ATE323152T1 - Biologische systeme zur herstellung von polyhydroxyalkanoate polymeren die 4-hydroxysäure enthalten - Google Patents

Biologische systeme zur herstellung von polyhydroxyalkanoate polymeren die 4-hydroxysäure enthalten

Info

Publication number
ATE323152T1
ATE323152T1 AT98948384T AT98948384T ATE323152T1 AT E323152 T1 ATE323152 T1 AT E323152T1 AT 98948384 T AT98948384 T AT 98948384T AT 98948384 T AT98948384 T AT 98948384T AT E323152 T1 ATE323152 T1 AT E323152T1
Authority
AT
Austria
Prior art keywords
bacteria
production
contain
integrated
gene encoding
Prior art date
Application number
AT98948384T
Other languages
English (en)
Inventor
Gjalt W Huisman
Frank A Skraly
David P Martin
Oliver P Peoples
Original Assignee
Metabolix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolix Inc filed Critical Metabolix Inc
Application granted granted Critical
Publication of ATE323152T1 publication Critical patent/ATE323152T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Enzymes And Modification Thereof (AREA)
AT98948384T 1997-09-19 1998-09-18 Biologische systeme zur herstellung von polyhydroxyalkanoate polymeren die 4-hydroxysäure enthalten ATE323152T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5937397P 1997-09-19 1997-09-19

Publications (1)

Publication Number Publication Date
ATE323152T1 true ATE323152T1 (de) 2006-04-15

Family

ID=22022544

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98948384T ATE323152T1 (de) 1997-09-19 1998-09-18 Biologische systeme zur herstellung von polyhydroxyalkanoate polymeren die 4-hydroxysäure enthalten

Country Status (8)

Country Link
US (6) US6316262B1 (de)
EP (1) EP1015565B1 (de)
JP (4) JP2001516574A (de)
AT (1) ATE323152T1 (de)
AU (1) AU725516B2 (de)
CA (1) CA2303070C (de)
DE (2) DE69838768T2 (de)
WO (1) WO1999014313A2 (de)

Families Citing this family (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7455999B2 (en) * 1998-01-22 2008-11-25 Metabolix, Inc. Transgenic systems for the manufacture of poly (3-hydroxy-butyrate-co-3-hydroxyhexanoate)
WO1999061624A2 (en) 1998-05-22 1999-12-02 Metabolix, Inc. Polyhydroxyalkanoate biopolymer compositions
EP1975236B1 (de) 1998-08-04 2015-05-06 Metabolix, Inc. Herstellung von Polyhydroxyalkanoat aus Polyolen
EP1105499B1 (de) 1998-08-18 2006-03-08 Metabolix, Inc. Transgene polyhydroxyalkanoat produzierende mikroben
EP1700909B1 (de) * 1998-08-18 2015-08-12 Metabolix, Inc. Transgene Polyhydroxyalkanoat produzierende Mikroben
PT1163019E (pt) 1999-03-25 2007-12-06 Metabolix Inc Dispositivos médicos e aplicações de polímeros de poli-hidroxialcanoato
US6623730B1 (en) 1999-09-14 2003-09-23 Tepha, Inc. Therapeutic uses of polymers and oligomers comprising gamma-hydroxybutyrate
ATE454456T1 (de) 2000-02-11 2010-01-15 Metabolix Inc Intein enthaltende multigen-expressionskonstrukte
AU2001275996B2 (en) 2000-07-21 2005-08-04 Cj Cheiljedang Corporation Production of polyhydroxyalkanoates from polyols
AU2002357355A1 (en) 2001-12-18 2003-06-30 Metabolix, Inc. Methods of making intermediates from polyhydroxyalkanoates
AU2002360695A1 (en) 2001-12-19 2003-07-09 Nmt Medical, Inc. Septal occluder and associated methods
US7318833B2 (en) 2001-12-19 2008-01-15 Nmt Medical, Inc. PFO closure device with flexible thrombogenic joint and improved dislodgement resistance
CA2471871A1 (en) * 2002-01-14 2003-07-24 Nmt Medical, Inc. Patent foramen ovale (pfo) closure method and device
WO2003082076A2 (en) 2002-03-25 2003-10-09 Nmt Medical, Inc. Patent foramen ovale (pfo) closure clips
WO2003103476A2 (en) 2002-06-05 2003-12-18 Nmt Medical, Inc. Patent foramen ovale (pfo) closure device with radial and circumferential support
AUPS318202A0 (en) * 2002-06-26 2002-07-18 Cochlear Limited Parametric fitting of a cochlear implant
US8071355B2 (en) 2002-09-12 2011-12-06 Metabolix, Inc. Polyhydroxyalkanoate production by coenzyme A-dependent aldehyde dehydrogenase pathways
US7766820B2 (en) 2002-10-25 2010-08-03 Nmt Medical, Inc. Expandable sheath tubing
WO2004043508A1 (en) * 2002-11-06 2004-05-27 Nmt Medical, Inc. Medical devices utilizing modified shape memory alloy
EP1572003B1 (de) 2002-12-09 2017-03-08 W.L. Gore & Associates, Inc. Vorrichtung zum reparieren von septumschäden
WO2004065609A1 (ja) 2003-01-22 2004-08-05 Showa Denko K.K. アシルコエンザイムａを用いるアシル基転移酵素反応方法
PT1638615E (pt) 2003-05-08 2015-02-04 Tepha Inc Fibras e tecidos médicos de polihidroxialcanoato
US8480706B2 (en) 2003-07-14 2013-07-09 W.L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
US9861346B2 (en) 2003-07-14 2018-01-09 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
EP1651116B1 (de) 2003-07-14 2013-06-26 W.L. Gore & Associates, Inc. Röhrenförmige verschlussvorrichtung für patentes foramen ovale (pfo) mit riegelsystem
ATE413898T1 (de) 2003-08-19 2008-11-15 Nmt Medical Inc Expandierbarer schleusenschlauch
US8735113B2 (en) 2003-10-15 2014-05-27 Newlight Technologies, Llc Methods and systems for production of polyhydroxyalkanoate
US7579176B2 (en) 2003-10-15 2009-08-25 Newlight Technologies, Llc Method for the production of polyhydroxyalkanoic acid
US7745197B1 (en) 2003-10-15 2010-06-29 Newlight Technologies, Llc Process for the utilization of ruminant animal methane emissions
US20050273119A1 (en) 2003-12-09 2005-12-08 Nmt Medical, Inc. Double spiral patent foramen ovale closure clamp
EP1737349A1 (de) 2004-03-03 2007-01-03 NMT Medical, Inc. Abgabe/rückholsystem für einen septumokkludierer
US20050267524A1 (en) * 2004-04-09 2005-12-01 Nmt Medical, Inc. Split ends closure device
US8361110B2 (en) 2004-04-26 2013-01-29 W.L. Gore & Associates, Inc. Heart-shaped PFO closure device
US7842053B2 (en) 2004-05-06 2010-11-30 Nmt Medical, Inc. Double coil occluder
US8308760B2 (en) 2004-05-06 2012-11-13 W.L. Gore & Associates, Inc. Delivery systems and methods for PFO closure device with two anchors
JP2007535997A (ja) 2004-05-07 2007-12-13 エヌエムティー メディカル， インコーポレイティッド 管状中隔オクルーダーの捕捉機構
JP4720114B2 (ja) * 2004-05-20 2011-07-13 三菱化学株式会社 オキザロ酢酸またはオキザロ酢酸誘導体の製造方法
PT1778305E (pt) 2004-08-03 2010-07-27 Tepha Inc Suturas de poli-hidroxialcanoato que n†o se enrolam
US8764848B2 (en) 2004-09-24 2014-07-01 W.L. Gore & Associates, Inc. Occluder device double securement system for delivery/recovery of such occluder device
JP2008532553A (ja) * 2005-03-16 2008-08-21 メタボリックス， インコーポレイテッド 生合成経路の化学的に誘導可能な発現
WO2006102213A1 (en) 2005-03-18 2006-09-28 Nmt Medical, Inc. Catch member for pfo occluder
KR100979694B1 (ko) 2005-05-24 2010-09-02 한국과학기술원 폴리락테이트 또는 그 공중합체 생성능을 가지는 세포 또는식물 및 이를 이용한 폴리락테이트 또는 그 공중합체의제조방법
EP2781593B1 (de) * 2005-08-22 2019-08-07 Newlight Technologies, Inc. Verfahren zur Behandlung von Methanemissionen
EP1948037A2 (de) * 2005-10-24 2008-07-30 NMT Medical, Inc. Röntgenopake biologisch resorbierbare okklusionsvorrichtung
US20070167981A1 (en) 2005-12-22 2007-07-19 Nmt Medical, Inc. Catch members for occluder devices
US8979921B2 (en) * 2006-02-07 2015-03-17 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
US9592325B2 (en) * 2006-02-07 2017-03-14 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
ES2395112T3 (es) * 2006-02-07 2013-02-08 Tepha, Inc. Polímeros y copolímeros de ácido poliláctico endurecidos
EP1981557B1 (de) * 2006-02-07 2017-03-29 Tepha, Inc. Vorrichtungen und verfahren zur reparatur der rotatorenmanschette
US8551135B2 (en) 2006-03-31 2013-10-08 W.L. Gore & Associates, Inc. Screw catch mechanism for PFO occluder and method of use
US8870913B2 (en) 2006-03-31 2014-10-28 W.L. Gore & Associates, Inc. Catch system with locking cap for patent foramen ovale (PFO) occluder
US8814947B2 (en) 2006-03-31 2014-08-26 W.L. Gore & Associates, Inc. Deformable flap catch mechanism for occluder device
US9089627B2 (en) 2006-07-11 2015-07-28 Abbott Cardiovascular Systems Inc. Stent fabricated from polymer composite toughened by a dispersed phase
JP5468779B2 (ja) * 2006-07-21 2014-04-09 株式会社カネカ 遺伝子置換微生物およびそれを用いたポリエステルの製造方法
WO2008042311A1 (en) * 2006-09-28 2008-04-10 Nmt Medical. Inc. Perforated expandable implant recovery sheath
EP2084209B1 (de) * 2006-11-21 2021-06-02 LG Chem, Ltd. Copolymer mit 4-hydroxybutyrat-einheit und lactat-einheit und herstellungsverfahren dafür
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
JP2010517638A (ja) * 2007-02-02 2010-05-27 トアニエ， インコーポレイテッド 腱および靱帯を修復するシステムおよび方法
JP5551448B2 (ja) 2007-03-16 2014-07-16 ジェノマティカ・インコーポレイテッド １，４−ブタンジオールおよびその前駆体の生合成のための組成物および方法
WO2008124603A1 (en) 2007-04-05 2008-10-16 Nmt Medical, Inc. Septal closure device with centering mechanism
US9138562B2 (en) 2007-04-18 2015-09-22 W.L. Gore & Associates, Inc. Flexible catheter system
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
CA2698125A1 (en) * 2007-08-30 2009-03-12 Plant Sensory System, Llc. Alternative methods for the biosynthesis of gaba
US8581040B2 (en) 2007-08-30 2013-11-12 Plant Sensory Systems, Llc Methods of producing GABA
US8581041B2 (en) 2007-08-30 2013-11-12 Plant Sensory Systems, Llc Methods of producing GABA
TWI356705B (en) * 2007-10-25 2012-01-21 Internat Chlorella Co Ltd Extracts from chlorella sorokiniana
BRPI0820981A2 (pt) * 2007-12-13 2014-10-14 Glycos Biotechnologies Inc Conversão microbiana de óleos e ácidos graxos para substâncias químicas de valor elevado
US8287909B2 (en) * 2007-12-19 2012-10-16 Tepha, Inc. Medical devices containing melt-blown non-wovens of poly-4-hydroxybutyrate and copolymers thereof
