ATE330634T1 - Nicht-peptidische ccr1 rezeptor-antagonisten in kombination mit cyclosporin a zur behandlung von herztransplantatabstossung - Google Patents

Nicht-peptidische ccr1 rezeptor-antagonisten in kombination mit cyclosporin a zur behandlung von herztransplantatabstossung

Info

Publication number: ATE330634T1
Authority: AT; Austria
Prior art keywords: cyclosporin; transplant rejection; peptidic; heart transplant; treatment
Prior art date: 2000-07-31

Application number

AT01956035T

Other languages

English (en)

Inventor

Richard Horuk

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-31

Filing date

2001-07-31

Publication date

2006-07-15

2001-07-31 Application filed by Schering Ag filed Critical Schering Ag

2006-07-15 Application granted granted Critical

2006-07-15 Publication of ATE330634T1 publication Critical patent/ATE330634T1/de

Links

102000004500 CCR1 Receptors Human genes 0.000 title abstract 2
108010017319 CCR1 Receptors Proteins 0.000 title abstract 2
229930105110 Cyclosporin A Natural products 0.000 title abstract 2
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
108010036949 Cyclosporine Proteins 0.000 title abstract 2
206010019315 Heart transplant rejection Diseases 0.000 title abstract 2
229960001265 ciclosporin Drugs 0.000 title abstract 2
239000002464 receptor antagonist Substances 0.000 title abstract 2
229940044551 receptor antagonist Drugs 0.000 title abstract 2
241000124008 Mammalia Species 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Transplantation (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT01956035T 2000-07-31 2001-07-31 Nicht-peptidische ccr1 rezeptor-antagonisten in kombination mit cyclosporin a zur behandlung von herztransplantatabstossung ATE330634T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US22205300P	2000-07-31	2000-07-31
US23128200P	2000-09-08	2000-09-08
US09/915,411 US6740636B2 (en)	2000-07-31	2001-07-25	Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection

Publications (1)

Publication Number	Publication Date
ATE330634T1 true ATE330634T1 (de)	2006-07-15

Family

ID=27397025

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01956035T ATE330634T1 (de)	2000-07-31	2001-07-31	Nicht-peptidische ccr1 rezeptor-antagonisten in kombination mit cyclosporin a zur behandlung von herztransplantatabstossung

Country Status (28)

Country	Link
US (1)	US6740636B2 (de)
EP (1)	EP1305047B1 (de)
JP (1)	JP2004530630A (de)
KR (1)	KR20030048000A (de)
CN (1)	CN1655818A (de)
AT (1)	ATE330634T1 (de)
AU (2)	AU7807301A (de)
BG (1)	BG107502A (de)
BR (1)	BR0113140A (de)
CA (1)	CA2417636A1 (de)
CY (1)	CY1105321T1 (de)
DE (1)	DE60120986T2 (de)
DK (1)	DK1305047T3 (de)
EE (1)	EE200300047A (de)
ES (1)	ES2261447T3 (de)
HR (1)	HRP20030121A2 (de)
HU (1)	HUP0300686A3 (de)
IL (1)	IL153933A0 (de)
LV (1)	LV13033B (de)
MX (1)	MXPA03000836A (de)
NO (1)	NO20030475L (de)
NZ (1)	NZ523688A (de)
PL (1)	PL364521A1 (de)
PT (1)	PT1305047E (de)
SI (1)	SI21123A (de)
SK (1)	SK1222003A3 (de)
WO (1)	WO2002009762A2 (de)
YU (1)	YU6703A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2116228A1 (de)	2001-10-19	2009-11-11	Isotechnika Inc.	Neuartige Cyclosporinanalog-Mikroemulsionspräkonzentrate
CA2534941A1 (en) *	2003-08-22	2005-03-03	Schering Aktiengesellschaft	Chemokine inhibiting piperazine derivatives and their use to treat myocarditis
US10499828B2 (en) *	2004-03-05	2019-12-10	Lifescience Solutions, Llc	System and method for heart monitoring
US7917195B2 (en)	2004-03-05	2011-03-29	Lifesciences Solutions LLC	Systems, methods and computer program products for heart monitoring
US8103065B2 (en) *	2006-01-05	2012-01-24	Lifescience Solutions Llc	Assessment of medical conditions
US20110009758A1 (en) *	2009-07-10	2011-01-13	Lifescience Solutions Llc	System and method for heart monitoring

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6323206B1 (en)	1996-07-12	2001-11-27	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
CN1248968A (zh)	1997-02-26	2000-03-29	辉瑞大药厂	杂芳基－己酸酰胺衍生物、其制备方法及其作为MIP－1α与其CCRI受体结合的选择性抑制剂的用途
US6207665B1 (en) *	1997-06-12	2001-03-27	Schering Aktiengesellschaft	Piperazine derivatives and their use as anti-inflammatory agents
WO1999037619A1 (en)	1998-01-21	1999-07-29	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
ATE309249T1 (de)	1998-01-21	2005-11-15	Millennium Pharm Inc	Chemokin rezeptor antagonisten und verwndung
TR200002248T2 (tr)	1998-02-05	2000-12-21	Pfizer Products Inc.	Yeni dihidroksiheksanoik asit türevleri
EP1000626A1 (de)	1998-09-18	2000-05-17	Applied Research Systems ARS Holding N.V.	Kombination von chemokin-rezeptor antagonisten und cyclosporin zur therapie
AU2862300A (en)	1999-01-29	2000-08-18	Millennium Pharmaceuticals, Inc.	Methods for preventing graft rejection and ischemia-reperfusion injury

