N)O GFQRKHUHTJYDPB-LURJTMIESA-O 0.000 abstract 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
235000018417 cysteine Nutrition 0.000 abstract 1
235000018102 proteins Nutrition 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT01990489T 2000-11-27 2001-11-27 Verfahren zur rückfaltung von chemisch hergestellten polypeptiden ATE322501T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP00204207		2000-11-27

Publications (1)

Publication Number	Publication Date
ATE322501T1 true ATE322501T1 (de)	2006-04-15

Family

ID=8172340

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01990489T ATE322501T1 (de)	2000-11-27	2001-11-27	Verfahren zur rückfaltung von chemisch hergestellten polypeptiden

Country Status (22)

Country	Link
US (2)	US20020082384A1 (de)
EP (2)	EP1679318A1 (de)
JP (1)	JP2004516300A (de)
KR (1)	KR20030081315A (de)
CN (2)	CN1830999A (de)
AT (1)	ATE322501T1 (de)
AU (2)	AU2960302A (de)
BR (1)	BR0113091A (de)
CA (1)	CA2416054A1 (de)
CU (1)	CU23034A3 (de)
DE (1)	DE60118598T2 (de)
DK (1)	DK1337549T3 (de)
ES (1)	ES2261509T4 (de)
HU (1)	HUP0302395A3 (de)
IL (1)	IL155506A0 (de)
MX (1)	MXPA03003576A (de)
NO (1)	NO20032356L (de)
NZ (1)	NZ523679A (de)
PL (1)	PL364932A1 (de)
RU (1)	RU2275377C2 (de)
WO (1)	WO2002050099A2 (de)
ZA (1)	ZA200300642B (de)

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US7091310B2 (en) *	2002-09-13	2006-08-15	Chemokine Therapeutics Corporation	Chemokine analogs for the treatment of human disease
US7173003B2 (en)	2001-10-10	2007-02-06	Neose Technologies, Inc.	Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7214660B2 (en)	2001-10-10	2007-05-08	Neose Technologies, Inc.	Erythropoietin: remodeling and glycoconjugation of erythropoietin
PL1615945T3 (pl)	2003-04-09	2012-03-30	Ratiopharm Gmbh	Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami
US9005625B2 (en)	2003-07-25	2015-04-14	Novo Nordisk A/S	Antibody toxin conjugates
US20080305992A1 (en)	2003-11-24	2008-12-11	Neose Technologies, Inc.	Glycopegylated erythropoietin
TW200637872A (en) *	2004-10-26	2006-11-01	Lonza Ag	Thiol group protection and cyclization in solid-phase peptide synthesis
WO2006050247A2 (en)	2004-10-29	2006-05-11	Neose Technologies, Inc.	Remodeling and glycopegylation of fibroblast growth factor (fgf)
US9029331B2 (en)	2005-01-10	2015-05-12	Novo Nordisk A/S	Glycopegylated granulocyte colony stimulating factor
WO2006121569A2 (en)	2005-04-08	2006-11-16	Neose Technologies, Inc.	Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
ES2553160T3 (es) *	2005-06-17	2015-12-04	Novo Nordisk Health Care Ag	Reducción y derivatización selectivas de proteínas Factor VII transformadas por ingeniería que comprenden al menos una cisteína no nativa
US20070105755A1 (en)	2005-10-26	2007-05-10	Neose Technologies, Inc.	One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (en)	2005-11-03	2007-05-18	Neose Technologies, Inc.	Nucleotide sugar purification using membranes
US20090081145A1 (en) *	2005-12-23	2009-03-26	Aplagen Gmbh	Process for forming disulphide bridges
CA2651070A1 (en) *	2006-05-03	2007-11-15	Mallinckrodt Inc.	Composition and method for the release of protected peptides from a resin
EP2049144B8 (de)	2006-07-21	2015-02-18	ratiopharm GmbH	Glycosylierung von peptiden über o-verbundene glycosylierungssequenzen
EP2054521A4 (de)	2006-10-03	2012-12-19	Novo Nordisk As	Verfahren zur reinigung von polypeptid-konjugate
WO2008077621A1 (de) *	2006-12-23	2008-07-03	Aplagen Gmbh	Verfahren zur ausbildung von disulfidbrücken
HRP20130382T1 (hr)	2007-04-03	2013-05-31	Biogenerix Ag	Postupci lijeäśenja pomoä†u glikopegiliranog g-csf
CA2690611C (en)	2007-06-12	2015-12-08	Novo Nordisk A/S	Improved process for the production of nucleotide sugars
PL2257311T3 (pl)	2008-02-27	2014-09-30	Novo Nordisk As	Koniugaty cząsteczek czynnika VIII
CN104844693B (zh) *	2015-06-10	2018-08-03	成都圣诺生物科技股份有限公司	一种合成利那洛肽的方法
WO2019149918A1 (en)	2018-02-02	2019-08-08	Novo Nordisk A/S	Drug injection device with deflectable transducer
CN111100188A (zh) *	2018-10-25	2020-05-05	成都医学院	一种制备蜘蛛抗菌肽的方法
CN109593119A (zh) *	2019-01-27	2019-04-09	上海丽珠制药有限公司	一种[2-d-组氨酸]-醋酸亮丙瑞林的制备方法
JP7453745B2 (ja) *	2019-03-28	2024-03-21	株式会社ヤクルト本社	毒性タンパク質の活性を阻害するペプチドのスクリーニング方法及び毒性タンパク質の製造方法
CN110845595A (zh) *	2019-11-14	2020-02-28	连云港职业技术学院	一种固相合成5-tmara标记的铁调素-25的方法
CN115397868A (zh) *	2020-03-30	2022-11-25	埃博灵克斯股份有限公司	用于产生和纯化多价免疫球蛋白单可变域的方法

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DE2923787A1 (de) *	1979-06-12	1980-12-18	Max Planck Gesellschaft	Verfahren zur selektiven bildung von disulfidbruecken in polypeptiden und die dabei erhaltenen produkte als wirkstoffe enthaltende arzneimittel
DE3236849A1 (de) *	1982-10-05	1984-04-05	Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen	Neue thiohydrazin-1,2-dicarbonsaeure-derivate, verfahren zu ihrer herstellung und ihre verwendung
IL96682A0 (en) *	1989-12-15	1991-09-16	Amgen Inc	Production of biologically active platelet-derived growth factor from high expression host cell systems
RU2148586C1 (ru) *	1991-03-15	2000-05-10	Эмджен Инк.	Ковалентное модифицирование полипептидов полиэтиленгликолями
CA2072249C (en) *	1991-06-28	2003-06-17	Saiko Hosokawa	Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane
EP0628573A1 (de) *	1993-05-24	1994-12-14	Kao Corporation	Verfahren zur Herstellung solubilisierten Proteins
US5663304A (en) *	1993-08-20	1997-09-02	Genentech, Inc.	Refolding of misfolded insulin-like growth factor-I
DE4431317A1 (de) *	1994-09-02	1996-03-07	Biotechnolog Forschung Gmbh	Schutz- bzw. Ankergruppen und deren Verwendung

2001
- 2001-11-27 EP EP06075237A patent/EP1679318A1/de not_active Withdrawn
- 2001-11-27 AT AT01990489T patent/ATE322501T1/de not_active IP Right Cessation
- 2001-11-27 EP EP01990489A patent/EP1337549B1/de not_active Expired - Lifetime
- 2001-11-27 NZ NZ523679A patent/NZ523679A/en unknown
- 2001-11-27 HU HU0302395A patent/HUP0302395A3/hu unknown
- 2001-11-27 MX MXPA03003576A patent/MXPA03003576A/es active IP Right Grant
- 2001-11-27 ES ES01990489T patent/ES2261509T4/es not_active Expired - Lifetime
- 2001-11-27 KR KR10-2003-7004957A patent/KR20030081315A/ko not_active Ceased
- 2001-11-27 DE DE60118598T patent/DE60118598T2/de not_active Expired - Fee Related
- 2001-11-27 CA CA002416054A patent/CA2416054A1/en not_active Abandoned
- 2001-11-27 WO PCT/EP2001/014163 patent/WO2002050099A2/en not_active Ceased
- 2001-11-27 DK DK01990489T patent/DK1337549T3/da active
- 2001-11-27 CN CNA2006100047520A patent/CN1830999A/zh active Pending
- 2001-11-27 IL IL15550601A patent/IL155506A0/xx unknown
- 2001-11-27 CN CNB018147968A patent/CN1249078C/zh not_active Expired - Fee Related
- 2001-11-27 PL PL01364932A patent/PL364932A1/xx not_active Application Discontinuation
- 2001-11-27 AU AU2960302A patent/AU2960302A/xx active Pending
- 2001-11-27 CU CU20030094A patent/CU23034A3/es unknown
- 2001-11-27 RU RU2003119075/04A patent/RU2275377C2/ru not_active IP Right Cessation
- 2001-11-27 BR BR0113091-9A patent/BR0113091A/pt not_active IP Right Cessation
- 2001-11-27 US US09/995,335 patent/US20020082384A1/en not_active Abandoned
- 2001-11-27 AU AU2002229603A patent/AU2002229603B2/en not_active Expired - Fee Related
- 2001-11-27 JP JP2002551992A patent/JP2004516300A/ja active Pending
2003
- 2003-01-23 ZA ZA200300642A patent/ZA200300642B/en unknown
- 2003-05-26 NO NO20032356A patent/NO20032356L/no unknown
2005
- 2005-05-19 US US11/132,987 patent/US20050239162A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CU23034A3 (es)	2005-03-22
DE60118598T2 (de)	2007-02-15
EP1337549A2 (de)	2003-08-27
MXPA03003576A (es)	2003-10-14
US20050239162A1 (en)	2005-10-27
US20020082384A1 (en)	2002-06-27
NO20032356D0 (no)	2003-05-26
DK1337549T3 (da)	2006-07-31
HUP0302395A3 (en)	2007-05-02
RU2275377C2 (ru)	2006-04-27
CN1449406A (zh)	2003-10-15
NO20032356L (no)	2003-05-26
JP2004516300A (ja)	2004-06-03
EP1337549B1 (de)	2006-04-05
HUP0302395A2 (hu)	2003-10-28
ES2261509T3 (es)	2006-11-16
ES2261509T4 (es)	2008-02-16
KR20030081315A (ko)	2003-10-17
DE60118598D1 (de)	2006-05-18
ZA200300642B (en)	2004-07-16
IL155506A0 (en)	2003-11-23
AU2002229603B2 (en)	2007-11-08
EP1679318A1 (de)	2006-07-12
WO2002050099A2 (en)	2002-06-27
CA2416054A1 (en)	2002-06-27
PL364932A1 (en)	2004-12-27
WO2002050099A3 (en)	2002-09-19
BR0113091A (pt)	2003-07-08
NZ523679A (en)	2005-10-28
CN1830999A (zh)	2006-09-13
AU2960302A (en)	2002-07-01
CN1249078C (zh)	2006-04-05

Legal Events

Date

Code

Title

Description

2007-01-15

UEP

Publication of translation of european patent specification

Ref document number: 1337549

Country of ref document: EP

2009-08-15

REN

Ceased due to non-payment of the annual fee

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ATE322501T1 (de)	2006-04-15	Verfahren zur rückfaltung von chemisch hergestellten polypeptiden
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