KR20090078925A (ko) * 2008-01-16 2009-07-21 주식회사 엘지화학 폴리락테이트 또는 그 공중합체 생성능을 가지는 재조합미생물 및 이를 이용한 폴리락테이트 또는 그 공중합체의제조방법
US20130165967A1 (en) 2008-03-07 2013-06-27 W.L. Gore & Associates, Inc. Heart occlusion devices
US20090253154A1 (en) * 2008-04-02 2009-10-08 Immunosciences Lab., Inc. Blood and saliva test for detection of delayed food allergy and intolerance against modified foods
US8487159B2 (en) * 2008-04-28 2013-07-16 Metabolix, Inc. Production of polyhydroxybutyrate in switchgrass
BRPI0915749A2 (pt) * 2008-07-08 2018-07-10 Opx Biotechnologies Inc métodos, composições e sistemas para produção biossintética de 1,4-butanodiol
AU2009291825B2 (en) 2008-09-10 2016-05-05 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
MY183971A (en) 2008-12-12 2021-03-17 Metabolix Inc Green process and compositions for producing poly(5hv) and 5 carbon chemicals
WO2010092959A1 (ja) * 2009-02-10 2010-08-19 協和発酵バイオ株式会社 アミノ酸の製造法
BRPI1012685A2 (pt) 2009-03-05 2015-09-15 Metabolix Inc método para melhorar as características de uma planta, método para propagação de plantas transgênicas, método para supertransformação de plantas transgênicas, planta trasngênica produzida pelo método, semente da planta transgênica e matéria-prima de biorefinaria
ES2625623T3 (es) 2009-06-04 2017-07-20 Genomatica, Inc. Procedimiento de separación de componentes de un caldo de fermentación
EP4056706A1 (de) 2009-06-04 2022-09-14 Genomatica, Inc. Mikroorganismen zur herstellung von 1,4-butandiol und entsprechende verfahren
US8956389B2 (en) 2009-06-22 2015-02-17 W. L. Gore & Associates, Inc. Sealing device and delivery system
US20120029556A1 (en) 2009-06-22 2012-02-02 Masters Steven J Sealing device and delivery system
US20120165500A1 (en) 2009-08-27 2012-06-28 Newlight Technologies, Llc Process for the production of polyhydroxyalkanoates
EP2477477A1 (de) 2009-09-15 2012-07-25 Metabolix, Inc. Erzeugung von ölsamen zur hohen polyhydroxybuttersäureproduktion
CN105441374A (zh) * 2009-10-13 2016-03-30 基因组股份公司 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法
US20110125118A1 (en) * 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an Organic Acid and/or Related Chemicals
US8530210B2 (en) 2009-11-25 2013-09-10 Genomatica, Inc. Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
WO2011068952A1 (en) 2009-12-02 2011-06-09 Entrigue Surgical, Inc. Devices for tongue stabilization
CN102781901B (zh) 2010-02-11 2016-08-03 梅塔玻利克斯公司 用于从经遗传修饰的聚羟基链烷酸酯生物质制备单体组分的方法
US8445244B2 (en) 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
GB2478588A (en) * 2010-03-12 2011-09-14 G5 Internat Holdings Pte Ltd Microbial production of polyhydroxyalkanoates (PHAs) using culture medium containing hydrogen
DK2558133T3 (da) 2010-03-26 2020-04-06 Tepha Inc Coatinger til fremstillingen og anvendelse af polyhydroxyalkanoat-lægemiddelindretninger
CA2802212C (en) 2010-06-15 2015-03-24 Tepha, Inc. Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers
US9511169B2 (en) 2010-06-15 2016-12-06 Tepha, Inc. Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers with anisotropic properties
EP2425865A1 (de) 2010-08-06 2012-03-07 Aesculap AG Medizinisches Gewinde mit Polyhydroxyalkanoatbeschichtung
WO2012037324A2 (en) 2010-09-15 2012-03-22 Metabolix, Inc. Increasing carbon flow for polyhydroxybutyrate production in biomass crops
WO2012064526A1 (en) 2010-11-09 2012-05-18 Tepha, Inc. Drug eluting cochlear implants
US8956835B2 (en) 2010-11-24 2015-02-17 Suny Research Foundation Methods for producing polyhydroxyalkanoates from biodiesel-glycerol
WO2012103315A2 (en) 2011-01-27 2012-08-02 Osa Holdings, Inc. Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
WO2012122343A2 (en) 2011-03-08 2012-09-13 Newlight Technologies, Llc Polyhydroxyalkanoate production method
WO2012149162A2 (en) * 2011-04-29 2012-11-01 Metabolix, Inc. Green process for producing polyhydroxyalkanoates and chemicals using a renewable feedstock
ES2722748T3 (es) 2011-04-29 2019-08-16 Cj Cheiljedang Corp Procedimiento para la producción de látex por emulsificación mediante fusión
US20140114082A1 (en) 2011-06-08 2014-04-24 Metabolix, Inc. Biorefinery Process For THF Production
BR112014001662B8 (pt) 2011-07-29 2021-10-05 Mitsui Chemicals Inc Microrganismo produtor de acetil-coa, métodos para produzir acetil-coa, acetona, álcool isopropílicoe e glutamato
EP2742143A1 (de) 2011-08-10 2014-06-18 Metabolix, Inc. Postprozessreinigung zur herstellung von gamma-butyrolacton
US9770232B2 (en) 2011-08-12 2017-09-26 W. L. Gore & Associates, Inc. Heart occlusion devices
JP5995109B2 (ja) 2011-09-05 2016-09-21 国立研究開発法人理化学研究所 長主鎖構造を有するポリヒドロキシアルカン酸の製造方法
ES2659525T3 (es) 2011-09-27 2018-03-16 Tepha, Inc. Hidrólisis controlada de poli-4-hidroxibutirato y copolímeros
CA2852531C (en) 2011-10-25 2020-04-28 Marrone Bio Innovations, Inc. Chromobacterium formulations, compostions, metabolites and their uses
WO2013067432A1 (en) 2011-11-02 2013-05-10 Genomatica, Inc. Microorganisms and methods for the production of caprolactone
US12060597B2 (en) 2011-12-02 2024-08-13 Newlight Technologies, Inc. Polyhydroxyalkanoate production methods and systems for same
US9085784B1 (en) 2012-03-29 2015-07-21 Newlight Technologies, Llc Polyhydroxyalkanoate production methods and materials and microorganisms used in same
US20200347417A1 (en) 2012-03-29 2020-11-05 Newlight Technologies, Inc Polyhydroxyalkanoate production methods and materials and microorganisms used in same
HK1206787A1 (en) * 2012-04-11 2016-01-15 Helmholtz-Zentrum Fuer Infektionsforschung Gmbh Pha-producing genetically engineered
US20130309275A1 (en) 2012-05-21 2013-11-21 Tepha, Inc. Resorbable Bioceramic Compositions of Poly-4-Hydroxybutyrate and Copolymers
US11932845B2 (en) 2012-06-04 2024-03-19 Genomatica, Inc. Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
CN104350034B (zh) 2012-06-08 2018-07-31 Cj 第一制糖株式会社 可再生丙烯酸生产和自其制备的产物
WO2014028943A1 (en) 2012-08-17 2014-02-20 Metabolix, Inc. Biobased rubber modifiers for polymer blends
US20150240273A1 (en) 2012-10-10 2015-08-27 Metabolix, Inc. Polyhydroxyalkanoate copolymer compositions and methods of making the same
ES2774932T3 (es) 2012-11-14 2020-07-23 Cj Cheiljedang Corp Producción de sales de 4-hidroxibutirato utilizando materias primas de base biológica
EP2945655B1 (de) 2013-01-15 2019-09-25 Tepha, Inc. Implantate zur regeneration von weichem und hartem gewebe
US10828019B2 (en) 2013-01-18 2020-11-10 W.L. Gore & Associates, Inc. Sealing device and delivery system
CN104718292B (zh) 2013-01-24 2019-09-10 三井化学株式会社 导入了二氧化碳固定循环的微生物
US20150376152A1 (en) 2013-02-13 2015-12-31 Metabolix, Inc. Process for Ultra Pure Chemical Production from Biobased Raw Starting Materials
US10201640B2 (en) 2013-03-13 2019-02-12 Tepha, Inc. Ultrafine electrospun fibers of poly-4-hydroxybutyrate and copolymers thereof
US9687585B2 (en) 2013-08-20 2017-06-27 Tepha, Inc. Thermoformed poly-4-hydroxybutyrate medical implants
US10689498B2 (en) 2013-08-20 2020-06-23 Tepha, Inc. Closed cell foams including poly-4-hydroxybutyrate and copolymers thereof
US9302029B2 (en) 2013-10-31 2016-04-05 Tepha, Inc. Pultrusion of poly-4-hydroxybutyrate and copolymers thereof
CA2928731A1 (en) 2013-11-05 2015-05-14 Tepha, Inc. Compositions and devices of poly-4-hydroxybutyrate
WO2015094619A1 (en) 2013-12-19 2015-06-25 Tornier, Inc. High-strength bioabsorbable suture
CA2933746C (en) 2013-12-26 2018-12-04 Tepha, Inc. Medical implants including laminates of poly-4-hydroxybutyrate and copolymers thereof
EP3119930B1 (de) 2014-03-18 2018-06-13 Tepha, Inc. Micro-faserbahnen von poly-4-hydroxybutyrat und copolymere davon durch zentrifugenspinnen hergestellt
ES2911675T3 (es) 2014-04-30 2022-05-20 Tepha Inc Implantes tridimensionales reabsorbibles para el refuerzo de tejidos y la reparación de hernias
ES2674807T3 (es) 2014-05-16 2018-07-04 Tepha, Inc. Dispositivos médicos que contienen materiales no tejidos hilados en seco de poli-4-hidroxibutirato y copolímeros con propiedades anisótropas
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
CA2958747C (en) 2014-08-15 2022-08-16 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
WO2016028292A1 (en) 2014-08-20 2016-02-25 Tepha, Inc. Thermoformed poly-4-hydroxybutyrate medical implants
US10525172B2 (en) 2014-09-22 2020-01-07 Tepha, Inc. Oriented P4HB implants containing antimicrobial agents
CA2962920C (en) 2014-10-01 2023-03-14 Cryosa, Llc Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
US9555155B2 (en) 2014-12-11 2017-01-31 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
EP3365427B1 (de) 2015-10-23 2020-08-19 Metabolic Explorer Modifizierter mikroorganismus zur assimilierung von levulinsäure
EP3400100B1 (de) 2016-01-06 2020-09-23 Archer Daniels Midland Company Verfahren zur herstellung von 1,3-butandiol und zur optionalen weiteren herstellung von (r)-3-hydroxybutyl (r)-3-hydroxybutyrat
KR101774431B1 (ko) 2016-01-28 2017-09-05 한국과학기술원 자일로즈로부터 폴리(락테이트-co-글라이콜레이트) 또는 그 공중합체 생산능을 가지는 재조합 미생물 및 이를 이용한 폴리(락테이트-co-글라이콜레이트) 또는 그 공중합체의 제조방법
US11040170B2 (en) 2017-05-25 2021-06-22 Tepha, Inc. Continuous formation of tubes of poly-4-hydroxybutyrate and copolymers thereof
CN109112151B (zh) * 2017-06-23 2021-10-29 北京蓝晶微生物科技有限公司 一种精细调控共聚物中4-羟基丁酸组成比例的基因盒及其应用
CA3074733C (en) 2017-09-06 2022-06-21 Tepha, Inc. Calendered surgical meshes comprising polyhydroxyalkanoates
WO2019112925A1 (en) 2017-12-04 2019-06-13 Tepha, Inc. Vacuum membrane thermoformed poly-4-hydroxybutyrate medical implants
EP3802062B1 (de) 2018-06-11 2024-09-18 Tepha, Inc. Verfahren zum 3d-drucken von poly-4-hydroxybutyrat
ES2956815T3 (es) 2018-10-29 2023-12-28 Tepha Inc Procedimientos de fabricación de suturas de malla a partir de poli-4-hidroxibutirato y sus copolímeros
AU2019419502A1 (en) 2018-12-31 2021-07-22 Cryosa Inc. Systems and methods for treatment of obstructive sleep apnea
TWI827804B (zh) * 2019-03-06 2024-01-01 日商三菱商事生命科學股份有限公司 蕈菌絲體之製造方法、含有蕈菌絲體的組成物、以及使用了蕈菌絲體之食品材料
WO2020251932A1 (en) 2019-06-10 2020-12-17 Yield10 Bioscience, Inc. Transgenic land plants that express a polyhydroxyalkanoate synthase seed specifically with cytosolic localization
US12551259B2 (en) 2020-02-19 2026-02-17 Cryosa, Inc. Systems and methods for treatment of obstructive sleep apnea
FR3109290B1 (fr) 2020-04-17 2025-04-11 Ph Tech Dispositif médical comprenant une matrice biologique acellulaire et au moins un polymère
FR3110077B1 (fr) 2020-05-12 2024-12-06 Ph Tech Procédé de fabrication d’un dispositif médical en trois dimensions et dispositif médical obtenu
FR3113371A1 (fr) 2020-08-12 2022-02-18 Ph Tech Dispositif médical comprenant un assemblage d’éléments de matrices biologiques acellulaires et au moins un polymère
JP2024510182A (ja) 2021-03-11 2024-03-06 テファ， インコーポレイテッド 乳房再建インプラント
CN113832084B (zh) * 2021-09-29 2024-01-05 北京化工大学 一种生产聚羟基脂肪酸酯的溶藻弧菌及其应用
CA3243280A1 (en) 2021-12-30 2023-07-06 Cryosa, Inc. SYSTEMS AND METHODS FOR THE TREATMENT OF OBSTRUCTIVE SLEEP APNEA
KR20250108103A (ko) * 2022-09-30 2025-07-15 킴벌리-클라크 월드와이드, 인크. 특정 사슬 길이 폴리(하이드록시알카노에이트) 단량체의 시험관 내 생합성
FR3165166A1 (fr) 2024-08-05 2026-02-06 Ph Tech Utilisation de l’Éther de dipropylène glycol monométhylique pour purifier un biomatériau

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS575693A (en) 1980-06-13 1982-01-12 Ajinomoto Co Inc Production of l-arginine through fermentation process
IE50442B1 (en) * 1980-11-21 1986-04-16 Loctite Corp Two part adhesive composition
US5250430A (en) 1987-06-29 1993-10-05 Massachusetts Institute Of Technology Polyhydroxyalkanoate polymerase
US5245023A (en) 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US4876331A (en) 1987-08-18 1989-10-24 Mitsubishi Kasei Corporation Copolyester and process for producing the same
US4876831A (en) * 1988-03-14 1989-10-31 Runyon John F Folding modular building structure
US5004664A (en) 1989-02-27 1991-04-02 Xerox Corporation Toner and developer compositions containing biodegradable semicrystalline polyesters
US5371002A (en) 1989-06-07 1994-12-06 James Madison University Method of production of poly-beta-hydroxyalkanoate copolymers
ATE227340T1 (de) 1989-07-10 2002-11-15 Massachusetts Inst Technology Eine zur herstellung von polyhydroxybutyrat oder einem anderen polyhydroxyalkanoat geeignete pflanze oder pflanzliche zelle
IE893328A1 (en) 1989-10-16 1991-04-24 Mcdaid Denis Telephone lock
GB9108756D0 (en) 1991-04-24 1991-06-12 Ici Plc Production of polyalkanoate in plants
EP0522422A3 (en) 1991-07-01 1993-03-17 Mitsubishi Kasei Corporation Process for producing a biodegradable polymer
GB9115245D0 (en) 1991-07-16 1991-08-28 Ici Plc Production of polyalkanoate
WO1993002187A1 (en) 1991-07-19 1993-02-04 Michigan State University Transgenic plants producing polyhydroxyalkanoates
US5610041A (en) 1991-07-19 1997-03-11 Board Of Trustees Operating Michigan State University Processes for producing polyhydroxybutyrate and related polyhydroxyalkanoates in the plastids of higher plants
PH30131A (en) 1991-08-07 1997-01-21 Ajinomoto Kk Process for producing l-glutamic acid by fermentation
JP2777757B2 (ja) 1991-09-17 1998-07-23 鐘淵化学工業株式会社 共重合体およびその製造方法
GB9223332D0 (en) * 1992-11-06 1992-12-23 Ici Plc Production of polyhydroxyalkanoate in plants
AU5676394A (en) 1992-11-20 1994-06-22 Agracetus, Inc. Transgenic cotton plants producing heterologous bioplastic
JP3263710B2 (ja) 1992-12-11 2002-03-11 高砂香料工業株式会社 生分解性光学活性ポリマー及びその製造方法
IL108947A0 (en) 1993-03-12 1994-06-24 Osteopharm Ltd Bone stimulating factor
US6849427B1 (en) 1993-03-12 2005-02-01 Immulogic Pharmaceutical Corp. Nucleic acids encoding a house dust mite allergen, Der p VII, and uses therefor
JP3241505B2 (ja) 1993-08-11 2001-12-25 高砂香料工業株式会社 生分解性光学活性コポリマー及びその製造方法
CZ221196A3 (en) 1994-01-28 1997-01-15 Procter & Gamble Biologically degradable copolymer and plastic parts, which contain biologically degradable copolymers of 3-hydroxyhexanoate
ID23491A (id) 1994-01-28 1995-09-07 Procter & Gamble Kopolimer-kopolimer yang dapat dibiodegradasi dan baha-bahan plastik yang terdiri dari kopolimer-kopolimer yang dapat dibiodegradasi
CA2125313A1 (en) * 1994-06-07 1995-12-08 Gerald E. O'grady Method and apparatus for producing electrical energy within the body of a ruminant
US5563239A (en) 1994-11-09 1996-10-08 Eastman Chemical Company Composition and process for the production of poly(3-hydroxyalkanoates)
BE1008983A6 (fr) 1994-12-30 1996-10-01 Faco Sa Bigoudi.
US5763270A (en) 1995-06-07 1998-06-09 Genemedicine, Inc. Plasmid for delivery of nucleic acids to cells and methods of use
GB9602796D0 (en) 1996-02-12 1996-04-10 Innes John Centre Innov Ltd Genetic control of plant growth and development
US6117658A (en) * 1997-02-13 2000-09-12 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units

Also Published As

Publication number Publication date
AU725516B2 (en) 2000-10-12
JP2009082147A (ja) 2009-04-23
JP2003310262A (ja) 2003-11-05
US7229804B2 (en) 2007-06-12
AU9496898A (en) 1999-04-05
US20060084155A1 (en) 2006-04-20
WO1999014313A2 (en) 1999-03-25
DE69838768T2 (de) 2008-10-30
US20040137586A1 (en) 2004-07-15
CA2303070A1 (en) 1999-03-25
US6689589B2 (en) 2004-02-10
EP1015565A2 (de) 2000-07-05
US6316262B1 (en) 2001-11-13
DE69838768D1 (de) 2008-01-03
WO1999014313A3 (en) 1999-06-03
CA2303070C (en) 2011-03-15
JP2001516574A (ja) 2001-10-02
DE69834199T2 (de) 2006-12-14
EP1015565B1 (de) 2006-04-12
US20020187530A1 (en) 2002-12-12
JP2009171960A (ja) 2009-08-06
US20110008856A1 (en) 2011-01-13
US20100093043A1 (en) 2010-04-15
DE69834199D1 (de) 2006-05-24
US7081357B2 (en) 2006-07-25

Similar Documents

Publication Publication Date Title
ATE323152T1 (de) Biologische systeme zur herstellung von polyhydroxyalkanoate polymeren die 4-hydroxysäure enthalten
RU2459871C2 (ru) Способ ферментативного получения 2-гидрокси-2-метилкарбоновых кислот
RU2003121547A (ru) Способ продукции целевого вещества путем ферментации
ATE385521T1 (de) Herstellung von polyhydroxyalkanoaten aus polyolen
CA2203264A1 (en) Process for producing polyhydroxylic fatty acids and recombinant bacterial strains for carrying out the process
ATE386121T1 (de) Verfahren zur herstellung von l-threonin durch enterobakteriaceae-stämmen mit verstärkter exprimierung des phoe-gens
EA018463B1 (ru) ПОЛУЧЕНИЕ ДИКАРБОНОВЫХ КИСЛОТ ПРИ НИЗКИХ pH
UA80976C2 (en) Processes and materials for production of d-lactic acid in yeast
DE60120619D1 (de) Verfahren zur Herstellung einer Zielsubstanz durch Fermentation
RU2006125499A (ru) Генные варианты, которые кодируют протеины метаболического пути химических веществ высокой степени чистоты
Xiao et al. Advances in Aureobasidium research: Paving the path to industrial utilization
JP2007074939A5 (de)
AU2002333878A1 (en) A process for the production of l-amino acids using strains of the enterobacteriaceae family which contain an enhanced fadr or iclr gene
DK1136559T3 (da) Nukleotidsekvenser, der koder for dapC-genet, og fremgangsmåde til fremstilling af L-lysin
CN104870645A (zh) 丁二醇的制造方法
JP2006238843A (ja) コハク酸の製造方法、コハク酸、生分解性プラスチックの製造方法および生分解性プラスチック
RU2004134579A (ru) Способ выделения поли-3-гидроксиалкановой кислоты
EP3279327B1 (de) Neuartiger promoter und verwendung davon
ATE171215T1 (de) Xyloseisomerase-gen von thermus aquaticus, xyloseisomerase und verfahren zur herstellung von fructose
ES8506094A1 (es) Un procedimiento para producir l-isoleucina
JP6778870B2 (ja) 藍藻変異株及びそれを用いたコハク酸及びｄ−乳酸産生方法
Koch et al. Cyanobacterial biopolymers
EP0863209A2 (de) Polyhydroxyalkanoat Depolymerase und Verfahren zu deren Herstellung
Dias et al. Synthesis of Polyhydroxyalkanoates by Halophilic Bacteria and Archaea
Abdelnabi Isolation and Study of Purple Non‐Sulfur Bacteria from Fuel Synthesis Wastewater Culture to Understand and Improve Their Polyhydroxyalkanoate Production

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties