ATE459707T1 - Negativ-strang rna-virus-vektoren, welche ein gen mit veränderten hypermutierbaren regionen tragen - Google Patents

Negativ-strang rna-virus-vektoren, welche ein gen mit veränderten hypermutierbaren regionen tragen

Info

Publication number
ATE459707T1
ATE459707T1 AT04747086T AT04747086T ATE459707T1 AT E459707 T1 ATE459707 T1 AT E459707T1 AT 04747086 T AT04747086 T AT 04747086T AT 04747086 T AT04747086 T AT 04747086T AT E459707 T1 ATE459707 T1 AT E459707T1
Authority
AT
Austria
Prior art keywords
gene
hypermutatible
altered
regions
strand rna
Prior art date
Application number
AT04747086T
Other languages
English (en)
Inventor
Jun You
Akihiro Iida
Mamoru Hasegawa
Original Assignee
Dnavec Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dnavec Research Inc filed Critical Dnavec Research Inc
Application granted granted Critical
Publication of ATE459707T1 publication Critical patent/ATE459707T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
    • C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT04747086T 2003-06-30 2004-06-30 Negativ-strang rna-virus-vektoren, welche ein gen mit veränderten hypermutierbaren regionen tragen ATE459707T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003187312 2003-06-30
PCT/JP2004/009617 WO2005001082A1 (ja) 2003-06-30 2004-06-30 高変異領域が改変された遺伝子を搭載するマイナス鎖rnaウイルスベクター

Publications (1)

Publication Number Publication Date
ATE459707T1 true ATE459707T1 (de) 2010-03-15

Family

ID=33549720

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04747086T ATE459707T1 (de) 2003-06-30 2004-06-30 Negativ-strang rna-virus-vektoren, welche ein gen mit veränderten hypermutierbaren regionen tragen

Country Status (10)

Country Link
US (1) US20070105208A1 (de)
EP (1) EP1642966B1 (de)
JP (1) JPWO2005001082A1 (de)
KR (1) KR20060028432A (de)
CN (1) CN1816618A (de)
AT (1) ATE459707T1 (de)
AU (1) AU2004252377A1 (de)
CA (1) CA2530627A1 (de)
DE (1) DE602004025810D1 (de)
WO (1) WO2005001082A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0863202T3 (da) * 1995-11-01 2010-09-27 Dnavec Research Inc Rekombinant Sendai-virus
US7314614B1 (en) 1999-11-02 2008-01-01 Dnavec Research, Inc. Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
JP2002142770A (ja) * 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
CN109112126B (zh) * 2010-06-23 2024-06-14 库尔纳公司 通过抑制电压门控钠通道α亚基(SCNA)的天然反义转录物而治疗SCNA相关疾病
EP3112474A1 (de) * 2015-06-29 2017-01-04 Evonik Degussa GmbH Verfahren zum nachweis von aviärer nekrotischer enteritis
CN111479920B (zh) * 2017-07-21 2025-08-01 株式会社爱医隆集团 用于修饰靶序列的多核苷酸及其用途

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240846A (en) * 1989-08-22 1993-08-31 The Regents Of The University Of Michigan Gene therapy vector for cystic fibrosis
US5670488A (en) * 1992-12-03 1997-09-23 Genzyme Corporation Adenovirus vector for gene therapy
JPH04355912A (ja) * 1990-08-09 1992-12-09 Seiko Epson Corp 半導体装置及びその製造方法
FR2705686B1 (fr) * 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
US5639661A (en) * 1994-03-23 1997-06-17 The University Of Iowa Research Foundation Genes and proteins for treating cystic fibrosis
US5824655A (en) * 1995-02-15 1998-10-20 The University Of Utah Anti-transforming growth factor-β gene therapy
DK0864645T3 (da) * 1995-10-31 2005-10-24 Dnavec Research Inc Negativstrenget RNA-virusvektor med autonom replikeringsaktivitet
DK0863202T3 (da) * 1995-11-01 2010-09-27 Dnavec Research Inc Rekombinant Sendai-virus
US5962274A (en) * 1998-03-13 1999-10-05 Wake Forest University Viral vector directed to predetermined target cells
US6828138B1 (en) * 1998-08-11 2004-12-07 Dnavec Research Inc. Recombinant sendai virus vector including a gene encoding a chemokine
JP2990268B1 (ja) * 1998-08-31 1999-12-13 工業技術院長 機能性核酸転写用発現系
US6468793B1 (en) * 1998-10-23 2002-10-22 Florida State University Research Foundation CFTR genes and proteins for cystic fibrosis gene therapy
US7226786B2 (en) * 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
US20030022376A1 (en) * 1999-05-18 2003-01-30 Kaio Kitazato Paramyxovirus-derived RNP
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
US20020169306A1 (en) * 1999-05-18 2002-11-14 Kaio Kitazato Envelope gene-deficient paramyxovirus vector
CN1367839A (zh) * 1999-09-06 2002-09-04 株式会社载体研究所 含有已改变的转录起始序列的副粘病毒
JP4838962B2 (ja) * 1999-11-02 2011-12-14 株式会社ディナベック研究所 気道上皮細胞への外因性遺伝子導入用組換えセンダイウイルスベクター
KR100774796B1 (ko) * 2000-01-19 2007-11-07 가부시키가이샤 디나벡크 겐큐쇼 파라믹소바이러스 벡터의 혈관으로의 유전자 도입용도
CN1248740C (zh) * 2000-03-30 2006-04-05 株式会社载体研究所 使用仙台病毒载体的aids病毒疫苗
CA2322057A1 (en) * 2000-05-18 2001-11-18 Dnavec Research Inc. Paramyxovirus vectors used for transfer of foreign genes
KR100807016B1 (ko) * 2000-06-01 2008-02-25 가부시키가이샤 디나벡크 겐큐쇼 헤마글루티닌 활성을 갖는 막단백질을 포함하는 슈도타입레트로바이러스 벡터
EP1297852A4 (de) * 2000-06-27 2004-12-29 Dnavec Research Inc Viraler vektor zur einbringung von genen in nierenzellen(03.02.03)
WO2002031138A1 (en) * 2000-10-06 2002-04-18 Dnavec Research Inc. Paramyxovirus vector for transferring foreign gene into skeletal muscle
JP2002142770A (ja) * 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
DE60133767T2 (de) * 2000-11-27 2009-06-25 Dnavec Research Inc., Tsukuba Für fibroblasten-wachstumsfaktor 2 (fgf2) kodierender paramyxovirus-vektor und dessen verwendung
US20050130123A1 (en) * 2001-09-18 2005-06-16 Makoto Inoue Methods of examining (-) strand rna virus vectors having lowered ability to form grains and method of constructing the same
JPWO2003092738A1 (ja) * 2002-04-30 2005-09-08 株式会社ディナベック研究所 ヘマグルチニン活性を低下させた薬剤または遺伝子運搬組成物
AU2003234775A1 (en) * 2002-04-30 2003-11-17 Dnavec Research Inc. Vector with modified protease-dependent tropism
US20050191617A1 (en) * 2002-06-03 2005-09-01 Makoto Inoue Pramyxovirusl vectors encoding antibody and utilization thereof
EP1561819A4 (de) * 2002-10-24 2006-03-22 Dnavec Research Inc Verfahren zur übertragung eines gens in t-zellen
US20060216824A1 (en) * 2003-01-31 2006-09-28 Tsuyoshi Tokusumi Paramyxovirus vector encoding ribozyme and utilization thereof
WO2005042737A1 (ja) * 2003-11-04 2005-05-12 Dnavec Research Inc. 遺伝子導入された樹状細胞の製造方法

Also Published As

Publication number Publication date
KR20060028432A (ko) 2006-03-29
DE602004025810D1 (de) 2010-04-15
EP1642966A1 (de) 2006-04-05
JPWO2005001082A1 (ja) 2006-08-10
WO2005001082A1 (ja) 2005-01-06
EP1642966B1 (de) 2010-03-03
CN1816618A (zh) 2006-08-09
EP1642966A4 (de) 2006-08-02
US20070105208A1 (en) 2007-05-10
AU2004252377A1 (en) 2005-01-06
CA2530627A1 (en) 2005-01-06

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