ATE321047T1 - Tricyclische diazepine als tocolytische oxytocin rezeptor antagonisten - Google Patents

Tricyclische diazepine als tocolytische oxytocin rezeptor antagonisten

Info

Publication number: ATE321047T1
Authority: AT; Austria
Prior art keywords: compounds; treatment; diazepins; tricyclic; prevention
Prior art date: 2001-04-12

Application number

AT02731343T

Other languages

English (en)

Inventor

Amedeo Arturo Failli

Jay Scott Shumsky

Thomas Joseph Caggiano

Joseph Peter Sabatucci

Kevin Anthony Memoli

Eugene John Trybulski

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-12

Filing date

2002-04-11

Publication date

2006-04-15

2002-04-11 Application filed by Wyeth Corp filed Critical Wyeth Corp

2006-04-15 Application granted granted Critical

2006-04-15 Publication of ATE321047T1 publication Critical patent/ATE321047T1/de

Links

229940122828 Oxytocin receptor antagonist Drugs 0.000 title 1
230000003195 tocolytic effect Effects 0.000 title 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000035475 disorder Diseases 0.000 abstract 2
230000002708 enhancing effect Effects 0.000 abstract 2
230000002265 prevention Effects 0.000 abstract 2
208000005171 Dysmenorrhea Diseases 0.000 abstract 1
206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
208000004145 Endometritis Diseases 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 abstract 1
101800000989 Oxytocin Proteins 0.000 abstract 1
102100031951 Oxytocin-neurophysin 1 Human genes 0.000 abstract 1
208000006399 Premature Obstetric Labor Diseases 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
125000002576 diazepinyl group Chemical class N1N=C(C=CC=C1)* 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000012173 estrus Effects 0.000 abstract 1
230000035558 fertility Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 abstract 1
229960001723 oxytocin Drugs 0.000 abstract 1
239000003336 oxytocin antagonist Substances 0.000 abstract 1
229940121361 oxytocin antagonists Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000001629 suppression Effects 0.000 abstract 1
230000004083 survival effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT02731343T 2001-04-12 2002-04-11 Tricyclische diazepine als tocolytische oxytocin rezeptor antagonisten ATE321047T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US28326401P	2001-04-12	2001-04-12

Publications (1)

Publication Number	Publication Date
ATE321047T1 true ATE321047T1 (de)	2006-04-15

Family

ID=23085252

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02731343T ATE321047T1 (de)	2001-04-12	2002-04-11	Tricyclische diazepine als tocolytische oxytocin rezeptor antagonisten

Country Status (12)

Country	Link
US (1)	US7109193B2 (de)
EP (1)	EP1377586B1 (de)
JP (1)	JP2004526768A (de)
CN (1)	CN1273469C (de)
AT (1)	ATE321047T1 (de)
BR (1)	BR0209014A (de)
CA (1)	CA2443490A1 (de)
DE (1)	DE60210067T2 (de)
DK (1)	DK1377586T3 (de)
ES (1)	ES2260434T3 (de)
MX (1)	MXPA03009331A (de)
WO (1)	WO2002083678A1 (de)

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CN106414465B (zh)	2014-02-28	2021-11-16	杭州多禧生物科技有限公司	带电荷链接体及其在共轭反应上的应用
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NZ739830A (en)	2015-07-12	2021-12-24	Hangzhou Dac Biotech Co Ltd	Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
CN116143678A (zh)	2016-11-14	2023-05-23	杭州多禧生物科技有限公司	偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用
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2002
- 2002-04-10 US US10/119,971 patent/US7109193B2/en not_active Expired - Fee Related
- 2002-04-11 DK DK02731343T patent/DK1377586T3/da active
- 2002-04-11 JP JP2002581433A patent/JP2004526768A/ja active Pending
- 2002-04-11 ES ES02731343T patent/ES2260434T3/es not_active Expired - Lifetime
- 2002-04-11 WO PCT/US2002/011527 patent/WO2002083678A1/en not_active Ceased
- 2002-04-11 AT AT02731343T patent/ATE321047T1/de not_active IP Right Cessation
- 2002-04-11 EP EP02731343A patent/EP1377586B1/de not_active Expired - Lifetime
- 2002-04-11 CA CA002443490A patent/CA2443490A1/en not_active Abandoned
- 2002-04-11 BR BR0209014-7A patent/BR0209014A/pt not_active IP Right Cessation
- 2002-04-11 MX MXPA03009331A patent/MXPA03009331A/es active IP Right Grant
- 2002-04-11 CN CNB028080394A patent/CN1273469C/zh not_active Expired - Fee Related
- 2002-04-11 DE DE60210067T patent/DE60210067T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
MXPA03009331A (es)	2004-11-12
WO2002083678A1 (en)	2002-10-24
EP1377586B1 (de)	2006-03-22
JP2004526768A (ja)	2004-09-02
BR0209014A (pt)	2005-01-11
DE60210067T2 (de)	2006-10-19
EP1377586A1 (de)	2004-01-07
CN1273469C (zh)	2006-09-06
CN1501932A (zh)	2004-06-02
DK1377586T3 (da)	2006-07-10
CA2443490A1 (en)	2002-10-24
ES2260434T3 (es)	2006-11-01
US20030008863A1 (en)	2003-01-09
US7109193B2 (en)	2006-09-19
DE60210067D1 (en)	2006-05-11

Legal Events

Date	Code	Title	Description
2006-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE321047T1 (de)	2006-04-15	Tricyclische diazepine als tocolytische oxytocin rezeptor antagonisten
ATE309244T1 (de)	2005-11-15	Neue 10-cyclohexenyl-phenyl-pyrrolobenzodiazepin- 3-carboxamide und derivate davon; tokolytische oxytocin-rezeptor-antagonisten
EA200700097A1 (ru)	2007-06-29	Производные хиназолин-4-илпиперидина и циннолин-4-илпиперидина в качестве ингибиторов pde10 для лечения расстройств цнс
DOP2005000022A (es)	2005-08-30	"derivados tetrahidroisoquinolinilo de quinazolina e isoquinolina"
SV2008002365A (es)	2008-02-08	Compuestos de quinolina heteroaromaticos ref. pc32593a
DK1377584T3 (da)	2005-05-23	Nye cyclohexenylphenyldiazepiner som vasopressin- og oxytocinreceptormodulatorer
BR0209015A (pt)	2005-01-11	Novas 10-ciclohexilbenzoil pirrolobenzodiazepinas substituìdas com 3-c(o)r e antagonistas receptores de ocitocina tocolìticos
CR9304A (es)	2008-03-31	Antagonistas del receptor de glucagon, preparaciones y usos terapeuticos
MX2007006301A (es)	2007-06-15	Derivados pirrolidilo de compuestos heteroaromaticos como inhibidores de fosfodiesterasa.
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