HRP20030121A2 - Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplant rejection - Google Patents

Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplant rejection Download PDF

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Publication number
HRP20030121A2
HRP20030121A2 HR20030121A HRP20030121A HRP20030121A2 HR P20030121 A2 HRP20030121 A2 HR P20030121A2 HR 20030121 A HR20030121 A HR 20030121A HR P20030121 A HRP20030121 A HR P20030121A HR P20030121 A2 HRP20030121 A2 HR P20030121A2
Authority
HR
Croatia
Prior art keywords
methyl
ccr1 receptor
receptor antagonist
piperazine
fluorobenzyl
Prior art date
Application number
HR20030121A
Other languages
English (en)
Croatian (hr)
Inventor
Horuk Richard
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of HRP20030121A2 publication Critical patent/HRP20030121A2/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20030121A 2000-07-31 2001-07-31 Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplant rejection HRP20030121A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22205300P 2000-07-31 2000-07-31
US23128200P 2000-09-08 2000-09-08
US09/915,411 US6740636B2 (en) 2000-07-31 2001-07-25 Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection
PCT/US2001/023862 WO2002009762A2 (en) 2000-07-31 2001-07-31 Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplant rejection

Publications (1)

Publication Number Publication Date
HRP20030121A2 true HRP20030121A2 (en) 2005-02-28

Family

ID=27397025

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030121A HRP20030121A2 (en) 2000-07-31 2001-07-31 Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplant rejection

Country Status (28)

Country Link
US (1) US6740636B2 (de)
EP (1) EP1305047B1 (de)
JP (1) JP2004530630A (de)
KR (1) KR20030048000A (de)
CN (1) CN1655818A (de)
AT (1) ATE330634T1 (de)
AU (2) AU7807301A (de)
BG (1) BG107502A (de)
BR (1) BR0113140A (de)
CA (1) CA2417636A1 (de)
CY (1) CY1105321T1 (de)
DE (1) DE60120986T2 (de)
DK (1) DK1305047T3 (de)
EE (1) EE200300047A (de)
ES (1) ES2261447T3 (de)
HR (1) HRP20030121A2 (de)
HU (1) HUP0300686A3 (de)
IL (1) IL153933A0 (de)
LV (1) LV13033B (de)
MX (1) MXPA03000836A (de)
NO (1) NO20030475L (de)
NZ (1) NZ523688A (de)
PL (1) PL364521A1 (de)
PT (1) PT1305047E (de)
SI (1) SI21123A (de)
SK (1) SK1222003A3 (de)
WO (1) WO2002009762A2 (de)
YU (1) YU6703A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL160761A0 (en) 2001-10-19 2004-08-31 Isotechnika Inc Novel cyclosporin analog microemulsion preconcentrates
EP1660089A1 (de) * 2003-08-22 2006-05-31 Schering Aktiengesellschaft Chemokin-hemmende piperazin-derivate und ihre verwendung zur behandlung von myokarditis
US7917195B2 (en) 2004-03-05 2011-03-29 Lifesciences Solutions LLC Systems, methods and computer program products for heart monitoring
US10499828B2 (en) * 2004-03-05 2019-12-10 Lifescience Solutions, Llc System and method for heart monitoring
US8103065B2 (en) * 2006-01-05 2012-01-24 Lifescience Solutions Llc Assessment of medical conditions
US20110009758A1 (en) * 2009-07-10 2011-01-13 Lifescience Solutions Llc System and method for heart monitoring

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323206B1 (en) 1996-07-12 2001-11-27 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
WO1998038167A1 (en) 1997-02-26 1998-09-03 Pfizer Inc. Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of mip-1-alpha binding to its ccr1 receptor
US6207665B1 (en) 1997-06-12 2001-03-27 Schering Aktiengesellschaft Piperazine derivatives and their use as anti-inflammatory agents
AU2331999A (en) 1998-01-21 1999-08-09 Kyowa Hakko Kogyo Co. Ltd. Chemokine receptor antagonists and methods of use therefor
CA2318088A1 (en) 1998-01-21 1999-07-29 Yoshisuke Nakasato Chemokine receptor antagonists and methods of use therefor
UA57824C2 (uk) 1998-02-05 2003-07-15 Пфайзер Продактс Інк. Похідні дигідроксигексанової кислоти, фармацевтична композиція, що їх містить (варіанти), та спосіб лікування (варіанти)
EP1000626A1 (de) 1998-09-18 2000-05-17 Applied Research Systems ARS Holding N.V. Kombination von chemokin-rezeptor antagonisten und cyclosporin zur therapie
CA2360672A1 (en) 1999-01-29 2000-08-03 Wayne W. Hancock Methods for preventing graft rejection and ischemia-reperfusion injury

Also Published As

Publication number Publication date
CA2417636A1 (en) 2002-02-07
LV13033B (en) 2004-02-20
EP1305047B1 (de) 2006-06-21
HUP0300686A2 (hu) 2003-08-28
US6740636B2 (en) 2004-05-25
AU2001278073B2 (en) 2005-06-30
HUP0300686A3 (en) 2005-03-29
EE200300047A (et) 2004-10-15
SK1222003A3 (en) 2003-09-11
CY1105321T1 (el) 2010-03-03
PT1305047E (pt) 2006-11-30
YU6703A (sh) 2006-05-25
SI21123A (sl) 2003-08-31
US20020039997A1 (en) 2002-04-04
EP1305047A2 (de) 2003-05-02
BG107502A (en) 2003-07-31
DK1305047T3 (da) 2006-10-23
AU7807301A (en) 2002-02-13
NO20030475L (no) 2003-03-28
CN1655818A (zh) 2005-08-17
PL364521A1 (en) 2004-12-13
IL153933A0 (en) 2003-07-31
ES2261447T3 (es) 2006-11-16
NO20030475D0 (no) 2003-01-30
WO2002009762A2 (en) 2002-02-07
BR0113140A (pt) 2003-06-24
WO2002009762A3 (en) 2003-01-09
ATE330634T1 (de) 2006-07-15
KR20030048000A (ko) 2003-06-18
DE60120986D1 (de) 2006-08-03
DE60120986T2 (de) 2006-11-23
NZ523688A (en) 2005-04-29
MXPA03000836A (es) 2003-06-06
JP2004530630A (ja) 2004-10-07

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