ATE321452T1 - Tetracycline verbindungen zur behandlung von spezifischen krebsarten - Google Patents
Tetracycline verbindungen zur behandlung von spezifischen krebsartenInfo
- Publication number
- ATE321452T1 ATE321452T1 AT98902437T AT98902437T ATE321452T1 AT E321452 T1 ATE321452 T1 AT E321452T1 AT 98902437 T AT98902437 T AT 98902437T AT 98902437 T AT98902437 T AT 98902437T AT E321452 T1 ATE321452 T1 AT E321452T1
- Authority
- AT
- Austria
- Prior art keywords
- cancer
- cells
- growth
- tetracycline compounds
- treatment
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- -1 TETRACYCLINE COMPOUNDS Chemical class 0.000 title abstract 2
- 239000004098 Tetracycline Substances 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 229960002180 tetracycline Drugs 0.000 title abstract 2
- 229930101283 tetracycline Natural products 0.000 title abstract 2
- 235000019364 tetracycline Nutrition 0.000 title abstract 2
- 206010027476 Metastases Diseases 0.000 abstract 2
- 230000005907 cancer growth Effects 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 230000009401 metastasis Effects 0.000 abstract 2
- NBRQRXRBIHVLGI-OWXODZSWSA-N (4as,5ar,12ar)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=CC=CC(O)=C2C(O)=C(C2=O)[C@@H]1C[C@@H]1[C@@]2(O)C(O)=C(C(=O)N)C(=O)C1 NBRQRXRBIHVLGI-OWXODZSWSA-N 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 208000029742 colonic neoplasm Diseases 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/783,655 US5837696A (en) | 1997-01-15 | 1997-01-15 | Method of inhibiting cancer growth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE321452T1 true ATE321452T1 (de) | 2006-04-15 |
Family
ID=25130005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98902437T ATE321452T1 (de) | 1997-01-15 | 1998-01-15 | Tetracycline verbindungen zur behandlung von spezifischen krebsarten |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5837696A (de) |
| EP (1) | EP0971585B1 (de) |
| JP (1) | JP4428727B2 (de) |
| KR (1) | KR20000070212A (de) |
| AT (1) | ATE321452T1 (de) |
| AU (1) | AU729886B2 (de) |
| CA (1) | CA2277865C (de) |
| DE (1) | DE69834024T2 (de) |
| ES (1) | ES2262221T3 (de) |
| PT (1) | PT971585E (de) |
| WO (1) | WO1998031224A1 (de) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6429204B1 (en) | 1997-01-15 | 2002-08-06 | University Of Miami | Method of inhibiting cancer growth |
| US5837696A (en) * | 1997-01-15 | 1998-11-17 | The Research Foundation Of State University Of New York | Method of inhibiting cancer growth |
| PT1041991E (pt) * | 1997-12-19 | 2008-10-03 | Univ New York | Tetraciclinas não antibacterianas para o tratamento de esclerose múltipla |
| US6277061B1 (en) * | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
| US6015804A (en) * | 1998-09-11 | 2000-01-18 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds to enhance interleukin-10 production |
| US5977091A (en) * | 1998-09-21 | 1999-11-02 | The Research Foundation Of State University Of New York | Method of preventing acute lung injury |
| AU2592600A (en) * | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6984619B1 (en) * | 1999-03-19 | 2006-01-10 | Arch Development Corporation | Method for protection against tumor metastasis formation |
| DE10032256C2 (de) * | 2000-07-03 | 2003-06-05 | Infineon Technologies Ag | Chip-ID-Register-Anordnung |
| AU2002256092C1 (en) * | 2001-04-05 | 2009-10-15 | Collagenex Pharmaceuticals, Inc. | Controlled delivery of tetracycline compounds and tetracycline derivatives |
| EP2329826A1 (de) | 2001-07-13 | 2011-06-08 | Paratek Pharmaceuticals, Inc. | Tetracycline zur Behandlung der multiplen Sklerose |
| US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| RU2300380C2 (ru) * | 2001-10-05 | 2007-06-10 | Тетрадженекс Фармасьютикалс, Инк. | Производные тетрациклина и способы их применения |
| PE20030701A1 (es) * | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
| EP2311799A1 (de) | 2002-01-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | 4-Dedimethylamin-Tetracyclinverbindungen |
| JP2005526754A (ja) | 2002-03-08 | 2005-09-08 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノメチル置換されたテトラサイクリン化合物 |
| KR101083498B1 (ko) | 2002-03-21 | 2011-11-16 | 파라테크 파마슈티컬스, 인크. | 치환된 테트라시클린 화합물 |
| US20050153943A1 (en) * | 2002-05-06 | 2005-07-14 | Ashley Robert A. | Methods of simultaneously treating mucositis and fungal infection |
| AU2003245295B2 (en) * | 2002-05-20 | 2008-01-03 | Collagenex Pharmaceuticals, Inc. | Methods of treating allergic reactions |
| CA2492273C (en) | 2002-07-12 | 2013-02-05 | Paratek Pharmaceuticals, Inc. | 3, 10, and 12a substituted tetracycline compounds |
| CA2503446C (en) | 2002-10-24 | 2012-12-18 | Paratek Pharmaceuticals, Inc. | Methods of using substituted tetracycline compounds to modulate rna |
| ES2534827T3 (es) | 2003-04-07 | 2015-04-29 | Supernus Pharmaceuticals, Inc. | Formulaciones de tetraciclinas en dosis única diaria |
| CA2531728A1 (en) | 2003-07-09 | 2005-02-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| JP4738333B2 (ja) | 2003-07-09 | 2011-08-03 | パラテック ファーマシューティカルズ インコーポレイテッド | ９−アミノメチルテトラサイクリン化合物のプロドラッグ |
| CA2553510C (en) * | 2004-01-15 | 2012-09-25 | Paratek Pharmaceuticals, Inc. | Aromatic a-ring derivatives of tetracycline compounds |
| EP2269985A3 (de) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituierte Tetracyclinverbindungen |
| AU2005299294B2 (en) | 2004-10-25 | 2012-06-07 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| JP2009502809A (ja) * | 2005-07-21 | 2009-01-29 | パラテック ファーマシューティカルズ インコーポレイテッド | １０−置換テトラサイクリンおよびその使用方法 |
| PT2120963T (pt) | 2006-12-21 | 2018-12-17 | Paratek Pharm Innc | Compostos tetraciclina substituídos para tratamento de distúrbios inflamatórios da pele |
| PL2109602T3 (pl) * | 2006-12-21 | 2014-09-30 | Paratek Pharm Innc | Pochodne tetracyliny do leczenia zakażeń bakteryjnych, wirusowych i pasożytniczych |
| JP2010525069A (ja) * | 2007-04-27 | 2010-07-22 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノアルキルテトラサイクリン化合物の合成方法および精製方法 |
| BRPI0823405A2 (pt) * | 2007-07-06 | 2012-12-25 | Paratek Pharmaceuticals, Inc. | mÉtodos para sintetizar compostos de tetraciclina substituÍda |
| TW202216656A (zh) | 2008-05-19 | 2022-05-01 | 美商Ｐｒｔｋ Ｓｐｖ２公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| PT2323972E (pt) | 2008-08-08 | 2013-10-09 | Tetraphase Pharmaceuticals Inc | Compostos de tetraciclina substituídos com c7-flúor |
| EP2427425B1 (de) | 2009-05-08 | 2017-03-08 | Tetraphase Pharmaceuticals, Inc. | Tetrazyklin verbindungen |
| IN2012DN02502A (de) | 2009-08-28 | 2015-08-28 | Tetraphase Pharmaceuticals Inc | |
| EP2544692A4 (de) * | 2010-03-10 | 2013-08-07 | Univ Health Network | Verwendung von tigecyclin zur behandlung von krebs |
| TWI592390B (zh) | 2010-03-31 | 2017-07-21 | 四相製藥公司 | 聚環狀四環素化合物 |
| BR112015004523B1 (pt) | 2012-08-31 | 2020-08-04 | Tetraphase Pharmaceuticals, Inc | Compostos de tetraciclina, composições farmacêuticas e seus usos |
| JP6513576B2 (ja) | 2013-01-14 | 2019-05-15 | ヘルス クリニックス リミテッド | 抗がん剤および使用 |
| CN110582486B (zh) | 2016-10-19 | 2024-01-12 | 四相制药公司 | 艾若威四环素的结晶形式 |
| US11197872B2 (en) | 2017-04-21 | 2021-12-14 | Lunella Biotech, Inc. | Vitamin C and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (CSCs) |
| EP3612177A4 (de) | 2017-04-21 | 2021-01-13 | Lunella Biotech, Inc. | Targeting von hypoxischen krebsstammzellen (cscs) mit doxycyclin: implikationen zur verbesserung der anti-angiogenesetherapie |
| CA3063450A1 (en) | 2017-05-19 | 2018-11-22 | Lunella Biotech, Inc. | Companion diagnostics for mitochondrial inhibitors |
| PH12019502594A1 (en) | 2017-05-19 | 2020-10-26 | Lunella Biotech Inc | Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells |
| US12570604B2 (en) | 2018-11-09 | 2026-03-10 | Tetraphase Pharmaceuticals, Inc. | Polymorphic forms of a tetracycline compound and uses thereof |
| CN115006411A (zh) * | 2022-07-26 | 2022-09-06 | 中南大学湘雅医院 | 依拉环素类化合物的应用、药物及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5308839A (en) * | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
| JP3016587B2 (ja) * | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
| US5668122A (en) * | 1993-07-28 | 1997-09-16 | Fife; Rose S. | Method to treat cancer with tetracyclines |
| US5567693A (en) * | 1994-12-13 | 1996-10-22 | American Cyanamid Company | Method for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
