ATE330945T1 - Verfahren zur herstellung von aliphatischen carboxylatenmit piperazinsubstituenten - Google Patents
Verfahren zur herstellung von aliphatischen carboxylatenmit piperazinsubstituentenInfo
- Publication number
- ATE330945T1 ATE330945T1 AT00947505T AT00947505T ATE330945T1 AT E330945 T1 ATE330945 T1 AT E330945T1 AT 00947505 T AT00947505 T AT 00947505T AT 00947505 T AT00947505 T AT 00947505T AT E330945 T1 ATE330945 T1 AT E330945T1
- Authority
- AT
- Austria
- Prior art keywords
- piperazine
- alkyl
- carboxylate
- substituted aliphatic
- substituted
- Prior art date
Links
- 150000007942 carboxylates Chemical class 0.000 title abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical group C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 aliphatic carboxylate Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001767 cationic compounds Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 229910001411 inorganic cation Inorganic materials 0.000 abstract 1
- 150000002892 organic cations Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/421,514 US6239277B1 (en) | 1999-10-20 | 1999-10-20 | Process for preparing piperazine-substituted aliphatic carboxylates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE330945T1 true ATE330945T1 (de) | 2006-07-15 |
Family
ID=23670848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00947505T ATE330945T1 (de) | 1999-10-20 | 2000-07-19 | Verfahren zur herstellung von aliphatischen carboxylatenmit piperazinsubstituenten |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6239277B1 (de) |
| EP (1) | EP1222179B1 (de) |
| AT (1) | ATE330945T1 (de) |
| DE (1) | DE60028990T2 (de) |
| WO (1) | WO2001029016A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1487810B9 (de) * | 2002-03-27 | 2011-02-23 | Sun Pharma Advanced Research Company Limited | 4-(diarylmethyl)-1-piperazinyl-derivate |
| AU2003237394A1 (en) * | 2002-06-05 | 2003-12-22 | Dr. Reddy's Laboratories Limited | Crystalline (2-(4-((4-chlorophenyl)-phenyl methyl)-1-piperazinyl) ethoxy) acetic acid dihydrochloride |
| SI22489A (sl) * | 2007-03-12 | 2008-10-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek za pripravo levocetirizina in njegovih intermediatov |
| EP2121643B1 (de) | 2007-03-12 | 2013-10-23 | Krka, tovarna zdravil, d.d., Novo mesto | Neues verfahren zur herstellung von levocetirizin und zwischenprodukte davon |
| WO2009150147A1 (en) * | 2008-06-11 | 2009-12-17 | Krka, Tovarna Zdravil, D.D., Novo Mesto | New process for the preparation of levocetirizine and intermediates thereof |
| US20110172425A1 (en) * | 2008-09-17 | 2011-07-14 | Calyx Chemicals And Pharmaceuticals Pvt. Ltd. | Novel water based process for the preparation of substituted diphenylmethyl piperazines |
| CN113861131B (zh) * | 2021-11-08 | 2024-04-19 | 深圳菲斯生物科技有限公司 | 一种西替利嗪杂质c的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO155805C (no) * | 1981-02-06 | 1987-06-10 | Ucb Sa | Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter. |
| BE1010095A3 (fr) * | 1996-04-10 | 1997-12-02 | Ucb Sa | Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels. |
| IL124195A (en) * | 1998-04-23 | 2000-08-31 | Chemagis Ltd | Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid |
-
1999
- 1999-10-20 US US09/421,514 patent/US6239277B1/en not_active Expired - Fee Related
-
2000
- 2000-07-19 AT AT00947505T patent/ATE330945T1/de not_active IP Right Cessation
- 2000-07-19 EP EP00947505A patent/EP1222179B1/de not_active Expired - Lifetime
- 2000-07-19 WO PCT/US2000/019625 patent/WO2001029016A1/en not_active Ceased
- 2000-07-19 DE DE60028990T patent/DE60028990T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1222179B1 (de) | 2006-06-21 |
| US6239277B1 (en) | 2001-05-29 |
| DE60028990D1 (de) | 2006-08-03 |
| WO2001029016A1 (en) | 2001-04-26 |
| DE60028990T2 (de) | 2007-02-01 |
| EP1222179A1 (de) | 2002-07-17 |
| EP1222179A4 (de) | 2003-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |