ATE323549T2 - Verfahren zur herstellung von nano- und mikro- teilchen - Google Patents
Verfahren zur herstellung von nano- und mikro- teilchen Download PDFInfo
- Publication number
- ATE323549T2 ATE323549T2 AT01970064T AT01970064T ATE323549T2 AT E323549 T2 ATE323549 T2 AT E323549T2 AT 01970064 T AT01970064 T AT 01970064T AT 01970064 T AT01970064 T AT 01970064T AT E323549 T2 ATE323549 T2 AT E323549T2
- Authority
- AT
- Austria
- Prior art keywords
- carbon dioxide
- solubilizing
- supercritical
- micronic
- conditions
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000011859 microparticle Substances 0.000 title 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 6
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 3
- 239000001569 carbon dioxide Substances 0.000 abstract 3
- 239000007788 liquid Substances 0.000 abstract 3
- 238000000889 atomisation Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000003381 solubilizing effect Effects 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH12092001 | 2001-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE323549T2 true ATE323549T2 (de) | 2006-05-15 |
Family
ID=4563123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01970064T ATE323549T2 (de) | 2001-07-02 | 2001-09-27 | Verfahren zur herstellung von nano- und mikro- teilchen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7276190B2 (de) |
| EP (1) | EP1401563B2 (de) |
| AT (1) | ATE323549T2 (de) |
| DE (1) | DE60118983T3 (de) |
| DK (1) | DK1401563T4 (de) |
| ES (1) | ES2261469T5 (de) |
| PT (1) | PT1401563E (de) |
| WO (1) | WO2003004142A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7767249B2 (en) * | 2001-06-07 | 2010-08-03 | Hewlett-Packard Development Company, L.P. | Preparation of nanoparticles |
| US8030194B2 (en) * | 2004-09-27 | 2011-10-04 | Technion Research And Development Foundation Ltd. | Spray method for producing semiconductor nano-particles |
| WO2006062980A2 (en) * | 2004-12-07 | 2006-06-15 | Nektar Therapeutics | Stable non-crystalline formulation comprising tiagabine |
| AU2006272438B2 (en) | 2005-07-15 | 2011-08-04 | Map Pharmaceuticals, Inc. | Method of particle formation |
| US20070023035A1 (en) * | 2005-07-29 | 2007-02-01 | Kane Kevin M | Method for processing drugs |
| US20080223136A1 (en) * | 2005-08-04 | 2008-09-18 | Tokyo Electron Limited | Minute structure inspection device, inspection method, and inspection program |
| WO2007028421A1 (en) * | 2005-09-09 | 2007-03-15 | Universita' Degli Studi Di Padova | Process for the production of nano-particles |
| US20070128291A1 (en) * | 2005-12-07 | 2007-06-07 | Tokie Jeffrey H | Method and Apparatus for Forming Chromonic Nanoparticles |
| WO2008058054A2 (en) * | 2006-11-06 | 2008-05-15 | Novartis Ag | Method for making parenteral pharmaceutical compositions in a unit dose container |
| CN100444943C (zh) * | 2007-02-14 | 2008-12-24 | 浙江大学 | 水力空化增强超临界辅助雾化制备微粒的系统及其方法 |
| RU2356609C1 (ru) * | 2008-02-07 | 2009-05-27 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт органической химии и технологии", ФГУП "ГосНИИОХТ" | Способ получения нано- и микрочастиц водорастворимых веществ с использованием сверхкритического диоксида углерода |
| US9291139B2 (en) | 2008-08-27 | 2016-03-22 | Woodward, Inc. | Dual action fuel injection nozzle |
| EP2181604A1 (de) | 2008-11-04 | 2010-05-05 | Feyecon Development & Implementation B.V. | Dispersionsstrukturierungsmittel |
