ATE323677T1 - Verfahren zur herstellung von 4-amino-2,5- bisheterocyclylchinazolinen - Google Patents

Verfahren zur herstellung von 4-amino-2,5- bisheterocyclylchinazolinen

Info

Publication number
ATE323677T1
ATE323677T1 AT02745749T AT02745749T ATE323677T1 AT E323677 T1 ATE323677 T1 AT E323677T1 AT 02745749 T AT02745749 T AT 02745749T AT 02745749 T AT02745749 T AT 02745749T AT E323677 T1 ATE323677 T1 AT E323677T1
Authority
AT
Austria
Prior art keywords
bisheterocyclylchinazolines
amino
producing
Prior art date
Application number
AT02745749T
Other languages
English (en)
Inventor
Lee Terence Boulton
Robert James Crook
Alan John Pettman
Robert Walton
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE323677T1 publication Critical patent/ATE323677T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT02745749T 2001-08-01 2002-07-19 Verfahren zur herstellung von 4-amino-2,5- bisheterocyclylchinazolinen ATE323677T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0118752.5A GB0118752D0 (en) 2001-08-01 2001-08-01 Process for the production of quinazolines

Publications (1)

Publication Number Publication Date
ATE323677T1 true ATE323677T1 (de) 2006-05-15

Family

ID=9919612

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02745749T ATE323677T1 (de) 2001-08-01 2002-07-19 Verfahren zur herstellung von 4-amino-2,5- bisheterocyclylchinazolinen

Country Status (27)

Country Link
US (1) US7026479B2 (de)
EP (1) EP1412331B1 (de)
JP (1) JP2005501054A (de)
KR (1) KR20040019097A (de)
CN (1) CN1533378A (de)
AP (1) AP1299A (de)
AR (1) AR036204A1 (de)
AT (1) ATE323677T1 (de)
BR (1) BR0211670A (de)
CA (1) CA2451075A1 (de)
CZ (1) CZ2004151A3 (de)
DE (1) DE60210778T2 (de)
DO (1) DOP2002000443A (de)
EG (1) EG23204A (de)
ES (1) ES2260457T3 (de)
GB (1) GB0118752D0 (de)
HN (1) HN2002000197A (de)
HU (1) HUP0401573A3 (de)
IL (1) IL158998A0 (de)
MX (1) MXPA04000978A (de)
PA (1) PA8550301A1 (de)
PE (1) PE20030346A1 (de)
PL (1) PL368520A1 (de)
RU (1) RU2261861C1 (de)
UY (1) UY27399A1 (de)
WO (1) WO2003011829A1 (de)
ZA (1) ZA200309043B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1521747B1 (de) 2002-07-15 2018-09-05 Symphony Evolution, Inc. Modulatoren von rezeptor-typ-kinase und anwendungsverfahren
EP2210607B1 (de) * 2003-09-26 2011-08-17 Exelixis Inc. N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamid zur Behandlung von Krebs
HRP20110958T1 (hr) * 2004-05-06 2012-01-31 Warner-Lambert Company Llc 4-fenilaminokinazolin-6-ilamidi
TW200823215A (en) * 2006-08-04 2008-06-01 Merz Pharma Gmbh & Amp Co Kgaa Pyrazolopyrimidines, a process for their preparation and the use as a medicine
TW201920110A (zh) 2009-01-16 2019-06-01 美商艾克塞里克斯公司 包含n-(4-{[6,7-雙(甲氧基)喹啉-4-基]氧基}苯基)-n'-(4-氟苯基)環丙烷-1,1-二甲醯胺之蘋果酸鹽之醫藥組合物及其用途
NZ617779A (en) 2009-03-18 2015-08-28 Resverlogix Corp Novel anti-inflammatory agents
IN2012DN00352A (de) * 2009-06-16 2015-08-21 Bikam Pharmaceuticals Inc
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
CA2862807A1 (en) * 2011-11-30 2013-06-06 Bikam Pharmaceuticals, Inc. Opsin-binding ligands, compositions and methods of use
ES2658221T3 (es) * 2012-10-15 2018-03-08 Resverlogix Corp. Compuestos útiles en la síntesis de compuestos de benzamida
CN114984016A (zh) 2015-03-13 2022-09-02 雷斯韦洛吉克斯公司 用于治疗补体相关疾病之组合物及治疗方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8719378D0 (en) * 1987-08-15 1987-09-23 Pfizer Ltd Antiarrythmic agents
US6069149A (en) * 1997-01-09 2000-05-30 Terumo Kabushiki Kaisha Amide derivatives and intermediates for the synthesis thereof
GB9700504D0 (en) * 1997-01-11 1997-02-26 Pfizer Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
PE20030346A1 (es) 2003-04-05
ZA200309043B (en) 2004-11-22
HN2002000197A (es) 2003-02-27
EP1412331B1 (de) 2006-04-19
UY27399A1 (es) 2003-02-28
ES2260457T3 (es) 2006-11-01
HUP0401573A2 (hu) 2005-01-28
BR0211670A (pt) 2004-07-13
DOP2002000443A (es) 2003-02-15
US20030100753A1 (en) 2003-05-29
DE60210778T2 (de) 2007-01-04
AR036204A1 (es) 2004-08-18
CN1533378A (zh) 2004-09-29
PL368520A1 (en) 2005-04-04
KR20040019097A (ko) 2004-03-04
HUP0401573A3 (en) 2005-06-28
PA8550301A1 (es) 2003-09-05
WO2003011829A1 (en) 2003-02-13
GB0118752D0 (en) 2001-09-26
IL158998A0 (en) 2004-05-12
US7026479B2 (en) 2006-04-11
RU2004102692A (ru) 2005-07-10
AP1299A (en) 2004-09-06
MXPA04000978A (es) 2004-04-20
EP1412331A1 (de) 2004-04-28
JP2005501054A (ja) 2005-01-13
RU2261861C1 (ru) 2005-10-10
AP2002002602A0 (en) 2002-09-30
EG23204A (en) 2004-07-31
CA2451075A1 (en) 2003-02-13
DE60210778D1 (de) 2006-05-24
CZ2004151A3 (cs) 2005-01-12

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties