ATE323113T1 - Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen - Google Patents

Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen

Info

Publication number
ATE323113T1
ATE323113T1 AT00943377T AT00943377T ATE323113T1 AT E323113 T1 ATE323113 T1 AT E323113T1 AT 00943377 T AT00943377 T AT 00943377T AT 00943377 T AT00943377 T AT 00943377T AT E323113 T1 ATE323113 T1 AT E323113T1
Authority
AT
Austria
Prior art keywords
water
polymers
soluble
probe
substrates
Prior art date
Application number
AT00943377T
Other languages
English (en)
Inventor
Gerrit Klaerner
Ralph B Nielsen
Paul Mansky
Didier Benoit
Dominique Charmot
Bernd Jandeleit
Laura T Mazzola
Original Assignee
Symyx Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/347,609 external-priority patent/US6472486B2/en
Priority claimed from US09/347,607 external-priority patent/US20020010267A1/en
Application filed by Symyx Technologies Inc filed Critical Symyx Technologies Inc
Application granted granted Critical
Publication of ATE323113T1 publication Critical patent/ATE323113T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44747—Composition of gel or of carrier mixture
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/8305—Miscellaneous [e.g., treated surfaces, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Electrochemistry (AREA)
  • Materials Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
  • Dental Preparations (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
AT00943377T 1999-07-02 2000-07-03 Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen ATE323113T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US34760699A 1999-07-02 1999-07-02
US34760899A 1999-07-02 1999-07-02
US09/347,609 US6472486B2 (en) 1999-03-09 1999-07-02 Controlled stable free radical emulsion polymerization processes
US09/347,607 US20020010267A1 (en) 1999-03-09 1999-07-02 Block copolymers
US14693699P 1999-07-31 1999-07-31
US17787900P 2000-01-24 2000-01-24

Publications (1)

Publication Number Publication Date
ATE323113T1 true ATE323113T1 (de) 2006-04-15

Family

ID=27558334

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00943377T ATE323113T1 (de) 1999-07-02 2000-07-03 Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen

Country Status (7)

