ATE324362T1 - Neue vinylbenzolderivate - Google Patents
Neue vinylbenzolderivateInfo
- Publication number
- ATE324362T1 ATE324362T1 AT99921168T AT99921168T ATE324362T1 AT E324362 T1 ATE324362 T1 AT E324362T1 AT 99921168 T AT99921168 T AT 99921168T AT 99921168 T AT99921168 T AT 99921168T AT E324362 T1 ATE324362 T1 AT E324362T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- phenyl
- carboxyl
- halogen
- ester
- Prior art date
Links
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical class C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4015—Esters of acyclic unsaturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3826—Acyclic unsaturated acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14330798 | 1998-05-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE324362T1 true ATE324362T1 (de) | 2006-05-15 |
Family
ID=15335728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99921168T ATE324362T1 (de) | 1998-05-25 | 1999-05-19 | Neue vinylbenzolderivate |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6329547B1 (de) |
| EP (1) | EP1094055B1 (de) |
| AT (1) | ATE324362T1 (de) |
| DE (1) | DE69931051D1 (de) |
| WO (1) | WO1999061403A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2443918C (en) | 2001-04-11 | 2012-06-05 | Senju Pharmaceutical Co., Ltd. | Visual function disorder improving agents containing rho kinase inhibitors |
| KR101076638B1 (ko) * | 2003-04-18 | 2011-10-27 | 센주 세이야꾸 가부시키가이샤 | 각막 지각 회복제 |
| WO2006047466A2 (en) * | 2004-10-21 | 2006-05-04 | Duke University | Ophthamological drugs |
| WO2008078762A1 (ja) * | 2006-12-26 | 2008-07-03 | Santen Pharmaceutical Co., Ltd. | ウレア構造を有する新規ｎ－(２－アミノフェニル)ベンズアミド誘導体 |
| KR20240045364A (ko) | 2007-08-29 | 2024-04-05 | 센주 세이야꾸 가부시키가이샤 | 각막 내피 세포 접착 촉진제 |
| TR201903889T4 (tr) | 2011-12-06 | 2019-04-22 | Astellas Inst For Regenerative Medicine | Korneal endotelyal hücreler üreten yönlendirilmiş diferansiyasyona yönelik yöntem. |
| US20150044178A1 (en) | 2011-12-28 | 2015-02-12 | Kyoto Prefectural Public University Corporation | Normalization of culture of corneal endothelial cells |
| CN103739482B (zh) * | 2012-06-29 | 2015-08-26 | 常州大学 | 酰基苯氧乙酸类化合物及其制备方法 |
| US10908161B2 (en) | 2013-07-30 | 2021-02-02 | Kyoto Prefectural Public University Corporation | Corneal endothelial cell marker |
| CA2927898C (en) | 2013-10-31 | 2021-11-16 | Kyoto Prefectural Public University Corporation | Therapeutic drug for diseases related to endoplasmic reticulum cell death in corneal endothelium |
| EP3416658B1 (de) | 2016-02-15 | 2023-03-22 | Kyoto Prefectural Public University Corporation | Menschliche funktionelle hornhautendothelzelle und anwendung davon |
| JPWO2020045642A1 (ja) | 2018-08-31 | 2021-08-12 | 学校法人同志社 | 眼細胞を保存または培養するための組成物および方法 |
| CN113015429A (zh) | 2018-10-02 | 2021-06-22 | 学校法人同志社 | 用于保存角膜内皮细胞的方法和容器 |
| US20230257700A1 (en) | 2020-02-27 | 2023-08-17 | Kyoto Prefectural Public University Corporation | Functional human corneal endothelial cells and application thereof |
| EP4234682A4 (de) | 2020-10-22 | 2024-11-27 | Kyoto Prefectural Public University Corporation | Konservierungsverfahren für menschliche hornhautendothelzellen und/oder menschliche hornhautendothelvorläuferzellen |
| AU2022270611A1 (en) | 2021-05-03 | 2023-10-12 | Astellas Institute For Regenerative Medicine | Methods of generating mature corneal endothelial cells |
| CA3238227A1 (en) | 2021-11-11 | 2023-05-19 | The Doshisha | Cryopreservation preparation for corneal endothelial cells and method for producing said cryopreservation preparation |
| WO2026128800A1 (en) | 2024-12-13 | 2026-06-18 | Aurion Biotech, Inc. | Stable corneal endothelial cell (cec) compositions and methods of use |
| US20260166089A1 (en) | 2024-12-17 | 2026-06-18 | Aurion Biotech, Inc. | Treatment of corneal endothelial disease |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6032048A (ja) * | 1983-08-01 | 1985-02-19 | Matsushita Electric Ind Co Ltd | パタ−ン形成方法 |
| US4757089A (en) | 1985-06-14 | 1988-07-12 | Massachusetts Eye And Ear Infirmary | Increasing aqueous humor outflow |
| EP0228415B1 (de) * | 1985-06-14 | 1993-05-26 | MASSACHUSETTS EYE & EAR INFIRMARY | Erhöhung des ausfliessens wässriger körperfluessigkeit |
| JPH0713013A (ja) | 1993-06-29 | 1995-01-17 | Casio Comput Co Ltd | カラーフィルタとブラックマスクの形成方法 |
| DE69713582T2 (de) * | 1996-03-29 | 2003-01-09 | G.D. Searle & Co., Chicago | Zimtsäurederivate und deren verwendung als integrin-antagonisten |
-
1999
- 1999-05-19 EP EP99921168A patent/EP1094055B1/de not_active Expired - Lifetime
- 1999-05-19 DE DE69931051T patent/DE69931051D1/de not_active Expired - Fee Related
- 1999-05-19 AT AT99921168T patent/ATE324362T1/de not_active IP Right Cessation
- 1999-05-19 US US09/701,112 patent/US6329547B1/en not_active Expired - Fee Related
- 1999-05-19 WO PCT/JP1999/002601 patent/WO1999061403A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE69931051D1 (de) | 2006-06-01 |
| EP1094055A4 (de) | 2005-03-02 |
| EP1094055A1 (de) | 2001-04-25 |
| US6329547B1 (en) | 2001-12-11 |
| WO1999061403A1 (en) | 1999-12-02 |
| EP1094055B1 (de) | 2006-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |