ATE321039T1 - Verfahren zur herstellung von losartan und losartan-kaliumsalz - Google Patents

Verfahren zur herstellung von losartan und losartan-kaliumsalz

Info

Publication number: ATE321039T1
Authority: AT; Austria
Prior art keywords: losartan; alcohol; triarylmethyl; potassium; producing
Prior art date: 2002-04-29

Application number

AT03726536T

Other languages

English (en)

Inventor

Ben-Zion Dolitzky

Gennady Nisnevich

Igor Rukhman

Julia Kaftanov

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-29

Filing date

2003-04-29

Publication date

2006-04-15

2003-04-29 Application filed by Teva Pharma filed Critical Teva Pharma

2006-04-15 Application granted granted Critical

2006-04-15 Publication of ATE321039T1 publication Critical patent/ATE321039T1/de

Links

239000002083 C09CA01 - Losartan Substances 0.000 title abstract 6
229960004773 losartan Drugs 0.000 title abstract 4
KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 title abstract 4
OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical class [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
239000007788 liquid Substances 0.000 abstract 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
150000002576 ketones Chemical class 0.000 abstract 2
229960000519 losartan potassium Drugs 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
150000004106 losartan derivatives Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229910001414 potassium ion Inorganic materials 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1
-1 triarylmethyl alcohol Chemical compound 0.000 abstract 1
125000005039 triarylmethyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

AT03726536T 2002-04-29 2003-04-29 Verfahren zur herstellung von losartan und losartan-kaliumsalz ATE321039T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US37632202P	2002-04-29	2002-04-29

Publications (1)

Publication Number	Publication Date
ATE321039T1 true ATE321039T1 (de)	2006-04-15

Family

ID=29401331

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03726536T ATE321039T1 (de)	2002-04-29	2003-04-29	Verfahren zur herstellung von losartan und losartan-kaliumsalz

Country Status (10)

Country	Link
US (1)	US7041832B2 (de)
EP (1)	EP1474417B1 (de)
AT (1)	ATE321039T1 (de)
AU (1)	AU2003228767A1 (de)
CA (1)	CA2482857A1 (de)
DE (1)	DE60304175T2 (de)
ES (1)	ES2259412T3 (de)
IL (1)	IL164902A0 (de)
PT (1)	PT1474417E (de)
WO (1)	WO2003093262A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7345071B2 (en)	2003-05-07	2008-03-18	Ipca Laboratories Limited	Process for the synthesis of Losartan potassium
EP1709034A2 (de) *	2004-01-06	2006-10-11	IPCA Laboratories Limited	Verbessertes verfahren zur synthese von losartan-kalium
ATE441637T1 (de) *	2005-02-03	2009-09-15	Ratiopharm Gmbh	Verfahren zur herstellung von losartan
WO2006097121A1 (en) *	2005-03-16	2006-09-21	Ulkar Kimya Sanayii Ve Ticaret A.S.	Method for producing biphenyl-tetrazole compounds
US20090076281A1 (en) *	2005-05-05	2009-03-19	Medichem, S.A.	Process for the preparation of losartan and its salts
EP1741711A1 (de) *	2005-07-04	2007-01-10	KRKA, D.D., Novo Mesto	Verfahren zur Herstellung von Losartanderivaten durch Chlorierung und Reduktion der entsprechenden 1H-imidazol-5-carbaldehyde
DE602005024726D1 (de) *	2005-12-01	2010-12-23	Ulkar Kimya Sanayii Ve Ticaret	Artan
WO2008155953A1 (ja) *	2007-06-15	2008-12-24	The University Of Tokyo	主鎖骨格が－Ｓｉ－Ｏ－から本質的になるポリロタキサン及びその製法、並びに該ポリロタキサンを架橋してなる架橋ポリロタキサン及びその製法
CN108047208B (zh) *	2018-01-12	2022-03-22	浙江华海药业股份有限公司	一种降低氯沙坦二聚物杂质的方法
US11327065B1 (en) *	2021-08-27	2022-05-10	Jubilant Generics Limited	Preparation of angiotensin receptor blockers or pharmaceutically acceptable salts thereof

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US5138069A (en) *	1986-07-11	1992-08-11	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking imidazoles
EP0842925A1 (de) *	1987-09-04	1998-05-20	Beecham Group Plc	Substituierte Thiazolidindionderivate
US5210079A (en) *	1988-01-07	1993-05-11	E. I. Du Pont De Nemours And Company	Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
US5354867A (en) *	1988-12-06	1994-10-11	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking imidazoles
US5155188A (en) *	1988-12-29	1992-10-13	The B. F. Goodrich Company	Oxide cocatalysts in ring opening polymerization of polycycloolefins
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US5187069A (en)	1990-08-06	1993-02-16	Henry Ford Health System	Active site labelling of plasminogen
GB9017482D0 (en)	1990-08-09	1990-09-26	Ici Plc	Manufacturing process
IE914572A1 (en) *	1991-01-17	1992-07-29	Zeneca Ltd	Chemical process
US5206374A (en) *	1991-11-18	1993-04-27	E. I. Du Pont De Nemours And Company	Process for preparing tetrazolylphenylboronic acid intermediates
US5130439A (en) *	1991-11-18	1992-07-14	Lo Young S	Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists
US5310928A (en) *	1991-11-18	1994-05-10	E. I. Du Pont De Nemours And Company	Process for preparing biphenyltetrazole compounds
US5484955A (en) *	1992-07-06	1996-01-16	Takeda Chemical Industries, Ltd.	Tri-higher alkyl tin azide and its use
AU685898B2 (en) *	1993-12-23	1998-01-29	Du Pont Merck Pharmaceutical Company, The	Polymorphs of losartan and the process for the preparation of form II of losartan
CA2186606A1 (en) *	1994-03-29	1995-10-05	Edward B. Nelson	Treatment of atherosclerosis with angiotensin ii receptor blocking imidazoles
GB9406573D0 (en) *	1994-03-31	1994-05-25	Merck Sharp & Dohme	Medicaments
US5952509A (en) *	1996-06-27	1999-09-14	Takeda Chemical Industries, Ltd.	Production of benzaldehyde compounds
IT1295405B1 (it)	1997-09-30	1999-05-12	Merck Sharp & Dohme Italia S P	Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
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BR0102252B1 (pt)	2001-04-10	2013-10-22		Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso

2003
- 2003-04-29 WO PCT/US2003/013369 patent/WO2003093262A2/en not_active Ceased
- 2003-04-29 PT PT03726536T patent/PT1474417E/pt unknown
- 2003-04-29 US US10/426,612 patent/US7041832B2/en not_active Expired - Fee Related
- 2003-04-29 AU AU2003228767A patent/AU2003228767A1/en not_active Abandoned
- 2003-04-29 AT AT03726536T patent/ATE321039T1/de not_active IP Right Cessation
- 2003-04-29 CA CA002482857A patent/CA2482857A1/en not_active Abandoned
- 2003-04-29 DE DE60304175T patent/DE60304175T2/de not_active Expired - Fee Related
- 2003-04-29 ES ES03726536T patent/ES2259412T3/es not_active Expired - Lifetime
- 2003-04-29 EP EP03726536A patent/EP1474417B1/de not_active Expired - Lifetime
2004
- 2004-10-28 IL IL16490204A patent/IL164902A0/xx unknown

Also Published As

Publication number	Publication date
DE60304175T2 (de)	2007-03-15
ES2259412T3 (es)	2006-10-01
US20040034077A1 (en)	2004-02-19
WO2003093262A3 (en)	2004-03-18
US7041832B2 (en)	2006-05-09
PT1474417E (pt)	2006-06-30
EP1474417B1 (de)	2006-03-22
EP1474417A2 (de)	2004-11-10
DE60304175D1 (de)	2006-05-11
AU2003228767A1 (en)	2003-11-17
WO2003093262A2 (en)	2003-11-13
IL164902A0 (en)	2005-12-18
CA2482857A1 (en)	2003-11-13

Legal Events

Date	Code	Title	Description
2006-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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