ATE327983T1 - Thia- und oxazole und deren verwendung als ppars- aktivatoren - Google Patents

Thia- und oxazole und deren verwendung als ppars- aktivatoren

Info

Publication number: ATE327983T1
Authority: AT; Austria
Prior art keywords: sup; sub; alkyl; independently; och
Prior art date: 2000-12-20

Application number

AT01990571T

Other languages

English (en)

Inventor

Paul John Beswick

Vipulkumar Patel

Michael L Sierra

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-20

Filing date

2001-12-18

Publication date

2006-06-15

2001-12-18 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2006-06-15 Application granted granted Critical

2006-06-15 Publication of ATE327983T1 publication Critical patent/ATE327983T1/de

Links

ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title 1
239000012190 activator Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
229910052799 carbon Inorganic materials 0.000 abstract 3
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052731 fluorine Inorganic materials 0.000 abstract 2
239000011737 fluorine Substances 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 2
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
208000000103 Anorexia Nervosa Diseases 0.000 abstract 1
208000032841 Bulimia Diseases 0.000 abstract 1
206010006550 Bulimia nervosa Diseases 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
208000032928 Dyslipidaemia Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
101000741788 Homo sapiens Peroxisome proliferator-activated receptor alpha Proteins 0.000 abstract 1
208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
206010022489 Insulin Resistance Diseases 0.000 abstract 1
208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
102100038831 Peroxisome proliferator-activated receptor alpha Human genes 0.000 abstract 1
206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
208000022531 anorexia Diseases 0.000 abstract 1
150000001721 carbon Chemical group 0.000 abstract 1
206010061428 decreased appetite Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT01990571T 2000-12-20 2001-12-18 Thia- und oxazole und deren verwendung als ppars- aktivatoren ATE327983T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0031109.2A GB0031109D0 (en)	2000-12-20	2000-12-20	Chemical compounds

Publications (1)

Publication Number	Publication Date
ATE327983T1 true ATE327983T1 (de)	2006-06-15

Family

ID=9905493

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01990571T ATE327983T1 (de)	2000-12-20	2001-12-18	Thia- und oxazole und deren verwendung als ppars- aktivatoren

Country Status (8)

