ATE453648T1 - Verfahren zur herstellung von hexahydrofuroc2,3- büfuran-3-ol - Google Patents

Verfahren zur herstellung von hexahydrofuroc2,3- büfuran-3-ol

Info

Publication number
ATE453648T1
ATE453648T1 AT02797968T AT02797968T ATE453648T1 AT E453648 T1 ATE453648 T1 AT E453648T1 AT 02797968 T AT02797968 T AT 02797968T AT 02797968 T AT02797968 T AT 02797968T AT E453648 T1 ATE453648 T1 AT E453648T1
Authority
AT
Austria
Prior art keywords
bufuran
producing
Prior art date
Application number
AT02797968T
Other languages
English (en)
Inventor
Bart Kesteleyn
Dominique Surleraux
Peter J L M Quaedflieg
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8180908&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE453648(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of ATE453648T1 publication Critical patent/ATE453648T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT02797968T 2001-09-10 2002-09-06 Verfahren zur herstellung von hexahydrofuroc2,3- büfuran-3-ol ATE453648T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01203416 2001-09-10
PCT/EP2002/010062 WO2003022853A1 (en) 2001-09-10 2002-09-06 Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol

Publications (1)

Publication Number Publication Date
ATE453648T1 true ATE453648T1 (de) 2010-01-15

Family

ID=8180908

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02797968T ATE453648T1 (de) 2001-09-10 2002-09-06 Verfahren zur herstellung von hexahydrofuroc2,3- büfuran-3-ol

Country Status (27)

Country Link
US (1) US7126015B2 (de)
EP (1) EP1448567B1 (de)
JP (1) JP4521185B2 (de)
KR (1) KR100894673B1 (de)
CN (2) CN100519561C (de)
AP (1) AP1758A (de)
AR (1) AR036501A1 (de)
AT (1) ATE453648T1 (de)
AU (1) AU2002333809C1 (de)
BR (1) BRPI0212341B8 (de)
CA (1) CA2459168C (de)
CY (1) CY1109974T1 (de)
DE (1) DE60234952D1 (de)
DK (1) DK1448567T3 (de)
EA (1) EA010883B1 (de)
ES (1) ES2338538T3 (de)
HR (1) HRP20040320B1 (de)
HU (1) HU229505B1 (de)
IL (2) IL160166A0 (de)
MX (1) MXPA04002247A (de)
NO (1) NO328934B1 (de)
NZ (1) NZ531641A (de)
PL (1) PL224030B1 (de)
PT (1) PT1448567E (de)
SI (1) SI21463B (de)
WO (1) WO2003022853A1 (de)
ZA (1) ZA200401501B (de)

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DE60308695T2 (de) * 2002-06-27 2007-08-16 Smithkline Beecham Corp. Herstellung von Stereoisomeren von (3Alpha,3alpha/beta,6alpha/beta) hexahydrofuro[2,3-b]furan-3-ol
EP1589018A4 (de) * 2002-12-27 2007-03-14 Sumitomo Chemical Co Herstellungsverfahren für hexahydrofurofuranol-derivate, zwischenprodukt davon und herstellungsverfahren dafür
JP4818124B2 (ja) 2003-12-23 2011-11-16 テイボテク・フアーマシユーチカルズ・リミテツド （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法
TWI383975B (zh) * 2004-03-31 2013-02-01 悌柏泰克醫藥有限公司 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法
JP5549898B2 (ja) * 2006-03-31 2014-07-16 独立行政法人産業技術総合研究所 ５−ヒドロキシメチル−２−フルフラールの製造法
CN102432621B (zh) * 2006-11-09 2016-02-17 爱尔兰詹森科学公司 六氢呋喃并[2,3-b]呋喃-3-醇的制备方法
CN101024646B (zh) * 2007-02-06 2010-07-14 启东东岳药业有限公司 4-甲氧基呋喃并呋喃-2-酮的纯化方法
WO2008132154A1 (en) 2007-04-27 2008-11-06 Tibotec Pharmaceuticals Ltd. Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives
US8592487B2 (en) 2007-10-26 2013-11-26 Concert Pharmaceuticals, Inc. Deuterated darunavir
TWI482775B (zh) 2008-09-01 2015-05-01 Tibotec Pharm Ltd 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法
WO2010047819A1 (en) * 2008-10-24 2010-04-29 Concert Pharmaceuticals, Inc. Hydroxyethylamino sulfonamide derivatives
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
WO2011051978A2 (en) 2009-10-30 2011-05-05 Lupin Limited A novel process for preparation of darunavir and darunavir ethanolate of fine particle size
EP2528923B1 (de) 2010-01-28 2014-07-30 Mapi Pharma Limited Verfahren zur herstellung von darunavir und darunavir-zwischenprodukten
US8841467B2 (en) 2010-11-23 2014-09-23 Mylan Laboratories Limited Process for the preparation of (3R, 3aS, 6aR)-hexahydrofuro [2, 3-b] furan-3-ol
WO2012075122A2 (en) * 2010-11-30 2012-06-07 Purdue Research Foundation Processes and intermediates for preparing substituted hexahydrofuro [2,3-b] furans
EP3795572B1 (de) 2012-07-24 2023-11-15 Laurus Labs Limited Solvat von darunavirpropionate
JPWO2014024898A1 (ja) * 2012-08-09 2016-07-25 住友化学株式会社 ヘキサヒドロフロフラノール誘導体の製造方法
CN103864813B (zh) * 2012-12-18 2017-02-22 上海迪赛诺化学制药有限公司 一种合成六氢呋喃并[2,3‑b]呋喃‑3‑醇及其对映体的方法
US10633390B2 (en) * 2015-06-25 2020-04-28 Msn Laboratories Private Limited Process for the preparation of [(1S,2R)-3-[[(4-aminophenyl)sulfonyl] (2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-carbamic acid (3R,3AS,6AR)hexahydro furo [2,3-B]furan-3-YL ester and its amorphous form
WO2017041228A1 (zh) * 2015-09-08 2017-03-16 浙江九洲药业股份有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
CN107043385B (zh) * 2016-02-05 2019-07-09 成都博腾药业有限公司 一种制备地瑞那韦中间体的方法
ES2881949T3 (es) 2016-10-27 2021-11-30 Gilead Sciences Inc Forma cristalina de base libre de darunavir
CN106928248B (zh) * 2017-02-04 2019-01-04 青岛科技大学 一种制备(3R,3aS,6aR)六氢呋喃并[2,3-b]呋喃-3-醇的方法
CN116103348A (zh) 2018-03-16 2023-05-12 江苏瑞科医药科技有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
US20240043438A1 (en) * 2020-08-11 2024-02-08 Arun K. Ghosh Methods for making darunavir p2-ligand precursors
CN114853774A (zh) * 2022-06-24 2022-08-05 盐城迪赛诺制药有限公司 一种达卢那韦关键中间体的制备方法
CN115557964A (zh) * 2022-10-18 2023-01-03 启东东岳药业有限公司 一种药物化合物的制备方法
CN117186053A (zh) * 2023-09-08 2023-12-08 上海凌凯医药科技有限公司 一种莱克酮中间体的制备方法

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SK285019B6 (sk) * 1997-01-30 2006-04-06 Novartis Ag Tvrdá želatínová tobolka
AU4828199A (en) * 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
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PL204924B1 (pl) 1999-10-06 2010-02-26 Tibotec Pharm Ltd Heksahydrofuro [2,3-b] furanylo-3-N-{3(1,3-benzodioksolilo-5-sulfonylo) (izobutylo) amino] -1-benzylo-2-hydroksypropylo} karbaminian oraz jego zastosowanie

Also Published As

Publication number Publication date
CN101172980A (zh) 2008-05-07
PL367817A1 (en) 2005-03-07
SI21463B (sl) 2011-08-31
CA2459168C (en) 2014-01-28
AP2004002981A0 (en) 2004-03-31
MXPA04002247A (es) 2005-09-07
US20040249175A1 (en) 2004-12-09
EA010883B1 (ru) 2008-12-30
HRP20040320A2 (en) 2005-04-30
AR036501A1 (es) 2004-09-15
PT1448567E (pt) 2010-03-12
EP1448567B1 (de) 2009-12-30
IL160166A (en) 2012-05-31
SI21463A (sl) 2004-10-31
NZ531641A (en) 2005-08-26
WO2003022853A1 (en) 2003-03-20
JP4521185B2 (ja) 2010-08-11
EP1448567A1 (de) 2004-08-25
KR20040029425A (ko) 2004-04-06
AU2002333809B2 (en) 2008-02-28
PL224030B1 (pl) 2016-11-30
KR100894673B1 (ko) 2009-04-24
AU2002333809B8 (en) 2008-07-03
CA2459168A1 (en) 2003-03-20
CN1553915A (zh) 2004-12-08
IL160166A0 (en) 2004-07-25
DE60234952D1 (de) 2010-02-11
ZA200401501B (en) 2005-07-27
AU2002333809B9 (en) 2008-06-26
AP1758A (en) 2007-07-30
AU2002333809C1 (en) 2009-02-05
ES2338538T3 (es) 2010-05-10
NO328934B1 (no) 2010-06-21
HU229505B1 (hu) 2014-01-28
EA200400430A1 (ru) 2004-08-26
HUP0402140A3 (en) 2007-05-29
BRPI0212341B8 (pt) 2021-05-25
US7126015B2 (en) 2006-10-24
CN100519561C (zh) 2009-07-29
HUP0402140A2 (hu) 2005-02-28
HK1068887A1 (en) 2005-05-06
CN101172980B (zh) 2011-11-16
BRPI0212341B1 (pt) 2019-04-02
HRP20040320B1 (hr) 2012-11-30
DK1448567T3 (da) 2010-04-26
CY1109974T1 (el) 2014-09-10
NO20041434L (no) 2004-06-10
JP2005502707A (ja) 2005-01-27
BR0212341A (pt) 2004-07-27

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