DK1377586T3 - Tricykliske diazepiner som tocolytiske oxytocinreceptorantagonister - Google Patents

Tricykliske diazepiner som tocolytiske oxytocinreceptorantagonister

Info

Publication number: DK1377586T3
Authority: DK; Denmark
Prior art keywords: compounds; treatment; prevention; useful; receptor antagonists
Prior art date: 2001-04-12

Application number

DK02731343T

Other languages

English (en)

Inventor

Amedeo Arturo Failli

Jay Scott Shumsky

Thomas Joseph Caggiano

Joseph Peter Sabatucci

Kevin Anthony Memoli

Eugene John Trybulski

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-12

Filing date

2002-04-11

Publication date

2006-07-10

2002-04-11 Application filed by Wyeth Corp filed Critical Wyeth Corp

2006-07-10 Application granted granted Critical

2006-07-10 Publication of DK1377586T3 publication Critical patent/DK1377586T3/da

Links

229940122828 Oxytocin receptor antagonist Drugs 0.000 title 1
150000004908 diazepines Chemical class 0.000 title 1
230000003195 tocolytic effect Effects 0.000 title 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000035475 disorder Diseases 0.000 abstract 2
230000002708 enhancing effect Effects 0.000 abstract 2
230000002265 prevention Effects 0.000 abstract 2
208000005171 Dysmenorrhea Diseases 0.000 abstract 1
206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
208000004145 Endometritis Diseases 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 abstract 1
101800000989 Oxytocin Proteins 0.000 abstract 1
102100031951 Oxytocin-neurophysin 1 Human genes 0.000 abstract 1
208000006399 Premature Obstetric Labor Diseases 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
125000002576 diazepinyl group Chemical class N1N=C(C=CC=C1)* 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000012173 estrus Effects 0.000 abstract 1
230000035558 fertility Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 abstract 1
229960001723 oxytocin Drugs 0.000 abstract 1
239000003336 oxytocin antagonist Substances 0.000 abstract 1
229940121361 oxytocin antagonists Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000001629 suppression Effects 0.000 abstract 1
230000004083 survival effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK02731343T 2001-04-12 2002-04-11 Tricykliske diazepiner som tocolytiske oxytocinreceptorantagonister DK1377586T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US28326401P	2001-04-12	2001-04-12

Publications (1)

Publication Number	Publication Date
DK1377586T3 true DK1377586T3 (da)	2006-07-10

Family

ID=23085252

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02731343T DK1377586T3 (da)	2001-04-12	2002-04-11	Tricykliske diazepiner som tocolytiske oxytocinreceptorantagonister

Country Status (12)

Country	Link
US (1)	US7109193B2 (da)
EP (1)	EP1377586B1 (da)
JP (1)	JP2004526768A (da)
CN (1)	CN1273469C (da)
AT (1)	ATE321047T1 (da)
BR (1)	BR0209014A (da)
CA (1)	CA2443490A1 (da)
DE (1)	DE60210067T2 (da)
DK (1)	DK1377586T3 (da)
ES (1)	ES2260434T3 (da)
MX (1)	MXPA03009331A (da)
WO (1)	WO2002083678A1 (da)

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US7326700B2 (en) *	2001-04-12	2008-02-05	Wyeth	Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
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US8420633B2 (en) *	2010-03-31	2013-04-16	Hoffmann-La Roche Inc.	Aryl-cyclohexyl-tetraazabenzo[e]azulenes
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CA2989269C (en)	2015-06-15	2020-09-22	Robert Yongxin Zhao	Hydrophilic linkers for conjugation of a cytotoxic agent or chromophore molecule to a cell-binding molecule
EP3319936B1 (en)	2015-07-12	2025-12-17	Hangzhou Dac Biotech Co., Ltd.	Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
AU2016429272A1 (en)	2016-11-14	2019-05-02	Hangzhou Dac Biotech Co., Ltd.	Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
CN117980327A (zh)	2021-11-03	2024-05-03	杭州多禧生物科技有限公司	抗体的特异性偶联

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2002
- 2002-04-10 US US10/119,971 patent/US7109193B2/en not_active Expired - Fee Related
- 2002-04-11 DK DK02731343T patent/DK1377586T3/da active
- 2002-04-11 DE DE60210067T patent/DE60210067T2/de not_active Expired - Fee Related
- 2002-04-11 CN CNB028080394A patent/CN1273469C/zh not_active Expired - Fee Related
- 2002-04-11 ES ES02731343T patent/ES2260434T3/es not_active Expired - Lifetime
- 2002-04-11 WO PCT/US2002/011527 patent/WO2002083678A1/en not_active Ceased
- 2002-04-11 EP EP02731343A patent/EP1377586B1/en not_active Expired - Lifetime
- 2002-04-11 JP JP2002581433A patent/JP2004526768A/ja active Pending
- 2002-04-11 BR BR0209014-7A patent/BR0209014A/pt not_active IP Right Cessation
- 2002-04-11 CA CA002443490A patent/CA2443490A1/en not_active Abandoned
- 2002-04-11 MX MXPA03009331A patent/MXPA03009331A/es active IP Right Grant
- 2002-04-11 AT AT02731343T patent/ATE321047T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
MXPA03009331A (es)	2004-11-12
DE60210067T2 (de)	2006-10-19
ES2260434T3 (es)	2006-11-01
WO2002083678A1 (en)	2002-10-24
US7109193B2 (en)	2006-09-19
CN1273469C (zh)	2006-09-06
DE60210067D1 (en)	2006-05-11
CN1501932A (zh)	2004-06-02
BR0209014A (pt)	2005-01-11
ATE321047T1 (de)	2006-04-15
EP1377586B1 (en)	2006-03-22
CA2443490A1 (en)	2002-10-24
JP2004526768A (ja)	2004-09-02
US20030008863A1 (en)	2003-01-09
EP1377586A1 (en)	2004-01-07

Publication	Publication Date	Title
ATE321047T1 (de)	2006-04-15	Tricyclische diazepine als tocolytische oxytocin rezeptor antagonisten
DOP2005000022A (es)	2005-08-30	"derivados tetrahidroisoquinolinilo de quinazolina e isoquinolina"
UY29028A1 (es)	2006-02-24	Nuevos derivados piperidilo de quinazolina e isoquinolina
CR9135A (es)	2007-08-14	Derivados novedosos pirrolidilo de compuestos heteroaromaticos
SV2008002365A (es)	2008-02-08	Compuestos de quinolina heteroaromaticos ref. pc32593a
ATE309244T1 (de)	2005-11-15	Neue 10-cyclohexenyl-phenyl-pyrrolobenzodiazepin- 3-carboxamide und derivate davon; tokolytische oxytocin-rezeptor-antagonisten
CR9304A (es)	2008-03-31	Antagonistas del receptor de glucagon, preparaciones y usos terapeuticos
DK1377584T3 (da)	2005-05-23	Nye cyclohexenylphenyldiazepiner som vasopressin- og oxytocinreceptormodulatorer
MXPA04003103A (es)	2004-07-27	Derivados de bencimidazolidinona como agentes muscarinicos.
BR0209015A (pt)	2005-01-11	Novas 10-ciclohexilbenzoil pirrolobenzodiazepinas substituìdas com 3-c(o)r e antagonistas receptores de ocitocina tocolìticos
ECSP067082A (es)	2007-01-26	Antagonistas de receptor de glucagon, preparacion y usos terapeuticos
ECSP066391A (es)	2006-08-30	[1,8] naftiridin-2-onas y compuestos relacionados para el tratamiento de la esquizofrenia
EA200801184A1 (ru)	2008-08-29	Производные пипередин-4-ил-пиридазин-3-иламина как быстро диссоциирующие антагонисты рецептора дофамина 2
BR0208942A (pt)	2004-04-27	Novas 10-ciclohexilbenzoil pirrolobenzodiazepinas substituìdas com 3-c(o)r e antagonistas receptores de ocitocina tocolìticos
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