ATE328608T1 - Verfahren und zusammensetzungen mit kombinationen aus terfenadinmetaboliten und leukotrienhemmer - Google Patents

Verfahren und zusammensetzungen mit kombinationen aus terfenadinmetaboliten und leukotrienhemmer

Info

Publication number: ATE328608T1
Authority: AT; Austria
Prior art keywords: methods; leucotrien; inhibitors; compositions; combinations
Prior art date: 1998-04-14

Application number

AT99918515T

Other languages

English (en)

Inventor

Paul D Rubin

Original Assignee

Sepracor Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-14

Filing date

1999-04-13

Publication date

2006-06-15

1999-04-13 Application filed by Sepracor Inc filed Critical Sepracor Inc

2006-06-15 Application granted granted Critical

2006-06-15 Publication of ATE328608T1 publication Critical patent/ATE328608T1/de

Links

GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical class C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
239000000203 mixture Substances 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title 1
206010061218 Inflammation Diseases 0.000 abstract 2
230000000172 allergic effect Effects 0.000 abstract 2
208000006673 asthma Diseases 0.000 abstract 2
208000010668 atopic eczema Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000035475 disorder Diseases 0.000 abstract 2
230000004054 inflammatory process Effects 0.000 abstract 2
239000003199 leukotriene receptor blocking agent Substances 0.000 abstract 2
230000002265 prevention Effects 0.000 abstract 2
208000024891 symptom Diseases 0.000 abstract 2
239000000850 decongestant Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Otolaryngology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT99918515T 1998-04-14 1999-04-13 Verfahren und zusammensetzungen mit kombinationen aus terfenadinmetaboliten und leukotrienhemmer ATE328608T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/059,570 US6194431B1 (en)	1998-04-14	1998-04-14	Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors

Publications (1)

Publication Number	Publication Date
ATE328608T1 true ATE328608T1 (de)	2006-06-15

Family

ID=22023833

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99918515T ATE328608T1 (de)	1998-04-14	1999-04-13	Verfahren und zusammensetzungen mit kombinationen aus terfenadinmetaboliten und leukotrienhemmer

Country Status (21)

Country	Link
US (4)	US6194431B1 (de)
EP (2)	EP1707216A1 (de)
JP (1)	JP2002511426A (de)
KR (1)	KR100686297B1 (de)
CN (2)	CN1768749A (de)
AT (1)	ATE328608T1 (de)
AU (1)	AU763979B2 (de)
BR (1)	BR9909641A (de)
CA (1)	CA2328074C (de)
CY (1)	CY1106800T1 (de)
DE (1)	DE69931771T2 (de)
DK (1)	DK1071463T3 (de)
ES (1)	ES2260910T3 (de)
HU (1)	HU228035B1 (de)
IL (2)	IL138993A0 (de)
NO (1)	NO20005147L (de)
NZ (1)	NZ507762A (de)
PL (1)	PL343526A1 (de)
PT (1)	PT1071463E (de)
WO (1)	WO1999052554A1 (de)
ZA (1)	ZA200005553B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
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US6194431B1 (en)	1998-04-14	2001-02-27	Paul D. Rubin	Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
US20020198246A1 (en) *	1998-09-30	2002-12-26	Ono Pharmaceutical Co., Ltd.	Agent for preventing and/or treating sinusitis
DE10007203A1 (de) *	2000-02-17	2001-08-23	Asta Medica Ag	Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis
US6440994B1 (en)	2000-03-29	2002-08-27	Richard J. Sanders, Jr.	Method of treating acne
US20020198228A1 (en) *	2001-04-03	2002-12-26	Kaura Sita R.	Composition and method for the treatment of respiratory desease
BR0306329A (pt) *	2002-05-29	2005-04-26	Aventis Pharmaceuticals Holdin	Método de tratamento de asma
US20040115647A1 (en) *	2002-12-12	2004-06-17	Paterson Thomas S.	Apparatus and method for identifying biomarkers using a computer model
US20090062242A1 (en) *	2007-08-28	2009-03-05	Agi Therapeutics Plc	Methods and compositions for treating gastrointestinal conditions
WO2016011254A1 (en) *	2014-07-16	2016-01-21	Henry J. Legere Md, Pa	Combinations of antihistamines and leukotriene antagonists and methods of use thereof