| ES2342140B1 (es) * | 2008-12-30 | 2011-05-17 | Consejo Superior Investigacion | Procedimiento para la obtencion de micro- o nanoparticulas solidas |
| EP2579973A4 (de) * | 2010-06-14 | 2017-01-18 | Xspray Microparticles Ab | Vorrichtung und verfahren zur herstellung von partikeln |
| EP3302423B1 (de) | 2015-06-04 | 2022-05-25 | Crititech, Inc. | Partikelproduktionssystem und partikelsammelvorrichtung |
| WO2017176628A1 (en) | 2016-04-04 | 2017-10-12 | Crititech, Inc. | Methods for solid tumor treatment |
| BR112019023948A2 (pt) | 2017-06-09 | 2020-06-09 | Crititech Inc | tratamento de cistos epiteliais por injeção intracística de partículas antineoplásicas |
| EP3615004B1 (de) | 2017-06-14 | 2025-02-19 | Crititech, Inc. | Verfahren zur behandlung von lungenerkrankungen |
| JP7792750B2 (ja) | 2017-10-03 | 2025-12-26 | クリティテック・インコーポレイテッド | 癌の治療のための免疫療法剤の全身送達と組み合わせた抗腫瘍粒子の局所送達 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4348422A (en) * | 1978-02-13 | 1982-09-07 | Studiengesellschaft Kohle M.B.H. | Process for the direct decaffeination of aqueous coffee extract solutions |
| DE3937287A1 (de) * | 1989-11-09 | 1991-05-16 | Henkel Kgaa | Verfahren und anlage zum abtrennen von fettsaeuremonoglycerid |
| US20020018815A1 (en) * | 1992-03-06 | 2002-02-14 | Sievers Robert E. | Methods and apparatus for fine particle formation |
| GB9313642D0 (en) * | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
| SI9400079B (sl) * | 1994-02-15 | 2003-02-28 | Dr. Weidner Eckhard, Dipl. Ing. | Postopek in naprava za pridobivanje in frakcioniranje majhnih delcev iz raztopin nasičenih s plinom |
| US5874029A (en) * | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
| WO1997031691A1 (en) * | 1996-03-01 | 1997-09-04 | The University Of Kansas | Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents |
| US6221153B1 (en) * | 1998-06-09 | 2001-04-24 | Trevor Percival Castor | Method for producing large crystals of complex molecules |
| SE9804000D0 (sv) * | 1998-11-23 | 1998-11-23 | Astra Ab | New composition of matter |
| GB9828204D0 (en) | 1998-12-21 | 1999-02-17 | Smithkline Beecham Plc | Process |
| ES2170008B1 (es) | 2000-08-25 | 2003-05-01 | Soc Es Carburos Metalicos Sa | Procedimiento para la precipitacion de particulas solidas finamente divididas. |
-
2001
- 2001-09-27 ES ES01970064.0T patent/ES2261469T5/es not_active Expired - Lifetime
- 2001-09-27 US US10/482,640 patent/US7276190B2/en not_active Expired - Fee Related
- 2001-09-27 DK DK01970064.0T patent/DK1401563T4/en active
- 2001-09-27 PT PT01970064T patent/PT1401563E/pt unknown
- 2001-09-27 WO PCT/IB2001/001780 patent/WO2003004142A1/en not_active Ceased
- 2001-09-27 AT AT01970064T patent/ATE323549T2/de active
- 2001-09-27 EP EP01970064.0A patent/EP1401563B2/de not_active Expired - Lifetime
- 2001-09-27 DE DE60118983.3T patent/DE60118983T3/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PT1401563E (pt) | 2006-08-31 |
| EP1401563B1 (de) | 2006-04-19 |
| DK1401563T4 (en) | 2016-01-11 |
| US20040178529A1 (en) | 2004-09-16 |
| EP1401563A1 (de) | 2004-03-31 |
| US7276190B2 (en) | 2007-10-02 |
| DE60118983T2 (de) | 2007-01-11 |
| ES2261469T5 (es) | 2015-12-22 |
| DE60118983T3 (de) | 2016-07-07 |
| DE60118983D1 (de) | 2006-05-24 |
| WO2003004142A1 (en) | 2003-01-16 |
| DK1401563T3 (da) | 2006-08-14 |
| EP1401563B2 (de) | 2015-09-16 |
| ES2261469T3 (es) | 2006-11-16 |
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| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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