ATE325343T1 - Diagnose und behandlung von arthritischen erkrankungen - Google Patents
Diagnose und behandlung von arthritischen erkrankungenInfo
- Publication number
- ATE325343T1 ATE325343T1 AT00965038T AT00965038T ATE325343T1 AT E325343 T1 ATE325343 T1 AT E325343T1 AT 00965038 T AT00965038 T AT 00965038T AT 00965038 T AT00965038 T AT 00965038T AT E325343 T1 ATE325343 T1 AT E325343T1
- Authority
- AT
- Austria
- Prior art keywords
- mitochondrial
- indicators
- altered
- methods
- treatment
- Prior art date
Links
- 230000002917 arthritic effect Effects 0.000 title abstract 3
- 238000003745 diagnosis Methods 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002438 mitochondrial effect Effects 0.000 abstract 3
- 230000004898 mitochondrial function Effects 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 108020005196 Mitochondrial DNA Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 230000036755 cellular response Effects 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 238000007423 screening assay Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4722—Proteoglycans, e.g. aggreccan
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/495—Transforming growth factor [TGF]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
- G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/105—Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15414599P | 1999-09-15 | 1999-09-15 | |
| US09/661,848 US7005274B1 (en) | 1999-09-15 | 2000-09-14 | Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE325343T1 true ATE325343T1 (de) | 2006-06-15 |
Family
ID=26851189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00965038T ATE325343T1 (de) | 1999-09-15 | 2000-09-15 | Diagnose und behandlung von arthritischen erkrankungen |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7005274B1 (de) |
| EP (1) | EP1236044B1 (de) |
| JP (1) | JP2003520575A (de) |
| AT (1) | ATE325343T1 (de) |
| CA (1) | CA2384855A1 (de) |
| DE (1) | DE60027762D1 (de) |
| WO (1) | WO2001020018A2 (de) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004060278A2 (en) | 2002-12-06 | 2004-07-22 | Isis Pharmaceuticals, Inc. | Methods for rapid identification of pathogens in humans and animals |
| US7226739B2 (en) | 2001-03-02 | 2007-06-05 | Isis Pharmaceuticals, Inc | Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations |
| US20030027135A1 (en) | 2001-03-02 | 2003-02-06 | Ecker David J. | Method for rapid detection and identification of bioagents |
| US20040121309A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues |
| US7666588B2 (en) | 2001-03-02 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy |
| US7217510B2 (en) | 2001-06-26 | 2007-05-15 | Isis Pharmaceuticals, Inc. | Methods for providing bacterial bioagent characterizing information |
| US8073627B2 (en) | 2001-06-26 | 2011-12-06 | Ibis Biosciences, Inc. | System for indentification of pathogens |
| EP1423122A4 (de) * | 2001-08-15 | 2008-12-10 | Univ Michigan | Zusammensetzungen und verfahren in verbindung mit neuen benzodiazepin-verbindungen und ihre ziele |
| JP2004331653A (ja) * | 2003-04-14 | 2004-11-25 | Mitsubishi Pharma Corp | 疼痛の予防及び／又は治療剤 |
| US8046171B2 (en) | 2003-04-18 | 2011-10-25 | Ibis Biosciences, Inc. | Methods and apparatus for genetic evaluation |
| US8057993B2 (en) | 2003-04-26 | 2011-11-15 | Ibis Biosciences, Inc. | Methods for identification of coronaviruses |
| US8158354B2 (en) | 2003-05-13 | 2012-04-17 | Ibis Biosciences, Inc. | Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
| US8097416B2 (en) | 2003-09-11 | 2012-01-17 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
| US8546082B2 (en) | 2003-09-11 | 2013-10-01 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
| KR101395370B1 (ko) | 2004-01-22 | 2014-05-14 | 유니버시티 오브 마이애미 | 국소용 코-엔자임 큐10 제형 및 그의 사용 방법 |
| US7666592B2 (en) | 2004-02-18 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for concurrent identification and quantification of an unknown bioagent |
| US8119336B2 (en) | 2004-03-03 | 2012-02-21 | Ibis Biosciences, Inc. | Compositions for use in identification of alphaviruses |
| ES2641832T3 (es) | 2004-05-24 | 2017-11-14 | Ibis Biosciences, Inc. | Espectrometría de masas con filtración de iones selectiva por establecimiento de umbrales digitales |
| US20050266411A1 (en) | 2004-05-25 | 2005-12-01 | Hofstadler Steven A | Methods for rapid forensic analysis of mitochondrial DNA |
| US7811753B2 (en) | 2004-07-14 | 2010-10-12 | Ibis Biosciences, Inc. | Methods for repairing degraded DNA |
| EP1802333A2 (de) | 2004-09-13 | 2007-07-04 | Arrowsmith Technologies LLP | In-vivo-antikörperpufferung eines liganden |
| US20060205040A1 (en) | 2005-03-03 | 2006-09-14 | Rangarajan Sampath | Compositions for use in identification of adventitious viruses |
| US8084207B2 (en) | 2005-03-03 | 2011-12-27 | Ibis Bioscience, Inc. | Compositions for use in identification of papillomavirus |
| JP2009502137A (ja) | 2005-07-21 | 2009-01-29 | アイシス ファーマシューティカルズ インコーポレイティッド | 核酸変種の迅速な同定および定量のための方法 |
| WO2007035397A1 (en) * | 2005-09-15 | 2007-03-29 | The Regents Of The University Of Michigan | Method and system for measuring cartilage condition biomarkers |
| EP3173068B1 (de) * | 2006-05-02 | 2020-09-09 | University of Miami | Topische co-enzym-q10-formulierungen und behandlung von wunden |
| ITMI20061375A1 (it) * | 2006-07-14 | 2008-01-15 | Fabio Conteduca | Maeriale protesico sintetico a ridotta ossidabilita' e relativo processo di preparazione |
| US9149473B2 (en) | 2006-09-14 | 2015-10-06 | Ibis Biosciences, Inc. | Targeted whole genome amplification method for identification of pathogens |
| US8821496B2 (en) * | 2006-09-29 | 2014-09-02 | DePuy Synthes Products, LLC | Osteotomy protective cover |
| US20080167277A1 (en) * | 2006-12-29 | 2008-07-10 | Charles Conrad | Methods of treating skin disorders with caffeic acid analogs |
| EP2126132B1 (de) | 2007-02-23 | 2013-03-20 | Ibis Biosciences, Inc. | Verfahren für schnelle forensische dna-analyse |
| AU2008247705B2 (en) * | 2007-05-01 | 2012-02-09 | Hill's Pet Nutrition, Inc. | Methods and compositions for diagnosing osteoarthritis in a feline |
| WO2008151023A2 (en) | 2007-06-01 | 2008-12-11 | Ibis Biosciences, Inc. | Methods and compositions for multiple displacement amplification of nucleic acids |
| KR101510494B1 (ko) | 2007-10-24 | 2015-04-08 | 모찌다 세이야쿠 가부시끼가이샤 | 관절 질환 치료용 조성물 |
| JP5241255B2 (ja) * | 2008-02-01 | 2013-07-17 | 生化学工業株式会社 | 関節痛の評価方法 |
| US8598150B1 (en) | 2008-04-02 | 2013-12-03 | Jonathan R. Brestoff | Composition and method for affecting obesity and related conditions |
| US8987245B2 (en) | 2008-04-02 | 2015-03-24 | Jonathan R. Brestoff Parker | Composition and method for affecting obesity and related conditions |
| MX2010011032A (es) | 2008-04-11 | 2011-03-01 | Cytotech Labs Llc Star | Metodos y uso de induccion de apoptosis en celulas cancerigenas. |
| EP2123775A1 (de) * | 2008-05-20 | 2009-11-25 | Stiftung Tierärztliche Hochschule Hannover | Analyse der genetischen Disposition für Hüftdysplasie bei Hunden |
| US8367637B2 (en) * | 2008-08-19 | 2013-02-05 | Mochida Pharmaceutical Co., Ltd. | Composition for treating arthritic disorder |
| US8148163B2 (en) | 2008-09-16 | 2012-04-03 | Ibis Biosciences, Inc. | Sample processing units, systems, and related methods |
| US8550694B2 (en) | 2008-09-16 | 2013-10-08 | Ibis Biosciences, Inc. | Mixing cartridges, mixing stations, and related kits, systems, and methods |
| WO2010033625A1 (en) | 2008-09-16 | 2010-03-25 | Ibis Biosciences, Inc. | Microplate handling systems and related computer program products and methods |
| US8450337B2 (en) * | 2008-09-30 | 2013-05-28 | Moleculin, Llc | Methods of treating skin disorders with caffeic acid analogs |
| CA2746650A1 (en) * | 2008-12-11 | 2010-06-17 | Proteus Biomedical, Inc. | Evaluation of gastrointestinal function using portable electroviscerography systems and methods of using the same |
| US8263069B2 (en) * | 2008-12-31 | 2012-09-11 | Johnson Lanny L | Compositions including anthocyanin or anthocyanidin for the prevention or treatment of articular cartilage-associated conditions |
| JP2012516995A (ja) | 2009-02-02 | 2012-07-26 | ネステク ソシエテ アノニム | 切迫性関節不全を診断するための方法 |
| EP2396803A4 (de) | 2009-02-12 | 2016-10-26 | Ibis Biosciences Inc | Ionisationssondenanordnungen |
| CN102481271A (zh) | 2009-05-11 | 2012-05-30 | 博格生物系统有限责任公司 | 利用表观代谢转变剂、多维细胞内分子或环境影响剂治疗代谢障碍的方法 |
| US8950604B2 (en) | 2009-07-17 | 2015-02-10 | Ibis Biosciences, Inc. | Lift and mount apparatus |
| EP2454000A4 (de) | 2009-07-17 | 2016-08-10 | Ibis Biosciences Inc | Systeme zur identifizierung von biowirkstoffen |
| EP2488656B1 (de) | 2009-10-15 | 2015-06-03 | Ibis Biosciences, Inc. | Mehrfache verschiebungsverstärkung |
| US20110306516A1 (en) * | 2010-06-15 | 2011-12-15 | The New York Stem Cell Foundation | Methods for producing induced pluripotent stem cells |
| CA2832324C (en) | 2011-04-04 | 2022-03-15 | Berg Llc | Methods of treating central nervous system tumors |
| EP2863910B1 (de) | 2012-06-20 | 2020-03-11 | University Of Virginia Patent Foundation | Zusammensetzungen und verfahren zur regulierung einer glucosehomöostase und einer insulinwirkung |
| WO2014038622A1 (ja) * | 2012-09-05 | 2014-03-13 | 国立大学法人大阪大学 | 自己免疫疾患のバイオマーカー |
| NZ713868A (en) | 2013-04-08 | 2021-12-24 | Berg Llc | Treatment of cancer using coenzyme q10 combination therapies |
| US9968623B2 (en) | 2013-08-29 | 2018-05-15 | Lanny Leo Johnson | Prepackaged sterile syringe or containers with various substance concentrations with or without bioactive reagent |
| KR102370843B1 (ko) | 2013-09-04 | 2022-03-04 | 버그 엘엘씨 | 코엔자임 q10의 연속주입에 의한 암치료 방법 |
| US20160095837A1 (en) * | 2014-10-07 | 2016-04-07 | University Of Iowa Research Foundation | Modulation of mitochondrial calcium uniporter activity for treating and preventing arrhythmias |
| WO2017087576A1 (en) | 2015-11-16 | 2017-05-26 | Berg Llc | Methods of treatment of temozolomide-resistant glioma using coenzyme q10 |
| ES3017696T3 (en) | 2017-05-17 | 2025-05-13 | Bpgbio Inc | Use of coenzyme q10 formulations in the treatment and prevention of epidermolysis bullosa |
| US20220195481A1 (en) * | 2019-05-17 | 2022-06-23 | The Regents Of The University Of Califormia | Mitochondrial respirometry in frozen specimens |
| CN110517776B (zh) * | 2019-08-16 | 2023-06-16 | 四川大学华西医院 | 一种老年人健康风险评估方法及其应用 |
| TWI857807B (zh) * | 2020-03-20 | 2024-10-01 | 台灣粒線體應用技術股份有限公司 | 含有粒線體之組合物及其用於作為皮膚纖維母細胞活性促進劑之用途 |
| WO2023073392A1 (en) * | 2021-10-29 | 2023-05-04 | Genodx | Biomarkers and uses therefor |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5902741A (en) | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
| US5041138A (en) | 1986-11-20 | 1991-08-20 | Massachusetts Institute Of Technology | Neomorphogenesis of cartilage in vivo from cell culture |
| US5736372A (en) | 1986-11-20 | 1998-04-07 | Massachusetts Institute Of Technology | Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure |
| US4846835A (en) | 1987-06-15 | 1989-07-11 | Grande Daniel A | Technique for healing lesions in cartilage |
| US4870210A (en) | 1987-12-18 | 1989-09-26 | American Home Products Corporation | Aminoguanidine derivative as anti-inflammatory agents |
| JP3694894B2 (ja) | 1994-02-19 | 2005-09-14 | 生化学工業株式会社 | 正常アグリカンの測定法および測定用キット |
| US5840493A (en) | 1994-03-30 | 1998-11-24 | Mitokor | Mitochondrial DNA mutations that segregate with late onset diabetes mellitus |
| US5888498A (en) | 1995-03-03 | 1999-03-30 | Mitokor | Cellular and animal models for diseases associated with mitochondrial defects |
| US5723331A (en) | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
| US5656450A (en) | 1994-05-27 | 1997-08-12 | Board Of Regents, The University Of Texas System | Activation of latent transforming growth factor β by matrix vesicles |
| US5935796A (en) | 1995-06-30 | 1999-08-10 | The University Of Melbourne | Diagnostic methods and compositions relating to the proteoglycan proteins of cartilage breakdown |
| JP3452366B2 (ja) | 1995-10-20 | 2003-09-29 | トランスティッシュウ テクノロジーズ ゲーエムベーハー | 新規人工組織、その製法およびその使用 |
| US5928945A (en) | 1996-11-20 | 1999-07-27 | Advanced Tissue Sciences, Inc. | Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage |
| US5827886A (en) * | 1997-05-07 | 1998-10-27 | Thione International, Inc. | Composition for relief of arthritis-induced symptoms |
| CA2319131A1 (en) | 1998-01-26 | 1999-07-29 | Walter H. Moos | Mitochondria protecting agents for treating mitochondria associated diseases |
| WO1999055321A1 (en) | 1998-04-24 | 1999-11-04 | Mitokor | Compounds and methods for treating mitochondria-associated diseases |
| PT1100488E (pt) | 1998-07-28 | 2003-09-30 | Synthes Ag | Utilizacao de compostos de creatina para tratamento das celulas e tecidos do osso ou cartilagem |
-
2000
- 2000-09-14 US US09/661,848 patent/US7005274B1/en not_active Expired - Fee Related
- 2000-09-15 EP EP00965038A patent/EP1236044B1/de not_active Expired - Lifetime
- 2000-09-15 DE DE60027762T patent/DE60027762D1/de not_active Expired - Lifetime
- 2000-09-15 AT AT00965038T patent/ATE325343T1/de not_active IP Right Cessation
- 2000-09-15 WO PCT/US2000/025317 patent/WO2001020018A2/en not_active Ceased
- 2000-09-15 CA CA002384855A patent/CA2384855A1/en not_active Abandoned
- 2000-09-15 JP JP2001523789A patent/JP2003520575A/ja not_active Withdrawn
-
2005
- 2005-06-29 US US11/172,386 patent/US20070021496A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001020018A3 (en) | 2002-07-11 |
| JP2003520575A (ja) | 2003-07-08 |
| EP1236044B1 (de) | 2006-05-03 |
| DE60027762D1 (de) | 2006-06-08 |
| US20070021496A1 (en) | 2007-01-25 |
| CA2384855A1 (en) | 2001-03-22 |
| WO2001020018A8 (en) | 2001-09-20 |
| US7005274B1 (en) | 2006-02-28 |
| EP1236044A2 (de) | 2002-09-04 |
| WO2001020018A2 (en) | 2001-03-22 |
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