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US3878217A (en)	1972-01-28	1975-04-15	Richardson Merrell Inc	Alpha-aryl-4-substituted piperidinoalkanol derivatives
US4254129A (en)	1979-04-10	1981-03-03	Richardson-Merrell Inc.	Piperidine derivatives
US4783465A (en)	1984-04-09	1988-11-08	Analgesic Associates	Cough/cold mixtures comprising non-sedating antihistamine drugs
US4552899A (en)	1984-04-09	1985-11-12	Analgesic Associates	Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
US4617407A (en) *	1984-08-30	1986-10-14	Merck Frosst Canada, Inc.	Leukotriene antagonists
US4742175A (en)	1986-05-07	1988-05-03	Merrell Dow Pharmaceuticals Inc.	Preparation of polymorphically pure terfenadine
US4800162A (en)	1987-04-01	1989-01-24	Sepracor, Inc.	Method for resolution of steroisomers in multiphase and extractive membrane reactors
US4829064A (en)	1987-06-08	1989-05-09	Analgesic Associates	Cough/cold mixtures comprising non-sedating antihistamine drugs
CN1053570C (zh)	1987-10-07	2000-06-21	默尔多药物公司	哌啶子基链烷醇的药用组合物-减充血剂复方的制备方法
US4996061A (en)	1987-10-07	1991-02-26	Merrell Dow Pharmaceuticals Inc.	Pharmaceutical composition for piperidinoalkanol-decongestant combination
US4929605A (en)	1987-10-07	1990-05-29	Merrell Dow Pharmaceuticals Inc.	Pharmaceutical composition for piperidinoalkanol derivatives
US5057427A (en)	1988-04-07	1991-10-15	Sepracor, Inc.	Method for resolution of stereoisomers
US4990259A (en)	1988-12-16	1991-02-05	The Amalgamated Sugar Company	Chromatographic separator sorbent bed preparation
US5019591A (en)	1989-02-17	1991-05-28	Pennsylvania Research Corporation	Method for treating retinopathy and other small vessel disorders associated with diabetes
CA2134211C (en)	1992-05-11	1999-06-29	James K. Woodward	Use of terfenadine derivatives as antihistaminics in a hepatically impaired patient
EP1688142A1 (de)	1992-08-03	2006-08-09	Sepracor Inc.	Terfenadin-Carboxylat und die Behandlung von Hautreizung
EP1369409B1 (de)	1993-06-24	2006-04-05	AMR Technology, Inc.	Verfahren zur Herstellung von Verbindungen geeignet als Zwischenprodukte
WO1995010278A1 (en)	1993-10-15	1995-04-20	Hoechst Marion Roussel, Inc.	Treatment of allergic disorders with terfenadine carboxylate
US5633272A (en) *	1995-02-13	1997-05-27	Talley; John J.	Substituted isoxazoles for the treatment of inflammation
ES2247604T3 (es) *	1995-06-12	2006-03-01	G.D. SEARLE & CO.	Composiciones que comprenden un inhibidor de ciclooxigenasa-2 y un inhibidor de 5-lipoxigenasa.
IL125446A0 (en)	1996-02-08	1999-03-12	Merck & Co Inc	Pharmaceutical composition for the treatment of asthma allergy and inflammation
JP2000504723A (ja) *	1996-02-13	2000-04-18	ジー．ディー．サールアンドカンパニー	シクロオキシゲナーゼ―２阻害剤および５―リポキシゲナーゼ阻害剤投与の免疫抑制効果
US5919776A (en) *	1996-12-20	1999-07-06	Merck & Co., Inc.	Substituted aminoquinolines as modulators of chemokine receptor activity
US5900421A (en) *	1997-02-11	1999-05-04	Sepracor Inc.	Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine
DK1041990T3 (da) *	1997-12-23	2006-10-02	Schering Corp	Præparat til behandling af respiratoriske sygdomme og hudsygdomme med mindst en leukotrien-antagonist og mindst et antihistamin
US6194431B1 (en) *	1998-04-14	2001-02-27	Paul D. Rubin	Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors

1998
- 1998-04-14 US US09/059,570 patent/US6194431B1/en not_active Expired - Lifetime
1999
- 1999-04-13 KR KR1020007011354A patent/KR100686297B1/ko not_active Expired - Fee Related
- 1999-04-13 AU AU36409/99A patent/AU763979B2/en not_active Ceased
- 1999-04-13 BR BR9909641-2A patent/BR9909641A/pt not_active Application Discontinuation
- 1999-04-13 IL IL13899399A patent/IL138993A0/xx active IP Right Grant
- 1999-04-13 EP EP06112687A patent/EP1707216A1/de active Pending
- 1999-04-13 DK DK99918515T patent/DK1071463T3/da active
- 1999-04-13 ES ES99918515T patent/ES2260910T3/es not_active Expired - Lifetime
- 1999-04-13 WO PCT/US1999/008077 patent/WO1999052554A1/en not_active Ceased
- 1999-04-13 CA CA2328074A patent/CA2328074C/en not_active Expired - Fee Related
- 1999-04-13 PL PL99343526A patent/PL343526A1/xx unknown
- 1999-04-13 AT AT99918515T patent/ATE328608T1/de active
- 1999-04-13 DE DE69931771T patent/DE69931771T2/de not_active Expired - Lifetime
- 1999-04-13 CN CNA2005100832028A patent/CN1768749A/zh active Pending
- 1999-04-13 CN CN99807374A patent/CN1305385A/zh active Pending
- 1999-04-13 NZ NZ507762A patent/NZ507762A/en not_active IP Right Cessation
- 1999-04-13 EP EP99918515A patent/EP1071463B1/de not_active Expired - Lifetime
- 1999-04-13 PT PT99918515T patent/PT1071463E/pt unknown
- 1999-04-13 JP JP2000543164A patent/JP2002511426A/ja active Pending
- 1999-04-13 HU HU0102239A patent/HU228035B1/hu not_active IP Right Cessation
2000
- 2000-10-10 ZA ZA200005553A patent/ZA200005553B/xx unknown
- 2000-10-12 IL IL138993A patent/IL138993A/en not_active IP Right Cessation
- 2000-10-13 NO NO20005147A patent/NO20005147L/no not_active Application Discontinuation
- 2000-11-28 US US09/722,395 patent/US6509353B1/en not_active Expired - Lifetime
2002
- 2002-12-06 US US10/314,269 patent/US20030083343A1/en not_active Abandoned
2006
- 2006-09-05 CY CY20061101264T patent/CY1106800T1/el unknown
2012
- 2012-02-16 US US13/398,669 patent/US8404715B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL138993A0 (en)	2001-11-25
PT1071463E (pt)	2006-10-31
KR100686297B1 (ko)	2007-02-23
CA2328074A1 (en)	1999-10-21
NO20005147D0 (no)	2000-10-13
IL138993A (en)	2011-01-31
EP1071463A1 (de)	2001-01-31
ES2260910T3 (es)	2006-11-01
DE69931771T2 (de)	2006-10-12
CA2328074C (en)	2012-02-21
AU3640999A (en)	1999-11-01
ZA200005553B (en)	2001-05-17
US20120149730A1 (en)	2012-06-14
CN1768749A (zh)	2006-05-10
DK1071463T3 (da)	2006-09-25
US6509353B1 (en)	2003-01-21
DE69931771D1 (de)	2006-07-20
EP1707216A1 (de)	2006-10-04
AU763979B2 (en)	2003-08-07
EP1071463B1 (de)	2006-06-07
BR9909641A (pt)	2000-12-19
US6194431B1 (en)	2001-02-27
US20030083343A1 (en)	2003-05-01
KR20010042655A (ko)	2001-05-25
HUP0102239A2 (hu)	2002-03-28
WO1999052554A1 (en)	1999-10-21
JP2002511426A (ja)	2002-04-16
NZ507762A (en)	2003-09-26
CN1305385A (zh)	2001-07-25
PL343526A1 (en)	2001-08-27
CY1106800T1 (el)	2012-05-23
US8404715B2 (en)	2013-03-26
HUP0102239A3 (en)	2002-06-28
HU228035B1 (en)	2012-08-28
NO20005147L (no)	2000-11-07

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