MA46567A - Formes cristallines de l'éravacycline - Google Patents

Formes cristallines de l'éravacycline

Info

Publication number
MA46567A
MA46567A MA046567A MA46567A MA46567A MA 46567 A MA46567 A MA 46567A MA 046567 A MA046567 A MA 046567A MA 46567 A MA46567 A MA 46567A MA 46567 A MA46567 A MA 46567A
Authority
MA
Morocco
Prior art keywords
eravacycline
crystalline forms
crystalline
forms
eravacycline crystalline
Prior art date
Application number
MA046567A
Other languages
English (en)
Inventor
Chi-Li Chen
Minsheng He
Philip C Hogan
Danny Lafrance
Yansheng Liu
John Niu
Original Assignee
Tetraphase Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tetraphase Pharmaceuticals Inc filed Critical Tetraphase Pharmaceuticals Inc
Publication of MA46567A publication Critical patent/MA46567A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
MA046567A 2016-10-19 2017-10-19 Formes cristallines de l'éravacycline MA46567A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662410230P 2016-10-19 2016-10-19

Publications (1)

Publication Number Publication Date
MA46567A true MA46567A (fr) 2019-08-28

Family

ID=60263035

Family Applications (1)

Application Number Title Priority Date Filing Date
MA046567A MA46567A (fr) 2016-10-19 2017-10-19 Formes cristallines de l'éravacycline

Country Status (15)

Country Link
US (4) US10961190B2 (fr)
EP (1) EP3529236B1 (fr)
JP (2) JP7492335B2 (fr)
KR (2) KR102880712B1 (fr)
CN (2) CN110582486B (fr)
DK (1) DK3529236T3 (fr)
ES (1) ES2978198T3 (fr)
HR (1) HRP20240605T1 (fr)
HU (1) HUE066360T2 (fr)
MA (1) MA46567A (fr)
PH (1) PH12019500822B1 (fr)
PL (1) PL3529236T3 (fr)
SG (1) SG11201903327PA (fr)
SI (1) SI3529236T1 (fr)
WO (1) WO2018075767A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT201900096T1 (it) 2012-08-31 2019-02-28 Tetraphase Pharmaceuticals Inc Composti di tetracicline
WO2017125557A1 (fr) 2016-01-22 2017-07-27 Sandoz Ag Bis-chlorhydrate d'éravacycline cristalline
MA46567A (fr) * 2016-10-19 2019-08-28 Tetraphase Pharmaceuticals Inc Formes cristallines de l'éravacycline
WO2020097450A1 (fr) 2018-11-09 2020-05-14 Tetraphase Pharmaceuticals, Inc. Formes polymorphes d'un composé et utilisations associées
CN119630403A (zh) * 2022-05-29 2025-03-14 本-古里安大学B.G.内盖夫技术和应用公司 用于治疗癌症的伊拉环素
CN115006411A (zh) * 2022-07-26 2022-09-06 中南大学湘雅医院 依拉环素类化合物的应用、药物及其制备方法

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB935384A (en) 1959-03-30 1963-08-28 Pfizer & Co C Tetracycline derivatives and preparation thereof
US3338963A (en) 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
GB1034933A (en) 1962-10-29 1966-07-06 American Cyanamid Co 4-demethylamino-4-substituted amino 6-demethyl tetracyclines
US3364123A (en) 1963-05-06 1968-01-16 Squibb & Sons Inc Production of 4n-demethyl-4n-ethyl tetracyclines
USRE26253E (en) 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
GB1065715A (en) 1964-04-16 1967-04-19 Pfizer & Co C Tetracycline derivatives
US3247226A (en) 1964-07-06 1966-04-19 American Cyanamid Co 4-dimethylamino and 4-hydroxytetracycloxides
US3394178A (en) 1965-01-26 1968-07-23 Merck & Co Inc Nu-ethyloxytetracycline
GB1077598A (en) 1965-05-12 1967-08-02 Pfizer & Co C Preparation of n-demethyl tetracyclines
US3304227A (en) 1965-07-15 1967-02-14 Loyal E Loveless Antibiotic-containing animal feed
US3433709A (en) 1965-12-07 1969-03-18 American Cyanamid Co Biological transformation of alpha-6-deoxytetracyclines to tetracyclines
US3849493A (en) 1966-08-01 1974-11-19 Pfizer D-ring substituted 6-deoxytetracyclines
US3824285A (en) 1967-09-13 1974-07-16 Pfizer 4-oxo-4-dedimethylaminotetracycline-4,6-hemiketals
US3947517A (en) 1969-06-12 1976-03-30 Research Corporation Stereoselective introduction of tetracyclines hydroxyl group at 12(a) position in synthesis of tetracyclines
DE2437487A1 (de) 1974-08-03 1976-02-19 Merck Patent Gmbh 7-methoxy-6-thia-tetracycline und verfahren zu ihrer herstellung
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
YU290176A (en) 1976-11-26 1982-05-31 Pliva Zagreb Process for preparing 4-dedimethylamino-4-arylsulfonamido-5a,6-anhydrotetracycline
US4704383A (en) 1983-12-29 1987-11-03 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
USRE34656E (en) 1983-12-29 1994-07-05 The Research Foundation Of State University Of New York Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency
US4935412A (en) 1983-12-29 1990-06-19 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
US4925833A (en) 1983-12-29 1990-05-15 The Research Foundation Of State University Of New York Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis
US4666897A (en) 1983-12-29 1987-05-19 Research Foundation Of State University Inhibition of mammalian collagenolytic enzymes by tetracyclines
JP3016587B2 (ja) 1989-12-04 2000-03-06 ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク 非ステロイド抗炎症剤及びテトラサイクリンの配合
US5308839A (en) 1989-12-04 1994-05-03 The Research Foundation Of State University Of New York Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
US5770588A (en) 1991-02-11 1998-06-23 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions of the prevention and treatment of root caries
US5231017A (en) 1991-05-17 1993-07-27 Solvay Enzymes, Inc. Process for producing ethanol
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
DE122006000058I2 (de) 1991-10-04 2007-09-13 Wyeth Corp 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline
US5258371A (en) 1992-05-29 1993-11-02 Kuraray Co., Ltd. Method to reduce connective tissue destruction
US6043225A (en) 1992-06-12 2000-03-28 Board Of Regents Of The University Of Washington Diagnosis and treatment of arterial chlamydial granuloma
US5442059A (en) 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5284963A (en) 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5328902A (en) 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5420272A (en) 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
DE69304292T2 (de) 1992-11-17 1997-01-02 Univ New York Tetracycline inclusive nicht antimicrobiel wirksame, chemisch modifizierte Tetracycline hemmende exzessive Kollagenquervernetzung bei Diabetes
US6043231A (en) 1993-03-02 2000-03-28 The Research Foundation Of State Univ. Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5523297A (en) 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5371076A (en) 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
US5668122A (en) 1993-07-28 1997-09-16 Fife; Rose S. Method to treat cancer with tetracyclines
