ATE325615T1 - Genetische manipulierte herpesviren zur behandlung von tumoren - Google Patents

Genetische manipulierte herpesviren zur behandlung von tumoren

Info

Publication number
ATE325615T1
ATE325615T1 AT00908465T AT00908465T ATE325615T1 AT E325615 T1 ATE325615 T1 AT E325615T1 AT 00908465 T AT00908465 T AT 00908465T AT 00908465 T AT00908465 T AT 00908465T AT E325615 T1 ATE325615 T1 AT E325615T1
Authority
AT
Austria
Prior art keywords
herpes viruses
genetically manipulated
treat tumors
tumors
treat
Prior art date
Application number
AT00908465T
Other languages
English (en)
Inventor
Ralph Weichselbaum
Bernard Roizman
Richard Whitley
Original Assignee
Arch Dev Corp
Uab Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arch Dev Corp, Uab Research Foundation filed Critical Arch Dev Corp
Application granted granted Critical
Publication of ATE325615T1 publication Critical patent/ATE325615T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/763—Herpes virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16632—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT00908465T 1999-02-05 2000-02-04 Genetische manipulierte herpesviren zur behandlung von tumoren ATE325615T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24474899A 1999-02-05 1999-02-05

Publications (1)

Publication Number Publication Date
ATE325615T1 true ATE325615T1 (de) 2006-06-15

Family

ID=22923971

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06009428T ATE402713T1 (de) 1999-02-05 2000-02-04 Genetisch manipulierte herpesviren zur behandlung von tumoren
AT00908465T ATE325615T1 (de) 1999-02-05 2000-02-04 Genetische manipulierte herpesviren zur behandlung von tumoren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT06009428T ATE402713T1 (de) 1999-02-05 2000-02-04 Genetisch manipulierte herpesviren zur behandlung von tumoren

Country Status (10)

Country Link
US (3) US20030207829A9 (de)
EP (2) EP1150696B1 (de)
JP (1) JP4623832B2 (de)
AT (2) ATE402713T1 (de)
AU (2) AU772471B2 (de)
CA (1) CA2361892C (de)
DE (2) DE60027870T2 (de)
DK (1) DK1695714T3 (de)
ES (2) ES2310382T3 (de)
WO (1) WO2000045853A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7780962B2 (en) 1997-10-09 2010-08-24 Wellstat Biologics Corporation Treatment of neoplasms with RNA viruses
US7470426B1 (en) 1997-10-09 2008-12-30 Wellstat Biologics Corporation Treatment of neoplasms with viruses
US20030044384A1 (en) 1997-10-09 2003-03-06 Pro-Virus, Inc. Treatment of neoplasms with viruses
IL145899A0 (en) 1999-04-15 2002-07-25 Pro Virus Inc Treatment of neoplasms with viruses
US8147822B1 (en) 1999-09-17 2012-04-03 Wellstat Biologics Corporation Oncolytic virus
AUPQ425699A0 (en) 1999-11-25 1999-12-23 University Of Newcastle Research Associates Limited, The A method of treating a malignancy in a subject and a pharmaceutical composition for use in same
EP2213300B1 (de) * 2001-05-09 2015-03-25 Takara Bio, Inc. Zusammensetzung und Verfahren zur Behandlung von krebs mittels Herpesviren
CA2476724A1 (en) * 2002-03-01 2003-09-12 Sloan-Kettering Institute For Cancer Research Prevention of recurrence and metastasis of cancer
JP2004099584A (ja) * 2002-05-02 2004-04-02 Keio Gijuku Ｈｓｖを用いた抗腫瘍剤
EP1549339B1 (de) 2002-10-07 2019-06-05 University Of Chicago Targeting von herpes simplex virus an spezifische rezeptoren
AU2002953436A0 (en) 2002-12-18 2003-01-09 The University Of Newcastle Research Associates Limited A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis
WO2006002394A2 (en) 2004-06-24 2006-01-05 New York University Avirulent oncolytic herpes simplex virus strains engineered to counter the innate host response
EP2144632B1 (de) * 2007-05-09 2016-11-16 Board of Supervisors of Louisiana State University and Agricultural and Mechanical College Synthetische herpes-simplex-viren typ 1 zur tumorbehandlung
WO2009148488A2 (en) * 2008-05-29 2009-12-10 The General Hospital Corporation Use of oncolytic herpes viruses for killing cancer stem cells
WO2016201450A2 (en) * 2015-06-11 2016-12-15 University Of Miami Cancer treatment and diagnosis
AU2016403583B2 (en) * 2016-04-22 2020-05-28 Immvira Co., Limited Construction of oncolytic herpes simplex viruses (oHSV) obligate vector and constructs for cancer therapy
TWI666321B (zh) * 2017-10-23 2019-07-21 大陸商深圳市亦諾微醫藥科技有限公司 用於癌症治療的溶瘤性單純皰疹病毒（ｏＨＳＶ）專性載體及其建構體的建構
KR101974169B1 (ko) * 2018-08-10 2019-04-30 의료법인 성광의료재단 재조합 단순 헤르페스 바이러스 및 이의 제조방법
KR102834430B1 (ko) * 2019-08-16 2025-07-15 임비라 컴퍼니 리미티드 전신 투여용 종양용해성 단순 포진 바이러스를 포함하는 약학적 조성물
EP4075980B1 (de) 2019-12-18 2025-07-23 Stinginn LLC Substituierte 1,2,4-triazole und verfahren zu deren verwendung
US11897888B1 (en) 2020-04-30 2024-02-13 Stinginn Llc Small molecular inhibitors of sting signaling compositions and methods of use
JP7235334B2 (ja) * 2020-11-26 2023-03-08 イムヴィラ・カンパニー・リミテッド 癌の治療に用いる腫瘍溶解性単純ヘルペスウイルス（ｏＨＳＶ）偏性ベクター及びその構築体の構築
US20240024392A1 (en) * 2020-12-04 2024-01-25 Immvira Co., Limited Oncolytic herpes simplex type 1 viruses for treatment of brain tumors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769331A (en) * 1981-09-16 1988-09-06 University Patents, Inc. Recombinant methods and materials
US4859587A (en) * 1984-06-04 1989-08-22 Institut Merieux Recombinant herpes simplex viruses, vaccines and methods
US5288641A (en) * 1984-06-04 1994-02-22 Arch Development Corporation Herpes Simplex virus as a vector
US5068192A (en) * 1986-01-27 1991-11-26 Prutech Research And Development Partnership Attenuated pseudorabies virus which includes foreign DNA encoding an amino acid sequence
US4999296A (en) * 1986-04-29 1991-03-12 Novagene, Inc. Thymidine kinase negative insertion mutants of pseudorabies virus and methods for the production of same
CA2039921A1 (en) 1990-04-16 1991-10-17 Xandra O. Breakefield Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication
US5328688A (en) * 1990-09-10 1994-07-12 Arch Development Corporation Recombinant herpes simplex viruses vaccines and methods
US5360893A (en) * 1992-07-20 1994-11-01 University Of Colorado Foundation, Inc. DNA sequences encoding proteins used to elicit and detect programmed cell death
US5593879A (en) * 1993-01-15 1997-01-14 Massachusetts Institute Of Technology Cell death genes of Drosophila melanogaster and vertebrate analogs
US5585096A (en) * 1994-06-23 1996-12-17 Georgetown University Replication-competent herpes simplex virus mediates destruction of neoplastic cells
ATE241994T1 (de) * 1996-01-25 2003-06-15 Univ Glasgow Hsv-mutant-1716 zur behandlung von mesotheliomen
CA2200633A1 (en) * 1997-03-21 1998-09-21 Yuman Fong Rapid production of autologous tumor vaccines

Also Published As

Publication number Publication date
US8772261B2 (en) 2014-07-08
US8318691B2 (en) 2012-11-27
ATE402713T1 (de) 2008-08-15
EP1695714B1 (de) 2008-07-30
WO2000045853A2 (en) 2000-08-10
DE60039730D1 (de) 2008-09-11
AU2004203458A1 (en) 2004-08-26
DE60027870D1 (de) 2006-06-14
JP2002536347A (ja) 2002-10-29
AU2004203458B2 (en) 2007-05-17
AU772471B2 (en) 2004-04-29
US20110002890A1 (en) 2011-01-06
ES2263454T3 (es) 2006-12-16
JP4623832B2 (ja) 2011-02-02
US20030207829A9 (en) 2003-11-06
WO2000045853A3 (en) 2001-05-31
US20020019362A1 (en) 2002-02-14
EP1695714A1 (de) 2006-08-30
AU2980000A (en) 2000-08-25
DE60027870T2 (de) 2006-12-28
CA2361892A1 (en) 2000-08-10
US20130039890A1 (en) 2013-02-14
EP1150696A2 (de) 2001-11-07
DK1695714T3 (da) 2008-11-10
EP1150696B1 (de) 2006-05-10
CA2361892C (en) 2010-05-25
ES2310382T3 (es) 2009-01-01

Similar Documents

Publication Publication Date Title
ATE325615T1 (de) Genetische manipulierte herpesviren zur behandlung von tumoren
EA200600582A1 (ru) Способы и композиции для лечения вирусного гепатита с
ATE371372T1 (de) Behandlung von neoplasmen mit interferon- empfindlichen, klonalen viren
NO20056057L (no) Triheterocykliske forbindelser, sammensetninger og fremgangsmater for behandling av cancer og virale sykdommer
DE69733834D1 (de) Thyroxin-analoge mit keiner signifikanten hormonellen aktivität zur behandlung von bösartigen tumoren
DE69830072D1 (de) Radioaktive zusammensetzungen zur behandlung von prostatatumoren
DE602004029651D1 (de) Verwendung von artemisinin zur behandlung von durch onkogene viren gebildeten tumoren und zur behandlung von viralen infektionen
DE602004025726D1 (de) Pharmazeutische verbindung zur behandlung von lokal fortgeschrittenem primär inoperablen pankreaskarzinom (lapc).
ATE222489T1 (de) Thyroxin-analoga ohne bedeutende hormonale wirkung zur behandlung von bösartigen tumoren
BR9607894A (pt) Processo para tratar tumores
ATE241994T1 (de) Hsv-mutant-1716 zur behandlung von mesotheliomen
ATE260282T1 (de) Aromatische ester von camptothecinen und verfahren zur behandlung von krebserkrankungen
ATE121622T1 (de) Verfahren zur sensibilisierung von tumorzellen.
MXPA02007271A (es) Compuestos de tipo pirrol, composiciones que los contienen, y metodos para el tratamiento de cancer o enfermedades virales.
DE69729004D1 (de) Photodynamische therapie zur behandlung von osteosrthritis
PT1140102E (pt) Compostos de triazinona para tratar doencas causadas por sarcosystis, neospora etoxoplasma
NO20002412D0 (no) FremgangsmÕte for behandling av tumorer og tumorceller ved anvendelse av ex vivo aktiverte T celler
DK0986393T3 (da) Anvendelse af et nitroxid eller et prodrug heraf ved profylaktisk og terapeutisk behandling af cancer
DK1237562T3 (da) Fremgangsmåde til fremstilling af mikania-ekstrakter, som indeholder mikanolid og dihydromikanolid, og anvendelse i behandlingen af prolifererende sygdomme
BR0311223A (pt) Método para o uso de derivados de piranindol para tratar infecção pelo vìrus da hepatite c
DK1140103T3 (da) Ponazuril til behandling af neurologiske og abortfremkaldende sygdomme forårsaget af Coccidia
ATE315387T1 (de) Verwendung von substituierten 6- dimethylaminomethyl-1-phenyl- cyclohexanverbindungen zur therapie der harninkontinenz
DE60034110D1 (de) Verwendung von 4-aminopyridin zur behandlung von peripheren neuropathien
RU97111568A (ru) Способ лечения онкологических больных
DE60334289D1 (de) Dithiolopyrrolon-derivate zur behandlung von proliferativen störungen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1150696

Country of ref document: EP