ATE321572T1 - Kombinierte tumortherapie auf der basis von substituierten acryloyl-distamycin-derivaten und protein-kinase (serin/threonin-kinase) inhibitoren - Google Patents

Kombinierte tumortherapie auf der basis von substituierten acryloyl-distamycin-derivaten und protein-kinase (serin/threonin-kinase) inhibitoren

Info

Publication number: ATE321572T1
Authority: AT; Austria
Prior art keywords: serine; inhibitors; distamycin derivatives; kinase; protein kinase
Prior art date: 2002-01-02

Application number

AT02787763T

Other languages

English (en)

Inventor

Maria Cristina Geroni

Camilla Fowst

Paolo Cozzi

Original Assignee

Pharmacia Italia Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-02

Filing date

2002-12-18

Publication date

2006-04-15

2002-12-18 Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa

2006-04-15 Application granted granted Critical

2006-04-15 Publication of ATE321572T1 publication Critical patent/ATE321572T1/de

Links

206010028980 Neoplasm Diseases 0.000 title abstract 3
102000001253 Protein Kinase Human genes 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
108060006633 protein kinase Proteins 0.000 title abstract 2
101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 title 1
102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 title 1
238000002560 therapeutic procedure Methods 0.000 title 1
-1 acryloyl distamycin derivatives Chemical class 0.000 abstract 2
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
206010027476 Metastases Diseases 0.000 abstract 1
102000009516 Protein Serine-Threonine Kinases Human genes 0.000 abstract 1
108010009341 Protein Serine-Threonine Kinases Proteins 0.000 abstract 1
102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
239000004473 Threonine Substances 0.000 abstract 1
230000009401 metastasis Effects 0.000 abstract 1
230000014399 negative regulation of angiogenesis Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Oncology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT02787763T 2002-01-02 2002-12-18 Kombinierte tumortherapie auf der basis von substituierten acryloyl-distamycin-derivaten und protein-kinase (serin/threonin-kinase) inhibitoren ATE321572T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02075052		2002-01-02

Publications (1)

Publication Number	Publication Date
ATE321572T1 true ATE321572T1 (de)	2006-04-15

Family

ID=8185508

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02787763T ATE321572T1 (de)	2002-01-02	2002-12-18	Kombinierte tumortherapie auf der basis von substituierten acryloyl-distamycin-derivaten und protein-kinase (serin/threonin-kinase) inhibitoren

Country Status (24)

Country	Link
US (1)	US20060084612A1 (de)
EP (1)	EP1461083B1 (de)
JP (1)	JP2005516025A (de)
KR (1)	KR20040078118A (de)
CN (1)	CN1617744A (de)
AT (1)	ATE321572T1 (de)
AU (1)	AU2002352090B8 (de)
BR (1)	BR0215454A (de)
CA (1)	CA2472008C (de)
CY (1)	CY1105269T1 (de)
DE (1)	DE60210329T2 (de)
DK (1)	DK1461083T3 (de)
ES (1)	ES2263835T3 (de)
HU (1)	HUP0402639A3 (de)
IL (2)	IL162820A0 (de)
MX (1)	MXPA04006543A (de)
NO (1)	NO20043217L (de)
NZ (1)	NZ533854A (de)
PL (1)	PL371179A1 (de)
PT (1)	PT1461083E (de)
RU (1)	RU2328306C2 (de)
SI (1)	SI1461083T1 (de)
WO (1)	WO2003055522A1 (de)
ZA (1)	ZA200405290B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8383605B2 (en)	2002-07-30	2013-02-26	Aeterna Zentaris Gmbh	Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals
UA82322C2 (uk) *	2002-07-30	2008-04-10	Центаріс Гмбх	Застосування алкілфосфохолінів в комбінації з протипухлинними лікарськими засобами
ATE447950T1 (de) *	2005-04-08	2009-11-15	Nerviano Medical Sciences Srl	Antitumorale kombination aus substituierten acryloyldistamycin-derivaten und wachstumsfaktoren oder ihre rezeptoren hemmende antikörper
US8383607B2 (en)	2010-03-31	2013-02-26	Aeterna Zentaris Gmbh	Perifosine and capecitabine as a combined treatment for cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8906709D0 (en) *	1989-03-23	1989-05-10	Creighton Andrew M	Acryloyl substituted pyrrole derivatives
US6274576B1 (en) *	1995-06-27	2001-08-14	The Henry Jackson Foundation For The Advancement Of Military Medicine	Method of dynamic retardation of cell cycle kinetics to potentiate cell damage
US5821072A (en) *	1996-02-20	1998-10-13	Sloan-Kettering Institute For Cancer Research	Combinations of PKC inhibitors and therapaeutic agents for treating cancers
GB9615692D0 (en) *	1996-07-25	1996-09-04	Pharmacia Spa	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB0015447D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015444D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors

2002
- 2002-12-18 DE DE60210329T patent/DE60210329T2/de not_active Expired - Lifetime
- 2002-12-18 IL IL16282002A patent/IL162820A0/xx unknown
- 2002-12-18 CN CNA028276744A patent/CN1617744A/zh active Pending
- 2002-12-18 MX MXPA04006543A patent/MXPA04006543A/es active IP Right Grant
- 2002-12-18 EP EP02787763A patent/EP1461083B1/de not_active Expired - Lifetime
- 2002-12-18 NZ NZ533854A patent/NZ533854A/en not_active IP Right Cessation
- 2002-12-18 ES ES02787763T patent/ES2263835T3/es not_active Expired - Lifetime
- 2002-12-18 RU RU2004123641/15A patent/RU2328306C2/ru not_active IP Right Cessation
- 2002-12-18 KR KR10-2004-7010472A patent/KR20040078118A/ko not_active Ceased
- 2002-12-18 DK DK02787763T patent/DK1461083T3/da active
- 2002-12-18 AT AT02787763T patent/ATE321572T1/de active
- 2002-12-18 WO PCT/EP2002/013092 patent/WO2003055522A1/en not_active Ceased
- 2002-12-18 CA CA002472008A patent/CA2472008C/en not_active Expired - Fee Related
- 2002-12-18 US US10/500,606 patent/US20060084612A1/en not_active Abandoned
- 2002-12-18 PL PL02371179A patent/PL371179A1/xx not_active Application Discontinuation
- 2002-12-18 JP JP2003556098A patent/JP2005516025A/ja active Pending
- 2002-12-18 SI SI200230335T patent/SI1461083T1/sl unknown
- 2002-12-18 BR BR0215454-4A patent/BR0215454A/pt not_active IP Right Cessation
- 2002-12-18 PT PT02787763T patent/PT1461083E/pt unknown
- 2002-12-18 HU HU0402639A patent/HUP0402639A3/hu unknown
- 2002-12-18 AU AU2002352090A patent/AU2002352090B8/en not_active Ceased
2004
- 2004-07-01 IL IL162820A patent/IL162820A/en not_active IP Right Cessation
- 2004-07-02 ZA ZA200405290A patent/ZA200405290B/xx unknown
- 2004-07-29 NO NO20043217A patent/NO20043217L/no not_active Application Discontinuation
2006
- 2006-06-05 CY CY20061100717T patent/CY1105269T1/el unknown

Also Published As

Publication number	Publication date
RU2328306C2 (ru)	2008-07-10
CA2472008C (en)	2009-07-28
US20060084612A1 (en)	2006-04-20
RU2004123641A (ru)	2005-06-10
CN1617744A (zh)	2005-05-18
PL371179A1 (en)	2005-06-13
CY1105269T1 (el)	2010-03-03
AU2002352090A1 (en)	2003-07-15
HUP0402639A3 (en)	2012-02-28
KR20040078118A (ko)	2004-09-08
IL162820A (en)	2010-04-15
PT1461083E (pt)	2006-08-31
WO2003055522A1 (en)	2003-07-10
SI1461083T1 (sl)	2006-08-31
DK1461083T3 (da)	2006-07-10
EP1461083A1 (de)	2004-09-29
ES2263835T3 (es)	2006-12-16
JP2005516025A (ja)	2005-06-02
BR0215454A (pt)	2004-11-23
ZA200405290B (en)	2005-06-17
NO20043217L (no)	2004-07-30
DE60210329D1 (de)	2006-05-18
DE60210329T2 (de)	2006-11-30
NZ533854A (en)	2007-05-31
CA2472008A1 (en)	2003-07-10
IL162820A0 (en)	2005-11-20
AU2002352090B2 (en)	2008-05-15
HUP0402639A2 (hu)	2005-04-28
EP1461083B1 (de)	2006-03-29
AU2002352090B8 (en)	2008-06-19
MXPA04006543A (es)	2004-10-04

Legal Events

Date

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Title

Description

2007-02-15

UEP

Publication of translation of european patent specification

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