ATE323084T1 - Für die behandlung von alzheimer krankheit geeignete makrocyclen - Google Patents

Für die behandlung von alzheimer krankheit geeignete makrocyclen

Info

Publication number
ATE323084T1
ATE323084T1 AT02752056T AT02752056T ATE323084T1 AT E323084 T1 ATE323084 T1 AT E323084T1 AT 02752056 T AT02752056 T AT 02752056T AT 02752056 T AT02752056 T AT 02752056T AT E323084 T1 ATE323084 T1 AT E323084T1
Authority
AT
Austria
Prior art keywords
disease
treatment
alzheimer
macrocycles
useful
Prior art date
Application number
AT02752056T
Other languages
English (en)
Inventor
Shon R Pulley
James P Beck
Ruth E Tenbrink
Original Assignee
Elan Pharm Inc
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc, Pharmacia & Upjohn Co Llc filed Critical Elan Pharm Inc
Application granted granted Critical
Publication of ATE323084T1 publication Critical patent/ATE323084T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT02752056T 2001-06-12 2002-06-12 Für die behandlung von alzheimer krankheit geeignete makrocyclen ATE323084T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29754601P 2001-06-12 2001-06-12
US33308301P 2001-11-19 2001-11-19

Publications (1)

Publication Number Publication Date
ATE323084T1 true ATE323084T1 (de) 2006-04-15

Family

ID=26970209

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02752056T ATE323084T1 (de) 2001-06-12 2002-06-12 Für die behandlung von alzheimer krankheit geeignete makrocyclen

Country Status (10)

Country Link
US (2) US6969709B2 (de)
EP (1) EP1404671B1 (de)
JP (1) JP2004534064A (de)
AT (1) ATE323084T1 (de)
BR (1) BR0210392A (de)
CA (1) CA2450202A1 (de)
DE (1) DE60210614T2 (de)
ES (1) ES2261699T3 (de)
MX (1) MXPA03011466A (de)
WO (1) WO2002100856A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002360508A1 (en) * 2001-12-06 2003-06-23 Elan Pharmaceuticals, Inc. Substituted hydroxyethylamines
WO2004062625A2 (en) 2003-01-07 2004-07-29 Merck & Co., Inc. Macrocyclic beta-secretase inhibitors for treatment of alzheimer's disease
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
DK1633774T3 (da) 2003-06-18 2010-05-25 Tranzyme Pharma Inc Makrocykliske motilinreceptorantagonister
GB0325830D0 (en) * 2003-11-05 2003-12-10 Novartis Ag Organic compounds
CA2575340A1 (en) * 2004-07-28 2006-02-09 Schering Corporation Macrocyclic beta-secretase inhibitors
KR20070102514A (ko) * 2005-01-13 2007-10-18 노파르티스 아게 Ｂａｃｅ 억제제로서 유용한 마크로시클릭 화합물
GB0500683D0 (en) * 2005-01-13 2005-02-23 Novartis Ag Organic compounds
NZ562314A (en) 2005-04-08 2010-02-26 Comentis Inc Compounds which inhibit beta-secretase activity and methods of use thereof
WO2007021793A1 (en) * 2005-08-12 2007-02-22 Bristol-Myers Squibb Company Macrocyclic diaminopropanes as beta-secretase inhibitors
GB0526614D0 (en) 2005-12-30 2006-02-08 Novartis Ag Organic compounds
BRPI0715437A2 (pt) * 2006-07-20 2013-04-16 Novartis Ag lactamas macrocÍclicas
JP2009544599A (ja) * 2006-07-20 2009-12-17 ノバルティス アクチエンゲゼルシャフト Ｂａｃｅ阻害剤として有用な大環状化合物
US7678784B2 (en) 2006-11-20 2010-03-16 Bristol-Myers Squibb Company Oxime-containing macrocyclic acyl guanidines as β-secretase inhibitors
US7772221B2 (en) 2007-02-09 2010-08-10 Bristol-Meyers Squibb Company Diaminopropane derived macrocycles as inhibitors of β amyloid production
WO2008116302A1 (en) * 2007-03-26 2008-10-02 Merck Frosst Canada Ltd. Cathepsin cysteine protease inhibitors
US7732434B2 (en) 2007-04-20 2010-06-08 Bristol-Myers Squibb Company Macrocyclic acyl guanidines as beta-secretase inhibitors
EP2967058A4 (de) * 2013-03-15 2017-03-01 The Board of Regents of The University of Texas System Verwendung von mtor-inhibitoren zur verbesserung der vaskulären funktionen bei apoe4-trägern
EP3089737B1 (de) 2013-12-31 2021-11-03 Rapamycin Holdings, LLC Orale rapamycinnanopartikelzubereitungen und verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPM982594A0 (en) 1994-12-02 1995-01-05 University Of Queensland, The HIV protease inhibitors
JP2003502342A (ja) * 1999-06-15 2003-01-21 エラン ファーマスーティカルズ インコーポレイテッド ベータ−セクレターゼのスタチン誘導テトラペプチド阻害剤

Also Published As

Publication number Publication date
DE60210614D1 (de) 2006-05-24
US7442691B2 (en) 2008-10-28
DE60210614T2 (de) 2007-03-01
CA2450202A1 (en) 2002-12-19
EP1404671B1 (de) 2006-04-12
EP1404671A1 (de) 2004-04-07
US20060040910A1 (en) 2006-02-23
US6969709B2 (en) 2005-11-29
BR0210392A (pt) 2004-10-13
MXPA03011466A (es) 2004-07-01
WO2002100856A1 (en) 2002-12-19
ES2261699T3 (es) 2006-11-16
JP2004534064A (ja) 2004-11-11
US20030236199A1 (en) 2003-12-25

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties