ATE329903T1 - Hochgradig lipophile camptothecin-derivate - Google Patents

Hochgradig lipophile camptothecin-derivate

Info

Publication number: ATE329903T1
Authority: AT; Austria
Prior art keywords: derivatives; camptothecin derivatives; highly lipophilic; lipophilic camptothecin; substitution
Prior art date: 1997-02-14

Application number

AT98904990T

Other languages

English (en)

Inventor

Frederick H Hausheer

Kochat Haridas

P Seetharamulu

Dasharatha G Reddy

Shijie Yao

Pavankumar N V Petluru

Dhanabalan Murali

Original Assignee

Bionumerik Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-14

Filing date

1998-02-11

Publication date

2006-07-15

1998-02-11 Application filed by Bionumerik Pharmaceuticals Inc filed Critical Bionumerik Pharmaceuticals Inc

2006-07-15 Application granted granted Critical

2006-07-15 Publication of ATE329903T1 publication Critical patent/ATE329903T1/de

Links

VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
238000006467 substitution reaction Methods 0.000 abstract 2
229940123780 DNA topoisomerase I inhibitor Drugs 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
239000000365 Topoisomerase I Inhibitor Substances 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000008024 pharmaceutical diluent Substances 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
229940124531 pharmaceutical excipient Drugs 0.000 abstract 1
239000000725 suspension Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Silicon Polymers (AREA)
Saccharide Compounds (AREA)

AT98904990T 1997-02-14 1998-02-11 Hochgradig lipophile camptothecin-derivate ATE329903T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US3714897P	1997-02-14	1997-02-14

Publications (1)

Publication Number	Publication Date
ATE329903T1 true ATE329903T1 (de)	2006-07-15

Family

ID=21892705

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98904990T ATE329903T1 (de)	1997-02-14	1998-02-11	Hochgradig lipophile camptothecin-derivate

Country Status (10)

Country	Link
EP (1)	EP1017675B1 (de)
JP (2)	JP4311765B2 (de)
AT (1)	ATE329903T1 (de)
AU (1)	AU6272598A (de)
CA (1)	CA2280905C (de)
DE (1)	DE69834923T2 (de)
DK (1)	DK1017675T3 (de)
ES (1)	ES2262223T3 (de)
PT (1)	PT1017675E (de)
WO (1)	WO1998035940A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6136978A (en) *	1993-06-30	2000-10-24	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
US6743917B2 (en)	1993-06-30	2004-06-01	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
US6150343A (en) *	1993-06-30	2000-11-21	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
FR2790261B1 (fr) *	1999-02-26	2004-09-10	Sod Conseils Rech Applic	Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
DE69834923T2 (de) *	1997-02-14	2006-10-19	Bionumerik Pharmaceuticals, Inc., San Antonio	Hochgradig lipophile camptothecin-derivate
US6057303A (en) *	1998-10-20	2000-05-02	Bionumerik Pharmaceuticals, Inc.	Highly lipophilic Camptothecin derivatives
US6207832B1 (en)	1999-04-09	2001-03-27	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
AU4822500A (en) *	1999-05-04	2000-11-17	Bionumerik Pharmaceuticals, Inc.	Novel highly lipophilic camptothecin analogs
US6350756B1 (en) *	2001-01-18	2002-02-26	California Pacific Medical Center	Camptothecin derivatives
US6855720B2 (en)	2001-03-01	2005-02-15	California Pacific Medical Center	Nitrogen-based camptothecin derivatives
US6372906B1 (en)	2001-04-12	2002-04-16	University Of Pittsburgh	Synthesis of silyl camptothecins and silyl homocamptothecins
US6723853B2 (en)	2001-08-27	2004-04-20	University Of Pittsburgh	Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
UA80409C2 (en)	2001-11-30	2007-09-25	Chugai Pharmaceutical Co Ltd	Hexacyclic compounds
US6933302B2 (en)	2002-06-03	2005-08-23	California Pacific Medical Center	Nitrogen-based homo-camptothecin derivatives
EP1393719A1 (de) *	2002-08-23	2004-03-03	Munich Biotech AG	Camptothecin-Carboxylat Formulierungen
US7067666B2 (en) *	2003-06-27	2006-06-27	Research Triangle Institute	7-substituted camptothecin and camptothecin analogs and methods for producing the same
DK1694242T3 (da) *	2003-12-17	2014-06-30	Bionumerik Pharmaceuticals Inc	Fremgangsmåde til fremstilling af farmaceutiske 7-(2-trimethylsilylethyl)camptothecinpræparater
US7910593B2 (en)	2004-04-09	2011-03-22	Chugai Seiyaku Kabushiki Kaisha	Water-soluble prodrugs
ITRM20040240A1 (it) *	2004-05-13	2004-08-13	Ist Naz Stud Cura Dei Tumori	Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
TW200744603A (en)	2005-08-22	2007-12-16	Chugai Pharmaceutical Co Ltd	Novel anticancer concomitant drug
US7875602B2 (en)	2005-10-21	2011-01-25	Sutter West Bay Hospitals	Camptothecin derivatives as chemoradiosensitizing agents
WO2007075492A1 (en) *	2005-12-16	2007-07-05	Sonus Pharmaceuticals, Inc.	Lipophilic anticancer drug compounds
BRPI0714277A2 (pt) *	2006-08-11	2013-04-24	Christus Stehlin Foundation For Cancer Res	mÉtodo paa fazer um Éster alifÁtico de camptotecina e Éster alifÁtico de camptotecina
CN103068404B (zh)	2010-06-11	2015-11-25	独立行政法人科学技术振兴机构	药物多聚物微粒及其制造方法
WO2014067960A2 (en) *	2012-10-30	2014-05-08	Nerviano Medical Sciences S.R.L.	Functionalized 9-bromo-camptothecin derivatives
FR3029637B1 (fr)	2014-12-05	2018-01-05	Universite De Strasbourg	Microdispositif de detection de composes organiques volatils et methode de detection d'au moins un compose organique volatil compris dans un echantillon gazeux
KR20260089547A (ko) *	2023-10-10	2026-06-15	상하이 이노브콩 파마슈티컬 테크놀로지 코., 엘티디	새로운 i형 토포이소머라아제 억제제 및 그 제조 방법과 용도
CN122497675A (zh) *	2024-06-05	2026-07-31	荣昌生物制药(烟台)股份有限公司	一种喜树碱类化合物及其用途
WO2026153464A1 (zh) *	2025-01-20	2026-07-23	四川科伦博泰生物医药股份有限公司	一种喜树碱类衍生物的制备方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5004758A (en) *	1987-12-01	1991-04-02	Smithkline Beecham Corporation	Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) *	1988-01-20	1994-03-02	株式会社ヤクルト本社	新規なカンプトテシン誘導体
US5446047A (en) *	1992-07-23	1995-08-29	Sloan-Kettering Institute For Cancer Research	Camptothecin analogues
US5468754A (en) *	1994-04-19	1995-11-21	Bionumerik Pharmaceuticals, Inc.	11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
GB9510716D0 (en) *	1995-05-26	1995-07-19	Pharmacia Spa	Substituted camptothecin derivatives and process for their preparation
DE69834923T2 (de) *	1997-02-14	2006-10-19	Bionumerik Pharmaceuticals, Inc., San Antonio	Hochgradig lipophile camptothecin-derivate

1998
- 1998-02-11 DE DE69834923T patent/DE69834923T2/de not_active Expired - Lifetime
- 1998-02-11 PT PT98904990T patent/PT1017675E/pt unknown
- 1998-02-11 ES ES98904990T patent/ES2262223T3/es not_active Expired - Lifetime
- 1998-02-11 JP JP53583598A patent/JP4311765B2/ja not_active Expired - Lifetime
- 1998-02-11 AT AT98904990T patent/ATE329903T1/de active
- 1998-02-11 DK DK98904990T patent/DK1017675T3/da active
- 1998-02-11 AU AU62725/98A patent/AU6272598A/en not_active Abandoned
- 1998-02-11 EP EP98904990A patent/EP1017675B1/de not_active Expired - Lifetime
- 1998-02-11 CA CA002280905A patent/CA2280905C/en not_active Expired - Lifetime
- 1998-02-11 WO PCT/US1998/002375 patent/WO1998035940A1/en not_active Ceased
2009
- 2009-03-02 JP JP2009047622A patent/JP5264561B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2001511807A (ja)	2001-08-14
AU6272598A (en)	1998-09-08
EP1017675A4 (de)	2001-08-22
JP2009149680A (ja)	2009-07-09
DE69834923D1 (en)	2006-07-27
JP5264561B2 (ja)	2013-08-14
CA2280905A1 (en)	1998-08-20
ES2262223T3 (es)	2006-11-16
EP1017675A1 (de)	2000-07-12
CA2280905C (en)	2006-08-29
WO1998035940A1 (en)	1998-08-20
DE69834923T2 (de)	2006-10-19
PT1017675E (pt)	2006-09-29
EP1017675B1 (de)	2006-06-14
JP4311765B2 (ja)	2009-08-12
DK1017675T3 (da)	2006-10-16

Legal Events

Date

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Title

Description

2007-03-15

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Publication of translation of european patent specification

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