DK1017675T3 - Stærkt lipofile camptothecinderivater - Google Patents

Stærkt lipofile camptothecinderivater

Info

Publication number: DK1017675T3
Authority: DK; Denmark
Prior art keywords: derivatives; camptothecin derivatives; strongly lipophilic; lipophilic camptothecin; substitution
Prior art date: 1997-02-14

Application number

DK98904990T

Other languages

English (en)

Inventor

Frederick H Hausheer

Kochat Haridas

Dasharatha G Reddy

Shijie Yao

Dhanabalan Murali

P Seetharamulu

Pavankumar N V Petluru

Original Assignee

Bionumerik Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-14

Filing date

1998-02-11

Publication date

2006-10-16

1998-02-11 Application filed by Bionumerik Pharmaceuticals Inc filed Critical Bionumerik Pharmaceuticals Inc

2006-10-16 Application granted granted Critical

2006-10-16 Publication of DK1017675T3 publication Critical patent/DK1017675T3/da

Links

VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
238000006467 substitution reaction Methods 0.000 abstract 2
229940123780 DNA topoisomerase I inhibitor Drugs 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
239000000365 Topoisomerase I Inhibitor Substances 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000008024 pharmaceutical diluent Substances 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
229940124531 pharmaceutical excipient Drugs 0.000 abstract 1
239000000725 suspension Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Silicon Polymers (AREA)
Saccharide Compounds (AREA)

DK98904990T 1997-02-14 1998-02-11 Stærkt lipofile camptothecinderivater DK1017675T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US3714897P	1997-02-14	1997-02-14

Publications (1)

Publication Number	Publication Date
DK1017675T3 true DK1017675T3 (da)	2006-10-16

Family

ID=21892705

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98904990T DK1017675T3 (da)	1997-02-14	1998-02-11	Stærkt lipofile camptothecinderivater

Country Status (10)

Country	Link
EP (1)	EP1017675B1 (da)
JP (2)	JP4311765B2 (da)
AT (1)	ATE329903T1 (da)
AU (1)	AU6272598A (da)
CA (1)	CA2280905C (da)
DE (1)	DE69834923T2 (da)
DK (1)	DK1017675T3 (da)
ES (1)	ES2262223T3 (da)
PT (1)	PT1017675E (da)
WO (1)	WO1998035940A1 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6150343A (en) *	1993-06-30	2000-11-21	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
US6136978A (en) *	1993-06-30	2000-10-24	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
US6743917B2 (en)	1993-06-30	2004-06-01	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
FR2790261B1 (fr) *	1999-02-26	2004-09-10	Sod Conseils Rech Applic	Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
ATE329903T1 (de) *	1997-02-14	2006-07-15	Bionumerik Pharmaceuticals Inc	Hochgradig lipophile camptothecin-derivate
US6057303A (en) *	1998-10-20	2000-05-02	Bionumerik Pharmaceuticals, Inc.	Highly lipophilic Camptothecin derivatives
US6207832B1 (en)	1999-04-09	2001-03-27	University Of Pittsburgh	Camptothecin analogs and methods of preparation thereof
WO2000066127A1 (en) *	1999-05-04	2000-11-09	Bionumerik Pharmaceuticals, Inc.	Novel highly lipophilic camptothecin analogs
US6350756B1 (en) *	2001-01-18	2002-02-26	California Pacific Medical Center	Camptothecin derivatives
US6855720B2 (en)	2001-03-01	2005-02-15	California Pacific Medical Center	Nitrogen-based camptothecin derivatives
US6372906B1 (en)	2001-04-12	2002-04-16	University Of Pittsburgh	Synthesis of silyl camptothecins and silyl homocamptothecins
US6723853B2 (en)	2001-08-27	2004-04-20	University Of Pittsburgh	Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
DE60227113D1 (de)	2001-11-30	2008-07-24	Chugai Pharmaceutical Co Ltd	Kondensierte camptothecine als antitumormittel
US6933302B2 (en)	2002-06-03	2005-08-23	California Pacific Medical Center	Nitrogen-based homo-camptothecin derivatives
EP1393719A1 (en) *	2002-08-23	2004-03-03	Munich Biotech AG	Camptothecin-carboxylate formulations
US7067666B2 (en) *	2003-06-27	2006-06-27	Research Triangle Institute	7-substituted camptothecin and camptothecin analogs and methods for producing the same
WO2005060871A1 (en) *	2003-12-17	2005-07-07	Bionumerik Pharmaceuticals, Inc.	Pharmaceutical formulations of camptothecins and process for making same
RU2413731C2 (ru)	2004-04-09	2011-03-10	Чугаи Сейяку Кабусики Кайся	Новые растворимые в воде пролекарства
ITRM20040240A1 (it) *	2004-05-13	2004-08-13	Ist Naz Stud Cura Dei Tumori	Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
TW200744603A (en)	2005-08-22	2007-12-16	Chugai Pharmaceutical Co Ltd	Novel anticancer concomitant drug
US7875602B2 (en)	2005-10-21	2011-01-25	Sutter West Bay Hospitals	Camptothecin derivatives as chemoradiosensitizing agents
WO2007075492A1 (en) *	2005-12-16	2007-07-05	Sonus Pharmaceuticals, Inc.	Lipophilic anticancer drug compounds
CN101522686A (zh) *	2006-08-11	2009-09-02	克里斯特斯斯特林癌症研究基金会	制备喜树碱酯的方法
CN103068404B (zh)	2010-06-11	2015-11-25	独立行政法人科学技术振兴机构	药物多聚物微粒及其制造方法
WO2014067960A2 (en) *	2012-10-30	2014-05-08	Nerviano Medical Sciences S.R.L.	Functionalized 9-bromo-camptothecin derivatives
FR3029637B1 (fr)	2014-12-05	2018-01-05	Universite De Strasbourg	Microdispositif de detection de composes organiques volatils et methode de detection d'au moins un compose organique volatil compris dans un echantillon gazeux
WO2025077773A1 (zh) *	2023-10-10	2025-04-17	上海翊维康医药有限责任公司	新的i型拓扑异构酶抑制剂及其制备方法和用途
WO2025252101A1 (zh) *	2024-06-05	2025-12-11	荣昌生物制药(烟台)股份有限公司	一种喜树碱类化合物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5004758A (en) *	1987-12-01	1991-04-02	Smithkline Beecham Corporation	Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) *	1988-01-20	1994-03-02	株式会社ヤクルト本社	新規なカンプトテシン誘導体
US5446047A (en) *	1992-07-23	1995-08-29	Sloan-Kettering Institute For Cancer Research	Camptothecin analogues
US5468754A (en) *	1994-04-19	1995-11-21	Bionumerik Pharmaceuticals, Inc.	11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
GB9510716D0 (en) *	1995-05-26	1995-07-19	Pharmacia Spa	Substituted camptothecin derivatives and process for their preparation
ATE329903T1 (de) *	1997-02-14	2006-07-15	Bionumerik Pharmaceuticals Inc	Hochgradig lipophile camptothecin-derivate

1998
- 1998-02-11 AT AT98904990T patent/ATE329903T1/de active
- 1998-02-11 AU AU62725/98A patent/AU6272598A/en not_active Abandoned
- 1998-02-11 DE DE69834923T patent/DE69834923T2/de not_active Expired - Lifetime
- 1998-02-11 PT PT98904990T patent/PT1017675E/pt unknown
- 1998-02-11 DK DK98904990T patent/DK1017675T3/da active
- 1998-02-11 JP JP53583598A patent/JP4311765B2/ja not_active Expired - Lifetime
- 1998-02-11 EP EP98904990A patent/EP1017675B1/en not_active Expired - Lifetime
- 1998-02-11 ES ES98904990T patent/ES2262223T3/es not_active Expired - Lifetime
- 1998-02-11 CA CA002280905A patent/CA2280905C/en not_active Expired - Lifetime
- 1998-02-11 WO PCT/US1998/002375 patent/WO1998035940A1/en not_active Ceased
2009
- 2009-03-02 JP JP2009047622A patent/JP5264561B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE329903T1 (de)	2006-07-15
CA2280905A1 (en)	1998-08-20
JP2001511807A (ja)	2001-08-14
ES2262223T3 (es)	2006-11-16
DE69834923T2 (de)	2006-10-19
PT1017675E (pt)	2006-09-29
AU6272598A (en)	1998-09-08
DE69834923D1 (en)	2006-07-27
JP4311765B2 (ja)	2009-08-12
EP1017675A1 (en)	2000-07-12
EP1017675A4 (en)	2001-08-22
CA2280905C (en)	2006-08-29
JP2009149680A (ja)	2009-07-09
JP5264561B2 (ja)	2013-08-14
EP1017675B1 (en)	2006-06-14
WO1998035940A1 (en)	1998-08-20

Publication	Publication Date	Title
DK1017675T3 (da)	2006-10-16	Stærkt lipofile camptothecinderivater
ATE261974T1 (de)	2004-04-15	Hoch-lipophile campothecin-derivate
EA200100111A1 (ru)	2001-06-25	Ингибиторы фарнезилпротеинтрансферазы, обладающие in vivo радиосенсибилизирующими свойствами
TR200000576T1 (tr)	2000-11-21	Lipozomal kapsüllenmiş taksan uygulanması için bir yöntem
AR022860A1 (es)	2002-09-04	Derivados de camptotecina que poseen actividad antitumoral
ATE472551T1 (de)	2010-07-15	Tocopherolmodifizierte therapeutische arzneimittelverbindung
CY1108070T1 (el)	2014-02-12	Παραγωγα κινολινονης, ως αναστολεις κινασης τυροσινης
CY1107074T1 (el)	2012-10-24	Συνθεση εναντιομερων 4-αμινο-θαλιδομιδης
PT1212312E (pt)	2003-08-29	Novos derivados de flavonas xantonas e cumarinas
DE60021381D1 (de)	2005-08-25	Chinonverbindungen zur behandlung von krankheiten
ATE344670T1 (de)	2006-11-15	Synergistische kombination zur behandlung von kolorektalkarzinom
CO5660287A2 (es)	2006-07-31	Derivados de tetrahidrocarbazol y su uso farmaceutico
NO20031410D0 (no)	2003-03-27	Antitumorterapi innbefattende distamycinderivater
PT1107793E (pt)	2005-02-28	Conjugados de dextrano-leptina, composicoes farmaceuticas e processos relacionados
ATE217531T1 (de)	2002-06-15	Verwendung von natriumchlorid zur verminderung der gastrointestinalen toxizität von camptotecinderivaten.
TR200302134T4 (tr)	2004-01-21	2-metil-tiazolidin-2,4-dikarboksilik asit ve/veya bunun fizyolojik olarak uygun tuzlarının anti-kanser ajanları olarak kullanımı.
DE69612056D1 (de)	2001-04-19	Terpenderivate (sarcodictyine) als antikrebsmittel
BR0014687A (pt)	2002-11-19	Compostos de taxano pentacìclico
SE9803107D0 (sv)	1998-09-14	Novel Compunds
SE9602262D0 (sv)	1996-06-06	New use of derivatives of cystine
DE60039122D1 (de)	2008-07-17	6-o-alkyl-2-nor-2-substituierte ketolidderivate
SE9803277D0 (sv)	1998-09-25	Novel compounds