ATE323149T1 - Paramyxovirus-vektor zum gentransfer ins kardiovaskuläre system - Google Patents
Paramyxovirus-vektor zum gentransfer ins kardiovaskuläre systemInfo
- Publication number
- ATE323149T1 ATE323149T1 AT01981031T AT01981031T ATE323149T1 AT E323149 T1 ATE323149 T1 AT E323149T1 AT 01981031 T AT01981031 T AT 01981031T AT 01981031 T AT01981031 T AT 01981031T AT E323149 T1 ATE323149 T1 AT E323149T1
- Authority
- AT
- Austria
- Prior art keywords
- cardiovascular system
- vector
- gene transfer
- paramyxovirus vector
- paramyxovirus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18811—Sendai virus
- C12N2760/18841—Use of virus, viral particle or viral elements as a vector
- C12N2760/18843—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000339942A JP2002142770A (ja) | 2000-11-08 | 2000-11-08 | 循環系への遺伝子送達用パラミクソウイルスベクター |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE323149T1 true ATE323149T1 (de) | 2006-04-15 |
Family
ID=18814933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01981031T ATE323149T1 (de) | 2000-11-08 | 2001-11-08 | Paramyxovirus-vektor zum gentransfer ins kardiovaskuläre system |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20040101965A1 (de) |
| EP (2) | EP1334174B1 (de) |
| JP (1) | JP2002142770A (de) |
| KR (1) | KR100852078B1 (de) |
| CN (1) | CN1555417B (de) |
| AT (1) | ATE323149T1 (de) |
| AU (1) | AU2002212733A1 (de) |
| CA (1) | CA2428073C (de) |
| DE (1) | DE60118771T2 (de) |
| DK (1) | DK1334174T3 (de) |
| ES (1) | ES2260301T3 (de) |
| WO (1) | WO2002038726A2 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6490775B1 (en) * | 1999-04-23 | 2002-12-10 | Veri-Tek Inc. | Press operation verification system |
| US7226786B2 (en) * | 1999-05-18 | 2007-06-05 | Dnavec Research Inc. | Envelope gene-deficient Paramyxovirus vector |
| CN1367839A (zh) | 1999-09-06 | 2002-09-04 | 株式会社载体研究所 | 含有已改变的转录起始序列的副粘病毒 |
| US7314614B1 (en) | 1999-11-02 | 2008-01-01 | Dnavec Research, Inc. | Recombinant sendai virus vector for introducing exogenous genes to airway epithelia |
| US20020002143A1 (en) | 2000-03-30 | 2002-01-03 | Munehide Kano | AIDS virus vaccines using sendai virus vector |
| KR100807016B1 (ko) * | 2000-06-01 | 2008-02-25 | 가부시키가이샤 디나벡크 겐큐쇼 | 헤마글루티닌 활성을 갖는 막단백질을 포함하는 슈도타입레트로바이러스 벡터 |
| KR20030014392A (ko) * | 2000-06-27 | 2003-02-17 | 가부시키가이샤 디나벡크 겐큐쇼 | 신장세포에 유전자를 도입하기 위한 바이러스 벡터 |
| WO2002031138A1 (en) * | 2000-10-06 | 2002-04-18 | Dnavec Research Inc. | Paramyxovirus vector for transferring foreign gene into skeletal muscle |
| DE60133767T2 (de) * | 2000-11-27 | 2009-06-25 | Dnavec Research Inc., Tsukuba | Für fibroblasten-wachstumsfaktor 2 (fgf2) kodierender paramyxovirus-vektor und dessen verwendung |
| WO2003092738A1 (en) * | 2002-04-30 | 2003-11-13 | Dnavec Research Inc. | Drug- or gene-carrier composition having lowered hemagglutinin activity |
| JPWO2004022731A1 (ja) * | 2002-09-04 | 2005-12-22 | 株式会社ディナベック研究所 | シアル酸結合活性を有する膜蛋白質をエンベロープに含むウイルスベクターをグラム陽性菌由来ノイラミニダーゼを用いて製造する方法 |
| AU2003275581A1 (en) * | 2002-10-24 | 2004-05-13 | Dnavec Research Inc. | Method of transferring gene into t cells |
| EP1642966B1 (de) * | 2003-06-30 | 2010-03-03 | Dnavec Research Inc. | Negativ-strang rna-virus-vektoren, welche ein gen mit veränderten hypermutierbaren regionen tragen |
| AU2005205441A1 (en) * | 2004-01-13 | 2005-07-28 | Dnavec Research Inc. | Gene therapy for tumor using minus-strand RNA virus vector encoding immunostimulating cytokine |
| WO2005071085A1 (ja) * | 2004-01-22 | 2005-08-04 | Dnavec Research Inc. | ウイルスベクターの製造方法 |
| JPWO2005097988A1 (ja) * | 2004-03-23 | 2008-02-28 | 株式会社ディナベック研究所 | 組織の維持および/または修復に関連する骨髄関連細胞 |
| KR20080031167A (ko) * | 2005-04-20 | 2008-04-08 | 디나벡크 가부시키가이샤 | 알츠하이머병 치료용의 고도로 안전한 비강투여용 유전자백신 |
| CA2612168A1 (en) * | 2005-06-14 | 2006-12-21 | Dnavec Corporation | Methods for producing antibodies |
| HUE028512T2 (en) * | 2005-10-28 | 2016-12-28 | Id Pharma Co Ltd | Gene transfer to airway epithelial stem cell using RNA virus spike protein pseudotyped lentiviral vector |
| KR20080094910A (ko) * | 2006-01-17 | 2008-10-27 | 디나벡크 가부시키가이샤 | 신규 단백질 발현계 |
| AU2014254019B2 (en) | 2013-04-18 | 2018-09-27 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| CA2914837A1 (en) | 2013-06-17 | 2014-12-24 | Armo Biosciences, Inc. | Method for assessing protein identity and stability |
| US10010588B2 (en) | 2013-08-30 | 2018-07-03 | Armo Biosciences, Inc. | Methods of using pegylated interleukin-10 for treating hyperlipidemia |
| MX2016005915A (es) | 2013-11-11 | 2016-12-16 | Armo Biosciences Inc | Metodos de uso de interleucina-10 para tratar enfermedades y trastornos. |
| US10293043B2 (en) | 2014-06-02 | 2019-05-21 | Armo Biosciences, Inc. | Methods of lowering serum cholesterol |
| ES2941234T3 (es) | 2014-10-22 | 2023-05-19 | Armo Biosciences Inc | Métodos de uso de la interleucina-10 para el tratamiento de enfermedades y trastornos |
| WO2016126615A1 (en) | 2015-02-03 | 2016-08-11 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| AU2016312510A1 (en) | 2015-08-25 | 2018-03-08 | Armo Biosciences, Inc. | Methods of using Interleukin-10 for treating diseases and disorders |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5155214A (en) * | 1984-03-05 | 1992-10-13 | The Salk Institute For Biological Studies | Basic fibroblast growth factor |
| JPS6147186A (ja) | 1984-08-09 | 1986-03-07 | Chemo Sero Therapeut Res Inst | インフルエンザウイルスの精製方法 |
| JPS6147185A (ja) | 1984-08-09 | 1986-03-07 | Chemo Sero Therapeut Res Inst | 日本脳炎ウイルスの精製方法 |
| JPS6147187A (ja) | 1984-08-10 | 1986-03-07 | Chemo Sero Therapeut Res Inst | 狂犬病ウイルスの精製方法 |
| US4994559A (en) * | 1985-12-17 | 1991-02-19 | Synergen, Inc. | Human basic fibroblast growth factor |
| US5215745A (en) * | 1988-04-27 | 1993-06-01 | United Cancer Research Institute | Method for treating viral diseases with attenuated virus |
| US5670488A (en) * | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
| US5827513A (en) * | 1990-06-29 | 1998-10-27 | Schering Corporation | Methods of treating insulin-dependent diabetes mellitus by administration of IL-10 |
| US5631237A (en) * | 1992-12-22 | 1997-05-20 | Dzau; Victor J. | Method for producing in vivo delivery of therapeutic agents via liposomes |
| FR2705686B1 (fr) * | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| US6562596B1 (en) * | 1993-10-06 | 2003-05-13 | Amgen Inc. | Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods |
| US5635380A (en) * | 1994-01-18 | 1997-06-03 | Vanderbilt University | Enhancement of nucleic acid transfer by coupling virus to nucleic acid via lipids |
| US5639661A (en) * | 1994-03-23 | 1997-06-17 | The University Of Iowa Research Foundation | Genes and proteins for treating cystic fibrosis |
| EP1394259A3 (de) * | 1994-07-18 | 2004-04-14 | Karl-Klaus Prof. Dr. Conzelmann | Rekombinantes infektiöses nicht-in-Segmente-geteiltes negativ-Strange-RNS-Virus |
| US5824655A (en) * | 1995-02-15 | 1998-10-20 | The University Of Utah | Anti-transforming growth factor-β gene therapy |
| US5744304A (en) * | 1995-05-30 | 1998-04-28 | Board Of Regents, The University Of Texas System | Inflammation-induced expression of a recombinant gene |
| US6022536A (en) * | 1995-08-09 | 2000-02-08 | Schering Corporation | Combined use of interleukin 10 and cyclosporin for immunosuppression therapy |
| US6121246A (en) * | 1995-10-20 | 2000-09-19 | St. Elizabeth's Medical Center Of Boston, Inc. | Method for treating ischemic tissue |
| KR100754091B1 (ko) | 1995-10-31 | 2007-08-31 | 가부시끼가이샤 디나벡 겡뀨쇼 | 자율 복제 능력을 갖는 (-)쇄 rna 바이러스 벡터 |
| AU7335296A (en) * | 1995-11-01 | 1997-05-22 | Dnavec Research Inc. | Recombinant sendai virus |
| KR100461701B1 (ko) | 1996-02-29 | 2005-04-06 | 다카라 바이오 가부시키가이샤 | 바이러스의정제및제거방법 |
| US5833651A (en) * | 1996-11-08 | 1998-11-10 | Medtronic, Inc. | Therapeutic intraluminal stents |
| EP0953647B1 (de) * | 1996-12-16 | 2008-05-28 | Eisai R&D Management Co., Ltd. | Verfahren zur herstellung von retroviralen vektoren für die gentherapie |
| CA2205076A1 (en) * | 1997-05-14 | 1998-11-14 | Jim Hu | Episomal expression cassettes for gene therapy |
| FR2766706B1 (fr) * | 1997-07-30 | 2001-05-25 | Biovector Therapeutics Sa | Complexes particulaires stables de charge globale neutre ou negative de structure multilamellaire composes par au moins une substance biologiquement active globalement anionique et un constituant cationique, leur preparation et utilisation |
| US5962274A (en) * | 1998-03-13 | 1999-10-05 | Wake Forest University | Viral vector directed to predetermined target cells |
| US6828138B1 (en) * | 1998-08-11 | 2004-12-07 | Dnavec Research Inc. | Recombinant sendai virus vector including a gene encoding a chemokine |
| DE69933528T2 (de) * | 1998-11-09 | 2007-08-09 | Nippon Biologicals, Inc. | Verfahren zur Cytokinproduktionn unter Verwendung eines Sendai Virus Expressionssystems |
| JP2000201689A (ja) * | 1998-11-09 | 2000-07-25 | Nippon Bio Capital Limited:Kk | センダイウイルス発現系を用いたサイトカインの製造方法 |
| JP2000253876A (ja) * | 1999-03-08 | 2000-09-19 | Dnavec Research Inc | センダイウイルスベクターを用いたワクチンおよびワクチンタンパク質 |
| DK1186667T3 (da) | 1999-05-18 | 2007-10-22 | Dnavec Research Inc | Kappegendeficient virusvektor af Paramyxoviridae |
| US20030166252A1 (en) * | 1999-05-18 | 2003-09-04 | Kaio Kitazato | Paramyxovirus-derived RNP |
| US20030022376A1 (en) * | 1999-05-18 | 2003-01-30 | Kaio Kitazato | Paramyxovirus-derived RNP |
| ATE399206T1 (de) | 1999-05-18 | 2008-07-15 | Dnavec Research Inc | Ribonukleoproteinkomplex aus paramyxovirus |
| US20020169306A1 (en) * | 1999-05-18 | 2002-11-14 | Kaio Kitazato | Envelope gene-deficient paramyxovirus vector |
| EP1067179A1 (de) | 1999-07-09 | 2001-01-10 | Pierre Fabre Medicament | Verfahren zur Selektion von attenuierten Paramyxoviridae verwenbare als Impstoffen und Therapeutika |
| CN1367839A (zh) | 1999-09-06 | 2002-09-04 | 株式会社载体研究所 | 含有已改变的转录起始序列的副粘病毒 |
| US7314614B1 (en) * | 1999-11-02 | 2008-01-01 | Dnavec Research, Inc. | Recombinant sendai virus vector for introducing exogenous genes to airway epithelia |
| KR100774796B1 (ko) * | 2000-01-19 | 2007-11-07 | 가부시키가이샤 디나벡크 겐큐쇼 | 파라믹소바이러스 벡터의 혈관으로의 유전자 도입용도 |
| US20020002143A1 (en) * | 2000-03-30 | 2002-01-03 | Munehide Kano | AIDS virus vaccines using sendai virus vector |
| CA2322057A1 (en) * | 2000-05-18 | 2001-11-18 | Dnavec Research Inc. | Paramyxovirus vectors used for transfer of foreign genes |
| KR100807016B1 (ko) * | 2000-06-01 | 2008-02-25 | 가부시키가이샤 디나벡크 겐큐쇼 | 헤마글루티닌 활성을 갖는 막단백질을 포함하는 슈도타입레트로바이러스 벡터 |
| KR20030014392A (ko) * | 2000-06-27 | 2003-02-17 | 가부시키가이샤 디나벡크 겐큐쇼 | 신장세포에 유전자를 도입하기 위한 바이러스 벡터 |
| WO2002031138A1 (en) * | 2000-10-06 | 2002-04-18 | Dnavec Research Inc. | Paramyxovirus vector for transferring foreign gene into skeletal muscle |
| DE60133767T2 (de) * | 2000-11-27 | 2009-06-25 | Dnavec Research Inc., Tsukuba | Für fibroblasten-wachstumsfaktor 2 (fgf2) kodierender paramyxovirus-vektor und dessen verwendung |
| AU2003275581A1 (en) * | 2002-10-24 | 2004-05-13 | Dnavec Research Inc. | Method of transferring gene into t cells |
| CN1768145A (zh) * | 2003-01-31 | 2006-05-03 | 株式会社载体研究所 | 编码核酶的副粘病毒载体及其应用 |
| EP1642966B1 (de) * | 2003-06-30 | 2010-03-03 | Dnavec Research Inc. | Negativ-strang rna-virus-vektoren, welche ein gen mit veränderten hypermutierbaren regionen tragen |
| AU2004286144A1 (en) * | 2003-11-04 | 2005-05-12 | Dnavec Research Inc. | Method for producing gene transferred dendritic cells |
| AU2005205441A1 (en) * | 2004-01-13 | 2005-07-28 | Dnavec Research Inc. | Gene therapy for tumor using minus-strand RNA virus vector encoding immunostimulating cytokine |
| JPWO2005097988A1 (ja) * | 2004-03-23 | 2008-02-28 | 株式会社ディナベック研究所 | 組織の維持および/または修復に関連する骨髄関連細胞 |
| KR20080031167A (ko) * | 2005-04-20 | 2008-04-08 | 디나벡크 가부시키가이샤 | 알츠하이머병 치료용의 고도로 안전한 비강투여용 유전자백신 |
-
2000
- 2000-11-08 JP JP2000339942A patent/JP2002142770A/ja active Pending
-
2001
- 2001-11-08 AU AU2002212733A patent/AU2002212733A1/en not_active Abandoned
- 2001-11-08 WO PCT/JP2001/009786 patent/WO2002038726A2/en not_active Ceased
- 2001-11-08 KR KR1020037006270A patent/KR100852078B1/ko not_active Expired - Fee Related
- 2001-11-08 EP EP01981031A patent/EP1334174B1/de not_active Expired - Lifetime
- 2001-11-08 AT AT01981031T patent/ATE323149T1/de not_active IP Right Cessation
- 2001-11-08 EP EP06002264A patent/EP1662003A3/de not_active Ceased
- 2001-11-08 CA CA2428073A patent/CA2428073C/en not_active Expired - Fee Related
- 2001-11-08 DK DK01981031T patent/DK1334174T3/da active
- 2001-11-08 ES ES01981031T patent/ES2260301T3/es not_active Expired - Lifetime
- 2001-11-08 CN CN018185673A patent/CN1555417B/zh not_active Expired - Fee Related
- 2001-11-08 DE DE60118771T patent/DE60118771T2/de not_active Expired - Lifetime
- 2001-11-08 US US10/416,252 patent/US20040101965A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DK1334174T3 (da) | 2006-06-26 |
| ES2260301T3 (es) | 2006-11-01 |
| JP2002142770A (ja) | 2002-05-21 |
| WO2002038726A3 (en) | 2003-03-20 |
| US20040101965A1 (en) | 2004-05-27 |
| CN1555417A (zh) | 2004-12-15 |
| EP1662003A3 (de) | 2006-06-14 |
| HK1070100A1 (zh) | 2005-06-10 |
| EP1334174B1 (de) | 2006-04-12 |
| KR20030074617A (ko) | 2003-09-19 |
| EP1334174A2 (de) | 2003-08-13 |
| AU2002212733A1 (en) | 2002-05-21 |
| CA2428073A1 (en) | 2002-05-16 |
| CN1555417B (zh) | 2010-04-28 |
| CA2428073C (en) | 2012-01-10 |
| WO2002038726A2 (en) | 2002-05-16 |
| DE60118771D1 (de) | 2006-05-24 |
| KR100852078B1 (ko) | 2008-08-13 |
| EP1662003A2 (de) | 2006-05-31 |
| DE60118771T2 (de) | 2007-04-12 |
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