| US5563130A (en) * | 1994-12-13 | 1996-10-08 | American Cyanamid Company | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
| US5574026A (en) * | 1994-12-13 | 1996-11-12 | American Cyanamid Company | Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth |
| US5837696A (en) * | 1997-01-15 | 1998-11-17 | The Research Foundation Of State University Of New York | Method of inhibiting cancer growth |
-
1997
- 1997-01-15 US US08/783,655 patent/US5837696A/en not_active Expired - Lifetime
-
1998
- 1998-01-15 PT PT98902437T patent/PT971585E/pt unknown
- 1998-01-15 WO PCT/US1998/000332 patent/WO1998031224A1/en not_active Ceased
- 1998-01-15 AT AT98902437T patent/ATE321452T1/de active
- 1998-01-15 CA CA002277865A patent/CA2277865C/en not_active Expired - Fee Related
- 1998-01-15 JP JP53443498A patent/JP4428727B2/ja not_active Expired - Fee Related
- 1998-01-15 ES ES98902437T patent/ES2262221T3/es not_active Expired - Lifetime
- 1998-01-15 AU AU59104/98A patent/AU729886B2/en not_active Ceased
- 1998-01-15 KR KR1019997006438A patent/KR20000070212A/ko not_active Ceased
- 1998-01-15 DE DE69834024T patent/DE69834024T2/de not_active Expired - Lifetime
- 1998-01-15 EP EP98902437A patent/EP0971585B1/de not_active Expired - Lifetime
- 1998-01-15 US US09/007,645 patent/US6100248A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000070212A (ko) | 2000-11-25 |
| AU729886B2 (en) | 2001-02-15 |
| JP2001508794A (ja) | 2001-07-03 |
| WO1998031224A1 (en) | 1998-07-23 |
| US5837696A (en) | 1998-11-17 |
| ES2262221T3 (es) | 2006-11-16 |
| JP4428727B2 (ja) | 2010-03-10 |
| CA2277865A1 (en) | 1998-07-23 |
| DE69834024D1 (de) | 2006-05-18 |
| DE69834024T2 (de) | 2006-12-07 |
| AU5910498A (en) | 1998-08-07 |
| EP0971585B1 (de) | 2006-03-29 |
| PT971585E (pt) | 2006-08-31 |
| EP0971585A4 (de) | 2001-01-24 |
| CA2277865C (en) | 2009-06-02 |
| US6100248A (en) | 2000-08-08 |
| EP0971585A1 (de) | 2000-01-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69834024D1 (de) | Tetracycline verbindungen zur behandlung von spezifischen krebsarten | |
| DE69830072D1 (de) | Radioaktive zusammensetzungen zur behandlung von prostatatumoren | |
| ATE368466T1 (de) | Androgensyntheseinhibitoren | |
| MX9804009A (es) | Inhibicion de crecimiento tumoral por oligonucleotidos de antisentido para il-8 y receptor de il-8. | |
| YU596A (sh) | Estrogen agonisti/antagonisti | |
| ATE415979T1 (de) | Behandlung mit anti-erbb2 antikörpern | |
| CY1107721T1 (el) | Παραγωγα τυροζινης | |
| ATE295519T1 (de) | Behandlung von kohlenwasserstoffgas | |
| ZA988826B (en) | Acylsulfamoylbenzamides crop protection compositions comprising them and processes for their preparation | |
| ATE355079T1 (de) | Behandlung von prostata-krebs mit anti-erbb2 antikörpern | |
| ATE208210T1 (de) | Kombination von proteintyrosin-kinaseinhibitoren und chemischer kastration zur behandlung von prostatakrebs | |
| ATE316785T1 (de) | Jak-3 hemmer zur behandlung von allergischen störungen | |
| AP9901478A0 (en) | Compounds for the treatment of ischemia. | |
| DE602004015811D1 (de) | Verfahren zur inhibierung der proliferation von tumorzellen, bei dem platinkomplexe eingesetzt werden | |
| HUP0104688A2 (hu) | Összetételek és eljárások a rákbetegség és a rákbetegséggel kapcsolódó csontveszteség megelőzéséhez és kezeléséhez | |
| BR9912327A (pt) | Inibidores da uroquinase | |
| BR0008788A (pt) | Sequencias anti-sentido antitumor dirigidas contra componentes r1 e r2 de ribonucleotìdeo reductase | |
| DE69902523D1 (de) | Verwendung von erythropoietin zur behandlung von multiple myelom | |
| ATE190352T1 (de) | Dorsalgewebe beeinflussender faktor und zusammensetzungen | |
| ATE196083T1 (de) | Verwendung von ferrioxamin-b zur behandlung septischen schocks | |
| TR199800243T1 (xx) | Prolil endopeptidaz inhibit�rleri. | |
| ATE411036T1 (de) | Verwendung von aplidine in der behandlung von pankreaskrebs | |
| ATE423129T1 (de) | Inhibitoren von lyn-verbundener signaltransduktion (last) und deren verwendung zur behandlung von prostatakrebs | |
| IL189502A0 (en) | Methods and compositions for inhibiting neoplastic cell growth | |
| DE69715668D1 (de) | N-(pyridinylamino)isoindoline und verwandte verbindungen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0971585 Country of ref document: EP |