ATE516289T1 - Verfahren zur herstellung von sildenafil - Google Patents

Verfahren zur herstellung von sildenafil

Info

Publication number: ATE516289T1
Authority: AT; Austria
Prior art keywords: compound; formula; iii; preparing; present
Prior art date: 2006-12-21

Application number

AT07857066T

Other languages

English (en)

Inventor

Guanghui Tian

Yi Zhu

Zheng Liu

Zhen Wang

Jingsham Shen

Sergeja Bombek

Tadej Stropnik

Original Assignee

Krka Tovarna Zdravil D D Novo Mesto

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-21

Filing date

2007-12-21

Publication date

2011-07-15

2007-12-21 Application filed by Krka Tovarna Zdravil D D Novo Mesto filed Critical Krka Tovarna Zdravil D D Novo Mesto

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE516289T1 publication Critical patent/ATE516289T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 4
BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 title abstract 4
229960003310 sildenafil Drugs 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 11
239000000543 intermediate Substances 0.000 abstract 2
KEQGZUUPPQEDPF-UHFFFAOYSA-N 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione Chemical compound CC1(C)N(Cl)C(=O)N(Cl)C1=O KEQGZUUPPQEDPF-UHFFFAOYSA-N 0.000 abstract 1
PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 abstract 1
101100313649 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) POT1 gene Proteins 0.000 abstract 1
101100161758 Yarrowia lipolytica (strain CLIB 122 / E 150) POX3 gene Proteins 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
XTHPWXDJESJLNJ-UHFFFAOYSA-N chlorosulfonic acid Substances OS(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-N 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000007086 side reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT07857066T 2006-12-21 2007-12-21 Verfahren zur herstellung von sildenafil ATE516289T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/CN2006/003530 WO2008074194A1 (en)	2006-12-21	2006-12-21	A process for the preparation of sildenafil and the intermediates thereof
PCT/EP2007/011355 WO2008074512A1 (en)	2006-12-21	2007-12-21	Process for the preparation of sildenafil

Publications (1)

Publication Number	Publication Date
ATE516289T1 true ATE516289T1 (de)	2011-07-15

Family

ID=39267890

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07857066T ATE516289T1 (de)	2006-12-21	2007-12-21	Verfahren zur herstellung von sildenafil

Country Status (12)

Country	Link
US (1)	US8071765B2 (de)
EP (1)	EP2125821B1 (de)
CN (1)	CN101563348B (de)
AT (1)	ATE516289T1 (de)
EA (1)	EA019160B1 (de)
ES (1)	ES2367976T3 (de)
NO (1)	NO20092573L (de)
PL (1)	PL2125821T3 (de)
PT (1)	PT2125821E (de)
SI (1)	SI2125821T1 (de)
UA (1)	UA99447C2 (de)
WO (2)	WO2008074194A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101563348B (zh) *	2006-12-21	2011-08-24	上海特化医药科技有限公司	西地那非的制备方法及其中间体
AT512084A1 (de)	2011-10-20	2013-05-15	Univ Wien Tech	Diazabicyclo- und diazaspiro-alkanderivate als phosphodiesterase-5 inhibitoren
CN102690273B (zh) *	2012-06-07	2014-11-05	杭州奥默医药技术有限公司	一种西地那非的制备方法
CN102993205B (zh) *	2012-12-27	2015-04-15	华润赛科药业有限责任公司	一种高收率制备高纯度西地那非游离碱的纯化方法
CN103755709B (zh) *	2014-01-15	2016-05-25	广东药学院	西地那非衍生物的微波辅助制备方法
CN105017255A (zh) *	2014-04-25	2015-11-04	浙江泰康药业集团有限公司	西地那非制备工艺
CN105085526B (zh) *	2014-05-15	2017-08-01	重庆圣华曦药业股份有限公司	一种改进的西地那非制备方法
CN104370915A (zh) *	2014-11-06	2015-02-25	成都医路康医学技术服务有限公司	枸橼酸西地那非的制备方法
CN107880048A (zh) *	2015-07-23	2018-04-06	青岛华之草医药科技有限公司	一种枸橼酸西地那非化合物
CN106117212B (zh) *	2016-06-25	2019-10-11	吉林医药学院	一种改进的西地那非合成工艺
WO2018069316A2 (en)	2016-10-10	2018-04-19	Transgene Sa	Immunotherapeutic product and mdsc modulator combination therapy
CN108558890A (zh) *	2018-06-28	2018-09-21	重庆康刻尔制药有限公司	一种西地那非中间体合成方法
CN109970744A (zh) *	2019-04-10	2019-07-05	重庆康刻尔制药有限公司	一种枸橼酸西地那非中间体的合成方法
CN115872998B (zh) *	2021-08-03	2024-09-20	山东特珐曼药业有限公司	西地那非及其中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9013750D0 (en)	1990-06-20	1990-08-08	Pfizer Ltd	Therapeutic agents
GB9311920D0 (en)	1993-06-09	1993-07-28	Pfizer Ltd	Therapeutic agents
GB9612514D0 (en)	1996-06-14	1996-08-14	Pfizer Ltd	Novel process
CA2235642C (en)	1998-05-15	2007-11-13	Torcan Chemical Ltd.	Processes for preparing sildenafil
CN1134419C (zh)	1999-07-27	2004-01-14	北京三雄高新技术开发有限责任公司	有用的昔多芬中间体及其制备
WO2001019827A1 (en)	1999-09-13	2001-03-22	Cipla Ltd.	A novel process for the synthesis of sildenafil citrate
GB0106661D0 (en) *	2001-03-16	2001-05-09	Pfizer Ltd	Pharmaceutically active compounds
CN1208337C (zh)	2001-09-04	2005-06-29	广州白云山医药科技发展有限公司	喜勃酮的制备方法
CN1176081C (zh)	2002-04-29	2004-11-17	广州白云山医药科技发展有限公司	制备喜勃酮用的中间体及其制备方法
CN101563348B (zh) *	2006-12-21	2011-08-24	上海特化医药科技有限公司	西地那非的制备方法及其中间体

2006
- 2006-12-21 CN CN2006800566709A patent/CN101563348B/zh active Active
- 2006-12-21 WO PCT/CN2006/003530 patent/WO2008074194A1/zh not_active Ceased
- 2006-12-21 US US12/448,425 patent/US8071765B2/en not_active Expired - Fee Related
2007
- 2007-12-21 EA EA200900690A patent/EA019160B1/ru not_active IP Right Cessation
- 2007-12-21 PT PT07857066T patent/PT2125821E/pt unknown
- 2007-12-21 WO PCT/EP2007/011355 patent/WO2008074512A1/en not_active Ceased
- 2007-12-21 ES ES07857066T patent/ES2367976T3/es active Active
- 2007-12-21 UA UAA200906452A patent/UA99447C2/ru unknown
- 2007-12-21 SI SI200730732T patent/SI2125821T1/sl unknown
- 2007-12-21 AT AT07857066T patent/ATE516289T1/de not_active IP Right Cessation
- 2007-12-21 EP EP07857066A patent/EP2125821B1/de active Active
- 2007-12-21 PL PL07857066T patent/PL2125821T3/pl unknown
2009
- 2009-07-07 NO NO20092573A patent/NO20092573L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO2008074194A1 (en)	2008-06-26
EA019160B1 (ru)	2014-01-30
ES2367976T3 (es)	2011-11-11
US8071765B2 (en)	2011-12-06
EP2125821A1 (de)	2009-12-02
WO2008074512A1 (en)	2008-06-26
US20100048897A1 (en)	2010-02-25
PL2125821T3 (pl)	2011-12-30
CN101563348B (zh)	2011-08-24
EA200900690A1 (ru)	2009-12-30
NO20092573L (no)	2009-09-18
UA99447C2 (ru)	2012-08-27
PT2125821E (pt)	2011-07-27
CN101563348A (zh)	2009-10-21
EP2125821B1 (de)	2011-07-13
SI2125821T1 (sl)	2011-11-30

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Legal Events

Date	Code	Title	Description
2012-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties