ATE305462T1 - Verfahren zur herstellung piperazin- substituierter carboxylate - Google Patents
Verfahren zur herstellung piperazin- substituierter carboxylateInfo
- Publication number
- ATE305462T1 ATE305462T1 AT00948797T AT00948797T ATE305462T1 AT E305462 T1 ATE305462 T1 AT E305462T1 AT 00948797 T AT00948797 T AT 00948797T AT 00948797 T AT00948797 T AT 00948797T AT E305462 T1 ATE305462 T1 AT E305462T1
- Authority
- AT
- Austria
- Prior art keywords
- piperazine
- alkyl
- carboxylate
- substituted aliphatic
- substituted
- Prior art date
Links
- 150000007942 carboxylates Chemical class 0.000 title abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical group C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 aliphatic carboxylate Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001767 cationic compounds Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 229910001411 inorganic cation Inorganic materials 0.000 abstract 1
- 150000002892 organic cations Chemical class 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/429,660 US6265579B1 (en) | 1999-10-29 | 1999-10-29 | Process for preparing piperazine-substituted aliphatic carboxylates |
| PCT/US2000/019713 WO2001032641A1 (en) | 1999-10-29 | 2000-07-19 | Process for preparing piperazine-substituted aliphatic carboxylates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE305462T1 true ATE305462T1 (de) | 2005-10-15 |
Family
ID=23704198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00948797T ATE305462T1 (de) | 1999-10-29 | 2000-07-19 | Verfahren zur herstellung piperazin- substituierter carboxylate |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6265579B1 (de) |
| EP (1) | EP1233955B1 (de) |
| AT (1) | ATE305462T1 (de) |
| DE (1) | DE60022898T2 (de) |
| WO (1) | WO2001032641A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002325355B8 (en) * | 2001-07-26 | 2007-10-25 | Ucb | Process for the preparation of 2-(2-(4-BIS(4-fluorophenyl)methyl-piperazin-1-YL)ethoxy)acetic acid derivatives or corresponding salt forms thereof and intermediates therefor |
| KR100503443B1 (ko) * | 2004-02-02 | 2005-07-22 | 한림제약(주) | 광학적으로 활성인 세티리진 또는 그의 염의 제조방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH619450A5 (de) * | 1976-01-15 | 1980-09-30 | Sandoz Ag | |
| FI75816C (fi) * | 1981-02-06 | 1988-08-08 | Ucb Sa | Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid. |
| GB8827390D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
| ATE178896T1 (de) * | 1993-02-25 | 1999-04-15 | Hoffmann La Roche | Verfahren zur herstellung von oxazolderivaten |
-
1999
- 1999-10-29 US US09/429,660 patent/US6265579B1/en not_active Expired - Fee Related
-
2000
- 2000-07-19 EP EP00948797A patent/EP1233955B1/de not_active Expired - Lifetime
- 2000-07-19 WO PCT/US2000/019713 patent/WO2001032641A1/en not_active Ceased
- 2000-07-19 DE DE60022898T patent/DE60022898T2/de not_active Expired - Fee Related
- 2000-07-19 AT AT00948797T patent/ATE305462T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1233955B1 (de) | 2005-09-28 |
| DE60022898D1 (de) | 2005-11-03 |
| US6265579B1 (en) | 2001-07-24 |
| EP1233955A4 (de) | 2002-11-20 |
| EP1233955A1 (de) | 2002-08-28 |
| DE60022898T2 (de) | 2006-07-06 |
| WO2001032641A1 (en) | 2001-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |