ATE327737T1 - Verfahren zur herstellung von arzneistoffgranulatkörnern, die arzneistoffgranulatkörner sowie diese enthaltende pharmazeutische zubereitungen - Google Patents

Verfahren zur herstellung von arzneistoffgranulatkörnern, die arzneistoffgranulatkörner sowie diese enthaltende pharmazeutische zubereitungen

Info

Publication number
ATE327737T1
ATE327737T1 AT02005224T AT02005224T ATE327737T1 AT E327737 T1 ATE327737 T1 AT E327737T1 AT 02005224 T AT02005224 T AT 02005224T AT 02005224 T AT02005224 T AT 02005224T AT E327737 T1 ATE327737 T1 AT E327737T1
Authority
AT
Austria
Prior art keywords
granules
medicinal
granulates
pharmaceutical preparations
preparations containing
Prior art date
Application number
AT02005224T
Other languages
English (en)
Inventor
Yasushi Ochiai
Kouji Wakisaka
Original Assignee
Dainippon Sumitomo Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Sumitomo Pharma Co filed Critical Dainippon Sumitomo Pharma Co
Application granted granted Critical
Publication of ATE327737T1 publication Critical patent/ATE327737T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT02005224T 2001-03-07 2002-03-07 Verfahren zur herstellung von arzneistoffgranulatkörnern, die arzneistoffgranulatkörner sowie diese enthaltende pharmazeutische zubereitungen ATE327737T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001064056 2001-03-07

Publications (1)

Publication Number Publication Date
ATE327737T1 true ATE327737T1 (de) 2006-06-15

Family

ID=18922942

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02005224T ATE327737T1 (de) 2001-03-07 2002-03-07 Verfahren zur herstellung von arzneistoffgranulatkörnern, die arzneistoffgranulatkörner sowie diese enthaltende pharmazeutische zubereitungen

Country Status (5)

Country Link
US (1) US7192608B2 (de)
EP (1) EP1238662B1 (de)
AT (1) ATE327737T1 (de)
DE (1) DE60211769T2 (de)
ES (1) ES2260345T3 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003261038A1 (en) * 2002-06-27 2004-01-19 Robert Janitzek Ciprofloxacin hci
WO2004075826A2 (en) * 2003-02-28 2004-09-10 Ranbaxy Laboratories Limited Extended release, multiple unit dosage forms of phenytoin sodium and processes for their preparation
US20090214644A1 (en) * 2003-07-31 2009-08-27 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations with reduced adverse effects
US20050025825A1 (en) 2003-07-31 2005-02-03 Xanodyne Pharmacal, Inc. Tranexamic acid formulations with reduced adverse effects
ITMI20032399A1 (it) * 2003-12-09 2005-06-10 Zambon Spa Composizione farmaceutica contenente gabapentina.
US8022106B2 (en) * 2004-03-04 2011-09-20 Ferring B.V. Tranexamic acid formulations
US20090215898A1 (en) * 2004-03-04 2009-08-27 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US20050244495A1 (en) 2004-03-04 2005-11-03 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US20050245614A1 (en) * 2004-03-04 2005-11-03 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US7947739B2 (en) 2004-03-04 2011-05-24 Ferring B.V. Tranexamic acid formulations
AT500144A1 (de) * 2004-03-05 2005-11-15 Sanochemia Pharmazeutika Ag Tolperison enthaltende, pharmazeutische zubereitung mit steuerbarer wirkstofffreisetzung zur oralen verabreichung
CA2607419C (en) * 2005-04-26 2014-06-17 Dainippon Sumitomo Pharma Co., Ltd. Granular preparation containing biguanide compound
US20080085318A1 (en) * 2005-07-16 2008-04-10 Cherukuri S R Coated compositions and methods for preparing same
JP5271081B2 (ja) * 2006-07-26 2013-08-21 旭化成ケミカルズ株式会社 球形素顆粒およびその製造方法
US8765187B2 (en) 2007-07-17 2014-07-01 Asahi Kasei Chemicals Corporation Aqueous composition
US20100120776A1 (en) * 2008-11-12 2010-05-13 Hall Bioscience Corporation Carbocysteine medical foods
US20100280117A1 (en) * 2009-04-30 2010-11-04 Xanodyne Pharmaceuticals, Inc. Menorrhagia Instrument and Method for the Treatment of Menstrual Bleeding Disorders
WO2010138439A1 (en) * 2009-05-28 2010-12-02 Aptapharma, Inc. Multiparticulate controlled-release selective serotonin reuptake inhibitor formulations
EP2338480A1 (de) * 2009-12-22 2011-06-29 LEK Pharmaceuticals d.d. Beschichtung von Partikeln mit pharmazeutischen Wirkstoffen mit Carbonatsalz oder Phosphatsalz
EP3721870A1 (de) * 2019-04-11 2020-10-14 ADD Advanced Drug Delivery Technologies, Ltd. Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
US20250000805A1 (en) * 2021-10-29 2025-01-02 Neurocrine Biosciences, Inc. Valbenazine compositions
ES3050159T3 (en) * 2022-04-20 2025-12-19 Athena Pharmaceutiques Sas High dose tranexamic acid composition and process for preparation thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1109425A (en) * 1964-06-16 1968-04-10 Mini Of Technology Polymeric coating of aspirin
NZ230763A (en) * 1988-09-27 1991-10-25 Takeda Chemical Industries Ltd Production of granules having a core by spraying the cores with a dispersion of hydroxypropylcellulose, optionally incorporating an active ingredient
DE69022861T2 (de) * 1989-01-24 1996-04-04 Spi Polyols Inc Kryoschützende kristalline Sorbitolkügelchen.
FR2663867B1 (fr) * 1990-06-29 1994-08-05 Rhone Poulenc Nutrition Animal Procede de lissage de granules de principes actifs.
JP3219787B2 (ja) 1991-05-28 2001-10-15 フロイント産業株式会社 球形粒子の製造方法
JPH09175999A (ja) 1995-12-22 1997-07-08 Freunt Ind Co Ltd 球形顆粒およびその製造方法
JP4090529B2 (ja) 1996-01-24 2008-05-28 フロイント産業株式会社 乳糖の球形粒及びその製造方法
JPH09295947A (ja) 1996-04-30 1997-11-18 Nippon Paper Ind Co Ltd 微小球形粒及びその製造方法
JPH10139659A (ja) 1996-09-10 1998-05-26 Freunt Ind Co Ltd 球形粒子群、その製造方法及びそれを用いた球形粒子製剤
JP3447042B2 (ja) 1997-07-23 2003-09-16 フロイント産業株式会社 単一物質球形粒の製造方法

Also Published As

Publication number Publication date
US7192608B2 (en) 2007-03-20
EP1238662A3 (de) 2003-01-15
US20030039699A1 (en) 2003-02-27
DE60211769D1 (de) 2006-07-06
EP1238662A2 (de) 2002-09-11
ES2260345T3 (es) 2006-11-01
EP1238662B1 (de) 2006-05-31
DE60211769T2 (de) 2007-05-24

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