ATE326963T1 - Indolverbindungen als spla2 inhibitoren - Google Patents

Indolverbindungen als spla2 inhibitoren

Info

Publication number: ATE326963T1
Authority: AT; Austria
Prior art keywords: indole compounds; spla2 inhibitors; compounds; spla2; inhibitors
Prior art date: 1998-08-03

Application number

AT99938936T

Other languages

English (en)

Inventor

Nicholas James Bach

Robert Delane Dillard

Susan Elizabeth Draheim

Edward David Mihelich

Tulio Suarez

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-03

Filing date

1999-08-02

Publication date

2006-06-15

1999-08-02 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2006-06-15 Application granted granted Critical

2006-06-15 Publication of ATE326963T1 publication Critical patent/ATE326963T1/de

Links

SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title abstract 3
239000003112 inhibitor Substances 0.000 title 1
102000005473 Secretory Phospholipases A2 Human genes 0.000 abstract 1
108010031873 Secretory Phospholipases A2 Proteins 0.000 abstract 1
206010040070 Septic Shock Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
235000014113 dietary fatty acids Nutrition 0.000 abstract 1
229930195729 fatty acid Natural products 0.000 abstract 1
239000000194 fatty acid Substances 0.000 abstract 1
150000004665 fatty acids Chemical class 0.000 abstract 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
230000036303 septic shock Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT99938936T 1998-08-03 1999-08-02 Indolverbindungen als spla2 inhibitoren ATE326963T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US9511498P	1998-08-03	1998-08-03

Publications (1)

Publication Number	Publication Date
ATE326963T1 true ATE326963T1 (de)	2006-06-15

Family

ID=22249768

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99938936T ATE326963T1 (de)	1998-08-03	1999-08-02	Indolverbindungen als spla2 inhibitoren

Country Status (8)

Country	Link
US (1)	US6451839B1 (de)
EP (1)	EP1100492B1 (de)
JP (1)	JP2002522385A (de)
AT (1)	ATE326963T1 (de)
CA (1)	CA2338855A1 (de)
DE (1)	DE69931496T2 (de)
ES (1)	ES2263283T3 (de)
WO (1)	WO2000007590A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002522386A (ja) *	1998-08-03	2002-07-23	イーライ・リリー・アンド・カンパニー	インドールｓＰＬＡ２インヒビター
CN1450893A (zh) *	2000-07-14	2003-10-22	伊莱利利公司	治疗脓毒症的方法
ES2264708T3 (es) *	2000-12-18	2007-01-16	Eli Lilly And Company	Derivados tetraciclicos como inhibidores de la spla2.
US6992100B2 (en)	2001-12-06	2006-01-31	Eli Lilly And Company	sPLA2 inhibitors
AUPS282602A0 (en)	2002-06-07	2002-06-27	Garvan Institute Of Medical Research	Method of inhibiting cell proliferation
EP1610779B1 (de) *	2003-03-31	2009-09-09	Eli Lilly And Company	3-oxo-1,3-dihydro-indazol-2-carbonsäureamid derivate als phospholipase inhibitoren
CA2565387A1 (en) *	2004-05-03	2005-11-17	Ilypsa, Inc.	Modulation of lysophosphatidylcholine and treatment of diet-induced conditions
EP1948604A1 (de) *	2005-11-03	2008-07-30	Ilypsa, Inc.	Indolverbindungen mit aciden c4-substituenten und deren verwendung als inhibitoren von phospholipase a2
EP1960356A2 (de) *	2005-11-03	2008-08-27	Ilypsa, Inc.	Mehrwertige indolverbindungen und deren verwendung als phospholipase-a2-inhibitoren
JP2009514883A (ja) *	2005-11-03	2009-04-09	イリプサ，インコーポレイテッド	アザインドール化合物およびホスホリパーゼａ２インヒビターとしてのその使用
EP1948602A2 (de) *	2005-11-03	2008-07-30	Ilypsa, Inc.	Indolverbindungen mit c4-amid-substituenten und ihre verwendung als phospholipase-a2-hemmer
MX2008005661A (es) *	2005-11-03	2008-12-15	Ilypsa Inc	Inhibidores de fosfolipasa, que incluyen inhibidores de fosfolipasa multivalente, y uso de los mismos, que incluyen como inhibidores de fosfolipasa localizadas en el lumen.
EP2211425A1 (de)	2009-01-23	2010-07-28	MTA S.p.A.	Elektrische Buchsenklemme
CN107233337A (zh)	2009-04-29	2017-10-10	阿马里纳药物爱尔兰有限公司	含有epa和心血管剂的药物组合物以及使用其的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5312928A (en) *	1991-02-11	1994-05-17	Cambridge Neuroscience	Calcium channel antagonists and methodology for their identification
US5132319A (en) *	1991-03-28	1992-07-21	Merck Frosst Canada, Inc.	1-(hydroxylaminoalkyl) indole derivatives as inhibitors of leukotriene biosynthesis
GB9204365D0 (en) *	1992-02-28	1992-04-08	Pfizer Ltd	Indoles
AU2945992A (en) *	1992-11-27	1994-06-22	Yason S.R.L.	Indole derivative having prolonged immunostimulating activity and pharmaceutical compositions therefrom
IL109311A0 (en)	1993-04-16	1994-07-31	Lilly Co Eli	1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en)	1993-04-16	2000-06-29	Lilly Co Eli	1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
US6252084B1 (en) *	1994-03-15	2001-06-26	Eli Lilly And Company	1H-indole-3-acetamide sPLA2 inhibitors
EP1950200B1 (de) *	1994-04-01	2012-01-11	Eli Lilly And Company	[[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-11H-indol-4-yl]oxy]essigsäure methyl ester als sPLA2 inhibitor
EP1039901A1 (de) *	1997-11-14	2000-10-04	Eli Lilly And Company	Behandlung der alzheimer'schen krankheit

1999
- 1999-08-02 CA CA002338855A patent/CA2338855A1/en not_active Abandoned
- 1999-08-02 US US09/762,069 patent/US6451839B1/en not_active Expired - Fee Related
- 1999-08-02 AT AT99938936T patent/ATE326963T1/de not_active IP Right Cessation
- 1999-08-02 DE DE69931496T patent/DE69931496T2/de not_active Expired - Fee Related
- 1999-08-02 ES ES99938936T patent/ES2263283T3/es not_active Expired - Lifetime
- 1999-08-02 JP JP2000563275A patent/JP2002522385A/ja not_active Withdrawn
- 1999-08-02 WO PCT/US1999/017459 patent/WO2000007590A1/en not_active Ceased
- 1999-08-02 EP EP99938936A patent/EP1100492B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69931496D1 (de)	2006-06-29
ES2263283T3 (es)	2006-12-01
CA2338855A1 (en)	2000-02-17
US6451839B1 (en)	2002-09-17
WO2000007590A1 (en)	2000-02-17
DE69931496T2 (de)	2006-11-23
EP1100492A4 (de)	2001-10-24
JP2002522385A (ja)	2002-07-23
EP1100492A1 (de)	2001-05-23
EP1100492B1 (de)	2006-05-24

Legal Events

Date	Code	Title	Description
2006-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE220394T1 (de)	2002-07-15	1h-indol-3-glyoxylamid spla2 inhibitoren
ATE246501T1 (de)	2003-08-15	Pyrrole als spla2 inhibitoren
BR9508298A (pt)	1998-11-03	Inibidores de indolizina de spla2
DE69931496D1 (de)	2006-06-29	INDOLVERBINDUNGEN ALS sPLA2 INHIBITOREN
ATE203744T1 (de)	2001-08-15	Naphthyl-acetamide als spla2-inhibitoren
ATE234850T1 (de)	2003-04-15	Phenylglyoxamide als spla2-inhibitoren
DE60032774D1 (de)	2007-02-15	Spla2 inhibitoren
ATE312817T1 (de)	2005-12-15	Cyclohept'bö indolderivate als spla2-inhibitoren
ATE247119T1 (de)	2003-08-15	Substituierte pyrroloindole
DE60032254D1 (de)	2007-01-18	Hydroxyfunktionelle amid-1h-indolderivate aktiv als spla2 inhibitoren
DE60126831D1 (de)	2007-04-05	Benz(g)indole und deren verwendung als spla2 inhibitoren
WO2002050028A8 (en)	2005-03-17	Substituted benzoindoles as spla2 inhibitors
WO2001049662A3 (en)	2002-06-27	Carbazole derivatives as inhibitors of spla2
DE60120758D1 (de)	2006-07-27	Tetracyclische derivate als spla2 inhibitoren