ATE371372T1 - Behandlung von neoplasmen mit interferon- empfindlichen, klonalen viren - Google Patents
Behandlung von neoplasmen mit interferon- empfindlichen, klonalen virenInfo
- Publication number
- ATE371372T1 ATE371372T1 AT98949797T AT98949797T ATE371372T1 AT E371372 T1 ATE371372 T1 AT E371372T1 AT 98949797 T AT98949797 T AT 98949797T AT 98949797 T AT98949797 T AT 98949797T AT E371372 T1 ATE371372 T1 AT E371372T1
- Authority
- AT
- Austria
- Prior art keywords
- viruses
- neoplasms
- treatment
- interferon sensitive
- clonal viruses
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18151—Methods of production or purification of viral material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- Communicable Diseases (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94824497A | 1997-10-09 | 1997-10-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE371372T1 true ATE371372T1 (de) | 2007-09-15 |
Family
ID=25487533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98949797T ATE371372T1 (de) | 1997-10-09 | 1998-10-09 | Behandlung von neoplasmen mit interferon- empfindlichen, klonalen viren |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP1905304A3 (de) |
| JP (3) | JP2001519175A (de) |
| CN (2) | CN101618049A (de) |
| AT (1) | ATE371372T1 (de) |
| AU (1) | AU9603898A (de) |
| CA (1) | CA2305269C (de) |
| DE (1) | DE69838340T2 (de) |
| ES (1) | ES2292207T3 (de) |
| HU (1) | HUP0003911A3 (de) |
| IL (1) | IL135507A0 (de) |
| NZ (4) | NZ518945A (de) |
| WO (1) | WO1999018799A1 (de) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136307A (en) | 1997-08-13 | 2000-10-24 | Oncolytics Biotech Inc. | Reovirus for the treatment of cellular proliferative disorders |
| US6565831B1 (en) | 1999-02-24 | 2003-05-20 | Oncolytics Biotech Inc. | Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders |
| US6110461A (en) | 1997-08-13 | 2000-08-29 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
| US20030044384A1 (en) | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
| US7470426B1 (en) | 1997-10-09 | 2008-12-30 | Wellstat Biologics Corporation | Treatment of neoplasms with viruses |
| US7780962B2 (en) | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
| CN101618049A (zh) * | 1997-10-09 | 2010-01-06 | 威尔斯塔特生物公司 | 使用病毒来治疗赘生物 |
| IL145899A0 (en) | 1999-04-15 | 2002-07-25 | Pro Virus Inc | Treatment of neoplasms with viruses |
| WO2000073479A1 (en) * | 1999-05-28 | 2000-12-07 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector |
| US8147822B1 (en) | 1999-09-17 | 2012-04-03 | Wellstat Biologics Corporation | Oncolytic virus |
| IL148621A0 (en) * | 1999-09-17 | 2002-09-12 | Pro Virus Inc | Oncolytic virus |
| DE19951795A1 (de) * | 1999-10-27 | 2001-05-10 | Knebel Doeberitz Magnus Von | Verwendung von Parvoviren zur Verbesserung des Allgemeinzustandes bei Tumorpatienten oder Patienten mit chronischen oder konsumierenden Erkrankungen |
| BR0015491A (pt) * | 1999-11-12 | 2002-10-15 | Oncolytics Biotech Inc | Métodos para tratar um distúrbio proliferativo celular mediado por ras em um mamìfero, para tratar um neoplasma tendo uma via-ras ativada em um humano, para inibir metástase de um neoplasma tendo uma via-ras ativada em um mamìfero, e para tratar um neoplasma suspeito de ter uma via-ras ativada em um mamìfero, composição farmacêutica, kit, e, método para tratar uma população de células compreendendo um neoplasma suspeito de ter uma via-ras ativada in vitro |
| AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
| AR028039A1 (es) | 2000-05-03 | 2003-04-23 | Oncolytics Biotech Inc | Remocion de reovirus de celulas neoplasticas intermediadas por ras a partir de composiciones celulares mixtas |
| US8491884B2 (en) | 2000-05-03 | 2013-07-23 | Oncolytics Biotech Inc. | Virus clearance of neoplastic cells from mixed cellular compositions |
| US7306902B2 (en) * | 2002-06-28 | 2007-12-11 | Oncolyties Biotech Inc. | Oncolytic viruses as phenotyping agents for neoplasms |
| CA2412493C (en) * | 2000-06-26 | 2010-11-09 | Wellstat Biologics Corporation | Purging of cells using viruses |
| AR035227A1 (es) | 2001-02-20 | 2004-05-05 | Oncolytics Biotech Inc | Uso de un agente quimioterapeutico para la manufactura de un medicamento para la sensibilizacion de celulas neoplasicas resistentes a agentes quimioterapeuticos con reovirus |
| US7306792B2 (en) * | 2001-03-27 | 2007-12-11 | New York University | Tumor therapy with alphavirus-based and high affinity laminin receptor-targeted vectors |
| HUP0400882A3 (en) | 2001-05-11 | 2011-01-28 | Wellstat Biologics Corp | Oncolytic virus therapy |
| US20140088177A1 (en) * | 2001-07-11 | 2014-03-27 | University Of Miami | Recombinant vsv for the treatment of tumor cells |
| US20040005546A1 (en) | 2002-02-28 | 2004-01-08 | Oncolytics Biotech Inc. | Use of ribozymes in the detection of adventitious agents |
| CA2374388C (en) | 2002-02-28 | 2005-07-12 | Matthew C. Coffey | The use of ribozymes in the detection of adventitious agents |
| JP5241059B2 (ja) * | 2002-05-09 | 2013-07-17 | オンコリティクス バイオテク,インコーポレーテッド | 腫瘍崩壊ウイルスを使用して疼痛を軽減するための方法 |
| EP1944035A1 (de) * | 2002-05-09 | 2008-07-16 | Oncolytics Biotech Inc. | Verfahren zur Schmerzlinderung durch onkolytische Viren |
| JP5213298B2 (ja) | 2002-05-27 | 2013-06-19 | ホルム,ペル・ゾンネ | アデノウイルスおよびそれをコードしている核酸の新たな使用 |
| US20050220818A1 (en) * | 2002-06-21 | 2005-10-06 | Wellstat Biologics Corporation | Administration of therapeutic viruses |
| KR20120002613A (ko) | 2002-08-12 | 2012-01-06 | 제네렉스, 인코포레이티드 | 폭스바이러스 및 암과 관련된 방법 및 조성물 |
| AU2002953436A0 (en) | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
| JP4800924B2 (ja) | 2003-03-07 | 2011-10-26 | ロバーツ リサーチ インスティテュート | 癌および慢性ウイルス感染の治療処置のための粘液腫症ウイルスの使用 |
| US7731974B2 (en) | 2003-03-27 | 2010-06-08 | Ottawa Hospital Research Institute | Mutant vesicular stomatitis viruses and uses thereof |
| ATE420160T1 (de) | 2003-06-18 | 2009-01-15 | Genelux Corp | Modifizierte rekombinante vacciniaviren, verwendungen davon |
| CA2503774C (en) | 2003-06-20 | 2007-09-25 | Microbix Biosystems Inc. | Improvements in virus production |
| WO2005014017A1 (ja) * | 2003-08-08 | 2005-02-17 | Yuji Shino | 癌治療用医薬組成物 |
| CA2546178A1 (en) | 2003-11-14 | 2005-06-09 | Per Sonne Holm | New use of adenovirus and nucleic acids coding therefor |
| WO2005111200A1 (en) * | 2004-05-17 | 2005-11-24 | Universite De Montreal | Novel strains of reoviruses and methods of uses thereof |
| FI20040704A0 (fi) * | 2004-05-21 | 2004-05-21 | Ari Hinkkanen | Replikatiivisen viruksen tai sen rekombinantin käyttö terapiassa |
| US20090035276A1 (en) | 2005-03-07 | 2009-02-05 | Robarts Research Institute | Use of a combination of myxoma virus and rapamycin for therapeutic treatment |
| US7303898B2 (en) | 2005-03-29 | 2007-12-04 | New York University | Defective sindbis viral vectors |
| US10668119B2 (en) | 2005-08-01 | 2020-06-02 | Virocure, Inc. | Attenuated reovirus |
| US10260049B2 (en) | 2005-08-01 | 2019-04-16 | Virocure, Inc. | Attenuated reovirus |
| KR101772375B1 (ko) | 2005-09-07 | 2017-08-29 | 신라젠(주) | Gm-csf를 발현하는 폭스바이러스를 사용한 전이성 및/또는 전신 파종성 암의 전신 치료법 |
| US8980246B2 (en) | 2005-09-07 | 2015-03-17 | Sillajen Biotherapeutics, Inc. | Oncolytic vaccinia virus cancer therapy |
| PL2251034T3 (pl) | 2005-12-02 | 2018-07-31 | Icahn School Of Medicine At Mount Sinai | Chimeryczne wirusy prezentujące nienatywne białka powierzchniowe i zastosowania tych wirusów |
| US7875446B2 (en) * | 2006-04-20 | 2011-01-25 | Wyeth Llc | Purification processes for isolating purified vesicular stomatitis virus from cell culture |
| WO2007143548A2 (en) | 2006-06-01 | 2007-12-13 | Robarts Research Institute | Myxoma virus mutants for cancer treatment |
| WO2009016433A2 (en) * | 2006-09-15 | 2009-02-05 | Ottawa Health Research Institute | Oncolytic rhabdovirus |
| EP2097517B1 (de) | 2006-10-16 | 2014-06-04 | Genelux Corporation | Rekombinantes Lister-Stamm Vaccinia Virus kodierend für einen einzelkettigen anti-VEGF Antikörper |
| US10369171B2 (en) | 2007-03-13 | 2019-08-06 | Virocure, Inc. | Attenuated reoviruses for selection of cell populations |
| JP2010533718A (ja) * | 2007-07-18 | 2010-10-28 | ジェネラックス・コーポレイション | 腫瘍溶解性ウイルス治療に付随する副作用の処置もしくは改善用医薬の製造における化学治療剤の使用 |
| JP2011500608A (ja) * | 2007-10-22 | 2011-01-06 | オンコリティクス バイオテク,インコーポレーテッド | 増殖性障害の治療レジメン |
| JP5748656B2 (ja) * | 2008-05-22 | 2015-07-15 | ジェ イル ファーマシューティカル カンパニー リミテッド | 過剰増殖細胞の腫瘍抑制因子に基づいた腫瘍崩壊ウイルスに対する感受性を判定する方法 |
| WO2009143611A1 (en) * | 2008-05-27 | 2009-12-03 | Oncolytics Biotech Inc. | Abrogating proinflammatory cytokine production during oncolytic reovirus therapy |
| US8691212B2 (en) * | 2008-09-16 | 2014-04-08 | Genomldea Inc. | Therapeutic/prophylactic agent for prostate cancer |
| EP2987856B1 (de) | 2009-02-05 | 2018-07-25 | Icahn School of Medicine at Mount Sinai | Chimäre newcastle-krankheitsviren und verwendungen davon |
| ES2848650T3 (es) | 2009-09-14 | 2021-08-11 | Sillajen Biotherapeutics Inc | Terapia combinada contra el cáncer con virus vaccinia oncolítico |
| ES2380289T3 (es) * | 2009-11-30 | 2012-05-10 | United Cancer Research Institute | Nuevo clon del virus de la enfermedad de Newcastle, su fabricación y aplicación en el tratamiento médico del cáncer |
| AU2012204467B2 (en) | 2011-01-04 | 2016-08-18 | Sillajen, Inc. | Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus |
| ES2733211T3 (es) | 2011-04-15 | 2019-11-28 | Genelux Corp | Cepas clonales de virus vaccinia atenuados y métodos de uso de las mismas |
| US20130129678A1 (en) * | 2011-11-17 | 2013-05-23 | Zahari Raykov | Co-administration of a parvovirus and a cytokine for therapy of pancreatic cancer |
| US20140328798A1 (en) * | 2011-11-17 | 2014-11-06 | Deutsches Krebsforschung-Szentrum | Co-Administration of a Parvovirus and a Cytokine for Therapy of Pancreatic Cancer |
| EP2968525A4 (de) | 2013-03-14 | 2016-10-26 | Icahn School Med Mount Sinai | Morbus-newcastle-viren und verwendungen davon |
| CA2914790C (en) * | 2013-06-14 | 2024-02-27 | Psioxus Therapeutics Limited | A dosing regime and formulations for type b adenoviruses |
| HUE035875T2 (hu) | 2013-10-25 | 2018-06-28 | Psioxus Therapeutics Ltd | Heterológ géneket tartalmazó onkolitikus adenovírusok |
| US10238700B2 (en) | 2014-01-02 | 2019-03-26 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
| EP3110443A4 (de) | 2014-02-27 | 2017-11-15 | Viralytics Limited | Kombinationsverfahren zur behandlung von krebs |
| BR112018012180A2 (pt) | 2015-12-17 | 2018-12-04 | Psioxus Therapeutics Ltd | vírus de codificação de um anticorpo ou fragmento de complexo anti-tcr |
| GB201713765D0 (en) | 2017-08-28 | 2017-10-11 | Psioxus Therapeutics Ltd | Modified adenovirus |
| IL303187A (en) | 2016-08-29 | 2023-07-01 | Akamis Bio Ltd | Adenovirus with bispecific T cell activator |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| GB201801614D0 (en) | 2018-01-31 | 2018-03-14 | Psioxus Therapeutics Ltd | Formulation |
| WO2020037215A1 (en) | 2018-08-17 | 2020-02-20 | Icahn School Of Medicine At Mount Sinai | Recombinant newcastle disease viruses and uses thereof for the prevention of rsv disease or human metapneumovirus disease |
| WO2021229270A1 (es) | 2020-05-13 | 2021-11-18 | Laboratorio Avi-Mex, S.A. De C.V. | Vacuna recombinante contra covid-19 en vector viral |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5833975A (en) * | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
| CN1054192A (zh) * | 1990-02-26 | 1991-09-04 | 张炳团 | 人体内诱导干扰素的制造方法 |
| CA2051289C (en) * | 1990-09-14 | 2002-11-26 | Robert L. Martuza | Viral mediated destruction of neoplastic cells |
| US5602023A (en) * | 1992-03-24 | 1997-02-11 | Csatary; Laszlo K. | Pharmaceutical product containing live, stabilized virus for the therapy of viral and malignant diseases and process for preparing the same |
| DZ1706A1 (fr) * | 1992-08-07 | 2002-02-17 | Merck & Co Inc | Vaccin contre le virus de l'hepatite a. |
| FR2699082B1 (fr) * | 1993-02-22 | 1995-05-05 | Pasteur Institut | Composition pour le traitement de tumeurs et l'immunisation d'organismes à l'encontre de tumeurs. |
| CA2161671A1 (en) * | 1993-04-30 | 1994-11-10 | Robert M. Lorence | Methods of treating and detecting cancer using viruses |
| US5585096A (en) | 1994-06-23 | 1996-12-17 | Georgetown University | Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
| WO1996024669A1 (en) * | 1995-02-10 | 1996-08-15 | The Regents Of The University Of California | Human pancreatic cell lines: developments and uses |
| DE69636863T2 (de) * | 1995-02-24 | 2007-11-15 | Trustees Of The University Of Pennsylvania | Benutzung von immunmodulatoren zur herstellung von medikamenten zur inhibierung einer immunantwort gegen gleichzeitig verabreichte rekombinante viren |
| CN101618049A (zh) * | 1997-10-09 | 2010-01-06 | 威尔斯塔特生物公司 | 使用病毒来治疗赘生物 |
-
1998
- 1998-10-09 CN CN200910147515A patent/CN101618049A/zh active Pending
- 1998-10-09 DE DE69838340T patent/DE69838340T2/de not_active Expired - Lifetime
- 1998-10-09 CN CN98812019A patent/CN1281336A/zh active Pending
- 1998-10-09 AU AU96038/98A patent/AU9603898A/en not_active Abandoned
- 1998-10-09 NZ NZ518945A patent/NZ518945A/en not_active IP Right Cessation
- 1998-10-09 EP EP07016086A patent/EP1905304A3/de not_active Withdrawn
- 1998-10-09 WO PCT/US1998/021230 patent/WO1999018799A1/en not_active Ceased
- 1998-10-09 NZ NZ553508A patent/NZ553508A/en not_active IP Right Cessation
- 1998-10-09 NZ NZ550147A patent/NZ550147A/en not_active IP Right Cessation
- 1998-10-09 NZ NZ503664A patent/NZ503664A/xx not_active IP Right Cessation
- 1998-10-09 CA CA2305269A patent/CA2305269C/en not_active Expired - Fee Related
- 1998-10-09 JP JP2000515443A patent/JP2001519175A/ja not_active Withdrawn
- 1998-10-09 IL IL13550798A patent/IL135507A0/xx unknown
- 1998-10-09 AT AT98949797T patent/ATE371372T1/de active
- 1998-10-09 HU HU0003911A patent/HUP0003911A3/hu not_active Application Discontinuation
- 1998-10-09 EP EP98949797A patent/EP1032269B1/de not_active Revoked
- 1998-10-09 ES ES98949797T patent/ES2292207T3/es not_active Expired - Lifetime
-
2009
- 2009-04-09 JP JP2009095352A patent/JP2009161558A/ja active Pending
-
2013
- 2013-07-16 JP JP2013147584A patent/JP2013213058A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2305269A1 (en) | 1999-04-22 |
| NZ503664A (en) | 2002-08-28 |
| HUP0003911A2 (hu) | 2001-02-28 |
| HUP0003911A3 (en) | 2007-11-28 |
| JP2009161558A (ja) | 2009-07-23 |
| JP2001519175A (ja) | 2001-10-23 |
| JP2013213058A (ja) | 2013-10-17 |
| EP1032269A4 (de) | 2001-09-19 |
| EP1905304A2 (de) | 2008-04-02 |
| EP1032269A1 (de) | 2000-09-06 |
| EP1032269B1 (de) | 2007-08-29 |
| CN101618049A (zh) | 2010-01-06 |
| DE69838340D1 (de) | 2007-10-11 |
| IL135507A0 (en) | 2001-05-20 |
| NZ553508A (en) | 2008-11-28 |
| CN1281336A (zh) | 2001-01-24 |
| WO1999018799A1 (en) | 1999-04-22 |
| ES2292207T3 (es) | 2008-03-01 |
| HK1028935A1 (en) | 2001-03-16 |
| NZ518945A (en) | 2007-03-30 |
| DE69838340T2 (de) | 2008-05-21 |
| NZ550147A (en) | 2008-09-26 |
| CA2305269C (en) | 2012-07-03 |
| EP1905304A3 (de) | 2008-08-13 |
| AU9603898A (en) | 1999-05-03 |
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