ATE321067T1 - Neuartige peptidderivate mit thiazolyl-alanin- resten - Google Patents
Neuartige peptidderivate mit thiazolyl-alanin- restenInfo
- Publication number
- ATE321067T1 ATE321067T1 AT97935856T AT97935856T ATE321067T1 AT E321067 T1 ATE321067 T1 AT E321067T1 AT 97935856 T AT97935856 T AT 97935856T AT 97935856 T AT97935856 T AT 97935856T AT E321067 T1 ATE321067 T1 AT E321067T1
- Authority
- AT
- Austria
- Prior art keywords
- thiazolyl
- peptide derivatives
- alanine residue
- novel peptide
- derivatives
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- WBZIGVCQRXJYQD-YFKPBYRVSA-N (2s)-2-amino-3-(1,3-thiazol-4-yl)propanoic acid Chemical group OC(=O)[C@@H](N)CC1=CSC=N1 WBZIGVCQRXJYQD-YFKPBYRVSA-N 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 2
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 abstract 1
- 229960004373 acetylcholine Drugs 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000000891 anti-reserpine Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003137 locomotive effect Effects 0.000 abstract 1
- 230000003578 releasing effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22638696 | 1996-08-28 | ||
| JP9052997 | 1997-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE321067T1 true ATE321067T1 (de) | 2006-04-15 |
Family
ID=26432009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97935856T ATE321067T1 (de) | 1996-08-28 | 1997-08-22 | Neuartige peptidderivate mit thiazolyl-alanin- resten |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0933379B1 (de) |
| JP (1) | JP3234236B2 (de) |
| KR (1) | KR100318804B1 (de) |
| CN (1) | CN1214040C (de) |
| AT (1) | ATE321067T1 (de) |
| AU (1) | AU713133B2 (de) |
| BR (1) | BR9712081B1 (de) |
| CA (1) | CA2264268C (de) |
| DE (1) | DE69735543T2 (de) |
| DK (1) | DK0933379T3 (de) |
| ES (1) | ES2259805T3 (de) |
| PT (1) | PT933379E (de) |
| TR (1) | TR199900477T2 (de) |
| TW (1) | TW492977B (de) |
| WO (1) | WO1998008867A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2642399A (en) * | 1998-03-02 | 1999-09-20 | Shionogi & Co., Ltd. | Process for producing 4-thiazolylmethyl derivative |
| WO1999053941A1 (fr) * | 1998-04-15 | 1999-10-28 | Shionogi & Co., Ltd. | Preparations orales contenant des derives de trh |
| EP1161415B1 (de) | 1999-03-15 | 2005-07-13 | Axys Pharmaceuticals, Inc. | N-cyanomethylamide als protease inhibitoren |
| KR100676095B1 (ko) * | 1999-08-30 | 2007-01-31 | 시오노기 앤드 컴파니, 리미티드 | 옥소-옥사졸린 또는 알로아미노산 유도체의 제조 방법 |
| JP4812225B2 (ja) * | 2000-07-11 | 2011-11-09 | 塩野義製薬株式会社 | 生理活性ペプチド含有腸溶性製剤 |
| AU2001282527A1 (en) | 2000-08-31 | 2002-03-13 | Shionogi And Co., Ltd. | Antiparkinsonism drugs |
| IL156577A0 (en) | 2000-12-22 | 2004-01-04 | Axys Pharm Inc | Selective cathepsin s inhibitors and pharmaceutical compositions containing the same |
| US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
| ES2296962T3 (es) * | 2001-06-27 | 2008-05-01 | Smithkline Beecham Corporation | Pirrolidinas como inhibidores de dipeptidil peptidasa. |
| WO2003024924A1 (en) | 2001-09-14 | 2003-03-27 | Aventis Pharmaceuticals Inc. | Novel compounds and compositions as cathepsin inhibitors |
| RU2004117877A (ru) | 2001-11-14 | 2006-01-10 | Авентис Фармасьютикалз Инк. (Us) | Олигопептиды и композиции, содержащие их, в качестве ингибиторов катепсина s |
| CA2508487A1 (en) * | 2002-12-04 | 2004-06-17 | Merck & Co., Inc. | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| JP5196641B2 (ja) * | 2004-09-09 | 2013-05-15 | 塩野義製薬株式会社 | 脊髄小脳変性症治療剤 |
| TWI350754B (en) * | 2004-09-09 | 2011-10-21 | Shionogi & Co | A pharmaceutical composition for treating spinocerebellar ataxia |
| WO2010143409A1 (ja) * | 2009-06-08 | 2010-12-16 | 株式会社カネカ | 光学活性チアゾリルアラニン誘導体およびその塩の製造方法 |
| CN101817870B (zh) * | 2010-04-01 | 2012-04-18 | 济南兆德生物科技有限公司 | 一种促甲状腺素释放激素及其可药用盐的制备方法 |
| JP7640815B2 (ja) | 2022-07-20 | 2025-03-05 | 塩野義製薬株式会社 | 生理活性ペプチド含有製剤 |
| CN115477684B (zh) * | 2022-09-16 | 2025-06-27 | 湖南科技大学 | 取代3-噻唑烷-2,4-二酮类Mcl-1蛋白抑制剂及制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2527723A1 (de) * | 1975-06-21 | 1976-12-30 | Gruenenthal Chemie | Verfahren zur herstellung von dipeptid-derivaten |
| JPS5944308B2 (ja) * | 1976-03-23 | 1984-10-29 | 武田薬品工業株式会社 | ペプタイド |
| JPS62234029A (ja) * | 1985-12-27 | 1987-10-14 | Tanabe Seiyaku Co Ltd | 中枢神経賦活剤 |
| CA2010312C (en) * | 1989-02-21 | 1998-05-12 | Akihiro Yasuda | Peptide derivatives and their pharmaceutical use |
| CZ288436B6 (en) * | 1994-10-05 | 2001-06-13 | Darwin Discovery Ltd | Peptidyl derivatives, their therapeutic use as inhibitors of metalloproteinases and pharmaceutical preparation in which they are comprised |
-
1997
- 1997-08-22 AT AT97935856T patent/ATE321067T1/de active
- 1997-08-22 JP JP51145998A patent/JP3234236B2/ja not_active Expired - Fee Related
- 1997-08-22 BR BRPI9712081-2A patent/BR9712081B1/pt not_active IP Right Cessation
- 1997-08-22 PT PT97935856T patent/PT933379E/pt unknown
- 1997-08-22 CA CA002264268A patent/CA2264268C/en not_active Expired - Fee Related
- 1997-08-22 TR TR1999/00477T patent/TR199900477T2/xx unknown
- 1997-08-22 DK DK97935856T patent/DK0933379T3/da active
- 1997-08-22 WO PCT/JP1997/002917 patent/WO1998008867A1/ja not_active Ceased
- 1997-08-22 AU AU38680/97A patent/AU713133B2/en not_active Ceased
- 1997-08-22 EP EP97935856A patent/EP0933379B1/de not_active Expired - Lifetime
- 1997-08-22 DE DE69735543T patent/DE69735543T2/de not_active Expired - Lifetime
- 1997-08-22 ES ES97935856T patent/ES2259805T3/es not_active Expired - Lifetime
- 1997-08-22 CN CNB971992487A patent/CN1214040C/zh not_active Expired - Fee Related
- 1997-08-22 KR KR1019997001667A patent/KR100318804B1/ko not_active Expired - Fee Related
- 1997-08-27 TW TW086112314A patent/TW492977B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TW492977B (en) | 2002-07-01 |
| DE69735543D1 (de) | 2006-05-11 |
| KR20000035930A (ko) | 2000-06-26 |
| TR199900477T2 (xx) | 1999-06-21 |
| WO1998008867A1 (en) | 1998-03-05 |
| CN1235610A (zh) | 1999-11-17 |
| AU3868097A (en) | 1998-03-19 |
| ES2259805T3 (es) | 2006-10-16 |
| BR9712081B1 (pt) | 2010-12-14 |
| DK0933379T3 (da) | 2006-06-26 |
| EP0933379A4 (de) | 2001-09-12 |
| AU713133B2 (en) | 1999-11-25 |
| BR9712081A (pt) | 1999-08-24 |
| KR100318804B1 (ko) | 2002-01-04 |
| PT933379E (pt) | 2006-07-31 |
| CN1214040C (zh) | 2005-08-10 |
| DE69735543T2 (de) | 2007-03-08 |
| EP0933379A1 (de) | 1999-08-04 |
| EP0933379B1 (de) | 2006-03-22 |
| JP3234236B2 (ja) | 2001-12-04 |
| CA2264268C (en) | 2003-11-11 |
| CA2264268A1 (en) | 1998-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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