2001
- 2001-07-25 US US09/915,411 patent/US6740636B2/en not_active Expired - Fee Related
- 2001-07-31 HR HR20030121A patent/HRP20030121A2/hr not_active Application Discontinuation
- 2001-07-31 DK DK01956035T patent/DK1305047T3/da active
- 2001-07-31 CN CNA018138004A patent/CN1655818A/zh active Pending
- 2001-07-31 HU HU0300686A patent/HUP0300686A3/hu unknown
- 2001-07-31 AU AU7807301A patent/AU7807301A/xx active Pending
- 2001-07-31 NZ NZ523688A patent/NZ523688A/en unknown
- 2001-07-31 SK SK122-2003A patent/SK1222003A3/sk unknown
- 2001-07-31 MX MXPA03000836A patent/MXPA03000836A/es unknown
- 2001-07-31 SI SI200120045A patent/SI21123A/sl not_active IP Right Cessation
- 2001-07-31 KR KR10-2003-7001483A patent/KR20030048000A/ko not_active Withdrawn
- 2001-07-31 BR BR0113140-0A patent/BR0113140A/pt not_active IP Right Cessation
- 2001-07-31 CA CA002417636A patent/CA2417636A1/en not_active Abandoned
- 2001-07-31 AT AT01956035T patent/ATE330634T1/de not_active IP Right Cessation
- 2001-07-31 EE EEP200300047A patent/EE200300047A/xx unknown
- 2001-07-31 ES ES01956035T patent/ES2261447T3/es not_active Expired - Lifetime
- 2001-07-31 IL IL15393301A patent/IL153933A0/xx unknown
- 2001-07-31 DE DE60120986T patent/DE60120986T2/de not_active Expired - Fee Related
- 2001-07-31 YU YU6703A patent/YU6703A/sh unknown
- 2001-07-31 AU AU2001278073A patent/AU2001278073B2/en not_active Expired - Fee Related
- 2001-07-31 EP EP01956035A patent/EP1305047B1/de not_active Expired - Lifetime
- 2001-07-31 PT PT01956035T patent/PT1305047E/pt unknown
- 2001-07-31 WO PCT/US2001/023862 patent/WO2002009762A2/en not_active Ceased
- 2001-07-31 JP JP2002515314A patent/JP2004530630A/ja not_active Withdrawn
- 2001-07-31 PL PL01364521A patent/PL364521A1/xx not_active Application Discontinuation
2003
- 2003-01-27 BG BG107502A patent/BG107502A/xx unknown
- 2003-01-30 NO NO20030475A patent/NO20030475L/no not_active Application Discontinuation
- 2003-02-28 LV LVP-03-25A patent/LV13033B/en unknown
2006
- 2006-09-05 CY CY20061101266T patent/CY1105321T1/el unknown

Also Published As

Publication number	Publication date
IL153933A0 (en)	2003-07-31
YU6703A (sh)	2006-05-25
KR20030048000A (ko)	2003-06-18
PL364521A1 (en)	2004-12-13
CN1655818A (zh)	2005-08-17
HRP20030121A2 (en)	2005-02-28
EE200300047A (et)	2004-10-15
WO2002009762A2 (en)	2002-02-07
NZ523688A (en)	2005-04-29
CY1105321T1 (el)	2010-03-03
SK1222003A3 (en)	2003-09-11
LV13033B (en)	2004-02-20
WO2002009762A3 (en)	2003-01-09
HUP0300686A3 (en)	2005-03-29
EP1305047A2 (de)	2003-05-02
DK1305047T3 (da)	2006-10-23
ES2261447T3 (es)	2006-11-16
NO20030475L (no)	2003-03-28
MXPA03000836A (es)	2003-06-06
CA2417636A1 (en)	2002-02-07
DE60120986T2 (de)	2006-11-23
BG107502A (en)	2003-07-31
BR0113140A (pt)	2003-06-24
SI21123A (sl)	2003-08-31
US20020039997A1 (en)	2002-04-04
DE60120986D1 (de)	2006-08-03
HUP0300686A2 (hu)	2003-08-28
JP2004530630A (ja)	2004-10-07
EP1305047B1 (de)	2006-06-21
PT1305047E (pt)	2006-11-30
NO20030475D0 (no)	2003-01-30
AU7807301A (en)	2002-02-13
US6740636B2 (en)	2004-05-25
AU2001278073B2 (en)	2005-06-30

Legal Events

Date

Code

Title

Description

2007-04-15

UEP

Publication of translation of european patent specification

Ref document number: 1305047

Country of ref document: EP

2009-04-15

REN

Ceased due to non-payment of the annual fee

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