Country Link
US (3) US6692914B1 (de)
EP (1) EP1208126B1 (de)
AT (1) ATE323113T1 (de)
AU (1) AU5785400A (de)
CA (1) CA2377739A1 (de)
DE (1) DE60027309T2 (de)
WO (1) WO2001002452A1 (de)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251691B1 (en) 1996-04-25 2001-06-26 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
CA2317179A1 (en) * 1999-09-01 2001-03-01 Affymetrix, Inc. Macromolecular arrays on polymeric brushes and methods for preparing the same
US7163712B2 (en) * 2000-03-03 2007-01-16 Duke University Microstamping activated polymer surfaces
US20040091451A1 (en) * 2000-05-29 2004-05-13 Marie-Therese Charreyre Biocompatible polymer for fixing biological ligands
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
AU7299301A (en) * 2000-06-21 2002-01-02 Bioarray Solutions Ltd Multianalyte molecular analysis using application-specific random particle arrays
DE60033665T2 (de) * 2000-10-31 2007-10-31 Micronas Gmbh Gemusterte Polymeroberflächen geeignet für Biokonjugationen und Verfahren zu ihrer Herstellung
US7205161B2 (en) * 2001-01-10 2007-04-17 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate having improved stability
DE10102623C2 (de) * 2001-01-20 2003-04-10 Geesthacht Gkss Forschung Verfahren und Vorrichtung zur Bestimmung des Molekulargewichts von Polymeren
JP4317744B2 (ja) * 2001-05-30 2009-08-19 ナノキャリア株式会社 高分子化合物末端への導入物結合方法
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US20030027356A1 (en) 2001-06-22 2003-02-06 Miroslav Petro Parallel inverse chromatography methods for simultaneous evaluation of interactions between modifying agents and receptors
ES2712173T3 (es) 2001-10-15 2019-05-09 Bioarray Solutions Ltd Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas
US20030092062A1 (en) * 2001-10-24 2003-05-15 Reddy M. Parameswara Immobilizing biological molecules
US6927029B2 (en) * 2001-12-03 2005-08-09 Agilent Technologies, Inc. Surface with tethered polymeric species for binding biomolecules
US8048408B2 (en) * 2002-01-16 2011-11-01 Biocompatibles Uk Limited Polymer conjugates
US7138468B2 (en) * 2002-03-27 2006-11-21 University Of Southern Mississippi Preparation of transition metal nanoparticles and surfaces modified with (CO)polymers synthesized by RAFT
US6791690B2 (en) * 2002-04-30 2004-09-14 Agilent Technologies, Inc. Reading dry chemical arrays
AU2003261220A1 (en) * 2002-07-19 2004-02-09 The Regents Of The University Of Colorado Fabrication of 3d photopolymeric devices
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
ATE402198T1 (de) 2002-11-29 2008-08-15 Marcella Chiari Verfahren zur immobilisierung biologischer moleküle an feste oberflächen
GB0301014D0 (en) * 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
US20040191538A1 (en) * 2003-02-28 2004-09-30 Xueying Huang Nanometer-controlled polymeric thin films that resist adsorption of biological molecules and cells
DE10310193A1 (de) * 2003-03-06 2004-09-23 Micronas Holding Gmbh Verfahren zur Immobilisierung von Glykoproteinen
US6747104B1 (en) * 2003-03-21 2004-06-08 3M Innovative Properties Company Azlactone photoiniferters for radical polymerization
US6908952B2 (en) * 2003-03-21 2005-06-21 3M Innovative Properties Company Ring-opened azlactone photoiniferters for radical polymerization
JP4428616B2 (ja) * 2003-05-06 2010-03-10 オルガノ株式会社 グラフト修飾有機多孔質体及びその製造方法並びに吸着剤、クロマトグラフィー用充填剤及びイオン交換体
US7198855B2 (en) * 2003-09-12 2007-04-03 Becton, Dickinson And Company Methods of surface modification of a flexible substrate to enhance cell adhesion
WO2005029705A2 (en) * 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
PT1664722E (pt) * 2003-09-22 2011-12-28 Bioarray Solutions Ltd Polielectrólito imobilizado à superfície com grupos funcionais múltiplos capazes de se ligarem covalentemente às biomoléculas
US7309593B2 (en) 2003-10-01 2007-12-18 Surmodics, Inc. Attachment of molecules to surfaces
US20050089916A1 (en) * 2003-10-28 2005-04-28 Xiongwu Xia Allele assignment and probe selection in multiplexed assays of polymorphic targets
EP1692298A4 (de) * 2003-10-28 2008-08-13 Bioarray Solutions Ltd Optimierung der genexpressionsanalyse unter verwendung immobilisierter fängersonden
WO2005045060A2 (en) 2003-10-29 2005-05-19 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded dna
US20050095602A1 (en) * 2003-11-04 2005-05-05 West Jason A. Microfluidic integrated microarrays for biological detection
NZ547173A (en) * 2003-11-14 2009-09-25 Inverness Medical Switzerland Fluid sample analysis device with sealable sample storage reservoir
US7893174B2 (en) * 2004-03-05 2011-02-22 Carnegie Mellon University Atom transfer radical polymerization process
US7795355B2 (en) * 2004-03-05 2010-09-14 Carnegie Mellon University Preparation of functional polymers
FR2867479B1 (fr) * 2004-03-15 2007-11-02 Commissariat Energie Atomique Polymere de haut poids moleculaire a base de n,n- dimethylacrylamide et de monomeres fonctionnalises par des molecules sondes et ses utilisations
DE602005019992D1 (de) 2004-03-30 2010-04-29 Relypsa Inc Kaliumbindende polymere und ihre verwendungen
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US20060160916A1 (en) * 2004-08-13 2006-07-20 Dyer Daniel J Process for modifying substrates with grafted polymers
KR20130019031A (ko) * 2004-09-23 2013-02-25 트리패스 이미징, 인코포레이티드 생물학적 시료의 고정을 위한 다가양이온성 중합체 코팅
WO2006113492A2 (en) 2005-04-14 2006-10-26 President And Fellows Of Harvard College Adjustable solubility in sacrificial layers for microfabrication
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US8357433B2 (en) 2005-06-14 2013-01-22 Siemens Energy, Inc. Polymer brushes
CN101356197B (zh) 2005-08-23 2016-02-17 卡内基梅隆大学 在微乳液中的原子转移自由基聚合和真实的乳液聚合
WO2007025310A1 (en) * 2005-08-26 2007-03-01 Carnegie Mellon University Polymerization process with catalyst reactivation
CN101321519A (zh) 2005-09-30 2008-12-10 伊立普萨公司 制备含有交联壳的核-壳型复合物的方法及其得到的核-壳型复合物
JP2009510126A (ja) 2005-09-30 2009-03-12 レリプサ, インコーポレイテッド 哺乳類の胃腸管からカリウムイオンを選択的に除去するための方法および組成物
EP1951413B1 (de) * 2005-11-01 2017-03-29 Northwestern University Matrix und dynamisches polymersystem und zusammensetzungen für die mikrokanaltrennung
US8871155B2 (en) * 2005-11-30 2014-10-28 Alere Switzerland Gmbh Devices for detecting analytes in fluid sample
JP5068765B2 (ja) * 2005-12-14 2012-11-07 ノバルティス アーゲー シリコーンヒドロゲルの製造方法
US8741813B2 (en) * 2005-12-15 2014-06-03 General Electric Company Composition, device and associated method
US8778845B2 (en) * 2005-12-15 2014-07-15 Genral Electric Company Composition, device and associated method
