ATE323780T1 - Verfahren zur bestimmung der effektivität der proteasen inhibitoren - Google Patents

Verfahren zur bestimmung der effektivität der proteasen inhibitoren

Info

Publication number
ATE323780T1
ATE323780T1 AT00117312T AT00117312T ATE323780T1 AT E323780 T1 ATE323780 T1 AT E323780T1 AT 00117312 T AT00117312 T AT 00117312T AT 00117312 T AT00117312 T AT 00117312T AT E323780 T1 ATE323780 T1 AT E323780T1
Authority
AT
Austria
Prior art keywords
protease
drug
patient
inhibitory activity
effectiveness
Prior art date
Application number
AT00117312T
Other languages
English (en)
Inventor
Ryoichi Nemori
Hiroshi Kaise
Mikihiro Kusama
Original Assignee
Fuji Photo Film Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuji Photo Film Co Ltd filed Critical Fuji Photo Film Co Ltd
Application granted granted Critical
Publication of ATE323780T1 publication Critical patent/ATE323780T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT00117312T 1999-08-18 2000-08-18 Verfahren zur bestimmung der effektivität der proteasen inhibitoren ATE323780T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11231424A JP2001054399A (ja) 1999-08-18 1999-08-18 プロテアーゼ阻害作用を有する医薬の有効性の判定方法

Publications (1)

Publication Number Publication Date
ATE323780T1 true ATE323780T1 (de) 2006-05-15

Family

ID=16923370

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00117312T ATE323780T1 (de) 1999-08-18 2000-08-18 Verfahren zur bestimmung der effektivität der proteasen inhibitoren

Country Status (5)

Country Link
US (1) US6413734B1 (de)
EP (1) EP1085097B1 (de)
JP (1) JP2001054399A (de)
AT (1) ATE323780T1 (de)
DE (1) DE60027373T2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60138053D1 (de) * 2000-03-24 2009-04-30 Fujifilm Corp Dünne Membran zur Messung von Protease Aktivität.
DE60216487T2 (de) * 2001-09-03 2007-09-13 Kyowa Hakko Kogyo Co., Ltd. Verfahren zur bestimmung eines zielproteins eines arzneistoffs
JP2024068358A (ja) * 2022-11-08 2024-05-20 Ｔｏｐｐａｎホールディングス株式会社 抗がん剤の評価方法及び抗がん剤評価用キット

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1178761A1 (ru) * 1983-10-11 1985-09-15 Всесоюзный Ордена Трудового Красного Знамени Научно-Исследовательский Институт Защиты Растений Способ идентификации ингибиторов протеиназ
US5990112A (en) * 1996-06-18 1999-11-23 Affymax Technologies N.V. Inhibitors of metalloproteases pharmaceutical compositions comprising same and methods of their use
ATE239092T1 (de) * 1996-02-29 2003-05-15 Fuji Photo Film Co Ltd Verfahren zur analyse von proteasen und dünne membran zur verwendung im diesem verfahren
US5853977A (en) 1996-07-12 1998-12-29 Schering Corporation Mammalian TNF-α convertases
WO1998011238A2 (en) 1996-09-13 1998-03-19 Dana-Farber Cancer Institute Protease m, a novel serine protease
US6017723A (en) * 1998-03-27 2000-01-25 Long Island Jewish Medical Center Method for isolating inhibitors of protease activity
EP1181939B1 (de) * 1999-05-24 2006-05-31 Shionogi & Co., Ltd. Methode zum auswerten der in vivo matrix-metalloproteinasen hemmenden aktivität

Also Published As

Publication number Publication date
DE60027373T2 (de) 2007-03-29
JP2001054399A (ja) 2001-02-27
DE60027373D1 (de) 2006-05-24
US6413734B1 (en) 2002-07-02
EP1085097A1 (de) 2001-03-21
EP1085097B1 (de) 2006-04-19

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