NO20043217L - Kombinert terapi mot tumorer omfattende substituerte acryloyl distamycin og protein kinase (serin/threonin kinase) inhibitorer - Google Patents

Kombinert terapi mot tumorer omfattende substituerte acryloyl distamycin og protein kinase (serin/threonin kinase) inhibitorer

Info

Publication number: NO20043217L
Authority: NO; Norway
Prior art keywords: serine; inhibitors; acryloyl distamycin; kinase; combined therapy
Prior art date: 2002-01-02

Application number

NO20043217A

Other languages

English (en)

Inventor

Paolo Cozzi

Maria Cristina Rosa Geroni

Camilla Fowst

Original Assignee

Pharmacia Italia Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-02

Filing date

2004-07-29

Publication date

2004-07-30

2004-07-29 Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa

2004-07-30 Publication of NO20043217L publication Critical patent/NO20043217L/no

Links

206010028980 Neoplasm Diseases 0.000 title abstract 3
-1 acryloyl distamycin Chemical compound 0.000 title abstract 3
102000001253 Protein Kinase Human genes 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
108060006633 protein kinase Proteins 0.000 title abstract 2
101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 title 1
102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 title 1
238000002648 combination therapy Methods 0.000 title 1
108010042747 stallimycin Proteins 0.000 title 1
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
206010027476 Metastases Diseases 0.000 abstract 1
102000009516 Protein Serine-Threonine Kinases Human genes 0.000 abstract 1
108010009341 Protein Serine-Threonine Kinases Proteins 0.000 abstract 1
102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
239000004473 Threonine Substances 0.000 abstract 1
230000009401 metastasis Effects 0.000 abstract 1
230000014399 negative regulation of angiogenesis Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Oncology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO20043217A 2002-01-02 2004-07-29 Kombinert terapi mot tumorer omfattende substituerte acryloyl distamycin og protein kinase (serin/threonin kinase) inhibitorer NO20043217L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02075052		2002-01-02
PCT/EP2002/013092 WO2003055522A1 (en)	2002-01-02	2002-12-18	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors

Publications (1)

Publication Number	Publication Date
NO20043217L true NO20043217L (no)	2004-07-30

Family

ID=8185508

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20043217A NO20043217L (no)	2002-01-02	2004-07-29	Kombinert terapi mot tumorer omfattende substituerte acryloyl distamycin og protein kinase (serin/threonin kinase) inhibitorer

Country Status (24)

Country	Link
US (1)	US20060084612A1 (no)
EP (1)	EP1461083B1 (no)
JP (1)	JP2005516025A (no)
KR (1)	KR20040078118A (no)
CN (1)	CN1617744A (no)
AT (1)	ATE321572T1 (no)
AU (1)	AU2002352090B8 (no)
BR (1)	BR0215454A (no)
CA (1)	CA2472008C (no)
CY (1)	CY1105269T1 (no)
DE (1)	DE60210329T2 (no)
DK (1)	DK1461083T3 (no)
ES (1)	ES2263835T3 (no)
HU (1)	HUP0402639A3 (no)
IL (2)	IL162820A0 (no)
MX (1)	MXPA04006543A (no)
NO (1)	NO20043217L (no)
NZ (1)	NZ533854A (no)
PL (1)	PL371179A1 (no)
PT (1)	PT1461083E (no)
RU (1)	RU2328306C2 (no)
SI (1)	SI1461083T1 (no)
WO (1)	WO2003055522A1 (no)
ZA (1)	ZA200405290B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8383605B2 (en)	2002-07-30	2013-02-26	Aeterna Zentaris Gmbh	Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals
UA82322C2 (uk) *	2002-07-30	2008-04-10	Центаріс Гмбх	Застосування алкілфосфохолінів в комбінації з протипухлинними лікарськими засобами
ATE447950T1 (de) *	2005-04-08	2009-11-15	Nerviano Medical Sciences Srl	Antitumorale kombination aus substituierten acryloyldistamycin-derivaten und wachstumsfaktoren oder ihre rezeptoren hemmende antikörper
US8383607B2 (en)	2010-03-31	2013-02-26	Aeterna Zentaris Gmbh	Perifosine and capecitabine as a combined treatment for cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8906709D0 (en) *	1989-03-23	1989-05-10	Creighton Andrew M	Acryloyl substituted pyrrole derivatives
US6274576B1 (en) *	1995-06-27	2001-08-14	The Henry Jackson Foundation For The Advancement Of Military Medicine	Method of dynamic retardation of cell cycle kinetics to potentiate cell damage
US5821072A (en) *	1996-02-20	1998-10-13	Sloan-Kettering Institute For Cancer Research	Combinations of PKC inhibitors and therapaeutic agents for treating cancers
GB9615692D0 (en) *	1996-07-25	1996-09-04	Pharmacia Spa	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB0015447D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015444D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors

2002
- 2002-12-18 DE DE60210329T patent/DE60210329T2/de not_active Expired - Lifetime
- 2002-12-18 IL IL16282002A patent/IL162820A0/xx unknown
- 2002-12-18 CN CNA028276744A patent/CN1617744A/zh active Pending
- 2002-12-18 MX MXPA04006543A patent/MXPA04006543A/es active IP Right Grant
- 2002-12-18 EP EP02787763A patent/EP1461083B1/en not_active Expired - Lifetime
- 2002-12-18 NZ NZ533854A patent/NZ533854A/en not_active IP Right Cessation
- 2002-12-18 ES ES02787763T patent/ES2263835T3/es not_active Expired - Lifetime
- 2002-12-18 RU RU2004123641/15A patent/RU2328306C2/ru not_active IP Right Cessation
- 2002-12-18 KR KR10-2004-7010472A patent/KR20040078118A/ko not_active Ceased
- 2002-12-18 DK DK02787763T patent/DK1461083T3/da active
- 2002-12-18 AT AT02787763T patent/ATE321572T1/de active
- 2002-12-18 WO PCT/EP2002/013092 patent/WO2003055522A1/en not_active Ceased
- 2002-12-18 CA CA002472008A patent/CA2472008C/en not_active Expired - Fee Related
- 2002-12-18 US US10/500,606 patent/US20060084612A1/en not_active Abandoned
- 2002-12-18 PL PL02371179A patent/PL371179A1/xx not_active Application Discontinuation
- 2002-12-18 JP JP2003556098A patent/JP2005516025A/ja active Pending
- 2002-12-18 SI SI200230335T patent/SI1461083T1/sl unknown
- 2002-12-18 BR BR0215454-4A patent/BR0215454A/pt not_active IP Right Cessation
- 2002-12-18 PT PT02787763T patent/PT1461083E/pt unknown
- 2002-12-18 HU HU0402639A patent/HUP0402639A3/hu unknown
- 2002-12-18 AU AU2002352090A patent/AU2002352090B8/en not_active Ceased
2004
- 2004-07-01 IL IL162820A patent/IL162820A/en not_active IP Right Cessation
- 2004-07-02 ZA ZA200405290A patent/ZA200405290B/xx unknown
- 2004-07-29 NO NO20043217A patent/NO20043217L/no not_active Application Discontinuation
2006
- 2006-06-05 CY CY20061100717T patent/CY1105269T1/el unknown

Also Published As

Publication number	Publication date
RU2328306C2 (ru)	2008-07-10
CA2472008C (en)	2009-07-28
US20060084612A1 (en)	2006-04-20
RU2004123641A (ru)	2005-06-10
CN1617744A (zh)	2005-05-18
PL371179A1 (en)	2005-06-13
CY1105269T1 (el)	2010-03-03
AU2002352090A1 (en)	2003-07-15
HUP0402639A3 (en)	2012-02-28
KR20040078118A (ko)	2004-09-08
IL162820A (en)	2010-04-15
PT1461083E (pt)	2006-08-31
WO2003055522A1 (en)	2003-07-10
SI1461083T1 (sl)	2006-08-31
DK1461083T3 (da)	2006-07-10
EP1461083A1 (en)	2004-09-29
ES2263835T3 (es)	2006-12-16
JP2005516025A (ja)	2005-06-02
BR0215454A (pt)	2004-11-23
ZA200405290B (en)	2005-06-17
DE60210329D1 (de)	2006-05-18
DE60210329T2 (de)	2006-11-30
NZ533854A (en)	2007-05-31
CA2472008A1 (en)	2003-07-10
ATE321572T1 (de)	2006-04-15
IL162820A0 (en)	2005-11-20
AU2002352090B2 (en)	2008-05-15
HUP0402639A2 (hu)	2005-04-28
EP1461083B1 (en)	2006-03-29
AU2002352090B8 (en)	2008-06-19
MXPA04006543A (es)	2004-10-04

Legal Events

Date	Code	Title	Description
2012-08-06	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
ATE297394T1 (de)	2005-06-15	Jun kinase inhibitoren
ATE499097T1 (de)	2011-03-15	Monozyklische heterozyklen als kinase-hemmer
AP1699A (en)	2006-12-26	New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
EA201000093A1 (ru)	2010-06-30	Производные пиридазинона
EA200901601A1 (ru)	2010-06-30	Производные пиридазинона
EA201001005A1 (ru)	2011-02-28	Производные 2-бензилпиридазинона в качестве ингибиторов мет киназы
EA201100334A1 (ru)	2011-08-30	Бициклические производные триазола для лечения опухолей
GEP20125368B (en)	2012-01-10	Kinase inhibitors
DK1485345T3 (da)	2008-11-03	Urokinaseinhibitorer, deres fremstilling og anvendelse
DK1292290T3 (da)	2006-07-10	Kombineret terapi mod tumorer omfattende substitueret acryloyl distamycinderivater og topoisomerase I og II inhibitorer
UA85087C2 (en)	2008-12-25	Monocyclic heterocycles as kinase inhibitors
DK1461083T3 (da)	2006-07-10	Kombineret terapi mod tumorer omfattende substitueret acryloyl distamycinderivater og proteinkinase- (serin/threoninkinase) inhibitorer
TW200503722A (en)	2005-02-01	Substituted 7-aza-quinazoline compounds
ATE435200T1 (de)	2009-07-15	Guanidinophenylalanin-verbindungen als urokinase- inhibitoren
UA90254C2 (ru)	2010-04-26	Производные пиразола и их применение в качестве ингибиторов рецепторных тирозинкиназ
TW200602023A (en)	2006-01-16	Monocyclic heterocycles as kinase inhibitors
ITMI20022739A1 (it)	2004-06-24	Derivati ftalazinici inibitori della fosfodiesterasi 4.