AU2007280929B2 (en) * 2006-07-26 2012-03-22 Abbott Rapid Diagnostics International Unlimited Company Analysis device for biological sample
US8367051B2 (en) * 2006-10-09 2013-02-05 Carnegie Mellon University Preparation of functional gel particles with a dual crosslink network
US8765643B2 (en) * 2006-12-04 2014-07-01 General Electric Company Composition, device and associated method
US8778846B2 (en) * 2006-12-04 2014-07-15 General Electric Company Composition, device and associated method
JP5340956B2 (ja) * 2006-12-20 2013-11-13 アーケマ・インコーポレイテッド ポリマーの封入および/または結合
US7994234B2 (en) * 2007-03-27 2011-08-09 Vanderbilt University Diamond polymer brushes
WO2008148000A1 (en) 2007-05-23 2008-12-04 Carnegie Mellon University Atom transfer dispersion polymerization
US8865797B2 (en) * 2007-05-23 2014-10-21 Carnegie Mellon University Hybrid particle composite structures with reduced scattering
US8796184B2 (en) * 2008-03-28 2014-08-05 Sentilus, Inc. Detection assay devices and methods of making and using the same
JP5384923B2 (ja) * 2008-12-05 2014-01-08 国立大学法人九州大学 高分子系ナノコンポジットの製造方法及び該製造方法によって形成された難燃性高分子系ナノコンポジット
GB2481561B (en) 2009-03-27 2013-12-11 Univ Carnegie Mellon Preparation of functional star macromolecules
CN102200536B (zh) 2010-03-25 2015-05-27 艾博生物医药(杭州)有限公司 测试液体样本中被分析物的检测装置
WO2012079030A2 (en) * 2010-12-10 2012-06-14 The Regents Of The University Of California Bioconjugation using bifunctional linkers
US9644042B2 (en) 2010-12-17 2017-05-09 Carnegie Mellon University Electrochemically mediated atom transfer radical polymerization
CN103492540B (zh) * 2011-05-09 2017-05-31 斯沃奇集团研究和开发有限公司 用油相容性聚合物刷润滑
WO2013028756A1 (en) 2011-08-22 2013-02-28 Carnegie Mellon University Atom transfer radical polymerization under biologically compatible conditions
WO2013158183A2 (en) * 2012-01-27 2013-10-24 Carnegie Mellon University Processable self-organizing nanoparticles
US9533297B2 (en) 2012-02-23 2017-01-03 Carnegie Mellon University Ligands designed to provide highly active catalyst complexes
WO2013138494A1 (en) 2012-03-13 2013-09-19 California Institute Of Technology Periodic nanostructures from self assembled wedge-type block-copolymers
US9382387B2 (en) 2012-03-13 2016-07-05 California Institute Of Technology Rapid self-assembly of block copolymers to photonic crystals
US9453943B2 (en) 2012-06-28 2016-09-27 California Institute Of Technology Photonic structures from self assembly of brush block copolymers and polymer blends
MY178616A (en) 2012-09-17 2020-10-19 Grace W R & Co Chromatography media and devices
MY195756A (en) 2012-09-17 2023-02-09 Grace W R & Co Functionalized Particulate Support Material and Methods of Making and Using the Same
CN102875195B (zh) * 2012-09-20 2014-03-12 华东理工大学 一种多重刺激响应聚合物刷膜的制备方法
EP2920230B1 (de) * 2012-11-19 2017-12-13 Aarhus Universitet Verbinden eines polymers mit einem oberflächenmodifizierten festen teil
CN107002117B (zh) * 2013-12-05 2021-12-10 生捷科技控股公司 核酸测序方法
CN111118121B (zh) 2013-12-05 2024-07-19 生捷科技控股公司 图案化阵列的制备
CN105940024B (zh) * 2013-12-05 2019-03-15 生捷科技控股公司 修饰的表面
JP6853670B2 (ja) 2014-01-16 2021-04-07 ダブリュー・アール・グレース・アンド・カンパニー−コーンW R Grace & Co−Conn 親和性クロマトグラフィー媒体及びクロマトグラフィーデバイス
US11060139B2 (en) 2014-03-28 2021-07-13 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
JP6914189B2 (ja) 2014-05-02 2021-08-04 ダブリュー・アール・グレース・アンド・カンパニー−コーンW R Grace & Co−Conn 官能化担体材料並びに官能化担体材料を作製及び使用する方法
CN107073176B (zh) 2014-06-09 2021-02-19 康奈尔大学 可植入治疗递送系统及其方法
FR3026742B1 (fr) * 2014-10-03 2016-12-23 Alveole Impression d'un motif adhesif sur un support anti-salissures
US9982070B2 (en) 2015-01-12 2018-05-29 Carnegie Mellon University Aqueous ATRP in the presence of an activator regenerator
US10608280B2 (en) 2015-03-09 2020-03-31 California Institute Of Technology Brush block copolymer electrolytes and electrocatalyst compositions
CN107921407B (zh) 2015-06-05 2022-07-05 格雷斯公司 生物处理吸附澄清剂及其制备和使用方法
US10733023B1 (en) * 2015-08-06 2020-08-04 D2Iq, Inc. Oversubscription scheduling
WO2018132582A1 (en) 2017-01-12 2018-07-19 Carnegie Mellon University Surfactant assisted formation of a catalyst complex for emulsion atom transfer radical polymerization processes
US11053356B2 (en) 2017-03-07 2021-07-06 California Institute Of Technology Control of polymer architectures by living ring-opening metathesis copolymerization
WO2018199181A1 (ja) * 2017-04-25 2018-11-01 国立大学法人京都大学 隙間狭小化材、隙間狭小化材複合体およびそれらを用いた物品
IT201900000418A1 (it) * 2019-01-10 2020-07-10 Consiglio Nazionale Ricerche Dispositivo sensorizzato per l'analisi di un fluido mediante onde acustiche
JP7689075B2 (ja) 2019-01-30 2025-06-05 コロラド・ステート・ユニバーシティ・リサーチ・ファウンデーション ポリマー複合フォトニック結晶コーティング
WO2020160299A1 (en) 2019-02-01 2020-08-06 Colorado State University Research Foundation Multi-coat polymer photonic crystal films
US12478684B2 (en) 2019-04-11 2025-11-25 Northeastern University Oligonucleotide-polymer miktoarm conjugates and methods of use
BR112022003937A2 (pt) * 2019-09-03 2022-05-31 Poliresin S R L Polímero acrílico, polímero de hidroxialquilamida, processo para fabricar um polímero de hidroxialquilamida, uso do polímero, método para reticular polímeros e mistura de monômeros
MX2022007772A (es) 2019-12-20 2022-09-09 Church & Dwight Co Inc Composiciones polimericas y productos formados con las mismas.
CN114846067A (zh) 2019-12-20 2022-08-02 丘奇和德怀特有限公司 聚合物组合物及由其形成的产品
CN112174921B (zh) * 2020-09-29 2022-07-08 大连大学 基于香豆素和丹磺酰胺的谷胱甘肽荧光传感器分子及其制备方法
HUE070248T2 (hu) 2020-11-04 2025-05-28 Alcon Inc Eljárás fotokróm kontaktlencsék elõállítására
HUE069913T2 (hu) 2020-11-04 2025-04-28 Alcon Inc Eljárás fotokróm kontaktlencsék elõállítására
WO2022104385A2 (en) 2020-11-13 2022-05-19 The Regents Of The University Of Colorado, A Body Corporate Stability and activity of enzymes by immobilization
US12140550B2 (en) * 2022-01-27 2024-11-12 Kla Corporation Selective marking of a substrate with fluorescent conjugated polymer probes having a small form factor
WO2023209570A1 (en) 2022-04-26 2023-11-02 Alcon Inc. Method for making embedded hydrogel contact lenses
CN116446055A (zh) * 2023-04-07 2023-07-18 吉林大学 一种具有高密度反应位点的基底的制备方法及应用
EP4777219A1 (de) * 2023-09-13 2026-07-22 Cascade Biocatalysts, Inc Chromatographische medien mit mehreren affinitäten und verfahren zu ihrer herstellung und verwendung
WO2025151866A1 (en) * 2024-01-11 2025-07-17 Cornell University Polymer functionalized substrates, methods of making same, and uses thereof

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US526021A (en) * 1894-09-18 Pocket-transit
US5512329A (en) 1982-09-29 1996-04-30 Bsi Corporation Substrate surface preparation
US5002582A (en) 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
US5217492A (en) 1982-09-29 1993-06-08 Bio-Metric Systems, Inc. Biomolecule attachment to hydrophobic surfaces
US4973493A (en) 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
DE3486145T2 (de) 1983-07-11 1993-09-23 Commw Scient Ind Res Org Verfahren zur polymerisation und nach diesem verfahren hergestellte polymere.
EP0205232A1 (de) * 1985-04-08 1986-12-17 Kelsius, Inc. Signalverstärkung von optischen Fasern
US5354825A (en) * 1985-04-08 1994-10-11 Klainer Stanley M Surface-bound fluorescent polymers and related methods of synthesis and use
DE3617672C2 (de) 1986-05-26 2000-02-17 Claus Heuck Verfahren zur Herstellung eines Reagenz, ein danach hergestelltes Reagenz sowie dessen Verwendung zur Bindung von Polymeren und Mikroorganismen aus wäßrigen Lösungen
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5240602A (en) * 1987-06-08 1993-08-31 Chromatochem, Inc. Chromatographic material
US6054270A (en) 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5258454A (en) 1988-09-01 1993-11-02 Riso National Laboratory Peptide synthesis method and solid support for use in the method
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
DE3921498A1 (de) 1988-09-28 1990-03-29 Bayer Ag Polymer-gebundene-farbstoffe, verfahren zu deren herstellung und verwendung
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5512439A (en) 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5126021A (en) 1991-07-17 1992-06-30 Applied Biosystems Inc. Low-viscosity polymer solution for capillary electrophoresis
DE69233087T2 (de) 1991-11-22 2003-12-24 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Verfahren zur Herstellung von Polymerarrays
JPH08507926A (ja) 1993-03-19 1996-08-27 シーケノム・インコーポレーテツド エキソヌクレアーゼ分解を介した質量分析法によるdna配列決定
US6027880A (en) 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
US6045996A (en) 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
FR2716263B1 (fr) 1994-02-11 1997-01-17 Pasteur Institut Procédé d'alignement de macromolécules par passage d'un ménisque et applications dans un procédé de mise en évidence, séparation et/ou dosage d'une macromolécule dans un échantillon.
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
ATE166079T1 (de) 1994-06-24 1998-05-15 Dow Chemical Co Herstellung von amphipatischen pfropfcopolymeren, zusammensetzung davon und deren verwendung
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5530079A (en) 1995-01-03 1996-06-25 Xerox Corporation Polymerization processes
FR2730240A1 (fr) 1995-02-07 1996-08-09 Atochem Elf Sa Stabilisation d'un polymere par un radical libre stable
US6100026A (en) 1995-04-25 2000-08-08 Irori Matrices with memories and uses thereof
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5753439A (en) 1995-05-19 1998-05-19 Trustees Of Boston University Nucleic acid detection methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5843655A (en) 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
DE19546136A1 (de) 1995-12-11 1997-06-12 Bayer Ag Chirale stationäre Phasen für die chromatographische Trennung von optischen Isomeren
US6013440A (en) 1996-03-11 2000-01-11 Affymetrix, Inc. Nucleic acid affinity columns
US5942555A (en) 1996-03-21 1999-08-24 Surmodics, Inc. Photoactivatable chain transfer agents and semi-telechelic photoactivatable polymers prepared therefrom
EP1005644B1 (de) 1996-04-25 2003-03-12 Pence, Inc. Biosensor-vorrichtung und verfahren
WO1997046313A1 (en) 1996-06-07 1997-12-11 Eos Biotechnology, Inc. Immobilised linear oligonucleotide arrays
US5998140A (en) 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
WO1998020967A1 (en) 1996-11-14 1998-05-22 Affymetrix, Inc. Chemical amplification for the synthesis of patterned arrays
KR100504055B1 (ko) 1997-01-10 2005-07-27 이 아이 듀폰 디 네모아 앤드 캄파니 중합체 분자량 및 구조의 조절 방법
US5932711A (en) 1997-03-05 1999-08-03 Mosaic Technologies, Inc. Nucleic acid-containing polymerizable complex
US5919626A (en) 1997-06-06 1999-07-06 Orchid Bio Computer, Inc. Attachment of unmodified nucleic acids to silanized solid phase surfaces
JP2001510208A (ja) 1997-07-15 2001-07-31 チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド ニトロソ化合物又はニトロン化合物から誘導されたアルコキシアミン化合物を含む重合可能な組成物
US6391655B1 (en) 1997-07-30 2002-05-21 Corning Incorporated Oxidized styrenic polymers for DNA binding
US5858653A (en) 1997-09-30 1999-01-12 Surmodics, Inc. Reagent and method for attaching target molecules to a surface
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
EP1047794A2 (de) 1998-01-13 2000-11-02 BioChip Technologies GmbH Verfahren zum nachweis von nukleinsäuresequenzen
US6004755A (en) 1998-04-07 1999-12-21 Incyte Pharmaceuticals, Inc. Quantitative microarray hybridizaton assays
WO1999061653A2 (en) 1998-05-27 1999-12-02 Syntrix Biochip Light-mediated regional analysis of biologic material
US6723517B1 (en) * 1998-06-02 2004-04-20 Minerva Biotechnologies Corporation Use of self-assembled monolayers to probe the structure of a target molecule
AU1831700A (en) 1998-12-01 2000-06-19 Syntrix Biochip, Inc. Methods and compositions for performing an array of chemical reactions on a support surface
US6951682B1 (en) 1998-12-01 2005-10-04 Syntrix Biochip, Inc. Porous coatings bearing ligand arrays and use thereof
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
DE60029561T2 (de) 1999-01-25 2007-07-19 Micronas Holding Gmbh Immobilisierung von molekülen auf oberflächen über polymerbürsten
EP1035218A1 (de) 1999-03-03 2000-09-13 BioChip Technologies GmbH Immobilisierung von Molekülen an Oberflächen über verzweigte Polymerketten
US6413587B1 (en) * 1999-03-02 2002-07-02 International Business Machines Corporation Method for forming polymer brush pattern on a substrate surface
JP4647792B2 (ja) 1999-04-28 2011-03-09 イジュノシッヒ テクニッヒ ホッフシューラ チューリッヒ 分析用デバイスおよびセンシングデバイスにおけるポリイオン性コーティング
CA2317179A1 (en) 1999-09-01 2001-03-01 Affymetrix, Inc. Macromolecular arrays on polymeric brushes and methods for preparing the same
EP1095711B1 (de) 1999-10-27 2004-01-28 Novartis AG Verfahren für die Oberflächenbeschichtung von Materialien
US6077674A (en) 1999-10-27 2000-06-20 Agilent Technologies Inc. Method of producing oligonucleotide arrays with features of high purity

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US6692914B1 (en) 2004-02-17
EP1208126A1 (de) 2002-05-29
US20050158879A1 (en) 2005-07-21
DE60027309D1 (de) 2006-05-24
WO2001002452A9 (en) 2002-07-25
EP1208126B1 (de) 2006-04-12
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DE60027309T2 (de) 2006-08-31
US20020001845A1 (en) 2002-01-03

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