AU1279095A (en) 1994-02-17 1995-09-04 Pfizer Inc. 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US5574026A (en) 1994-12-13 1996-11-12 American Cyanamid Company Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth
US5843925A (en) 1994-12-13 1998-12-01 American Cyanamid Company Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US5834449A (en) 1996-06-13 1998-11-10 The Research Foundation Of State University Of New York Treatment of aortic and vascular aneurysms with tetracycline compounds
US5827840A (en) 1996-08-01 1998-10-27 The Research Foundation Of State University Of New York Promotion of wound healing by chemically-modified tetracyclines
US5789395A (en) 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
US5919774A (en) 1996-12-10 1999-07-06 Eli Lilly And Company Pyrroles as sPLA2 inhibitors
US5837696A (en) 1997-01-15 1998-11-17 The Research Foundation Of State University Of New York Method of inhibiting cancer growth
US5773430A (en) 1997-03-13 1998-06-30 Research Foundation Of State University Of New York Serine proteinase inhibitory activity by hydrophobic tetracycline
US5929055A (en) 1997-06-23 1999-07-27 The Research Foundation Of State University Of New York Therapeutic method for management of diabetes mellitus
JP2002501026A (ja) 1998-01-23 2002-01-15 トルスティーズ オブ トゥフツ カレッジ 薬学的に活性の化合物及びその利用法
US6277061B1 (en) 1998-03-31 2001-08-21 The Research Foundation Of State University Of New York Method of inhibiting membrane-type matrix metalloproteinase
US6015804A (en) 1998-09-11 2000-01-18 The Research Foundation Of State University Of New York Method of using tetracycline compounds to enhance interleukin-10 production
US5977091A (en) 1998-09-21 1999-11-02 The Research Foundation Of State University Of New York Method of preventing acute lung injury
US5998390A (en) 1998-09-28 1999-12-07 The Research Foundation Of State University Of New York Combination of bisphosphonate and tetracycline
JP2002525299A (ja) 1998-09-28 2002-08-13 ザ リサーチ ファウンデーション オブ ステイト ユニヴァーシティ オブ ニューヨーク 新規白内障形成抑制剤
US6914057B1 (en) 1998-09-28 2005-07-05 The Research Foundation Of State University Of New York Inhibitor of cataract formation
US6231894B1 (en) 1999-10-21 2001-05-15 Duke University Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase
AU2000257445A1 (en) 2000-06-16 2002-01-02 Trustees Of Tufts College 7-n-substituted phenyl tetracycline compounds
SI1301467T1 (sl) 2000-07-07 2007-02-28 Tufts College 9-substituirane minociklinske spojine
ATE504562T1 (de) 2000-07-07 2011-04-15 Tufts College 7-, 8- und 9-substitutierte tetracyclinverbindungen
IL153672A0 (en) 2000-07-07 2003-07-06 Tufts College 7-substituted tetracycline compounds
EP1368305B1 (fr) 2001-03-13 2008-08-13 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues en position 7,9
WO2002072031A2 (fr) 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques
CA2457234A1 (fr) 2001-03-14 2002-09-19 Mark L. Nelson Composes de tetracycline substitues, en tant qu'agents antifongiques
US8088820B2 (en) 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
DE60235083D1 (de) 2001-04-24 2010-03-04 Paratek Pharm Innc Substituierte tetracyclin-verbindungen zur behandlung von malaria
JP2004537544A (ja) 2001-07-13 2004-12-16 パラテック ファーマシューティカルズ インコーポレイテッド 標的治療活性を有するテトラサイクリン化合物
US20060194773A1 (en) 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
ES2551708T3 (es) 2002-01-08 2015-11-23 Paratek Pharmaceuticals, Inc. Compuestos de 4-desdimetilamino tetraciclina
EP1482926A4 (fr) 2002-03-08 2006-04-12 Paratek Pharm Innc Composes a base de tetracycline a substitution aminomethyle
WO2003079984A2 (fr) 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Composes de tetracycline substituee
EA200900540A1 (ru) 2002-07-12 2009-12-30 Пэрэтек Фамэсьютикэлс, Инк. Замещённые соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
AU2003287218C1 (en) 2002-10-24 2010-07-15 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
CA2503446C (fr) 2002-10-24 2012-12-18 Paratek Pharmaceuticals, Inc. Procedes d'utilisation de composes tetracycline substituee pour moduler l'arn
EP1648859B1 (fr) 2003-07-09 2013-02-27 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues
WO2005082860A1 (fr) 2004-02-27 2005-09-09 National Research Council Of Canada Tetracyclines et leur utilisation en tant qu'inhibiteurs de la calpaine
JP2007535565A (ja) 2004-04-30 2007-12-06 バイエル ファーマシューティカルス コーポレーション 癌の治療に有用な置換ピラゾリル尿素誘導体
US7807842B2 (en) 2004-05-21 2010-10-05 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
EP2269991A3 (fr) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Composés de tetracycline substitués
WO2006047671A2 (fr) 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines et procedes d'utilisation
WO2006084265A1 (fr) 2005-02-04 2006-08-10 Paratek Pharmaceuticals, Inc. Derives 11a, 12 de composes de tetracycline
AU2006214543A1 (en) 2005-02-15 2006-08-24 Wyeth 9-substituted tetracyclines
JP2009502809A (ja) 2005-07-21 2009-01-29 パラテック ファーマシューティカルズ インコーポレイテッド １０−置換テトラサイクリンおよびその使用方法
US9078811B2 (en) 2006-01-24 2015-07-14 Paratek Pharmaceuticals, Inc. Methods of increasing oral bioavailability of tetracyclines
EP2016044B1 (fr) 2006-04-07 2020-06-10 President and Fellows of Harvard College Dérivés de pentacycline pour le traitement d'infections
CA2652347A1 (fr) 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methodes de regulation de l'expression de genes ou de produits geniques a l'aide de composes de tetracycline substituee
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
EP2479169B1 (fr) 2006-10-11 2014-12-03 President and Fellows of Harvard College Synthèse d'un intermédiaire de l'énone
EP2450347B1 (fr) 2006-12-21 2015-06-24 Paratek Pharmaceuticals, Inc. Dérivés de tétracycline pour le traitement d'infections bactériennes, virales et parasites
WO2008127722A1 (fr) 2007-04-12 2008-10-23 Paratek Pharmaceuticals, Inc. Procédés pour le traitement de l'amyotrophie spinale à l'aide de composés tétracyclines.
BRPI0813990A2 (pt) 2007-07-06 2011-09-13 Paratek Pharmaceuticals, Inc. métodos para sintetizar compostos de minociclina substituìda
US7939513B2 (en) 2007-09-07 2011-05-10 Dr. Reddy's Laboratories Limited Tetracycline derivatives as antibacterial agents
JP2011517697A (ja) 2008-04-14 2011-06-16 パラテック ファーマシューティカルズ インコーポレイテッド 置換テトラサイクリン化合物
TWI680117B (zh) * 2008-05-19 2019-12-21 派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
CA2730377C (fr) 2008-07-11 2017-09-19 Neumedics Derives de tetracycline presentant une activite antibiotique reduite et des benefices neuroprotecteurs
ES2558512T3 (es) 2008-08-08 2016-02-04 Tetraphase Pharmaceuticals, Inc. Compuestos de tetraciclina sustituida con C7-fluoro
WO2010126607A2 (fr) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthèse de tétracyclines et intermédiaires de celles-ci
WO2010129055A1 (fr) 2009-05-08 2010-11-11 Tetraphase Pharmaceuticals, Inc. Composés de 8-aza tétracycline
WO2010129057A2 (fr) 2009-05-08 2010-11-11 Tetraphase Pharmaceuticals, Inc. Composés de tétracycline
US20120115819A1 (en) 2009-05-13 2012-05-10 Clark Roger B Pentacycline Compounds
HUE037852T2 (hu) 2009-08-28 2018-09-28 Tetraphase Pharmaceuticals Inc Tetraciklin-vegyületek
EP2544692A4 (fr) 2010-03-10 2013-08-07 Univ Health Network Utilisation de la tigécycline pour le traitement du cancer
JP5820462B2 (ja) 2010-03-31 2015-11-24 テトラフェース ファーマシューティカルズ，インコーポレイテッド 多環式テトラサイクリン化合物
AR082633A1 (es) 2010-08-12 2012-12-19 Tetraphase Pharmaceuticals Inc Analogos de tetraciclina
WO2012047907A1 (fr) 2010-10-04 2012-04-12 President And Fellows Of Harvard College Synthèse de tétracyclines substituées en c5, leurs utilisations, et intermédiaires dans la synthèse de celles-ci
US9255068B2 (en) 2011-05-12 2016-02-09 Warner Chilcott Company, Llc Crystalline salts of (4S,4AS,5AR,12AS)-4-dimethylamino-3,10,12,12A-tetrahydroxy-7-[methoxy(methyl)amino)-methyl] acid amide and methods of using the same
SMT201900096T1 (it) 2012-08-31 2019-02-28 Tetraphase Pharmaceuticals Inc Composti di tetracicline
MA40836A (fr) * 2014-10-23 2017-08-29 Tetraphase Pharmaceuticals Inc Procédures de semi-synthèse
WO2017097891A1 (fr) * 2015-12-10 2017-06-15 Sandoz Ag Éravacycline cristalline
WO2017125557A1 (fr) * 2016-01-22 2017-07-27 Sandoz Ag Bis-chlorhydrate d'éravacycline cristalline
WO2018045084A1 (fr) 2016-08-30 2018-03-08 Tetraphase Pharmaceuticals, Inc. Composés de tétracycline et méthodes de traitement
MA46567A (fr) 2016-10-19 2019-08-28 Tetraphase Pharmaceuticals Inc Formes cristallines de l'éravacycline

Also Published As

Publication number Publication date
KR102880712B1 (ko) 2025-11-03
CN110582486B (zh) 2024-01-12
US20230416212A1 (en) 2023-12-28
CN110582486A (zh) 2019-12-17
PL3529236T4 (pl) 2024-07-08
KR102660864B1 (ko) 2024-04-25
SI3529236T1 (sl) 2024-08-30
US20260055070A1 (en) 2026-02-26
US20190256462A1 (en) 2019-08-22
EP3529236B1 (fr) 2024-02-07
ES2978198T3 (es) 2024-09-06
EP3529236A1 (fr) 2019-08-28
US12269807B2 (en) 2025-04-08
HUE066360T2 (hu) 2024-07-28
CN117903083A (zh) 2024-04-19
US20210363103A1 (en) 2021-11-25
PL3529236T3 (pl) 2024-07-08
US11578044B2 (en) 2023-02-14
JP7492335B2 (ja) 2024-05-29
KR20190065414A (ko) 2019-06-11
WO2018075767A1 (fr) 2018-04-26
US10961190B2 (en) 2021-03-30
JP2022186979A (ja) 2022-12-15
PH12019500822B1 (en) 2024-02-21
PH12019500822A1 (en) 2019-08-19
JP2019531321A (ja) 2019-10-31
KR20240058958A (ko) 2024-05-07
SG11201903327PA (en) 2019-05-30
JP7598913B2 (ja) 2024-12-12
DK3529236T3 (da) 2024-05-13
HRP20240605T1 (hr) 2024-07-19

Similar Documents

Publication Publication Date Title
EP3464313A4 (fr) Nucléotides modifiés 5 '-cyclo-phosphonate
EP3430731A4 (fr) Architecture d'iugw
MA51819A (fr) Nouvelles formes cristallines
EP3544492A4 (fr) Gestionnaire de protocoles d'imagerie
EP3488670A4 (fr) Technologies d'architecture de bâti
ES1243880Y (es) Cepillo de dientes
PT4039675T (pt) Compostos de fenil-2-hidroxi-acetilamino-2-metil-fenilo
EP3437540A4 (fr) Support d'endoscope
EP3455077C0 (fr) Impression
EP3378606A4 (fr) Combinaison d'assistance
EP3338142A4 (fr) Agents de développement d'encre
EP3379317A4 (fr) Lentille d'imagerie
EP3337485A4 (fr) Formes cristallines d'ibrutinib
DK3829402T3 (da) Tæppe
EP3390422A4 (fr) Formes cristallines de lnt
EP3431808A4 (fr) Butée d'arrêt
EP3898809C0 (fr) Composition de polypropylène
EP3338446A4 (fr) Projections d'image
EP2986597A4 (fr) Fluorescence réglable à l'aide de lieurs clivables
EP3444345A4 (fr) Dérivé d'arnmicro-143
PT3419979T (pt) Compostos de 6,7-dihidro-5h-pirazolo[5,1-b][1,3]oxazina-2-carboxamida
EP3297632A4 (fr) Clairance de galantamine d'amyloides
MA46266A (fr) Formes cristallines
MA48944A (fr) Forme cristalline de n-butyldéoxygalactonojirimycine
EP3426675A4 (fr) Formes salines cristallines