ATE321887T1 - Verfahren zur identifizierung von modulatoren des cholesterinrückwärtstransportes - Google Patents

Verfahren zur identifizierung von modulatoren des cholesterinrückwärtstransportes

Info

Publication number
ATE321887T1
ATE321887T1 AT02701394T AT02701394T ATE321887T1 AT E321887 T1 ATE321887 T1 AT E321887T1 AT 02701394 T AT02701394 T AT 02701394T AT 02701394 T AT02701394 T AT 02701394T AT E321887 T1 ATE321887 T1 AT E321887T1
Authority
AT
Austria
Prior art keywords
methods
reverse transport
identifying modulators
compounds capable
cholesterol reverse
Prior art date
Application number
AT02701394T
Other languages
English (en)
Inventor
Bart Staels
Original Assignee
Genfit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genfit filed Critical Genfit
Application granted granted Critical
Publication of ATE321887T1 publication Critical patent/ATE321887T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT02701394T 2001-02-05 2002-02-04 Verfahren zur identifizierung von modulatoren des cholesterinrückwärtstransportes ATE321887T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0101486A FR2820435B1 (fr) 2001-02-05 2001-02-05 Procedes d'identification de composes modulant le transport inverse du cholesterol

Publications (1)

Publication Number Publication Date
ATE321887T1 true ATE321887T1 (de) 2006-04-15

Family

ID=8859595

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02701394T ATE321887T1 (de) 2001-02-05 2002-02-04 Verfahren zur identifizierung von modulatoren des cholesterinrückwärtstransportes

Country Status (14)

Country Link
US (1) US20040115666A1 (de)
EP (1) EP1358354B1 (de)
JP (1) JP2004537272A (de)
KR (1) KR20030074740A (de)
CN (1) CN1568374A (de)
AT (1) ATE321887T1 (de)
AU (1) AU2002234729B2 (de)
CA (1) CA2437434A1 (de)
DE (1) DE60210253T2 (de)
DK (1) DK1358354T3 (de)
ES (1) ES2260413T3 (de)
FR (1) FR2820435B1 (de)
IL (1) IL156218A0 (de)
WO (1) WO2002063038A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050159362A1 (en) * 2003-04-22 2005-07-21 Sircar Jagadish C. Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
FR2864105B1 (fr) * 2003-12-23 2008-02-01 Genfit S A Procede pour identifier des composes modulant le transport inverse du cholesterol
TW200603794A (en) * 2004-06-09 2006-02-01 Avanir Pharmaceuticals Small molecules for treatment of hypercholesterolemia and related diseases
US20060009487A1 (en) * 2004-06-09 2006-01-12 Sircar Jagadish C Heterocyclic derivatives for treatment of hyperlipidemia and related diseases
EP1753782A1 (de) * 2004-06-09 2007-02-21 Avanir Pharmaceuticals Reverse-cholesterintransport-mediatoren zur behandlung von hypercholesterinämie
KR100784859B1 (ko) * 2005-01-14 2007-12-14 한국과학기술연구원 형광편광도를 이용한 파네소이드 ｘ 수용체-리간드복합체의 상호작용 분석방법 및 결합 저해물질 검색방법
WO2007055873A2 (en) * 2005-11-04 2007-05-18 Avanir Pharmaceuticals Process for the manufacture of peptide facilitators of reverse cholesterol transport

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721096A (en) * 1991-01-24 1998-02-24 Children's Medical Center Corporation Methods of screening for compounds with ability to alter apolipoprotein AI gene expression
DE19709125A1 (de) * 1997-03-06 1998-09-10 Bayer Ag Substituierte Chinoline
JP2000109455A (ja) * 1998-08-06 2000-04-18 Shionogi & Co Ltd アポリポタンパク質ａｉ遺伝子発現亢進作用を有する化合物
WO2000040965A1 (en) * 1999-01-07 2000-07-13 Tularik, Inc. Fxr receptor-mediated modulation of cholesterol metabolism
US20020132223A1 (en) * 1999-03-26 2002-09-19 City Of Hope Methods for modulating activity of the FXR nuclear receptor
EP1165135B1 (de) * 1999-03-26 2004-09-01 City of Hope Verfahren zur selektion von fxr-rezeptormodulatoren

Also Published As

Publication number Publication date
FR2820435B1 (fr) 2004-02-27
WO2002063038A1 (fr) 2002-08-15
CA2437434A1 (fr) 2002-08-15
DK1358354T3 (da) 2006-07-31
ES2260413T3 (es) 2006-11-01
EP1358354A1 (de) 2003-11-05
CN1568374A (zh) 2005-01-19
EP1358354B1 (de) 2006-03-29
FR2820435A1 (fr) 2002-08-09
US20040115666A1 (en) 2004-06-17
IL156218A0 (en) 2003-12-23
KR20030074740A (ko) 2003-09-19
JP2004537272A (ja) 2004-12-16
DE60210253T2 (de) 2007-03-15
DE60210253D1 (de) 2006-05-18
AU2002234729B2 (en) 2007-05-31

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