ATE329904T1 - Östrogenrezeptormodulatoren - Google Patents
ÖstrogenrezeptormodulatorenInfo
- Publication number
- ATE329904T1 ATE329904T1 AT01995915T AT01995915T ATE329904T1 AT E329904 T1 ATE329904 T1 AT E329904T1 AT 01995915 T AT01995915 T AT 01995915T AT 01995915 T AT01995915 T AT 01995915T AT E329904 T1 ATE329904 T1 AT E329904T1
- Authority
- AT
- Austria
- Prior art keywords
- estrogen
- receptor modulators
- compounds
- estrogen receptor
- functioning
- Prior art date
Links
- 239000002834 estrogen receptor modulator Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000010392 Bone Fractures Diseases 0.000 abstract 1
- 206010065687 Bone loss Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 208000033830 Hot Flashes Diseases 0.000 abstract 1
- 206010060800 Hot flush Diseases 0.000 abstract 1
- 206010021639 Incontinence Diseases 0.000 abstract 1
- 238000008214 LDL Cholesterol Methods 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 206010046798 Uterine leiomyoma Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 230000001149 cognitive effect Effects 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 102000015694 estrogen receptors Human genes 0.000 abstract 1
- 108010038795 estrogen receptors Proteins 0.000 abstract 1
- 201000010260 leiomyoma Diseases 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 210000002307 prostate Anatomy 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 208000010579 uterine corpus leiomyoma Diseases 0.000 abstract 1
- 201000007954 uterine fibroid Diseases 0.000 abstract 1
- 210000004291 uterus Anatomy 0.000 abstract 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25311400P | 2000-11-27 | 2000-11-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE329904T1 true ATE329904T1 (de) | 2006-07-15 |
Family
ID=22958920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01995915T ATE329904T1 (de) | 2000-11-27 | 2001-11-21 | Östrogenrezeptormodulatoren |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1339683B1 (de) |
| JP (1) | JP4119246B2 (de) |
| AT (1) | ATE329904T1 (de) |
| AU (2) | AU2002226965B2 (de) |
| CA (1) | CA2428019C (de) |
| DE (1) | DE60120746T2 (de) |
| ES (1) | ES2265453T3 (de) |
| WO (1) | WO2002041835A2 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005502654A (ja) * | 2001-08-13 | 2005-01-27 | メルク エンド カムパニー インコーポレーテッド | 選択的エストロゲン受容体調節剤 |
| CN100506795C (zh) * | 2003-06-18 | 2009-07-01 | 中国科学院上海药物研究所 | 茚酮并吲哚类化合物、制备方法及它的医学用途 |
| CN1839114A (zh) | 2003-08-21 | 2006-09-27 | 默克弗罗斯特加拿大有限公司 | 组织蛋白酶半胱氨酸蛋白酶抑制剂 |
| US20070191438A1 (en) * | 2004-04-06 | 2007-08-16 | Rohrer Susan P | Methods for the treatment of hypertension |
| US7709508B2 (en) | 2004-12-09 | 2010-05-04 | Merck Sharp & Dohme | Estrogen receptor modulators |
| WO2006062876A2 (en) * | 2004-12-09 | 2006-06-15 | Merck & Co., Inc. | Estrogen receptor modulators |
| AU2006302797B2 (en) | 2005-03-02 | 2012-02-02 | Merck Canada Inc. | Composition for inhibition of cathepsin K |
| EP1943224B1 (de) * | 2005-10-05 | 2011-07-27 | Merck Sharp & Dohme Corp. | Östrogenrezeptormodulatoren |
| CA2628856A1 (en) * | 2005-11-08 | 2007-05-18 | Jordi Frigola-Constansa | Indene derivatives, their preparation and use as medicaments |
| NL2000351C2 (nl) | 2005-12-22 | 2007-09-11 | Pfizer Prod Inc | Estrogeen-modulatoren. |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| KR101638035B1 (ko) | 2007-01-22 | 2016-07-11 | 지티엑스, 인코포레이티드 | 핵 수용체에 결합하는 물질 |
| US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| EP2675440B1 (de) | 2011-02-14 | 2020-03-25 | Merck Sharp & Dohme Corp. | Cathepsin-cysteinproteasehemmer |
| RU2500670C1 (ru) * | 2012-08-07 | 2013-12-10 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Нижегородский Государственный Университет Им. Н.И. Лобачевского" | ПРОИЗВОДНОЕ 1',2',3'-ТРИМЕТОКСИБЕНЗО[4',5':4,5]-6,7-ДИГИДРОЦИКЛОГЕПТА-[2,3-e]-1H-1-МЕТИЛИНДОЛА И ЕГО ПРИМЕНЕНИЕ |
| RU2500671C1 (ru) * | 2012-08-07 | 2013-12-10 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Нижегородский Государственный Университет Им. Н.И. Лобачевского" | ПРОИЗВОДНОЕ 1',2',3'-ТРИМЕТОКСИБЕНЗО[4',5':4,5]-6,7-ДИГИДРОЦИКЛОГЕПТА-[3,2-f]-1H-1-МЕТИЛИНДОЛА И ЕГО ПРИМЕНЕНИЕ |
| RU2692799C2 (ru) | 2013-10-08 | 2019-06-27 | Мерк Шарп И Доум Корп. | Ингибиторы цистеинпротеаз катепсинов |
| WO2015051479A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| CN105960236A (zh) | 2013-12-05 | 2016-09-21 | 卡罗医药股份公司 | 用于治疗间皮瘤的雌激素受体β激动剂 |
| WO2015120580A1 (en) | 2014-02-11 | 2015-08-20 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
-
2001
- 2001-11-21 JP JP2002544016A patent/JP4119246B2/ja not_active Expired - Fee Related
- 2001-11-21 AU AU2002226965A patent/AU2002226965B2/en not_active Ceased
- 2001-11-21 AT AT01995915T patent/ATE329904T1/de not_active IP Right Cessation
- 2001-11-21 ES ES01995915T patent/ES2265453T3/es not_active Expired - Lifetime
- 2001-11-21 EP EP01995915A patent/EP1339683B1/de not_active Expired - Lifetime
- 2001-11-21 WO PCT/US2001/044010 patent/WO2002041835A2/en not_active Ceased
- 2001-11-21 CA CA2428019A patent/CA2428019C/en not_active Expired - Fee Related
- 2001-11-21 AU AU2696502A patent/AU2696502A/xx active Pending
- 2001-11-21 DE DE60120746T patent/DE60120746T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002041835A3 (en) | 2003-01-23 |
| AU2002226965B2 (en) | 2006-05-18 |
| AU2696502A (en) | 2002-06-03 |
| DE60120746D1 (de) | 2006-07-27 |
| WO2002041835A2 (en) | 2002-05-30 |
| EP1339683B1 (de) | 2006-06-14 |
| CA2428019C (en) | 2010-09-21 |
| EP1339683A2 (de) | 2003-09-03 |
| EP1339683A4 (de) | 2005-07-27 |
| JP2004523486A (ja) | 2004-08-05 |
| JP4119246B2 (ja) | 2008-07-16 |
| CA2428019A1 (en) | 2002-05-30 |
| DE60120746T2 (de) | 2007-05-24 |
| ES2265453T3 (es) | 2007-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE524170T1 (de) | Östrogenrezeptor modulatoren | |
| EP1501819A4 (de) | Modulatoren des östrogenrezeptors | |
| DE60120746D1 (de) | Östrogenrezeptormodulatoren | |
| WO2002091993A3 (en) | Estrogen receptor modulators | |
| WO2002032377A3 (en) | Estrogen receptor modulators | |
| MX2007006878A (es) | Moduladores del receptor de estrogeno. | |
| TW200631933A (en) | Estrogen receptor modulators | |
| WO2004073612A3 (en) | Estrogen receptor modulators | |
| WO2004091488A3 (en) | Estrogen receptor modulators | |
| WO2007062230A3 (en) | Nuclear receptor binding agents | |
| WO2002032373A3 (en) | Estrogen receptor modulators | |
| AU2003288644A1 (en) | Mercapto-phenyl-naphthyl-methane derivatives and preparation thereof | |
| WO2006081152A3 (en) | Estrogen receptor modulators | |
| WO2005097141A3 (en) | Estrogen receptor modulators | |
| EP1943224A4 (de) | Östrogenrezeptormodulatoren | |
| WO2002058639A3 (en) | Pyranoflavonoid compounds and their use as estrogen receptor modulators | |
| WO2002053522A3 (en) | Novel estrogen receptor ligands and methods i | |
| AR039282A1 (es) | Moduladores de receptores de estrogeno | |
| WO2004073610A3 (en) | Estrogen receptor modulators | |
| WO2004026887A3 (en) | Estrogen receptor modulators | |
| WO2008057309A3 (en) | Estrogen receptor modulators | |
| WO2009059806A3 (en) | Preparation of 6-oxa-8alpha-steroid estrogen analogues - a new group of unnatural estrogens and their use in medicine | |
| MA32477B1 (fr) | Derives estratrienes comprenant des bioisosteres heterocycliques pour le cycle a phenolique | |
| DOP2002000384A (es) | Moduladores de receptores estrogenicos. | |
| DOP2005000224A (es) | Moduladores de los receptores de estrogeno |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |