ATE323683T1 - Verfahren zur herstellung von 1-(carboxymethyl)- und 1(aminocarbonyl)-pyrimidin-4-on derivaten - Google Patents

Verfahren zur herstellung von 1-(carboxymethyl)- und 1(aminocarbonyl)-pyrimidin-4-on derivaten

Info

Publication number
ATE323683T1
ATE323683T1 AT02794787T AT02794787T ATE323683T1 AT E323683 T1 ATE323683 T1 AT E323683T1 AT 02794787 T AT02794787 T AT 02794787T AT 02794787 T AT02794787 T AT 02794787T AT E323683 T1 ATE323683 T1 AT E323683T1
Authority
AT
Austria
Prior art keywords
aminocarbonyl
pyrimidin
carboxymethyl
derivatives
producing
Prior art date
Application number
AT02794787T
Other languages
English (en)
Inventor
Keith Raymond Mulholland
Andrew R Ross
Graham Ralph Slater
Gillian Elizabeth Smith
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of ATE323683T1 publication Critical patent/ATE323683T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT02794787T 2001-08-14 2002-08-13 Verfahren zur herstellung von 1-(carboxymethyl)- und 1(aminocarbonyl)-pyrimidin-4-on derivaten ATE323683T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0119795.3A GB0119795D0 (en) 2001-08-14 2001-08-14 Novel process

Publications (1)

Publication Number Publication Date
ATE323683T1 true ATE323683T1 (de) 2006-05-15

Family

ID=9920363

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02794787T ATE323683T1 (de) 2001-08-14 2002-08-13 Verfahren zur herstellung von 1-(carboxymethyl)- und 1(aminocarbonyl)-pyrimidin-4-on derivaten

Country Status (13)

Country Link
US (1) US7232902B2 (de)
EP (1) EP1456183B1 (de)
JP (1) JP4386723B2 (de)
AR (1) AR035111A1 (de)
AT (1) ATE323683T1 (de)
AU (1) AU2002333415A1 (de)
DE (1) DE60210816T2 (de)
ES (1) ES2260503T3 (de)
GB (1) GB0119795D0 (de)
HU (1) HUP0401296A3 (de)
PL (1) PL368870A1 (de)
TW (1) TW591019B (de)
WO (1) WO2003016287A2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0208280D0 (en) * 2002-04-10 2002-05-22 Glaxo Group Ltd Novel compounds
SI21507A (sl) 2003-05-16 2004-12-31 LEK farmacevtska dru�ba d.d. Postopek za pripravo spojin z ace inhibitornim delovanjem
US20080090852A1 (en) * 2006-10-13 2008-04-17 Colin Andrew Leach Bicyclic Heteroaromatic Compounds
US7705005B2 (en) * 2006-10-13 2010-04-27 Glaxo Group Limited Bicyclic heteroaromatic compounds
US20080090851A1 (en) * 2006-10-13 2008-04-17 Colin Andrew Leach Bicyclic Heteroaromatic Compounds
US8962633B2 (en) 2007-05-11 2015-02-24 Thomas Jefferson University Methods of treatment and prevention of metabolic bone diseases and disorders
EP2977452A3 (de) 2007-05-11 2016-05-25 Thomas Jefferson University Verfahren zur behandlung und vorbeugung von neurodegenerativen erkrankungen und störungen
CN101687009A (zh) 2007-05-11 2010-03-31 宾夕法尼亚大学理事会 治疗皮肤溃疡的方法
US8637524B2 (en) 2009-07-28 2014-01-28 Auspex Pharmaceuticals, Inc Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2
TW201209043A (en) * 2010-05-17 2012-03-01 Glaxo Group Ltd Novel processes
KR101861883B1 (ko) 2010-12-06 2018-05-28 글락소 그룹 리미티드 Lp-PLA₂에 의해 매개되는 질환 또는 상태의 치료에 사용하기 위한 피리미디논 화합물
ES2847883T3 (es) 2010-12-17 2021-08-04 Glaxo Group Ltd Uso de inhibidores de LP-PLA2 en el tratamiento y prevención de enfermedades oculares
WO2012129792A1 (zh) * 2011-03-30 2012-10-04 中国科学院上海药物研究所 嘧啶酮类化合物、其制备方法及药物组合物和用途
EP2725024A4 (de) 2011-06-27 2014-12-03 Shanghai Inst Materia Medica Heterocyclische azolverbindung, herstellungsverfahren dafür, pharmazeutische zusammensetzung und verwendung davon
EP2736908A1 (de) 2011-07-27 2014-06-04 Glaxo Group Limited Bicyclische pyrimidonverbindungen
EP2739627A4 (de) 2011-07-27 2015-01-21 Glaxo Group Ltd 2,3-dihydroimidazo-[1,2-c-] pyrimidin-5 (1h)-on-verbindungen als lp-pla²- inhibitoren
CN102924290A (zh) * 2012-09-25 2013-02-13 同济大学 一种darapladib中间体的合成方法
BR112015017397A2 (pt) 2013-01-25 2017-07-11 Glaxosmithkline Ip Dev Ltd compostos pirimidona bicíclica como inibidores de lp-pla2
CA2899124A1 (en) 2013-01-25 2014-07-31 Glaxosmithkline Intellectual Property Development Limited Compounds
UY35276A (es) 2013-01-25 2014-08-29 Glaxosmithkline Ip Dev Ltd Nuevos compuestos que inhiben la actividad de Lp-PLA2
WO2015087239A1 (en) 2013-12-11 2015-06-18 Ranbaxy Laboratories Limited Processes for the preparation of darapladib and its intermediates
WO2015092687A2 (en) 2013-12-17 2015-06-25 Ranbaxy Laboratories Limited Process for the purification of darapladib
WO2016012917A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012916A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
CN114805389B (zh) 2019-11-09 2023-08-29 上海赛默罗生物科技有限公司 三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途
TWI896037B (zh) 2023-07-17 2025-09-01 大陸商上海樞境生物科技有限公司 雙環[5,6]咪唑嘧啶酮類衍生物、其製備方法和應用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ520752A (en) 2000-02-16 2004-03-26 Smithkline Beecham P Pyrimidine-4-one derivatives as LDL-PLA2 inhibitors

Also Published As

Publication number Publication date
US20040242875A1 (en) 2004-12-02
JP2005502660A (ja) 2005-01-27
GB0119795D0 (en) 2001-10-03
DE60210816D1 (de) 2006-05-24
ES2260503T3 (es) 2006-11-01
HUP0401296A3 (en) 2004-11-29
WO2003016287A2 (en) 2003-02-27
TW591019B (en) 2004-06-11
AR035111A1 (es) 2004-04-14
HUP0401296A2 (hu) 2004-10-28
WO2003016287A3 (en) 2003-10-16
DE60210816T2 (de) 2006-10-05
EP1456183A2 (de) 2004-09-15
PL368870A1 (en) 2005-04-04
EP1456183B1 (de) 2006-04-19
JP4386723B2 (ja) 2009-12-16
AU2002333415A1 (en) 2003-03-03
US7232902B2 (en) 2007-06-19

Similar Documents

Publication Publication Date Title
ATE323683T1 (de) Verfahren zur herstellung von 1-(carboxymethyl)- und 1(aminocarbonyl)-pyrimidin-4-on derivaten
ATE386736T1 (de) Verfahren zur herstellung von benzimidazol-2-yl - chinolinonderivaten
AT7110U9 (de) Verfahren zur herstellung von amlodipinmaleat
DE60214243D1 (de) Verfahren zur herstellung von metallpulver
ATE506351T1 (de) Verfahren zur herstellung von 10,11-dihydro-10- oxo-5h-dibenzoäb,füazepin-5-carboxamid
ATE296287T1 (de) Verfahren zur herstellung von repaglinide
ATE316959T1 (de) Verfahren zur herstellung von 2- halogenpyridincarbonsäureamiden
ATE284875T1 (de) Verfahren zur herstellung von mesylaten von piperazinderivaten
ATE316518T1 (de) Verfahren zur herstellung von (r)-2-alkyl-3- phenyl-1-propanolen
DE50102444D1 (de) Verfahren zur herstellung von isocyanatoorganosilanen
ATE441662T1 (de) Verfahren zur herstellung von echinocandinderivaten
ATE266004T1 (de) Verfahren zur herstellung von 3-amino-2-chlor-4- methylpyridin
DE50111560D1 (de) Verfahren zur herstellung von guerbetalkoholen
ATE374757T1 (de) Verfahren zur herstellung von (1,4,5)- oxadiazepinderivaten
ATE301634T1 (de) Verfahren zur herstellung von alpha- hydroxycarbonsäureamiden
ATE273315T1 (de) Verfahren zur herstellung von n- phosphonomethyliminodiessigsäure
ATE323677T1 (de) Verfahren zur herstellung von 4-amino-2,5- bisheterocyclylchinazolinen
DE50200870D1 (de) Verfahren zur herstellung von hydroxyalkylpolysiloxanen
ATE234269T1 (de) Verfahren zur herstellung von cis-1-2-(4-(6-
ATE424892T1 (de) Verfahren zur herstellung von derivaten des 4a,5, 9,10,11,12-hexahydrobenzofuro ä3a,3,2üä 2 ü- benzazepins
ATE466836T1 (de) Verfahren zur herstellung von alpha- difluormethylornithin (dfmo)
DE60105991D1 (de) Verfahren zur herstellung von 6-aminocapronamid
DE50204977D1 (de) Verfahren zur herstellung von polykondensaten
DE60134994D1 (de) Verfahren zur herstellung von polyurethanharnstoffpulver
DE50205026D1 (de) Verfahren zur herstellung von n-substituierten 2,6-dialkylmorpholinen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties