ATE323113T1 - Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen - Google Patents

Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen

Info

Publication number
ATE323113T1
ATE323113T1 AT00943377T AT00943377T ATE323113T1 AT E323113 T1 ATE323113 T1 AT E323113T1 AT 00943377 T AT00943377 T AT 00943377T AT 00943377 T AT00943377 T AT 00943377T AT E323113 T1 ATE323113 T1 AT E323113T1
Authority
AT
Austria
Prior art keywords
water
polymers
soluble
probe
substrates
Prior art date
Application number
AT00943377T
Other languages
English (en)
Inventor
Gerrit Klaerner
Ralph B Nielsen
Paul Mansky
Didier Benoit
Dominique Charmot
Bernd Jandeleit
Laura T Mazzola
Original Assignee
Symyx Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/347,609 external-priority patent/US6472486B2/en
Priority claimed from US09/347,607 external-priority patent/US20020010267A1/en
Application filed by Symyx Technologies Inc filed Critical Symyx Technologies Inc
Application granted granted Critical
Publication of ATE323113T1 publication Critical patent/ATE323113T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52Amides or imides
    • C08F220/54Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00Polymerisation catalysts
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44747Composition of gel or of carrier mixture
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/8305Miscellaneous [e.g., treated surfaces, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Microbiology (AREA)
  • Electrochemistry (AREA)
  • Food Science & Technology (AREA)
  • Materials Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
  • Dental Preparations (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
AT00943377T 1999-07-02 2000-07-03 Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen ATE323113T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US34760899A 1999-07-02 1999-07-02
US34760699A 1999-07-02 1999-07-02
US09/347,609 US6472486B2 (en) 1999-03-09 1999-07-02 Controlled stable free radical emulsion polymerization processes
US09/347,607 US20020010267A1 (en) 1999-03-09 1999-07-02 Block copolymers
US14693699P 1999-07-31 1999-07-31
US17787900P 2000-01-24 2000-01-24

Publications (1)

Publication Number Publication Date
ATE323113T1 true ATE323113T1 (de) 2006-04-15

Family

ID=27558334

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00943377T ATE323113T1 (de) 1999-07-02 2000-07-03 Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen

Country Status (7)

Country Link
US (3) US6692914B1 (de)
EP (1) EP1208126B1 (de)
AT (1) ATE323113T1 (de)
AU (1) AU5785400A (de)
CA (1) CA2377739A1 (de)
DE (1) DE60027309T2 (de)
WO (1) WO2001002452A1 (de)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US6994964B1 (en) * 1999-09-01 2006-02-07 Affymetrix, Inc. Macromolecular arrays on polymeric brushes and methods for preparing the same
US7163712B2 (en) * 2000-03-03 2007-01-16 Duke University Microstamping activated polymer surfaces
WO2001092361A1 (fr) * 2000-05-29 2001-12-06 Bio Merieux Polymere biocompatible pour la fixation de ligands biologiques
AU2001272993B2 (en) * 2000-06-21 2005-03-10 Bioarray Solutions, Ltd. Multianalyte molecular analysis
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
ATE355526T1 (de) * 2000-10-31 2006-03-15 Micronas Gmbh Gemusterte polymeroberflächen geeignet für biokonjugationen und verfahren zu ihrer herstellung
AU2002246978A1 (en) * 2001-01-10 2002-07-24 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface
DE10102623C2 (de) * 2001-01-20 2003-04-10 Geesthacht Gkss Forschung Verfahren und Vorrichtung zur Bestimmung des Molekulargewichts von Polymeren
EP1405871A4 (de) * 2001-05-30 2004-11-17 Mitsubishi Kagaku Iatron Inc Verfahren zum binden einer an einem polymerende zu inkorporierenden substanz
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
AU2002316372A1 (en) 2001-06-22 2003-01-08 Symyx Technologies, Inc. Inverse chromatography methods and apparatus for evaluation of interactions between modifying agents and receptors
KR20040068122A (ko) 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 공동 검색과 효소-매개된 탐지에 의한 다형성 좌위의 다중분석
US20030092062A1 (en) * 2001-10-24 2003-05-15 Reddy M. Parameswara Immobilizing biological molecules
US6927029B2 (en) * 2001-12-03 2005-08-09 Agilent Technologies, Inc. Surface with tethered polymeric species for binding biomolecules
WO2003062290A1 (en) 2002-01-16 2003-07-31 Biocompatibles Uk Limited Polymer conjugates
US7138468B2 (en) * 2002-03-27 2006-11-21 University Of Southern Mississippi Preparation of transition metal nanoparticles and surfaces modified with (CO)polymers synthesized by RAFT
US6791690B2 (en) * 2002-04-30 2004-09-14 Agilent Technologies, Inc. Reading dry chemical arrays
JP2005534063A (ja) * 2002-07-19 2005-11-10 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド, ア ボディー コーポレイト 3d光重合デバイスの製造
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
ATE402198T1 (de) * 2002-11-29 2008-08-15 Marcella Chiari Verfahren zur immobilisierung biologischer moleküle an feste oberflächen
GB0301014D0 (en) * 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
US20040191538A1 (en) * 2003-02-28 2004-09-30 Xueying Huang Nanometer-controlled polymeric thin films that resist adsorption of biological molecules and cells
DE10310193A1 (de) * 2003-03-06 2004-09-23 Micronas Holding Gmbh Verfahren zur Immobilisierung von Glykoproteinen
US6908952B2 (en) * 2003-03-21 2005-06-21 3M Innovative Properties Company Ring-opened azlactone photoiniferters for radical polymerization
US6747104B1 (en) * 2003-03-21 2004-06-08 3M Innovative Properties Company Azlactone photoiniferters for radical polymerization
JP4428616B2 (ja) * 2003-05-06 2010-03-10 オルガノ株式会社 グラフト修飾有機多孔質体及びその製造方法並びに吸着剤、クロマトグラフィー用充填剤及びイオン交換体
US7198855B2 (en) * 2003-09-12 2007-04-03 Becton, Dickinson And Company Methods of surface modification of a flexible substrate to enhance cell adhesion
WO2005029705A2 (en) * 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
US7595279B2 (en) * 2003-09-22 2009-09-29 Bioarray Solutions Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
US7309593B2 (en) 2003-10-01 2007-12-18 Surmodics, Inc. Attachment of molecules to surfaces
US20050089916A1 (en) * 2003-10-28 2005-04-28 Xiongwu Xia Allele assignment and probe selection in multiplexed assays of polymorphic targets
EP1692298A4 (de) * 2003-10-28 2008-08-13 Bioarray Solutions Ltd Optimierung der genexpressionsanalyse unter verwendung immobilisierter fängersonden
NZ547495A (en) 2003-10-29 2008-05-30 Bioarray Solutions Ltd Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
US20050095602A1 (en) * 2003-11-04 2005-05-05 West Jason A. Microfluidic integrated microarrays for biological detection
NZ547173A (en) * 2003-11-14 2009-09-25 Inverness Medical Switzerland Fluid sample analysis device with sealable sample storage reservoir
US7893174B2 (en) * 2004-03-05 2011-02-22 Carnegie Mellon University Atom transfer radical polymerization process
US7795355B2 (en) * 2004-03-05 2010-09-14 Carnegie Mellon University Preparation of functional polymers
FR2867479B1 (fr) * 2004-03-15 2007-11-02 Commissariat Energie Atomique Polymere de haut poids moleculaire a base de n,n- dimethylacrylamide et de monomeres fonctionnalises par des molecules sondes et ses utilisations
EP2158902B1 (de) 2004-03-30 2017-12-06 Relypsa, Inc. Ionen bindende polymere und ihre verwendung
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US20060160916A1 (en) * 2004-08-13 2006-07-20 Dyer Daniel J Process for modifying substrates with grafted polymers
CN104133060B (zh) * 2004-09-23 2016-06-29 三路影像公司 分析生物样品的方法
JP2008536699A (ja) 2005-04-14 2008-09-11 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ マイクロ加工のための犠牲層における調節可能な溶解度
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US8357433B2 (en) 2005-06-14 2013-01-22 Siemens Energy, Inc. Polymer brushes
EP1928919B1 (de) 2005-08-23 2010-02-17 Carnegie-Mellon University Radikalische atomtransfer-polymerisation in mikroemulsion und echte emulsionspolymerisation
DE602006017416D1 (de) * 2005-08-26 2010-11-18 Univ Carnegie Mellon Polymerisationsverfahren mit katalysatorreaktivierung
BRPI0616603A2 (pt) 2005-09-30 2012-12-25 Ilypsa Inc mÉtodo para preparar um compàsito de nécleo-envoltàrio, e para a manufatura de um medicamento, composiÇço farmacÊutica, e, uso da mesma
DE112006002618T5 (de) 2005-09-30 2008-08-28 Ilypsa Inc., Santa Clara Verfahren und Zusammensetzungen zum selektiven Entfernen von Kaliumionen aus dem Gastrointestinaltrakt eines Säugers
CN101351260B (zh) * 2005-11-01 2011-12-21 西北大学 用于微通道分离的基质和动态聚合物体系和组合物
CA2631025A1 (en) * 2005-11-30 2007-06-07 Inverness Medical Switzerland Gmbh A device for detecting the presence or amount of an analyte in a fluid sample and method thereof
EP1969397B1 (de) * 2005-12-14 2017-11-08 Novartis AG Verfahren zum herstellen von silikon-hydrogelen
US8778845B2 (en) * 2005-12-15 2014-07-15 Genral Electric Company Composition, device and associated method
US8741813B2 (en) * 2005-12-15 2014-06-03 General Electric Company Composition, device and associated method
DE212007000054U1 (de) * 2006-07-26 2009-03-19 Abon Biopharm Hangzhou Testvorrichtung zum Nachweisen eines Analyten in einer flüssigen Probe
US8367051B2 (en) * 2006-10-09 2013-02-05 Carnegie Mellon University Preparation of functional gel particles with a dual crosslink network
US8778846B2 (en) * 2006-12-04 2014-07-15 General Electric Company Composition, device and associated method
US8765643B2 (en) * 2006-12-04 2014-07-01 General Electric Company Composition, device and associated method
JP5340956B2 (ja) * 2006-12-20 2013-11-13 アーケマ・インコーポレイテッド ポリマーの封入および/または結合
US7994234B2 (en) * 2007-03-27 2011-08-09 Vanderbilt University Diamond polymer brushes
US8865797B2 (en) * 2007-05-23 2014-10-21 Carnegie Mellon University Hybrid particle composite structures with reduced scattering
GB2463199B (en) 2007-05-23 2012-09-26 Univ Carnegie Mellon Atom transfer dispersion polymerization
US8796184B2 (en) * 2008-03-28 2014-08-05 Sentilus, Inc. Detection assay devices and methods of making and using the same
JP5384923B2 (ja) * 2008-12-05 2014-01-08 国立大学法人九州大学 高分子系ナノコンポジットの製造方法及び該製造方法によって形成された難燃性高分子系ナノコンポジット
US8962764B2 (en) 2009-03-27 2015-02-24 Carnegie Mellon University Preparation of functional star macromolecules
CN105044320B (zh) 2010-03-25 2017-02-22 艾博生物医药(杭州)有限公司 测试液体样本中被分析物的检测装置
WO2012079030A2 (en) * 2010-12-10 2012-06-14 The Regents Of The University Of California Bioconjugation using bifunctional linkers
US9644042B2 (en) 2010-12-17 2017-05-09 Carnegie Mellon University Electrochemically mediated atom transfer radical polymerization
JP5753943B2 (ja) * 2011-05-09 2015-07-22 ザ・スウォッチ・グループ・リサーチ・アンド・ディベロップメント・リミテッド 油相溶性ポリマーブラシによる潤滑
EP2747753B1 (de) 2011-08-22 2023-03-29 Carnegie Mellon University Radikalische atomtransfer-polymerisation unter biologisch verträglichen bedingungen
WO2013158183A2 (en) * 2012-01-27 2013-10-24 Carnegie Mellon University Processable self-organizing nanoparticles
WO2013126745A2 (en) 2012-02-23 2013-08-29 Carnegie Mellon University Ligands designed to provide highly active catalyst complexes
US9382387B2 (en) 2012-03-13 2016-07-05 California Institute Of Technology Rapid self-assembly of block copolymers to photonic crystals
WO2013138494A1 (en) 2012-03-13 2013-09-19 California Institute Of Technology Periodic nanostructures from self assembled wedge-type block-copolymers
US9453943B2 (en) 2012-06-28 2016-09-27 California Institute Of Technology Photonic structures from self assembly of brush block copolymers and polymer blends
IN2015DN02055A (de) 2012-09-17 2015-08-14 Grace W R & Co
KR102226564B1 (ko) 2012-09-17 2021-03-10 더블유.알. 그레이스 앤드 캄파니-콘. 작용화된 미립자 지지체 물질 및 이의 제조 및 사용 방법
CN102875195B (zh) * 2012-09-20 2014-03-12 华东理工大学 一种多重刺激响应聚合物刷膜的制备方法
WO2014075695A1 (en) * 2012-11-19 2014-05-22 Aarhus Universitet Joining of polymer and surface-modified solid part
GB2537077B (en) * 2013-12-05 2018-05-09 Centrillion Tech Holdings Corp Methods for sequencing nucleic acids
CN111118121B (zh) 2013-12-05 2024-07-19 生捷科技控股公司 图案化阵列的制备
EP3077430A4 (de) 2013-12-05 2017-08-16 Centrillion Technology Holdings Corporation Modifizierte oberfläche
US11229896B2 (en) 2014-01-16 2022-01-25 W.R. Grace & Co.—Conn. Affinity chromatography media and chromatography devices
US11060139B2 (en) 2014-03-28 2021-07-13 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
ES2929099T3 (es) 2014-05-02 2022-11-24 Grace W R & Co Material de soporte funcionalizado y métodos de fabricación y uso de material de soporte funcionalizado
WO2015191547A1 (en) * 2014-06-09 2015-12-17 Cornell University Implantable therapeutic delivery system and methods thereof
FR3026742B1 (fr) * 2014-10-03 2016-12-23 Alveole Impression d'un motif adhesif sur un support anti-salissures
US9982070B2 (en) 2015-01-12 2018-05-29 Carnegie Mellon University Aqueous ATRP in the presence of an activator regenerator
US10153513B2 (en) 2015-03-09 2018-12-11 California Institute Of Technology Triblock brush block copolymers
ES2896897T3 (es) 2015-06-05 2022-02-28 Grace W R & Co Agentes de clarificación para el bioprocesamiento de adsorbentes y métodos para producir y usar los mismos
US10733023B1 (en) * 2015-08-06 2020-08-04 D2Iq, Inc. Oversubscription scheduling
US11174325B2 (en) 2017-01-12 2021-11-16 Carnegie Mellon University Surfactant assisted formation of a catalyst complex for emulsion atom transfer radical polymerization processes
US11053356B2 (en) 2017-03-07 2021-07-06 California Institute Of Technology Control of polymer architectures by living ring-opening metathesis copolymerization
US11168170B2 (en) * 2017-04-25 2021-11-09 Kyoto University Clearance narrowing material, clearance narrowing material composite, and article using same
IT201900000418A1 (it) * 2019-01-10 2020-07-10 Consiglio Nazionale Ricerche Dispositivo sensorizzato per l'analisi di un fluido mediante onde acustiche
JP7689075B2 (ja) 2019-01-30 2025-06-05 コロラド・ステート・ユニバーシティ・リサーチ・ファウンデーション ポリマー複合フォトニック結晶コーティング
JP7391098B2 (ja) 2019-02-01 2023-12-04 コロラド・ステート・ユニバーシティ・リサーチ・ファウンデーション マルチコートポリマーフォトニック結晶フィルム
US12478684B2 (en) 2019-04-11 2025-11-25 Northeastern University Oligonucleotide-polymer miktoarm conjugates and methods of use
EP4025617A1 (de) * 2019-09-03 2022-07-13 Poliresin S.r.l. Hydroxyalkylamidfunktionalisierte acrylpolymere und verfahren zu ihrer herstellung
CN114845849A (zh) 2019-12-20 2022-08-02 丘奇和德怀特有限公司 聚合物组合物及由其形成的产品
EP4077519A4 (de) 2019-12-20 2024-04-10 Church & Dwight Co., Inc. Polymerzusammensetzungen und damit hergestellte produkte
CN112174921B (zh) * 2020-09-29 2022-07-08 大连大学 基于香豆素和丹磺酰胺的谷胱甘肽荧光传感器分子及其制备方法
US11886045B2 (en) 2020-11-04 2024-01-30 Alcon Inc. Method for making photochromic contact lenses
HUE069913T2 (hu) 2020-11-04 2025-04-28 Alcon Inc Eljárás fotokróm kontaktlencsék elõállítására
US12140550B2 (en) * 2022-01-27 2024-11-12 Kla Corporation Selective marking of a substrate with fluorescent conjugated polymer probes having a small form factor
US12539650B2 (en) 2022-04-26 2026-02-03 Alcon Inc. Method for making embedded hydrogel contact lenses
CN116446055A (zh) * 2023-04-07 2023-07-18 吉林大学 一种具有高密度反应位点的基底的制备方法及应用
WO2025059534A1 (en) * 2023-09-13 2025-03-20 Cascade Biocatalysts, Inc Chromatographic media with multiple affinities and methods for the use and production thereof
WO2025151866A1 (en) * 2024-01-11 2025-07-17 Cornell University Polymer functionalized substrates, methods of making same, and uses thereof

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US526021A (en) * 1894-09-18 Pocket-transit
US4973493A (en) 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
US5512329A (en) 1982-09-29 1996-04-30 Bsi Corporation Substrate surface preparation
US5002582A (en) 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
US5217492A (en) 1982-09-29 1993-06-08 Bio-Metric Systems, Inc. Biomolecule attachment to hydrophobic surfaces
US4581429A (en) 1983-07-11 1986-04-08 Commonwealth Scientific And Industrial Research Organization Polymerization process and polymers produced thereby
EP0205232A1 (de) * 1985-04-08 1986-12-17 Kelsius, Inc. Signalverstärkung von optischen Fasern
US5354825A (en) 1985-04-08 1994-10-11 Klainer Stanley M Surface-bound fluorescent polymers and related methods of synthesis and use
DE3617672C2 (de) 1986-05-26 2000-02-17 Claus Heuck Verfahren zur Herstellung eines Reagenz, ein danach hergestelltes Reagenz sowie dessen Verwendung zur Bindung von Polymeren und Mikroorganismen aus wäßrigen Lösungen
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5240602A (en) * 1987-06-08 1993-08-31 Chromatochem, Inc. Chromatographic material
US6054270A (en) 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5258454A (en) 1988-09-01 1993-11-02 Riso National Laboratory Peptide synthesis method and solid support for use in the method
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
DE3921498A1 (de) 1988-09-28 1990-03-29 Bayer Ag Polymer-gebundene-farbstoffe, verfahren zu deren herstellung und verwendung
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5512439A (en) 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5126021A (en) 1991-07-17 1992-06-30 Applied Biosystems Inc. Low-viscosity polymer solution for capillary electrophoresis
DE69233087T2 (de) 1991-11-22 2003-12-24 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Verfahren zur Herstellung von Polymerarrays
ATE220114T1 (de) 1993-03-19 2002-07-15 Sequenom Inc Dns-sequenzbestimmung durch massenspektrometrie auf dem weg des abbaus mit exonuklease
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US6027880A (en) 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
US6045996A (en) 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
FR2716263B1 (fr) 1994-02-11 1997-01-17 Pasteur Institut Procédé d'alignement de macromolécules par passage d'un ménisque et applications dans un procédé de mise en évidence, séparation et/ou dosage d'une macromolécule dans un échantillon.
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
CA2192666A1 (en) 1994-06-24 1996-01-04 Craig J. Bott Novel amphipathic graft copolymers, their preparation, compositions thereof, and methods of their use
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5530079A (en) 1995-01-03 1996-06-25 Xerox Corporation Polymerization processes
FR2730240A1 (fr) 1995-02-07 1996-08-09 Atochem Elf Sa Stabilisation d'un polymere par un radical libre stable
US6100026A (en) 1995-04-25 2000-08-08 Irori Matrices with memories and uses thereof
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5753439A (en) 1995-05-19 1998-05-19 Trustees Of Boston University Nucleic acid detection methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5843655A (en) 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
DE19546136A1 (de) 1995-12-11 1997-06-12 Bayer Ag Chirale stationäre Phasen für die chromatographische Trennung von optischen Isomeren
US6013440A (en) 1996-03-11 2000-01-11 Affymetrix, Inc. Nucleic acid affinity columns
US5942555A (en) 1996-03-21 1999-08-24 Surmodics, Inc. Photoactivatable chain transfer agents and semi-telechelic photoactivatable polymers prepared therefrom
IL126581A (en) 1996-04-25 2004-03-28 Pence Inc Biosensor for detecting a binding event between a ligand and ligand-binding receptor
US6057100A (en) 1996-06-07 2000-05-02 Eos Biotechnology, Inc. Oligonucleotide arrays
US5998140A (en) 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
WO1998020967A1 (en) 1996-11-14 1998-05-22 Affymetrix, Inc. Chemical amplification for the synthesis of patterned arrays
EP0951485B1 (de) 1997-01-10 2003-04-02 E.I. Du Pont De Nemours And Company Verfahren zur kontrolle des molekulargewichts und der struktur eines polymers
US5932711A (en) 1997-03-05 1999-08-03 Mosaic Technologies, Inc. Nucleic acid-containing polymerizable complex
US5919626A (en) 1997-06-06 1999-07-06 Orchid Bio Computer, Inc. Attachment of unmodified nucleic acids to silanized solid phase surfaces
WO1999003894A1 (en) 1997-07-15 1999-01-28 Ciba Specialty Chemicals Holding Inc. Polymerizable compositions containing alkoxyamine compounds derived from nitroso- or nitrone compounds
US6391655B1 (en) 1997-07-30 2002-05-21 Corning Incorporated Oxidized styrenic polymers for DNA binding
US5858653A (en) 1997-09-30 1999-01-12 Surmodics, Inc. Reagent and method for attaching target molecules to a surface
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
WO1999036571A2 (en) 1998-01-13 1999-07-22 Biochip Technologies Gmbh Method for the detection or nucleic acid of nucleic acid sequences
US6004755A (en) 1998-04-07 1999-12-21 Incyte Pharmaceuticals, Inc. Quantitative microarray hybridizaton assays
AU4218499A (en) 1998-05-27 1999-12-13 Syntrix Biochip Light-mediated method and apparatus for the regional analysis of biologic material
US6723517B1 (en) * 1998-06-02 2004-04-20 Minerva Biotechnologies Corporation Use of self-assembled monolayers to probe the structure of a target molecule
US6951682B1 (en) 1998-12-01 2005-10-04 Syntrix Biochip, Inc. Porous coatings bearing ligand arrays and use thereof
JP2002531470A (ja) 1998-12-01 2002-09-24 シントリクス バイオチップ, インコーポレイテッド 支持体表面上で化学反応のアレイを行うための方法および組成物
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
EP1035218A1 (de) 1999-03-03 2000-09-13 BioChip Technologies GmbH Immobilisierung von Molekülen an Oberflächen über verzweigte Polymerketten
JP4970654B2 (ja) 1999-01-25 2012-07-11 ミクロナス ゲゼルシャフト ミット ベシュレンクテル ハフツング ポリマーブラシを介する表面上での分子の固定化
US6413587B1 (en) * 1999-03-02 2002-07-02 International Business Machines Corporation Method for forming polymer brush pattern on a substrate surface
JP4647792B2 (ja) 1999-04-28 2011-03-09 イジュノシッヒ テクニッヒ ホッフシューラ チューリッヒ 分析用デバイスおよびセンシングデバイスにおけるポリイオン性コーティング
US6994964B1 (en) 1999-09-01 2006-02-07 Affymetrix, Inc. Macromolecular arrays on polymeric brushes and methods for preparing the same
EP1095711B1 (de) 1999-10-27 2004-01-28 Novartis AG Verfahren für die Oberflächenbeschichtung von Materialien
US6077674A (en) 1999-10-27 2000-06-20 Agilent Technologies Inc. Method of producing oligonucleotide arrays with features of high purity

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DE60027309T2 (de) 2006-08-31
CA2377739A1 (en) 2001-01-11
US20020001845A1 (en) 2002-01-03
EP1208126B1 (de) 2006-04-12
US20050158879A1 (en) 2005-07-21
US6692914B1 (en) 2004-02-17
DE60027309D1 (de) 2006-05-24
WO2001002452A9 (en) 2002-07-25

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