ATE321784T1 - Pthrp analogen - Google Patents

Pthrp analogen

Info

Publication number
ATE321784T1
ATE321784T1 AT97951595T AT97951595T ATE321784T1 AT E321784 T1 ATE321784 T1 AT E321784T1 AT 97951595 T AT97951595 T AT 97951595T AT 97951595 T AT97951595 T AT 97951595T AT E321784 T1 ATE321784 T1 AT E321784T1
Authority
AT
Austria
Prior art keywords
pthrp analogue
pthrp
analogue
Prior art date
Application number
AT97951595T
Other languages
English (en)
Inventor
Zheng Xin Dong
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/779,768 external-priority patent/US5969095A/en
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Application granted granted Critical
Publication of ATE321784T1 publication Critical patent/ATE321784T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT97951595T 1997-01-07 1997-12-08 Pthrp analogen ATE321784T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/779,768 US5969095A (en) 1995-07-13 1997-01-07 Analogs of parathyroid hormone
US08/813,534 US5955574A (en) 1995-07-13 1997-03-07 Analogs of parathyroid hormone

Publications (1)

Publication Number Publication Date
ATE321784T1 true ATE321784T1 (de) 2006-04-15

Family

ID=27119618

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05026436T ATE471342T1 (de) 1997-01-07 1997-12-08 Parathyroidhormon analoge
AT97951595T ATE321784T1 (de) 1997-01-07 1997-12-08 Pthrp analogen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT05026436T ATE471342T1 (de) 1997-01-07 1997-12-08 Parathyroidhormon analoge

Country Status (23)

Country Link
US (1) US5955574A (de)
EP (3) EP1645566B1 (de)
JP (1) JP3963482B2 (de)
KR (2) KR100497709B1 (de)
CN (1) CN1137898C (de)
AR (3) AR011517A1 (de)
AT (2) ATE471342T1 (de)
AU (1) AU741584B2 (de)
BR (1) BR9714200A (de)
CA (1) CA2276614C (de)
CZ (2) CZ301497B6 (de)
DE (2) DE69739912D1 (de)
DK (2) DK1645566T3 (de)
ES (2) ES2258286T3 (de)
HU (1) HUP9904596A3 (de)
IL (1) IL130794A0 (de)
NO (1) NO993341L (de)
NZ (1) NZ336610A (de)
PL (1) PL191898B1 (de)
PT (2) PT948541E (de)
RU (1) RU2198182C2 (de)
SI (2) SI0948541T1 (de)
WO (1) WO1998030590A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544949B1 (en) * 1995-07-13 2003-04-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
US7410948B2 (en) * 1995-07-13 2008-08-12 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Analogs of parathyroid hormone
CA2302255C (en) 1997-09-09 2011-11-08 F. Hoffmann-La Roche Ag Fracture healing using pthrp analogs
US7531621B1 (en) * 1998-05-05 2009-05-12 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. PTH2 receptor selective compounds
PL345583A1 (en) * 1998-07-20 2001-12-17 Sod Conseils Rech Applic Peptide analogues of pacap
US6660843B1 (en) † 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
WO2001060862A1 (en) 2000-02-18 2001-08-23 Dabur Research Foundation Vasoactive intestinal peptide analogs
US20050124537A1 (en) * 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US6756480B2 (en) * 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
KR101320817B1 (ko) * 2001-06-01 2013-10-21 노파르티스 아게 부갑상선 호르몬 및 칼시토닌의 경구 투여
WO2003009804A2 (en) 2001-07-23 2003-02-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
WO2005016265A2 (en) * 2003-08-06 2005-02-24 Rhodia Inc. Method for promoting bone growth
BRPI0618469A2 (pt) 2005-11-10 2011-08-30 Univ Michigan Tech hormÈnio paratiróide de urso preto e métodos de uso de hormÈnio paratiróide de urso preto
US7803770B2 (en) * 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
CA2664734C (en) * 2006-10-03 2023-08-01 Radius Health, Inc. Method of drug delivery for bone anabolic protein
BRPI0719885B8 (pt) * 2006-10-13 2021-05-25 Lilly Co Eli peptídeos peguilados como moduladores de receptores de pth, seus usos, e composição.
CN101784281B (zh) 2007-08-01 2014-07-02 总医院有限公司 确定g蛋白偶联受体激动剂的方法
EP2411038B1 (de) 2009-03-27 2016-12-28 Van Andel Research Institute Parathryoidhormonpeptide und parathyroidhormonbezogene proteinpeptide sowie anwendungsverfahren dafür
CA2782640A1 (en) 2009-12-07 2011-06-16 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
PT2568806T (pt) 2010-05-12 2016-08-05 Radius Health Inc Regimes terapêuticos
US9492508B2 (en) 2010-05-13 2016-11-15 The General Hospital Corporation Parathyroid hormone analogs and uses thereof
ES2550319T3 (es) 2010-09-28 2015-11-06 Radius Health, Inc Moduladores selectivos del receptor de andrógenos
RS67458B1 (sr) 2014-03-28 2025-12-31 Univ Duke Lečenje kancera dojke pozitivnog na receptor estrogena upotrebom selektivnih modulatora receptora estrogena
KR102676629B1 (ko) 2015-04-29 2024-06-18 래디어스 파마슈티컬스, 인코포레이티드 암을 치료하는 방법
WO2017007777A2 (en) * 2015-07-06 2017-01-12 Zhengxin Dong NOVEL FORMULATIONS OF PTHrP ANALOGUE
RS63311B1 (sr) 2016-06-22 2022-07-29 Ellipses Pharma Ltd Ar+ metode lečenja raka dojke
KR102881465B1 (ko) 2017-01-05 2025-11-04 래디어스 파마슈티컬스, 인코포레이티드 Rad1901-2hcl의 다형 형태
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
CN112423844B (zh) 2018-07-04 2024-08-13 雷迪厄斯制药公司 Rad1901-2hcl的多晶型形式
JOP20210218A1 (ar) 2019-02-12 2023-01-30 Radius Pharmaceuticals Inc عمليات ومركبات

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
FR2550204B1 (fr) * 1983-08-05 1987-11-13 Toyo Jozo Kk Derives peptidiques de (nle8,nle1b, tyr34)-h-pth
EP0293158A3 (de) * 1987-05-26 1990-05-09 Merck & Co. Inc. Parathyroide Hormon-Antagonisten
JPH03504201A (ja) * 1989-02-23 1991-09-19 ゲゼルシャフト・フュア・ビオテクノロギッシェ・フォルシュンク・ミット・ベシュレンクテル・ハフツング　（ゲー・ベー・エフ） Ｐｔｈ変種をコードするｄｎａ配列、ｐｔｈ変種、発現ベクター、細菌宿主、利用と治療用組成物
CA2040264A1 (en) * 1990-04-12 1991-10-13 Tatsuhiko Kanmera Parathyroid hormone antagonists
JPH0532696A (ja) * 1990-09-28 1993-02-09 Takeda Chem Ind Ltd 副甲状腺ホルモン誘導体
WO1993006846A1 (en) * 1991-10-10 1993-04-15 Pang Peter K T Parathyroid hormone analogues and use in osteoporosis treatment
US5434246A (en) * 1992-03-19 1995-07-18 Takeda Chemical Industries, Ltd. Parathyroid hormone derivatives
CA2098639A1 (en) * 1992-06-19 1993-12-20 K. Anne Kronis Bone stimulating, non-vasoactive parathyroid hormone variants
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5821225A (en) * 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
JPH08505395A (ja) 1993-01-06 1996-06-11 キナートン リミティド 生物分解性ポリエステルと生物活性ポリペプチドのイオン分子結合体
WO1995002610A1 (en) * 1993-07-13 1995-01-26 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
JPH10511095A (ja) * 1994-12-19 1998-10-27 ベス イスラエル ディーコネス メディカル センター インコーポレイテッド 副甲状腺ホルモン又はその作動薬の低用量継続投与
CA2178894A1 (en) * 1995-06-15 1996-12-16 Tsunehiko Fukuda Parathyroid hormone derivatives and their use
US5723577A (en) * 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone

Also Published As

Publication number Publication date
JP3963482B2 (ja) 2007-08-22
IL130794A0 (en) 2001-01-28
ES2347154T3 (es) 2010-10-26
EP1645566A3 (de) 2006-10-11
EP0948541A2 (de) 1999-10-13
KR100699422B1 (ko) 2007-03-28
AR038552A2 (es) 2005-01-19
SI0948541T1 (sl) 2006-06-30
PT1645566E (pt) 2010-08-31
RU2198182C2 (ru) 2003-02-10
DK0948541T3 (da) 2006-07-17
ES2258286T3 (es) 2006-08-16
CZ298937B6 (cs) 2008-03-19
NO993341D0 (no) 1999-07-06
PL191898B1 (pl) 2006-07-31
CZ239899A3 (cs) 2000-01-12
DE69735603D1 (de) 2006-05-18
DE69735603T2 (de) 2006-11-30
DE69739912D1 (de) 2010-07-29
AU5519998A (en) 1998-08-03
CA2276614C (en) 2002-06-11
ATE471342T1 (de) 2010-07-15
AR051906A2 (es) 2007-02-14
EP0948541B1 (de) 2006-03-29
EP2206725A1 (de) 2010-07-14
SI1645566T1 (sl) 2010-11-30
NO993341L (no) 1999-09-06
HK1026215A1 (en) 2000-12-08
BR9714200A (pt) 2000-03-28
CN1137898C (zh) 2004-02-11
EP1645566A2 (de) 2006-04-12
WO1998030590A3 (en) 1998-12-10
HUP9904596A1 (hu) 2000-06-28
AR011517A1 (es) 2000-08-30
US5955574A (en) 1999-09-21
DK1645566T3 (da) 2010-09-27
KR100497709B1 (ko) 2005-06-23
NZ336610A (en) 2001-07-27
WO1998030590A2 (en) 1998-07-16
CZ301497B6 (cs) 2010-03-24
EP1645566B1 (de) 2010-06-16
PT948541E (pt) 2006-07-31
KR20000069952A (ko) 2000-11-25
CA2276614A1 (en) 1998-07-16
WO1998030590A9 (en) 1999-08-19
CN1254347A (zh) 2000-05-24
JP2001508439A (ja) 2001-06-26
AU741584B2 (en) 2001-12-06
HUP9904596A3 (en) 2000-07-28
PL334438A1 (en) 2000-02-28
KR20060030006A (ko) 2006-04-07

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