ATE258598T1 - Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht - Google Patents

Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht

Info

Publication number
ATE258598T1
ATE258598T1 AT98943346T AT98943346T ATE258598T1 AT E258598 T1 ATE258598 T1 AT E258598T1 AT 98943346 T AT98943346 T AT 98943346T AT 98943346 T AT98943346 T AT 98943346T AT E258598 T1 ATE258598 T1 AT E258598T1
Authority
AT
Austria
Prior art keywords
molecular weight
low molecular
protein refolding
refolding method
zwitterionic agents
Prior art date
Application number
AT98943346T
Other languages
English (en)
Inventor
Steven M Vicik
Original Assignee
Inst Genetics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Genetics Llc filed Critical Inst Genetics Llc
Application granted granted Critical
Publication of ATE258598T1 publication Critical patent/ATE258598T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98943346T 1997-10-08 1998-08-24 Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht ATE258598T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/946,839 US20020052026A1 (en) 1997-10-08 1997-10-08 Methods of refolding proteins
PCT/US1998/017499 WO1999018196A1 (en) 1997-10-08 1998-08-24 Methods of refolding proteins by use of zwitterionic low molecular weight agents

Publications (1)

Publication Number Publication Date
ATE258598T1 true ATE258598T1 (de) 2004-02-15

Family

ID=25485053

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98943346T ATE258598T1 (de) 1997-10-08 1998-08-24 Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht

Country Status (8)

Country Link
US (5) US20020052026A1 (de)
EP (1) EP1021528B1 (de)
JP (1) JP2001519149A (de)
AT (1) ATE258598T1 (de)
AU (1) AU757692B2 (de)
CA (1) CA2305559A1 (de)
DE (1) DE69821376D1 (de)
WO (1) WO1999018196A1 (de)

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FR2801219A1 (fr) * 2000-09-18 2001-05-25 Pf Medicament Procede de preparation de proteine recombinante renaturee en presence de detergent
EP1314739A1 (de) * 2001-11-22 2003-05-28 Bayer Ag Verfahren zur Renaturierung rekombinanter, Disulfid-enthaltender Proteine bei hohen Proteinkonzentrationen in Gegenwart von Aminen
ATE505201T1 (de) * 2002-02-14 2011-04-15 Univ Leland Stanford Junior Enzymbehandlung von nahrungsmitteln für zöliakie- sprue
US8143210B2 (en) 2002-02-14 2012-03-27 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
JP4401618B2 (ja) 2002-04-15 2010-01-20 キヤノン株式会社 記録装置、及び、バッファ管理方法
SI21273A (sl) * 2002-07-31 2004-02-29 LEK farmacevtska dru�ba d.d. Priprava inkluzijskih teles z visokim deležem pravilno zvitega prekurzorja heterolognega proteina
CA2502700C (en) 2002-11-20 2017-01-17 Chaitan Khosla Diagnostic method for celiac sprue
EP1449848A1 (de) * 2003-02-20 2004-08-25 GBF German Research Centre for Biotechnology Verfahren zur Herstellung von Proteinen aus der Cystine-Knoten-Familie
US7579313B2 (en) * 2003-11-18 2009-08-25 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof
GB0604938D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Proteins, nucleic acids and medicaments
GB0604964D0 (en) * 2006-03-11 2006-04-19 Renovo Ltd Protein folding
GB0604966D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
MX2009009780A (es) * 2007-03-16 2010-05-20 Univ Leland Stanford Junior Terapia de enzima de combinacion para la digestion de gluten dietetico.
WO2008115428A2 (en) * 2007-03-16 2008-09-25 The Board Of Trustees Of The Leland Stanford Junior University A scaleable manufacturing process for cysteine endoprotease b, isoform 2
EA018715B1 (ru) * 2007-07-03 2013-10-30 Эмджен Инк. Количественное определение белков с использованием сухого веса внутриклеточных телец
CN102482321B (zh) 2009-06-22 2015-06-17 安姆根有限公司 使用化学控制的氧化还原态重折叠蛋白质
WO2010151688A2 (en) 2009-06-25 2010-12-29 Amgen Inc. Capture purification processes for proteins expressed in a non-mammalian system
EP2612674A4 (de) 2010-09-01 2014-03-26 Osteopharma Inc Gefriergetrocknete rekombinante humane knochenmorphogenetische protein-2-zubereitung
GB201315321D0 (en) * 2013-08-28 2013-10-09 Koninklijke Nederlandse Akademie Van Wetenschappen Transduction Buffer
US9630916B2 (en) 2014-08-19 2017-04-25 Wisconsin Alumni Research Foundation Organocatalysts of oxidative protein folding
EP3344651B1 (de) 2015-09-02 2022-03-02 Merck Sharp & Dohme Corp. Verfahren zur gewinnung von insulin mit korrekt geformten disulfidbindungen
BR112021012694A2 (pt) * 2018-12-27 2021-10-05 Riken Nanopartícula, agente de contraste para imagem de ressonância magnética compreendendo a mesma e composto de ligante zwitteriônico
US20220340630A1 (en) * 2019-09-13 2022-10-27 National Science And Technology Development Agency Composition of renaturation buffer solution for dimeric proteins and method of renaturation dimeric proteins using the composition thereof
CN119684427A (zh) * 2024-12-25 2025-03-25 无锡傲锐东源生物科技有限公司 一种重组bmp4蛋白复性液及重组bmp4蛋白的制备方法

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DE69518760T2 (de) 1994-07-13 2001-05-23 The Johns Hopkins University School Of Medicine, Baltimore Wachstumsdifferenzierungsfaktor-12
US5635372A (en) 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions

Also Published As

Publication number Publication date
EP1021528A1 (de) 2000-07-26
US6593107B1 (en) 2003-07-15
US6596511B1 (en) 2003-07-22
AU9116798A (en) 1999-04-27
WO1999018196A1 (en) 1999-04-15
JP2001519149A (ja) 2001-10-23
DE69821376D1 (de) 2004-03-04
CA2305559A1 (en) 1999-04-15
US6632635B1 (en) 2003-10-14
EP1021528B1 (de) 2004-01-28
AU757692B2 (en) 2003-03-06
US6593106B1 (en) 2003-07-15
US20020052026A1 (en) 2002-05-02

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