Country	Link
US (1)	US7196107B2 (de)
EP (1)	EP1343772B1 (de)
AT (1)	ATE327983T1 (de)
AU (1)	AU2002229669A1 (de)
DE (1)	DE60120217T2 (de)
ES (1)	ES2265448T3 (de)
GB (1)	GB0031109D0 (de)
WO (1)	WO2002050048A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL152979A0 (en)	2000-05-26	2003-06-24	Nippon Shinyaku Co Ltd	Heterocyclic compounds
US20040072838A1 (en)	2000-12-20	2004-04-15	Pierette Banker	Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors
US7105551B2 (en) *	2000-12-20	2006-09-12	Smithkline Beecham Corporation	Thiazole derivatives for treating PPAR related disorders
WO2003016291A1 (en)	2001-08-10	2003-02-27	Nippon Chemiphar Co., Ltd.	ACTIVATOR FOR PEROXISOME PROLIFERATOR-RESPONSIVE RECEPTOR δ
HRP20040098B1 (en) *	2001-08-13	2012-08-31	Janssen Pharmaceutica N.V.	2,4,5-TRlSUBSTITUTED THIAZOLYL DERIVATIVES AND THEIR ANTIINFLAMMATORY ACTIVITY
IL160845A0 (en)	2001-09-14	2004-08-31	Tularik Inc	Linked biaryl compounds
MXPA04003398A (es) *	2001-10-12	2004-11-22	Nippon Chemiphar Co	Activador para el receptor o activado con el proliferador de peroxisoma.
US6833380B2 (en)	2002-03-07	2004-12-21	Warner-Lambert Company, Llc	Compounds that modulate PPAR activity and methods of preparation
US6875780B2 (en)	2002-04-05	2005-04-05	Warner-Lambert Company	Compounds that modulate PPAR activity and methods for their preparation
DE10251513A1 (de) *	2002-11-04	2004-05-19	Basf Ag	Übergangsmetallkatalysatoren für (Co)Polymerisation von olefinischen Monomeren
US7244763B2 (en)	2003-04-17	2007-07-17	Warner Lambert Company Llc	Compounds that modulate PPAR activity and methods of preparation
WO2005009104A2 (en) *	2003-07-16	2005-02-03	Ligand Pharmacueticals Incorporated	Benzoic and phenyl acetic acid derivatives as hnf-4 modulators
ES2352085T3 (es)	2004-05-05	2011-02-15	High Point Pharmaceuticals, Llc	Nuevos compuestos, su preparación y uso.
WO2005105736A1 (en)	2004-05-05	2005-11-10	Novo Nordisk A/S	Novel compounds, their preparation and use
ES2372617T3 (es)	2005-06-30	2012-01-24	High Point Pharmaceuticals, Llc	Ácidos fenoxiacéticos como activadores de ppar-delta.
EA201101085A1 (ru)	2005-12-22	2012-05-30	ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи	Феноксиуксусные кислоты в качестве активаторов ppar дельта
EP1999098A2 (de)	2006-03-09	2008-12-10	High Point Pharmaceuticals, LLC	Verbindungen, die die ppar-aktivität modulieren, ihre herstellung und ihre verwendung
EP2014652B1 (de)	2006-04-18	2014-08-06	Nippon Chemiphar Co., Ltd.	Aktivierungsmittel für den peroxisomproliferatoraktivierten rezeptor
WO2007122970A1 (ja) *	2006-04-20	2007-11-01	Osaka University	核内受容体に結合するリガンド
FR2910893A1 (fr) *	2006-12-29	2008-07-04	Genfit Sa	Derives de (phenylthiazolyl)-phenyl-propan-1-one et de (phenyloxazolyl)-phenyl-propan-1-one substitues, preparations et utilisations.
MX2010011252A (es)	2008-04-15	2010-11-30	Nippon Chemiphar Co	Activador para el receptor activado por el proliferador de peroxisoma.
JP5694941B2 (ja)	2008-10-17	2015-04-01	シーマベイセラピューティクス，インコーポレイティド	小型高密度ｌｄｌ粒子を減少させる方法
US20110092517A1 (en) *	2009-08-14	2011-04-21	Cerenis Therapeutics S.A. & Nippon Chemiphar Co., Ltd.	Use of PPAR Delta Ligands for the Treatment or Prevention of Inflammation or Energy Metabolism/Production Related Diseases
WO2015035171A1 (en)	2013-09-09	2015-03-12	High Point Pharmaceuticals, Llc	Use of a ppar-delta agonist for treating muscle atrophy
CN109897013B (zh) *	2019-03-31	2023-04-07	无锡科华生物科技有限公司	一种选择性PPARδ激动剂GW501516的制备方法
WO2023147309A1 (en)	2022-01-25	2023-08-03	Reneo Pharmaceuticals, Inc.	Use of ppar-delta agonists in the treatment of disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2174121C2 (ru) *	1996-08-19	2001-09-27	Джапан Тобакко Инк.	Производные пропионовой кислоты и фармацевтическая композиция на их основе
GB9914977D0 (en) *	1999-06-25	1999-08-25	Glaxo Group Ltd	Chemical compounds
WO2001016120A1 (en)	1999-08-27	2001-03-08	Eli Lilly And Company	Biaryl-oxa(thia)zole derivatives and their use as ppars modulators
PE20011010A1 (es) *	1999-12-02	2001-10-18	Glaxo Group Ltd	Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano
JP4790969B2 (ja)	2000-08-11	2011-10-12	日本ケミファ株式会社	ペルオキシソーム増殖剤応答性受容体δの活性化剤
GB0031107D0 (en)	2000-12-20	2001-01-31	Glaxo Group Ltd	Chemical compounds
GB0031103D0 (en)	2000-12-20	2001-01-31	Glaxo Group Ltd	Chemical compounds

2000
- 2000-12-20 GB GBGB0031109.2A patent/GB0031109D0/en not_active Ceased
2001
- 2001-12-18 ES ES01990571T patent/ES2265448T3/es not_active Expired - Lifetime
- 2001-12-18 EP EP01990571A patent/EP1343772B1/de not_active Expired - Lifetime
- 2001-12-18 AT AT01990571T patent/ATE327983T1/de not_active IP Right Cessation
- 2001-12-18 WO PCT/EP2001/014887 patent/WO2002050048A1/en not_active Ceased
- 2001-12-18 DE DE60120217T patent/DE60120217T2/de not_active Expired - Fee Related
- 2001-12-18 AU AU2002229669A patent/AU2002229669A1/en not_active Abandoned
- 2001-12-18 US US10/451,307 patent/US7196107B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2002229669A1 (en)	2002-07-01
DE60120217D1 (de)	2006-07-06
US7196107B2 (en)	2007-03-27
GB0031109D0 (en)	2001-01-31
US20040102493A1 (en)	2004-05-27
EP1343772A1 (de)	2003-09-17
DE60120217T2 (de)	2007-03-29
EP1343772B1 (de)	2006-05-31
WO2002050048A1 (en)	2002-06-27
ES2265448T3 (es)	2007-02-16

Legal Events

Date	Code	Title	Description
2006-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60120217D1 (de)	2006-07-06	Thia- und oxazole und deren verwendung als ppars-aktivatoren
DE69327944D1 (de)	2000-04-06	Thiazolidindione-Derivate, ihre Herstellung und Verwendung
NO20035367D0 (no)	2003-12-02	Modulatorer av peroksisomproliferatoraktiverte reseptorer (PPAR)
NZ312161A (en)	2000-08-25	The use of human Cb2 receptor agonists for preparing immunomodulating compounds
DE68912952D1 (de)	1994-03-24	Hypoglykämische Thiazolidindion-Derivate.
PE20011010A1 (es)	2001-10-18	Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano
ATE369855T1 (de)	2007-09-15	Modulatoren von peroxisome proliferator- aktivierten rezeptoren
WO2007075629A3 (en)	2007-10-18	Phenoxypiperidines and analogs thereof useful as histamine h3 antagonists
JP2003502369A5 (de)	2007-04-12
NO894425L (no)	1989-11-07	Hypoglykemiske tiazolidinon-derivater.
AU562113B2 (en)	1987-05-28	Benzoxazolinones
DK1277736T3 (da)	2007-10-01	Hidtil ukendte bicykliske forbindelser
ATE198200T1 (de)	2001-01-15	Durch einen pyridinring substituierte thiazolidine und oxazolidine und ihre anwendung als hypoglykämische mittel
ATE382043T1 (de)	2008-01-15	Sulfonamid-derivate als ppar-modulatoren
JP2005529965A5 (de)	2006-03-16
ES2125611T3 (es)	1999-03-01	Nuevos derivados de dioxadiazol como agentes antihiperglicemicos.
AR034051A1 (es)	2004-01-21	Compuesto de oxazol o tiazol, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion
ATE90664T1 (de)	1993-07-15	3,5-dihydroxy-6,8-nonadiensaeuren und -derivate als hypocholesterolemische mittel.
ATE111460T1 (de)	1994-09-15	2-(aminoalkyl)-5-(arylalkyl)1,3-dioxanderivate, ihre herstellung und ihre anwendung in der therapeutik.
NO20074738L (no)	2007-11-08	Aktivator for peroksisom-proliferator som aktiverer reseptor delta
JP2008514634A5 (de)	2008-10-09
ATE190311T1 (de)	2000-03-15	Oxazolochinolinonderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3763591D1 (de)	1990-08-16	Azolverbindungen und diese enthaltende fungizide und wachstumsregulatoren.
FI883285A0 (fi)	1988-07-08	2-amino-5 -hydroxi-4-pyrimidoner.
ATE206050T1 (de)	2001-10-15	Okulares hypotensium